Month: September 2021

Reference of 4442-79-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4442-79-9 as follows.

General procedure: To a solution of Ph3P(OAc)2, was added 3-phenylpropanol (1 mmol, 0.137 mL). The progress of the reaction was monitored by TLC (Table 3, entry 2). After completion of the reaction (0.3 h) the reaction mixture was filtered to remove the precipitated NH4Br followed by evaporation of the solvent. Column chromatography of the crude mixture on silica gel using n-hexane/EtOAc (3:1) as the eluent gave 3-phenylpropyl acetate in 90% yield (0.159 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4442-79-9, its application will become more common.

Reference:
Article; Iranpoor, Nasser; Firouzabadi, Habib; Elham, Etemadi Davan; Tetrahedron Letters; vol. 54; 14; (2013); p. 1813 – 1816;,
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Electric Literature of 932-01-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, molecular weight is 128.21, as common compound, the synthetic route is as follows.

N,N’-carbonyldiimidazole (118 mg) was added to a mixture of 4,4-dimethylcyclohexanol (72 mg) and acetonitrile (7 ml). The reaction mixture was stirred at 45C for 1 hour, added with water and chloroform and washed with water. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. The product (190 mg) of the above (2), triethylamine (0.21 ml), 4-dimethylaminopyridine (10 mg) and DMF (5 ml) were added to the residue and the reaction mixture was heated at 80C for 1 hour. The reaction mixture was evaporated under reduced pressure, and water and chloroform were added thereto. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent: hexane/ethyl acetate = 100/0 to 0/100 gradient) to obtain 135 mg of 4,4-dimethylcyclohexyl (S)-3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-piperidine-1-carboxylate.

Statistics shows that 932-01-4 is playing an increasingly important role. we look forward to future research findings about 4,4-Dimethylcyclohexanol.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2277861; (2011); A1;,
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Related Products of 178312-48-6 ,Some common heterocyclic compound, 178312-48-6, molecular formula is C7H12F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The above (4, 4-difluorocyclohexyl) methanol was dissolved in 5 ml of pyridine. Thereto 2.2 g of p- toluenesulfonyl chloride was added at 0C and the mixture was stirred at room temperature overnight. Thereafter, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed successively with water, dilute hydrochloric acid and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 3.1 g of 4, 4- difluorocyclohexylmethyl p-toluenesulfonate. 4, 4-Difluorocyclohexylmethyl p-toluenesulfonate: lH-NMR (CDC13, TMS) 5 (ppm): 1.18-1. 37 (2H, m), 1.56-1. 86 (5H, m), 2.00-2. 17 (2H, br), 2.46 (3H, s), 3. 86 (2H, d), 7. 35 (2H, d), 7.78 (2H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178312-48-6, (4,4-Difluorocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2005/63694; (2005); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 623-50-7, name is Ethyl 2-hydroxyacetate, the common compound, a new synthetic route is introduced below. Safety of Ethyl 2-hydroxyacetate

Step 1; Benzyloxy-acetic acid ethyl ether; 1 1 5 g of ethyl glycolate is dissolved in 120 ml of dry THF under an atmosphere of nitrogen and cooled to 0 4 9 g of sodium hydride is added portionwise over 40 minutes and the reaction mixture stirred at 0 for 15 minutes and then 4 3 g of tetrabutylammonium iodide is added followed by 13 3 ml of benzyl bromide The mixture allowed to warm to RT and stirred for 3 hours The reaction then quenched with 20 ml of a saturated aqueous ammonium chloride solution and the THF then removed in vacuo The residue is partitioned between EtOAc (100 ml) and H2O (150 ml) The aqueous then extracted twice with EtOAc and the combined EtOAc extracts washed with 50 ml brine then dried over magnesium sulfate, filtered and the solvent evaporated The residue is purified by flash chromatography on silica eluting with a 19 1 /so-hexane/diethyl ether to 4 1 /so-hexane/diethyl ether mixture to yield the title compound

The synthetic route of 623-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; WO2009/106539; (2009); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17100-64-0, name is (4-Bromo-3-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of (4-Bromo-3-methoxyphenyl)methanol

4-Bromo-3-methoxybenzyl alcohol (2l.7 g, 0.l m) dissolved in toluene (200 ml) containing pyridine (ll.8 g, 0.l5 m) is stirred at 5° and treated with thionyl chloride (23.8 g, 0.2 m). The mixture is stirred, diluted with water and the organic layer washed with dilute hydrochloric acid, dried and concentrated in vacuo to give 4-bromo-3-methoxybenzyl chloride.

With the rapid development of chemical substances, we look forward to future research findings about 17100-64-0.

Reference:
Patent; SMITHKLINE BECKMAN CORPORATION; EP244088; (1989); A3;,
Alcohol – Wikipedia,
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Electric Literature of 5020-41-7 ,Some common heterocyclic compound, 5020-41-7, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5020-41-7, 2-(3-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
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Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, blongs to alcohols-buliding-blocks compound. name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol

Method A – From US 3,932,415 7,7′-Methylenebis(2,3,6,7-tetrahydrobenzo[i,j]quinolizine-8,8′-diol)Hydrochloric acid (0.8 cm3, 32%) was added drop wise to a solution of 8-hydroxyjulolidine (3.00 g, 15.9 mmol) in methanol (16 cm3) at 5C. Formalin (0.593 cm3, 40% in water) was then added to the reaction and the resulting mixture was allowed to stand overnight at 5C. The mixture was then poured into water (50 cm3) before being neutralised with a saturated solution of sodium bicarbonate. The mixture was extracted with chloroform (3 x 40 cm3), the combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (3:7 ethyl acetate/hexane) gave the target material as a colourless solid (2.11 g, 68%).deltaH (250 MHz, CDCI3): 6.68 (2H, s, CH), 3.64 (2H, s, CH2), 3.00 (8H, t, J1 = 6 Hz, CH2), 2.67 (4H, J1 = 6 Hz, CH2), 2.60 (4H1 1, J2 = 7 Hz1 CH2), 1.97 – 1.90 (8H, m, CH2); deltac (100 MHz, CDCI3): 149.3, 142.7, 127.6, 114.6, 114.5, 108.5, 50.2, 49.4, 30.9, 27.0, 22.5, 21.7, 21.2; vmax (KBr)/cm 1: 3431 , 2927, 2853, 2842, 1618, 1494, 1450, 1350, 1332, 1310, 1281 , 1270, 1153, 1132; m/z (ESI): 389.3 (100%, [M-H]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, and friends who are interested can also refer to it.

Reference:
Patent; WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel; WO2010/67078; (2010); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

[0382] N-Cyclohexyl N-Methyl-2E,6E,10E-Geranylgeranyl amine (17a): To a dry reaction flask equipped with stir bar, N2 in let was placed alcohol 1 (0.145g, 0.5 mmol), t riphenylphosphine (0.196g, 0.75 m mol) and N-methylcyclohexylam ine (0.065 m L, 0.5 m mol) in anhydrous THF (1 mL). The reaction was cooled to 0 C and to it was added DIAD (0.151 g, 0.75 m mol) drop wise and the resu lting reaction was stirred at room temperatu re for overnight (~16h). After quenching it with H20 (5 m L), it was extracted with DCM (2 x 10 m L), dried over anhydrous sodiu m su lfate and the solvent was removed under a reduced pressure. The resu lting residue was chromatographed over silica gel using n-hexane and then 2-5% EtOAc in n-hexane to afford the desired amine 17a, yield : 0.072g (38%). LCMS: MS (m/z): 408.4 (M+N a).

With the rapid development of chemical substances, we look forward to future research findings about 24034-73-9.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below., SDS of cas: 24034-73-9

[0287] 2E, 6E, 10E-Geranylgeranyl acetate (2a) (R= Methyl): A dry reaction flask equipped with a stir bar and N2 inlet was charged with Geranylgeranyl alcohol 1 (0.087 g, 0.3 mmol), triethyl amine (0.062 m L, 0.45 mmol) and dichloromethane, DCM (1 mL) and cooled to 0 C. To it was added acetyl chloride (1M solution in DCM, 0.42 mL, 0.042 mmol) drop-wise and the resulting reaction was stirred at room temperature for overnight, ~24h. The reaction was quenched with aqueous IMaHC03 solution, extracted with DCM (3 x 20 mL), the DCM extract was washed with water (20 mL), dried over anhydrous Na2S04 and solvent was evaporated u nder a reduced pressure. The resulting oily residue was purified by a silica gel colum n chromatography using n-hexa nes to 1-2% EtOAC in n-hexanes to afford a colorless liq u id of ester 2a. Yield : 0.059 mg (60%); TLC Rf: 0.58 (10% EtOAc/n-Hexanes); LCMS: MS ( m/z): 333.4 (M+H); Ret. Time: 14.13 minutes.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 96-35-5, name is Methyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Methyl 2-hydroxyacetate

[00382] Step A: Preparation of 4-oxotetrahvdrofuran-3-carbonitrile: To a suspension of KOtBu (996.6 mg, 8.881 mmol) in THF (640.4 mg, 8.881 mmol) cooled to 0 C was added dropwise methyl 2-hydroxyacetate (675.7 iL, 8.881 mmol) and stirred for 10 minutes. The acrylonitrile (589.1 mu, 8.881 mmol) was then added and the reaction stirred at ambient temperature. After 3 hours, the reaction was diluted with H20 (50 mL), then extracted with Et20 (25 mL) to remove any starting ester. The basic aqueous phase was acidified with 2M HC1 (5 mL), then extracted with Et20 (2 x 50 mL). The combined organic phases were dried with MgS04, filtered, and concentrated to afford a light brown oil (446 mg, 45.2% yield). 1H NMR (CDC13) delta 4.63 (t, 1H), 4.24 (t, 1H), 4.14 (d, 1H), 4.02 (d, 1H), 3.57 (t, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 96-35-5.

Reference:
Patent; ARRAY BIOPHARMA INC.; BRANDHUBER, Barbara, J.; JIANG, Yutong; KOLAKOWSKI, Gabrielle, R.; WINSKI, Shannon, L.; WO2014/78322; (2014); A1;,
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