Tag: M.W=50-100

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Safety of Oxetan-3-ol

Wu, Hongxiang;Guo, Weijie;Daniel, Stelck;Li, Yue;Liu, Chao;Zeng, Zhuo research published 《 Fluoride-Catalyzed Esterification of Amides》, the research content is summarized as follows. A new method was designed for fluoride-catalyzed activation of secondary and primary amides. This method was enabled the synthesis of esters I [R¹ = Ph, 2-thienyl, cyclohexyl, etc.; R² = n-hexyl, CH₂-2-furyl, 3-oxetanyl, etc.] from a wide range of amides using fluoride as a catalyst and alc. as a nucleophiles. This method was showing high functional group tolerance and notably it requires only a slight excess of the alc. nucleophile, which was a rare case in transition-metal-free amide transformations. This approach might provide a new understanding for further studies on esterification of amides and was expected to stimulate the development of alternative methods for direct functionalization of amides.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Product Details of C3H6O

Wang, Jia-Xin;Ge, Wei;Fu, Ming-Chen;Fu, Yao research published 《 Photoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition》, the research content is summarized as follows. Herein, a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes ArC(CF₃):CH₂ (Ar = 4-BrC₆H₄, naphthalen-2-yl, 6-methoxypyridin-3-yl, etc.) enabled by intermol. alkoxycarbonyl radical addition is disclosed. A wide variety of alc. oxalate derivatives ROC(O)CO₂H (R = Me, t-Bu, cyclopentyl, L-menthyl, N-Boc-piperidin-4-yl, etc.) was amenable, affording various β-gem-difluoroalkene esters ArC(:CF₂)CH₂COOR with excellent functional group tolerance. Notably, the potential synthetic value of this method is highlighted by successful late-stage modification for bioactive mols.

Product Details of C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Wang, Le;Pratt, John K.;Soltwedel, Todd;Sheppard, George S.;Fidanze, Steven D.;Liu, Dachun;Hasvold, Lisa A.;Mantei, Robert A.;Holms, James H.;McClellan, William J.;Wendt, Michael D.;Wada, Carol;Frey, Robin;Hansen, T. Matthew;Hubbard, Robert;Park, Chang H.;Li, Leiming;Magoc, Terrance J.;Albert, Daniel H.;Lin, Xiaoyu;Warder, Scott E.;Kovar, Peter;Huang, Xiaoli;Wilcox, Denise;Wang, Rongqi;Rajaraman, Ganesh;Petros, Andrew M.;Hutchins, Charles W.;Panchal, Sanjay C.;Sun, Chaohong;Elmore, Steven W.;Shen, Yu;Kati, Warren M.;McDaniel, Keith F. research published 《 Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors》, the research content is summarized as follows. Members of the BET family of bromodomain containing proteins have been identified as potential targets for blocking proliferation in a variety of cancer cell lines. A 2-dimensional NMR fragment screen for binders to the bromodomains of BRD4 identified a Ph pyridazinone fragment with a weak binding affinity (I, K_i = 160 μM). SAR investigation of fragment I, aided by X-ray structure-based design, enabled the synthesis of potent pyridone and macrocyclic pyridone inhibitors exhibiting single digit nanomolar potency in both biochem. and cell based assays, e.g. II. Advanced analogs in these series exhibited high oral exposures in rodent PK studies and demonstrated significant tumor growth inhibition efficacy in mouse flank xenograft models.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Synthetic Route of 7748-36-9

Wang, Xueqin;Xu, Ruiqiu;Zhang, Pang research published 《 Synthesis of 3-hydroxyoxetane and the Finkelstein reaction of its p-toluenesulfonate with sodium iodide》, the research content is summarized as follows. Successive tosylation and benzoylation of HOCH₂CH(OCH₂Ph)CH₂OH gave PhCO₂CH₂CH(OCH₂Ph)CH₂OTs (Ts = p-tosyl), which was cyclized with MeONa in boiling MeOH to give I (R = PhCH₂) (II) in 30% overall yield. Catalytic hydrogenolysis of II gave 90% title compound (I; R = H), which was tosylated to give 86% I (R = Ts) (III). III underwent a slower Finkelstein reaction with NaI than 1,3-di-O-methylglycerol p-tosylate due to the electron-withdrawing inductive effect of the ring O atom.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. SDS of cas: 7748-36-9

Wang, Yang;Hong, Lei;Tapriyal, Deepak;Kim, In Chul;Paik, Ik-Hyeon;Crosthwaite, Jacob M.;Hamilton, Andrew D.;Thies, Mark C.;Beckman, Eric J.;Enick, Robert M.;Johnson, J. Karl research published 《 Design and Evaluation of Nonfluorous CO₂-Soluble Oligomers and Polymers》, the research content is summarized as follows. Ab initio mol. modeling is used to design nonfluorous polymers that are potentially soluble in liquid CO₂. We have used calculations to design three nonfluorous compounds meant to model the monomeric repeat units of polymers that exhibit multiple favorable binding sites for CO₂. These compounds are methoxy iso-Pr acetate, 2-methoxy ethoxy-propane, and 2-methoxy methoxy-propane. We have synthesized oligomers or polymers based on these small compounds and have tested their solubility in CO₂. All three of these exhibit appreciable solubility in CO₂. At 25°C, oligo(3-acetoxy oxetane)₆ is 5 weight % soluble at 25 MPa, the random copolymer (vinyl methoxymethyl ether₃₀-co-vinyl acetate₉) is 5 weight % soluble at 70 MPa and random copolymer (vinyl 1-methoxyethyl ether₃₀-co-vinyl acetate₉) is 3 weight % soluble at 120 MPa. These oligomers and polymers represent new additions to the very short list of nonfluorous CO₂-soluble polymers. However, none of these are more soluble than poly(vinyl acetate), which exhibits the highest CO₂ solubility of any known polymer containing only the elements C, H, and O.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Cyclopropanol

Wang, Yanmei;Wei, Jie;Cao, Ling;Zhang, Bing;Zhang, Song research published 《 The ultrafast nonradiative processes and photodissociation dynamics investigation of S₁ state in propanal》, the research content is summarized as follows. The ultrafast nonradiative dynamics in the S1 electronic excited state and the corresponding photodissociation dynamics in propanal mols. have been studied with time-resolved photoelectron imaging and time-of-flight mass spectrometry at an excitation wavelength of 320 nm. The population of the S₁ state undergoes ultrafast internal conversion (IC) to the highly vibrationally hot S₀ state in a timescale of <100 fs and nonradiative deactivation by intersystem crossing (ISC) to triplet T₁ state occurring with a time constant of about several hundreds of femtoseconds. The ISC process is then followed by the dissociation on the T¹ surface because the excitation energy is higher than the dissociation barrier along the C-C(HO) bond length coordinate. The dissociation product of the CHO radical has an appearance time of about 540 fs, which agrees well with the measured ISC relaxation time constant of 430 fs. The CO mol. is proposed to form at about 170 fs after the excitation, supporting the dissociation mechanism via the mol. channel following the IC decay of the S₁ state. The energy of the first excited electronic state of the C₃H₆O⁺ is obtained to be 12.25 eV. (c) 2022 American Institute of Physics.

Safety of Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Application of C3H6O

Ueoka, Reiko;Bortfeld-Miller, Miriam;Morinaka, Brandon I.;Vorholt, Julia A.;Piel, Joern research published 《 Toblerols: cyclopropanol-containing polyketide modulators of antibiosis in Methylobacteria》, the research content is summarized as follows. Trans-AT polyketide synthases (PKSs) are a family of biosynthetically versatile modular type I PKSs that generate bioactive polyketides of impressive structural diversity. In this study, we detected, in the genome of several bacteria a cryptic, architecturally unusual trans-AT PKS gene cluster which eluded automated PKS prediction. Genomic mining of one of these strains, the model methylotroph Methylobacterium extorquens AM1, revealed unique epoxide- and cyclopropanol-containing polyketides named toblerols. Relative and absolute stereochem. were determined by NMR experiments, chem. derivatization, and the comparison of CD data between the derivatized natural product and a synthesized model compound Biosynthetic data suggest that the cyclopropanol moiety is generated by carbon-carbon shortening of a more extended precursor. Surprisingly, a knock-out strain impaired in polyketide production showed strong inhibitory activity against other methylobacteria in contrast to the wild-type producer. The activity was inhibited by complementation with toblerols, thus suggesting that these compounds modulate an as-yet unknown methylobacterial antibiotic.

Application of C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: Cyclopropanol

van der Westhuyzen, Renier;Winks, Susan;Wilson, Colin R.;Boyle, Grant A.;Gessner, Richard K.;Soares de Melo, Candice;Taylor, Dale;de Kock, Carmen;Njoroge, Mathew;Brunschwig, Christel;Lawrence, Nina;Rao, Srinivasa P. S.;Sirgel, Frederick;van Helden, Paul;Seldon, Ronnett;Moosa, Atica;Warner, Digby F.;Arista, Luca;Manjunatha, Ujjini H.;Smith, Paul W.;Street, Leslie J.;Chibale, Kelly research published 《 Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration》, the research content is summarized as follows. High-throughput screening of a library of small polar mols. against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester hit compound I, which was optimized for metabolic stability by replacing the ester moiety with a Me oxadiazole bioisostere. A route utilizing polymer-supported reagents was designed and executed to explore structure-activity relationships with respect to the N-benzyl substituent, leading to compounds with nanomolar activity. The front runner compound II from these studies was well tolerated in mice. A M. tuberculosis cytochrome bd oxidase deletion mutant (ΔcydKO) was hyper-susceptible to compounds from this series, and a strain carrying a single point mutation in qcrB, the gene encoding a subunit of the menaquinol cytochrome c oxidoreductase, was resistant to compounds in this series. In combination, these observations indicate that this novel class of antimycobacterial compounds inhibits the cytochrome bc1 complex, a validated drug target in M. tuberculosis.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Recommanded Product: Cyclopropanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Name: Oxetan-3-ol

Vandenberg, E. J.;Mullis, J. C.;Juvet, R. S. Jr.;Miller, T.;Nieman, R. A. research published 《 Poly(3-hydroxyoxetane) – an analog of poly(vinyl alcohol): synthesis, characterization, and properties》, the research content is summarized as follows. The spontaneous polymer formed from 3-hydroxyoxetane (I) is linear, low-mol.-weight, water-soluble, atactic poly(3-hydroxyoxetane) (II) of high crystallinity with -OCH₂CH(OH)CH₂OH end units. The highly crystalline nature of II may be related to the crystalline nature of atactic poly(vinyl alc.) since I can be considered a copolymer of vinyl alc. and HCHO. Spontaneous II apparently is formed in a cationic polymerization by the carboxylic acids produced by the air oxidation of I on standing at room temperature for several months. The polymerization can be duplicated by the addition of 2% hydroxyacetic acid to I. The rate of this unusual cationic polymerization increases greatly with acid strength, e.g., trifluoromethanesulfonic acid reacts explosively with pure I. A mechanism is proposed for this cationic polymerization High-mol.-weight, water-soluble, linear, atactic, and highly crystalline II (m.p. = 155°) was made by polymerizing the trimethylsilyl ether of I with the iso-Bu₃Al-0.7H₂O cationic catalyst followed by hydrolysis. Two ¹H NMR methods for measuring the tacticity of II were developed based on finding two different types of methylene units at 400 MHz with the methine protons decoupled. Also, an ¹H-NMR method was developed for measuring branching in II. High-mol.-weight, linear II with enhanced isotacticity (80%) was obtained in low yield as a water-insoluble fraction with T_m = 223°. The low-mol.-weight II prepared previously by the base-catalyzed, rearrangement polymerization of glycidol is highly branched.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. HPLC of Formula: 16545-68-9

Vellakkaran, Mari;Kim, Taehwan;Hong, Sungwoo research published 《 Visible-Light-Induced C4-Selective Functionalization of Pyridinium Salts with Cyclopropanols》, the research content is summarized as follows. The site-selective C-H functionalization of heteroarenes is of considerable importance for streamlining the rapid modification of bioactive mols. A general strategy for visible-light-induced β-carbonyl alkylation at the C4 position of pyridines with high site selectivity using various cyclopropanols and N-amidopyridinium salts. In this process, hydrogen-atom transfer between the generated sulfonamidyl radicals and O-H bonds of cyclopropanols generates β-carbonyl radicals, provided efficient access to synthetically valuable β-pyridylated (aryl)ketones, aldehydes, and esters with broad functional-group tolerance. In addition, the mild method served as an effective tool for the site-selective late-stage functionalization of complex and medicinally relevant mols.

HPLC of Formula: 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts