Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4249-72-3, name is 2-Phenoxy-1-phenylethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Phenoxy-1-phenylethanol

0.2 mmol of lignin template compound,20mg catalyst,1.5mL of methanol was added to the 25mL inflation tube,After the oxygen was replaced three times, it was reacted in an oil bath at 80 to 120 C for 12 to 24 hours.After the reaction was cooled, the catalyst and the reaction liquid were separated, and the organic phase was evaporated to remove the solvent.The starting materials and yields are shown in the table below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4249-72-3, 2-Phenoxy-1-phenylethanol.

Reference:
Patent; Nanjing University of Science and Technology; Lu Guoping; Sun Kangkang; (6 pag.)CN108821952; (2018); A;,
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Reference of 1611-56-9 , The common heterocyclic compound, 1611-56-9, name is 11-Bromoundecan-1-ol, molecular formula is C11H23BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3,4-Dihydro-2H-pyran (21.87 g, 260 mmol) was added dropwise to a solution of 11-bromoundecanol (50.24 g, 200 mmol) and toluene-4-sulphonic acid monohydrate (80 mg, 0.4 mmol) in dichloromethane (100 ml). The reaction mixture was stirred at room temperature. After 24 h, the brown solution was filtered over a thin layer of silica gel. The filtrate was concentrated on the rotary evaporator and dried under fine vacuum. 65.85 g (196 mmol, 98% yield) of a light yellowish oil was obtained. 1H-NMR (CDCl3, 400 MHz): delta=1.23-1.37 (m, 12H), 1.37-1.47 (m, 2H), 1.48-1.64 (m, 6H), 1.65-1.76 (m, 1H), 1.77-1.90 (m, 3H), 3.35-3.42 (m, 3H), 3.46-3.53 (m, 1H), 3.70-3.75 (m, 1H), 3.84-3.90 (m, 1H), 4.56-4.58 (m, 1H). 13C-NMR (CDCl3, 100.6 MHz): delta=19.7, 25.4, 26.2, 28.2, 28.8, 29.4, 29.5, 29.6, 29.8, 30.8, 32.9, 33.9, 62.3, 67.7, 98.8.

The synthetic route of 1611-56-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IVOCLAR VIVADENT AG; Moszner, Norbert; Lamparth, Iris; Bock, Thorsten; Fischer, Urs Karl; Salz, Ulrich; Rheinberger, Volker; Liska, Robert; US2014/329929; (2014); A1;,
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Synthetic Route of 83647-43-2 ,Some common heterocyclic compound, 83647-43-2, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step B: 5-Bromo-4-methyl-2-benzofuran-l(3H)-one: To a flask charged with (3-bromo-2- methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of ThalliumTrifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at RT. Analysis by LC showed a formation of product within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The solution was filtered through a celite pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to provide the title compound

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83647-43-2, (3-Bromo-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; PIO, Barbara; CHOBANIAN, Harry, R.; WO2013/62900; (2013); A1;,
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Reference of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

Example 500 2-Acetyl-5-(cyclopropylsulfamoyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydro-1H-isoindole-1-carboxamide DIPEA (0.162 mL, 0.92 mmol) was added to 2-acetyl-5-(cyclopropylsulfamoyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid (100 mg, 0.31 mmol), 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (88 mg, 0.34 mmol) and HATU (129 mg, 0.34 mmol) in DCM (5 mL) under nitrogen. The resulting solution was stirred at room temperature for 1 hour. The reaction mixture was quenched with saturated NH4C1 (20 mL), extracted with DCM (3*20 mL), the organic layer was dried over Na2SO4, filtered and evaporated to afford dark solid. The crude product was purified by flash silica chromatography, elution gradient 0 to 100percent EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford 2-acetyl-5-(cyclopropylsulfamoyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydro-1H-isoindole-1-carboxamide (40.0 mg, 22.94percent) as a colorless solid. LC/MS: m/z=566 [M+H]+. HRMS: calculated for (C23H21F6N3O5S+H)+566.1184. found (ESI [M+H]+) 566.1185. 1H NMR (400 MHz, DMSO-d6, mixture of rotamers, 4.5*:1) delta 0.36-0.54 (m, 4H), 1.99, 2.15*(s, 3H), 2.08-2.10 (m, 1H), 4.76-4.93, 5.00-5.09*(m, 2H), 5.71*, 5.91 (s, 1H), 7.61-7.70 (m, 3H), 7.71-7.82 (m, 3H), 7.84-7.92 (m, 1H), 8.00, 8.02*(d, 1H), 8.67*, 8.69 (s, 1H), 10.71*, 10.94 (s, 1H).

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; NARJES, Frank; OLSSON, Roine Ingemar; VON BERG, Stefan; LEVER, Sarah; (112 pag.)US2017/166527; (2017); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 722-92-9

To a solution of 4( 1 hydroxy-1 rifluoromethyl2,2,24ritiuoroethyl)aniline (60mg, 0.232 mmol) in CH2CI2 (2 mL) were successively added at RT N,Ndiisopropylethylamine (80 pL, 0.463 mmol) and 2chlorobenzoyl chloride (41 pL, 0.324 mmd). The mixture was stirred for 3 h and concentrated under reduce pressure. The crude residue was directly purified by cdumn chromatography on siNca gel without any workup by hexane/AcOEt (812) to obt&n 65 mg (71percent) 0 SR987 as a white powder: FTR cm1 3338. 3028, 1643, 1521, 1410; 1254. 1219, 1188, 1112, 968, 944, 826; 1H NMR (400 MHz, MeODd4) S =797 (t, J = 1.8 Hz, 1 H), 7.91 7.86 (m, I H), 7.85 7.80 (m, 2 H), 7.75 7.70 (m, 2 H),7.63 7.58 (m, I H), 7.51 (t, J 7.8 Hz, 1 H); 13C NMR (101 MHz, MeODd4) S = 167.5,141.5, 138.2, 135.9, 133.1, 131.4, 129.0 (2C), 128.9, 128.5, 127.3 (2C), 121.7 Thereare tree carbons msshg for the descdpton of SR1078. They correspond to the three carbons of the (1 hydroxy- 1 trmuoromethy2 2 ,24fiuoroethy) moety. The fluodne coupng with these carbons gkte muWpets that are very dUflcuft to see on the ?3C spectrum even with a proonged number of scans. HRMS (ES) m/z [M+H] c&cd for C16H10CF6NO2, 398.0377; found, 398.0395; Mp = 170A72C.

The synthetic route of 722-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; GRIFFIN, Patrick; KAMENECKA, Theodore; CHANG, Mi, Ra; DOEBELIN, Christelle; (58 pag.)WO2017/79120; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1H,1H,2H,2H-Nonafluoro-1-hexanol, blongs to alcohols-buliding-blocks compound. Quality Control of 1H,1H,2H,2H-Nonafluoro-1-hexanol

Maleic anhydride (17.2 g, 176 mmol), lH,lH,2H,2H,-perfluorohexanol (93.1 g, 353 mmol), /?-toluenesulfonyl hydroxide (/?-TsOH) (3.4 g, 17.6 mmol) and toluene (50OmL) were heated to reflux for 8 h. An additional amount ofp- TsOH (3.4 g, 17.6 mmol) was added after 4 h of reflux. The solution was stirred overnight at room temperature. The solution was diluted with ethyl acetate (50OmL) and washed three times with brine (25OmL each). The combined extracts were washed with a further washing of ethyl acetate (30OmL). The combined organics were dried over anhydrous MgStheta4 and concentrated to yield a colorless oil (85.8 g, 80% yield, 98% purity). The structure of the product was confirmed by 1H NMR and LC/MS as di(lH,lH,2H,2H-perfluorohexyl) maleate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, and friends who are interested can also refer to it.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; MURPHY, Peter, Michael; HEWAT, Tracy; WO2010/2623; (2010); A2;,
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Related Products of 6642-34-8 , The common heterocyclic compound, 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.31-0.53 mmol), alkyl acrylate (methyl, ethyl and tertiary butyl acrylate, or acrylo-nitrile) (1.55-2.67 mmol) and Cs2CO3 (0.62-1.07 mmol) followed by addition of toluene (2 mL) at room temperature under a nitrogen atmosphere. The stirred reaction mixture was heated in an oil bath at 50 C for 48 h. Progress of the Michael addition was monitored by TLC till the reaction is completed.GP-2 was followed to the alcohol 1f (100 mg, 0.43 mmol) with acrylonitrile (115 mg, 2.16 mmol) and Cs2CO3 (282 mg, 0.86 mmol) in toluene (2 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was heated in an oil bath at 50 C for 48 h.

The synthetic route of 6642-34-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
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Related Products of 149104-89-2 ,Some common heterocyclic compound, 149104-89-2, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of l-bromo-4-(bromomethyl)-2-methylbenzene [0164] To a solution of (4-bromo-3-methylphenyl)methanol (27.5 g, 136.8 mmol) in dichloromethane (250 mL) was added PPh3 (39.4 g, 150.5 mmol) and CBr4 (49.9 g, 150.5 mmol) and the mixture was stirred for 2 hrs at room temperature. Water was added. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by chromatography to give l-bromo-4- (bromomethyl)-2-methylbenzene (34 g, 94percent). 1H NMR (400 MHz, CDC13) delta 7.94- 7.92 (d, 1H), 7.70 (s, 1H), 7.53-7.51 (d, 1H), 4.86 (s, 2H), 2.83 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149104-89-2, its application will become more common.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; AKAMA, Tsutomu; PLATTNER, Jacob J.; WO2015/42532; (2015); A1;,
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Synthetic Route of 2077-19-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.

1.1 4-[4-(1-Hydroxy-1-methyl-ethyl)-benzoyl]-piperidine-1-carboxylic acid tert- butyl ester To a solution of 2-(4-bromo-phenyl)-propan-2-ol (5.00 g; 22.78 mmol) in THF (100 mL) under nitrogen atmosphere, n-butyl lithium (23 % in hexanes) (13.92 ml; 50.12 mmol) was added dropwise at -78 C and stirred for 15 min at the same temperature. A solution of 4-(methoxy-methyl-carbamoyl)-piperidine-1- carboxylic acid tert-butyl ester (6.96 g; 25.06 mmol) in THF ( 00 mL) was added dropwise at -78 C and stirred for 2 h at -78 C. The reaction mixture was stirred for 4 h at -78 C and quenched with saturated NH4CI solution (100 mL). The reaction mixture was extracted with ethyl acetate (2 x 100 mL). The combined extracts were washed with water (200 mL), brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography using silica gel (60-120) and petrol ether – ethyl acetate (1 :1) as gradient elution to afford the title compound (2.30 g; 29 %) as a pale yellow oil; H NMR (400 MHz, CDCI3) delta 7.92 (d, J = 8.48 Hz, 2H), 7.60 (d, J = 8.52 Hz, 2H), 5.18 (s, 1 H), 3.96 (d, J = 12.56 Hz, 2H), 3.63-3.57 (m, 1 H), 2.90 (s, 2H), 1.74 (d, J = 11.52 Hz, 2H), 1.43-1.38 (m, 17H); LC/MS (B), Rt: 4.50 min; (M+H-BOC) 248.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK PATENT GMBH; DORSCH, Dieter; BUCHSTALLER, Hans-Peter; WO2015/14442; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 397323-70-5, (2-Amino-3-bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 397323-70-5, blongs to alcohols-buliding-blocks compound. Formula: C7H8BrNO

Step 2.; The benzylic alcohol (3.56g, 17.7 mmol) was taken up in DCM (80 mL) and treated with manganese dioxide (35g). The heterogeneous mixture was stirred at room temp for Ih, filtered and concentrated to provide the aldehyde (3.27g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,397323-70-5, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; WO2007/11658; (2007); A1;,
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