Tag: M.W=200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

To a solution of A5 (147.6g, 0.71mol) in THF (3L) was added 60% NaH (28.4g, 0.71mol) at 0C, the resulting mixture was stirred at that temperature for 30min, was then added A3 (147g, 0.71mmol) quickly. The resulting mixture was heated under reflux overnight and evaporated. The residue was purified by column chromatography (PE:EA=4:1) to provide the advanced intermediate A6 (89.3g, 37.6%).

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
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Application of 7073-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.8 g (0.0037 mol) of palladium(II) acetate, 20.5 g (0.25 mol) of sodium acetate, 64.5 g (0.20 mol) of tetrabutylammonium bromide were placed under an argon atmosphere and 23.7 g (0.1 1 mol) of bromo-carbinol (III, X=Br) dissolved in 170 cm3 of toluene was added. The mixture was heated to 120C and then 32.2 g (0.10 mol) of chloroquinaldine-alcohol (II) dissolved in 70 cm3 of N-methyl-2-pirrolidone (NMP) was added. The mixture was stirred at 120 C until the reaction was complete. 100 cm3 of saturated NaHC03 solution, 100 cm3 of distilled water and 200 cm3 of ethyl acetate were then added. The mixture was stirred for 5 minutes. The layers were separated. The organic phase was washed three times with 200 cm3 of distilled water and with 200 cm3 of brine. The organic solution was dried over 30 g of sodium sulfate. The drying agent was filtered, washed with 200 cm3 of ethyl acetate and the filtrate was evaporated in vacuum. Yield: 54.7 g crude 1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(l-hydroxy-l- methyl-ethyl)-phenyl]-propan-l-one (IV) as a brown oil. A small amount of the product was purified by chromatography; the structure was checked by NMR spectroscopy: 1H NMR (DMSO-i/6) delta 1.57 (s, 6H, Me2C), 3.26-3.35 (m, 2H, CH2Ar), 3.40-3.48 (m, 2H, CH2CO), 5.04 (s, 1H, OH), 7.11-7.22 (m, 2H), 7.27-7.32 (m, 1H), 7.36-7.42 (m, 1H), 7.55-7.64 (m, 3H), 7.89-8.04 (m, 6H), 8.32-8.36 (m, 1H), 8.41 (d, 1H, J= 8.6 Hz) ppm.13C NMR (DMSO-i? delta 28.5 (CH2Ar), 2 31.8 ( e2C), 41.7 ( H2CO), 72.0 (Me2Q, 120.3, 125.5, 125.5, 125.6, 126.5, 126.8, 127.0, 127.2, 128.0, 129.3, 129.4, 129.7, 131.4, 131.5, 134.1, 134.4, 136.6, 136.6, 137.3, 139.8, 146.8, 148.0, 156.6, 199.6 (CO) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; RICHTER GEDEON NYRT.; BODI, Jozsef; FARAGO, Janos; SZOeKE, Katalin; UJVARI, Viktor; TEMESVARI, Krisztina; ARANYI, Antal; SANTA, Zsuzsanna; NAGY, Melinda Magdolna; WO2012/20271; (2012); A1;,
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Electric Literature of 2425-41-4, Adding some certain compound to certain chemical reactions, such as: 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol,molecular formula is C12H16O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2425-41-4.

General procedure: Toa solution of (5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)methanol (0.66 g) inDMF (10 mL) was added NaH (0.12 g). The mixture was stirred at RT for 1 hr. Tothe mixture was added 2-{3-[4-(4-Cyclopropylbenzyloxy)-3-methoxyphenyl]-azetidine-1-carbonyl}pyridin-4-ylmethylmethanesulfonate (0.7 g). The reaction mixture was stirred at RT for 1 hr.Water was added to the reaction mixture and the mixture was extracted withethyl acetate. The organic layer was washed with water, and then dried overMgSO4. The solvent wasremoved under reduced pressure to give the crude title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ikegashira, Kazutaka; Ikenogami, Taku; Yamasaki, Takayuki; Oka, Takahiro; Hase, Yasunori; Miyagawa, Naoki; Inagaki, Koji; Kawahara, Iichiro; Koga, Yoshihisa; Hashimoto, Hiromasa; Bioorganic and Medicinal Chemistry Letters; vol. 29; 7; (2019); p. 873 – 877;,
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Reference of 1261524-75-7, Adding some certain compound to certain chemical reactions, such as: 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1261524-75-7.

To (3-bromo-2-chlorophenyl)methanol (CAS 1261524-75-7) (0.253 g, 1.142 mmol) in DCM (1 1.4 mL) at 0 C was added TEA (0.398 mL, 2.86 mmol) followed by MsCI (0.134 mL, 1.713 mmol) and the ice bath was removed and the solution was allowed to stir at room temperature for 30 minutes. At this point, the reaction was placed in an ice bath and diluted with DCM and a saturated solution of sodium bicarbonate. This mixture was passed thorugh a phase separator to remove the water layer. The organics were dried and concentrated to obtain the title compound. 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.85 (dd, J=8.07, 1.47 Hz, 1 H) 7.63 (dd, J=7.70, 1.47 Hz, 1 H) 7.37 (t, J=7.83 Hz, 1 H) 5.37 (s, 2 H) 3.29 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1261524-75-7, 3-Bromo-2-chlorobenzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
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Reference of 1611-56-9, Adding some certain compound to certain chemical reactions, such as: 1611-56-9, name is 11-Bromoundecan-1-ol,molecular formula is C11H23BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1611-56-9.

To a solution of 1-bromoundecanol 1 (30 g, 119.4 mmol) in DMF (150 ml_) was added NaN3 (15.5 g, 238.9 mmol) and the resulting mixture was stirred at 70 C for 12 h. The mixture was cooled to 23 C, filtered and the filtrate extracted with hexane (5 x 200 ml_). The hexanes fractions were combined and washed with H20 (2 x 100ml_), dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 11-azidoundecan-1-ol 2 (24.19 g, 95%) as a colorless oil. 1H NMR (CDCI3) delta 3.62 (t, J = 6.6 Hz, 2H), 3.24 (t, J = 6.9 Hz, 2H), 1.61 -1.51 (m, 4H), 1.39-1.24 (m, 14H); 13C NMR (CDCI3) delta 63.15, 51.60, 32.89, 29.66, 29.56, 29.51 , 29.25, 28.95, 26.82, 25.84.

According to the analysis of related databases, 1611-56-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RHODIA OPERATIONS; UNIVERSITY OF PENNSYLVANIA; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.); DONNIO, Bertrand; JISHKARIANI, Davit; DIROLL, Benjamin, T.; HOUGH, Lawrence; MURRAY, Christopher; CARGNELLO, Matteo; MALASSIS, Ludivine; (83 pag.)WO2016/201310; (2016); A1;,
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Reference of 7541-49-3 , The common heterocyclic compound, 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol, molecular formula is C20H40O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Product obtained by hydrogenating phytol. To a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) in argon is added platinum dioxide (PtO2, 1.15 g, 6.61 mmol). The medium is placed under 1 bar of dihydrogen then stirred for 4 h at ambient temperature. After filtration under celite by rinsing with THF, a black oil of molecule 47 is obtained after concentration under reduced pressure. Yield: 29.00 g (96%) 1H NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

The synthetic route of 7541-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ADOCIA; CHAN, You-Ping; GEISSLER, Alexandre; NOEL, Romain; ROGER, Walter; CHARVET, Richard; LAURENT, Nicolas; (80 pag.)US2019/275115; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

In a 250mL three-neck bottle,Under the protection of nitrogen,Add 0.03 mol of dibenzofuran-3-amine,0.04 mol of 2-(2-bromophenyl)propan-2-ol,150mL toluene was stirred and mixed,Then add 0.05 mol of sodium t-butoxide,0.0015mol Pd2 (dba)3,0.0015 mol of tri-tert-butylphosphine, heated to 115 C,Reflow reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column.Obtaining 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (48 pag.)CN108203428; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 23783-42-8, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of triethyl amine (4.368 g, 40 mmol) and 2,5,8, 1 l-tetraoxatridecan-l3-ol (4.165 g, 20 mmol) in dichloromethane (30 mL) was added methanesulfonyl chloride (4.165 g, (0286) 20 mmol, diluted in 20 ml of dichloromethane) dropwise over 30 minutes at 0 C. The reaction was then stirred at room temperature overnight. Water (40 mL) was next added to the reaction. It was extracted with dichloromethane (3x 150 mL), and the organic phase was washed with 0.3 N HC1 (2×80 mL) and water (3 x 100 mL). After drying with NaiSOr. removal of the solvent provided the title compound (5.507 g, 96% yield). NMR (500 MHz, DMSO-riri) d: 4.33-4.29 (m, 2H), 3.70-3.64 (m, 2H), 3.59-3.49 (m, 10H), 3.45-3.42 (m, 2H), 3.24 (s, 3H), 3.17 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23783-42-8, its application will become more common.

Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
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Electric Literature of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.

Reference Example 29; (6-hydroxy-l-benzofuran-3-yl) acetic acid; 4- (Chloromethyl)-7-hydroxy-2H-chromen-2-one (10.9 g, 51.8 mmol) was dissolved in 1 M aqueous sodium hydroxide solution (500 mL) , and the mixture was heated under reflux for 2 hr.The reaction mixture was allowed to cool, acidified with concentrated sulfuric acid, and extracted with ethyl acetate.The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (8.27 g, yield 83%) as brown crystals .MS m/z 193 (M + H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/1931; (2008); A2;,
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Application of 395-23-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of methyl 2-hydroxy-5-nitrobenzoate (1.93 g, 9.81 mmol), (4-trifluoromethylphenyl)(phenyl)methanol (3.00 g, 11.8 mmol), 40% solution of diethyl azodicarbonate in toluene (6.83 g, 15.7 mmol) and a solution (8 ML) of triphenylphosphine (3.09 g, 11.8 mmol) in DMF was stirred at room temperature for 12 hours, and the reaction solution was poured into ice-water and was extracted with ethyl acetate.. The extracted solution was washed with water, was dried with anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.. The residue was purified by silicagel column chromatography (hexane:ethyl acetate = 20:1), to obtain the titled compound as oil. 3.37 g (79.7%) 1H-NMR (CDCl3) delta; 4.00 (3H, s), 6.46 (1H, s), 7.00 (1H, d, J = 9.2 Hz), 7.26 to 7.72 (9H, m), 8.20 (1 H, dd, J = 3.0, 9.2 Hz), 8.74 (1H, d, J = 3.0 Hz)

According to the analysis of related databases, 395-23-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1437344; (2004); A1;,
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