Tag: M.W=50-100

Aubineau, Thomas published the artcileA One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines, SDS of cas: 96-20-8, the publication is Organic Letters (2018), 20(23), 7419-7423, database is CAplus and MEDLINE.

The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcs. under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Simond, Mickael published the artcileExcess Molar Enthalpies of Water + Primary Alkanolamines with a Common N-C-C-O Skeleton, Name: 2-Aminobutan-1-ol, the publication is Journal of Chemical & Engineering Data (2021), 66(11), 4206-4214, database is CAplus.

The excess molar enthalpies of binary mixtures of 2-amino-ethan-1-ol (MEA) and 1-aminopropane-2-ol (MIPA), 2-amino-butan-1-ol (ABU), and 2-amino-2-methyl-propan-1-ol (AMP) with water were measured vs. temperatures from 318.15 to 393.15 K and at a pressure of 0.5 MPa. The Redlich-Kister equation was used to fit the exptl. data and to estimate the molar enthalpies of alkanolamine and water at infinite dilution The effect of the substitution of alkyl groups on the carbon of the hydroxyl function is discussed on the basis of mol. simulation results published on alkanolamines earlier.

Journal of Chemical & Engineering Data published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C14H14N2O2, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Punt, Philip M. published the artcileTailored Transition-Metal Coordination Environments in Imidazole-Modified DNA G-Quadruplexes, Computed Properties of 57044-25-4, the publication is Chemistry – A European Journal (2019), 25(61), 13987-13993, database is CAplus and MEDLINE.

Two types of imidazole ligands were introduced both at the end of tetramol. and into the loop region of unimol. DNA G-quadruplexes. The modified oligonucleotides were shown to complex a range of different transition-metal cations including Ni^II, Cu^II, Zn^II and Co^II, as indicated by UV/Vis absorption spectroscopy and ion mobility mass spectrometry. Mol. dynamics simulations were performed to obtain structural insight into the investigated systems. Variation of ligand number and position in the loop region of unimol. sequences derived from the human telomer region (htel) allows for a controlled design of distinct coordination environments with fine-tuned metal affinities. It is shown that Cu^II, which is typically square-planar coordinated, has a higher affinity for systems offering four ligands, whereas Ni^II prefers G-quadruplexes with six ligands. Likewise, the positioning of ligands in a square-planar vs. tetrahedral fashion affects binding affinities of Cu^II and Zn^II cations, resp. Gaining control over ligand arrangement patterns will spur the rational development of transition-metal-modified DNAzymes. Furthermore, this method is suited to combine different types of ligands, for example, those typically found in metalloenzymes, inside a single DNA architecture.

Chemistry – A European Journal published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Computed Properties of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yongchen published the artcileSynthesis of the C50 diastereomers of the C33-C51 fragment of stambomycin D, HPLC of Formula: 57044-25-4, the publication is Organic Chemistry Frontiers (2022), 9(2), 445-449, database is CAplus.

Herein, syntheses of the two C50 diastereomers of the C33-C51 region of the stambomycins I and II, which support the polyketide synthase-based configurational assignment were described, and established a strategy suitable for access to the extended stambomycin framework.

Organic Chemistry Frontiers published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C33H22N4, HPLC of Formula: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zema, Zelalem Anja published the artcileTuning the CO₂ absorption and physicochemical properties of K⁺ chelated dual functional ionic liquids by changing the structure of primary alkanolamine ligands, Application of 2-Aminobutan-1-ol, the publication is Journal of Molecular Liquids (2021), 117983, database is CAplus.

To reveal the effects of the alkyl substitutions at alpha (α) or beta (β) position adjacent to amino group of primary alkanolamine ligands on CO₂ absorption and physicochem. properties of metal chelated dual functional ionic liquids (DFILs), four DFILs were prepared by reacting potassium imidazole salt (KIm) with alkanolamine ligands, including 2-amino-2-methyl-1-propanol (AMP), 2-amino-1-butanol (AMB), DL-1-amino-2-propanol (DLAMP), and monoethanolamine (MEA). CO₂ absorption behavior and mechanism of DFILs were studied, and d. (ρ), speed of sound (u), and viscosity (η) of DFILs were measured to correlate with the CO₂ absorption performance. DFT calculations were employed to explore the influence of the interactions between K⁺ and alkanolamine on the CO₂ absorption and physicochem. properties of DFILs. The results show that CO₂ capacity at 333.2 K is as follows: [K(AMP)₂][Im] > [K(AMB)₂][Im] > [K(DLAMP)₂][Im] > [K(MEA)₂][Im], indicating that the introduction of alkyl group at α or β position of alkanolamines can enhance CO₂ capacity, and the effect of the α position is more significant than the β position. Both ρ and u follow the order: [K(AMP)₂][Im] < [K(AMB)₂][Im] < [K(DLAMP)₂][Im] < [K(MEA)₂][Im], while η is in the reverse order. Moreover, the saturated CO₂ capacity of DFILs has an approx. linear relation with the thermal expansion coefficient DFT calculations show that the presence of the alkyl group at α or β position of alkanolamines reduces the Mulliken charge of N and O atom, thereby weakening the cation coordination interaction between K⁺ with ligand, resulting in the decrease in ρ and u of DFILs. Moreover, the decrease in the Mulliken charge of N and O atom in alkanolamine leads to the increase of chelated cation-[Im]^– interaction, thereby increasing η of DFILs. Consequently, [K(AMP)₂][Im] exhibits higher CO₂ capacity and good reversibility, due to the fact that CO₂ can react with the chelated cation and [Im]^– simultaneously. The present study provides a new method for effectively regulating the performance of DFILs.

Journal of Molecular Liquids published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C13H15NO6S, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Yugang published the artcileSynthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase, Application In Synthesis of 57044-25-4, the publication is Bioorganic & Medicinal Chemistry (2015), 23(20), 6632-6640, database is CAplus and MEDLINE.

Compounds I.HCl (ND-322) and II (ND-364) are potent selective inhibitors for gelatinases, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9). However, both of them are racemates. Herein the authors report facile synthesis of optically active (R)- and (S)-enantiomers of compounds I.HCl and II. And the sulfonyl of II was transformed to sulfinyl to obtain four epimeric mixtures All synthesized thiirane-based compounds were evaluated in MMP2 and MMP9 inhibitory assays. The results indicated that the configuration of thiirane moiety had little effects on gelatinase inhibition, but the substitution of sulfinyl for sulfonyl was detrimental to gelatinase inhibition. Besides, all target compounds exhibited no inhibition against other two Zn²⁺ dependent metalloproteases, aminopeptidase N (APN) and histone deacetylases (HDACs), which confirmed the unique Zn²⁺ chelation mechanism of thiirane moiety against gelatinases.

Bioorganic & Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C18H24N6O6S4, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Peng published the artcileIBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines, HPLC of Formula: 96-20-8, the publication is Journal of Organic Chemistry (2020), 85(12), 7939-7951, database is CAplus and MEDLINE.

An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alc., followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sengupta, Debasis published the artcileStudies on the Norrish type II reactions of aliphatic α-diketones and the accompanying cyclization and disproportionation of 1 : 4 biradicals, Safety of 1-Methylcyclobutan-1-ol, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (1993), 75(2), 151-62, database is CAplus.

The Norrish type II process of several alkyl diketones was examined using the AM1 semi-empirical MO method with complete geometry optimization at the CI level in the RHF frame. UHF calculations of the triplet state of the diketone lead to a decrease in symmetry and strong localization of excitation on one carbonyl. The results of RHF+CI reveal that diketones have much lower reactivities than monoketones and the barriers to conformational change in diketones play an important role in the triplet reaction. The cyclization and disproportionation reactions of the resulting 1:4 biradicals were studied in the UHF frame and the results were compared with those derived from alkyl monoketones. In many respects, the reactions of 1:4 biradicals derived from alkyl monoketones parallel those derived from diketones. The free valence indexes on the radical sites correlate qual. with the radical-like reactivities.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C16H25BO2, Safety of 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jadhav, Sandip B. published the artcileDiastereoselective Desymmetrization of p-Quinamines through Regioselective Ring Opening of Epoxides and Aziridines, SDS of cas: 57044-25-4, the publication is Organic Letters (2019), 21(24), 10115-10119, database is CAplus and MEDLINE.

A highly diastereoselective desymmetrization of p-quinamines via regioselective ring opening of epoxides and aziridines under mild conditions has been developed. A chairlike six-membered transition state with minimized 1,3-diaxial interactions explains the relative stereoselectivity of the cyclization reaction. This transition-metal free [3 + 3] annulation reaction provides rapid access to fused bicyclic morpholines and piperazines with a tetrasubstituted carbon center in high yields. In addition, it also allows the synthesis of enantioenriched products by using easily accessible chiral nonracemic epoxides and aziridines.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheuka, Peter Mubanga published the artcileNew Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase, Name: 2-Aminobutan-1-ol, the publication is ACS Infectious Diseases (2021), 7(1), 34-46, database is CAplus and MEDLINE.

Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated analogs and demonstrate that these compounds potently inhibit Plasmodium phosphatidylinositol-4-kinase (PI4K) type IIIβ while moderately inhibiting cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) activity in vitro. Using in silico docking, we predict key binding interactions for these analogs within the ATP (ATP)-binding site of PI4K and PKG, paving the way for structure-based optimization of imidazopyridazines targeting both Plasmodium PI4K and PKG. While several derivatives showed low nanomolar antiplasmodium activity (IC₅₀ < 100 nM), some compounds, including piperazine analog I, resulted in strong dual PI4K and PKG inhibition. The compounds also demonstrated transmission-blocking potential, evident from their potent inhibition of early- and late-stage gametocytes. Finally, the current compounds generally showed improved aqueous solubility and reduced hERG (human ether-a-go-go-related gene) channel inhibition.

ACS Infectious Diseases published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts