Tag: M.W=50-100

Norris, Paul C. published the artcileResolvin D3 multi-level proresolving actions are host protective during infection, Product Details of C3H6O2, the publication is Prostaglandins, Leukotrienes and Essential Fatty Acids (2018), 81-89, database is CAplus and MEDLINE.

Resolution of infection and inflammation is governed by innate immune cells. The resolvin family of n-3 mediators produced by resolving exudates stimulates clearance of neutrophils and attenuates pro-inflammatory signals. Using metabololipidomics, endogenous resolvin D3 (RvD3) was identified in self-resolving exudates during active E. coli infection. Through a new, independent synthetic route for RvD3, we matched endogenous and synthetic RvD3 and determined that RvD3 (ng doses) potently reduced the resolution interval (R_i) by ∼4.5 h during E. coli peritonitis after administration at peak inflammation (T_max=12 h) and increased leukocyte phagocytosis of E. coli and neutrophils as well as reduced proinflammatory cytokines, chemokines, MMP-2 and MMP-9. At pM-nM concentrations, RvD3 also enhanced human macrophage efferocytosis and bacterial phagocytosis, increased neutrophil bacterial phagocytosis and intracellular ROS generation, and reduced human platelet-PMN aggregation. These results provide addnl. evidence for potent RvD3 immunoresolvent actions in host defense, host protection and antimicrobial defense.

Prostaglandins, Leukotrienes and Essential Fatty Acids published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Product Details of C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Verevkin, Sergey P. published the artcileEvaluation of vaporization thermodynamics of pure amino-alcohols, Quality Control of 96-20-8, the publication is Journal of Molecular Liquids (2021), 116568, database is CAplus.

The absolute vapor pressures of three amino-alcs. were measured using the transpiration method. The consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. Correlation of vaporization enthalpies with normal boiling temperatures was established. Vaporization enthalpies of amino-alcs. obey the group-additivity rules. The averaged values of vaporization enthalpies were recommended as reliable benchmark properties for the heat management of CO₂ capture technologies.

Journal of Molecular Liquids published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H16O2, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Verevkin, Sergey P. published the artcilePaving the way to the sustainable hydrogen storage: Thermochemistry of amino-alcohols as precursors for liquid organic hydrogen carriers, Name: 2-Aminobutan-1-ol, the publication is Journal of Chemical Thermodynamics (2021), 106610, database is CAplus.

The absolute vapor pressures of four amino-alcs. were measured using the transpiration method. A consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. The averaged values of vaporization enthalpies are recommended as reliable benchmark properties for thermochem. calculations of the energetics of chem. reactions including synthesis of alkyl-substituted pyrazines, compounds considered as seminal liquid organic hydrogen carriers (LOHC).

Journal of Chemical Thermodynamics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C17H14N2O2, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kurouchi, Hiroaki published the artcileControlling Selectivity by Controlling Energy Partitioning in a Thermal Reaction in Solution, HPLC of Formula: 20117-47-9, the publication is Journal of the American Chemical Society (2016), 138(44), 14534-14537, database is CAplus and MEDLINE.

The comparison of exptl. and predicted kinetic isotope effects in the α-cleavage of alkoxy radicals is used here to judge the applicability of statistical rate theories. It is found that the governing rate theory and the statistical vs. nonstatistical nature of the cleavage depend on the cleavage barrier and how much energy is imparted to the radical. The latter can then be controlled by changing the size of substituents in the system. With a large alkyl group substituent, the vibrational energy of the alkoxy radical is increased, but this energy is not statistically distributed, leading to a lower isotope effect than predicted by statistical theories. The observed isotope effect can be approx. rationalized using a semistatistical localized RRKM model.

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, HPLC of Formula: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kajanus, Johan published the artcilePotassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents, Name: (R)-Oxiran-2-ylmethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(10), 1241-1245, database is CAplus and MEDLINE.

Herein, synthesis and optimization of a novel series of 1,2-diarylethane-1,2-diamines with selectivity for Kv1.5 over other potassium ion channels is presented. The effective refractory period in the right atrium (RAERP) in a rabbit PD model was investigated for a selection of potent and selective compounds with balanced DMPK properties. The most advanced compound I showed nanomolar potency in blocking Kv1.5 in human atrial myocytes and based on the PD data, the estimated dose to man is 700 mg/day. As previously reported, compound I efficiently converted AF to sinus rhythm in a dog disease model.

Bioorganic & Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alstermark, Christer published the artcileSynthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABA_B) Receptor Agonists as Gastroesophageal Reflux Inhibitors, Product Details of C3H8FNO, the publication is Journal of Medicinal Chemistry (2008), 51(14), 4315-4320, database is CAplus and MEDLINE.

We have previously demonstrated that the prototypical GABA_B receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the most important mechanism for gastroesophageal reflux. Thus, GABA_B agonists could be exploited for the treatment of gastroesophageal reflux disease. However, baclofen, which is used as an antispastic agent, and other previously known GABA_B agonists can produce CNS side effects such as sedation, dizziness, nausea, and vomiting at higher doses. We now report the discovery of atypical GABA_B agonists devoid of classical GABA_B agonist related CNS side effects at therapeutic doses and the optimization of this type of compound for inhibition of TLESRs, which has resulted in a candidate drug (R)-7 (AZD3355)(I) that is presently being evaluated in man.

Journal of Medicinal Chemistry published new progress about 344413-79-2. 344413-79-2 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Fluorinated Building Blocks, name is (R)-3-Amino-2-fluoropropan-1-ol, and the molecular formula is C3H8FNO, Product Details of C3H8FNO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Fengqian published the artcileCopper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides, Product Details of C4H11NO, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202200062, database is CAplus and MEDLINE.

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions.

Angewandte Chemie, International Edition published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H6O3, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolli, Martin H. published the artcileNovel S1P₁ Receptor Agonists – Part 3: From Thiophenes to Pyridines, Application In Synthesis of 57044-25-4, the publication is Journal of Medicinal Chemistry (2014), 57(1), 110-130, database is CAplus and MEDLINE.

In preceding communications the authors summarized the authors’ medicinal chem. efforts leading to the identification of thiophene derivatives acting as potent, selective, and orally active S1P₁ agonists. As a continuation of these efforts, the authors replaced the thiophene by a 2-, 3-, or 4-pyridine and obtained less lipophilic, potent, and selective S1P₁ agonists (e.g., efficiently reducing blood lymphocyte count in the rat). Structural features influencing the compounds’ receptor affinity profile and pharmacokinetics are discussed. In addition, the ability to penetrate brain tissue has been studied for several compounds As a typical example for these pyridine based S1P₁ agonists, N-((S)-3-{4-[5-(2-Diethylamino-6-methylpyridin4-yl)[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide showed EC₅₀ values of 0.6 and 352 nM for the S1P₁ and S1P₃ receptor, resp., displayed favorable PK properties, and penetrated well into brain tissue. In the rat, N-((S)-3-{4-[5-(2-Diethylamino-6-methylpyridin4-yl)[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide maximally reduced the blood lymphocyte count for at least 24 h after oral dosing of 3 mg/kg.

Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Basu Baul, Tushar published the artcileSynthesis, characterization and structural systematics in diorganotin complexes with O,N,O’-tris-chelating semirigid diaza-scaffolds: Mono- vs. di-nuclear compounds, Synthetic Route of 96-20-8, the publication is Journal of Organometallic Chemistry (2020), 121522, database is CAplus.

Nine novel diorganotin(IV) complexes of O,N,O’ chelating ligands were synthesized viz., [Bu₂Sn(L²)]₂·0.25 (C₆H₁₄) (1), [Me₂Sn(L¹)]₂·(C₇H₈) (2), [Bu₂Sn(L¹)]₂·(C₇H₈) (3), [Me₂Sn(L³)]₂·(C₇H₈) (4), 2 [Bu₂Sn(L³)]₂·4 (Bu₂Sn(L³)) (5), [Ph₂Sn(L³)] (6), [Ph₂Sn(L¹)] (7), [Ph₂Sn(L⁴)] (8) and [Ph₂Sn(L²)] (9) and structurally characterized. The ligand scaffolds differ with respect to the chem. link between the coordinating N and O atoms, which is either an alkyl or an aryl moiety. Diffraction results indicate that the smallest Me groups favor dimerization via Sn-O-Sn bridging and six-coordination at the cation. Among these dinuclear derivatives, more asym. O bridges and longer Sn···Sn separations are found for the less nucleophilic phenolate O. In contrast, the bulky Ph substituents prevent aggregation for both classes of ligands and always lead to five-coordinated mononuclear species. The Bu groups are sterically more demanding than Me but flexible, resulting in an intermediate behavior. When the O,N,O’ ligand with phenolate O coordinates a SnBu₂ fragment, a borderline situation occurs and both mono- and dinuclear complexes coexist in the same crystalline solid. For better comparability the authors introduce a slightly modified geometry index τ’₅, in which the basal angle α is subtended by the organic substituents, regardless of its absolute value. τ’₅ represents a sensitive indicator for the coordination geometry about Sn^IV. Sn NMR results revealed that all compounds exist as mononuclear pentacoordinated species in solution

Journal of Organometallic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Basu Baul, Tushar S. published the artcileSynthesis and structural characterization of diorganotin(IV) complexes with heteroditopic pyridyl-ONO’-ligands, Application In Synthesis of 96-20-8, the publication is Inorganica Chimica Acta (2020), 119892, database is CAplus.

A series of eight novel diorganotin(IV) complexes with heteroditopic pyridyl-ONO’-ligands were prepared viz., [Me₂Sn(L¹)]₂·2(H₂O) (1), [n-Bu₂Sn(L¹)]₂ (2), [Ph₂Sn(L¹)] (3), [Me₂Sn(L²)]₂·2(H₂L²) (4), [n-Bu₂Sn(L²)]₂ (5), [Ph₂Sn(L²)]·0.5(C₆H₆) (6), [Me₂Sn(L³)]₂ (7) and [n-Bu₂Sn(L³)]₂ (8) and structurally characterized. Irresp. of the type of diazo L ligand, the dimethyl- and di-n-butyltin(IV) compounds are dinuclear species with an inversion center in the middle of the {Sn₂O₂} cores affording metals with coordination number six. The mononuclear compounds 3 and 6, with the bulky Ph ligands, present the tin cations with highly distorted square pyramid geometries. The detection of a conformation in the (Lⁿ)^2- ligand in the solid state structures of 3, 4 and 8 which is different from the one in the remaining compounds suggests that the packing of the mols. conceivably have a greater influence than the imine substituents or the metal co-ligands. The solution ¹H and ¹³C NMR of compounds 4–6 displayed an anisochronous behavior of dimethyl-, di-n-butyl- and diphenyltin parts while those of compounds 1–3 are isochronous. The ¹¹⁹Sn NMR chem. shift displacements of all the compounds are indicative of five-coordinate tin atoms, thus revealing dissociation in solution of the dinuclear 1, 2, 4, 5, 7 and 8 complexes.

Inorganica Chimica Acta published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts