Tag: M.W=200-300

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,4,6-Trichlorobenzyl alcohol

Tert-butyl 4-{6-[(2,4,6-trichlorophenyl)methoxy]-2H-spiro[l- benzofuran-3,4′-piperidine]-l’-yl}butanoate. To a solution of (2,4,6- trichlorophenyl)methanol (164.5 mg; 0.78 mmol) and tert-butyl 4-{6-hydroxy- 2H-spiro[l-benzofuran-3,4′-piperidine]- l’-yl}butanoate (250 mg; 0.62 mmol) in dichloromethane (20 mL) was added triphenylphosphine (204 mg; 0.78 mmol), followed, after 30 minutes by DIAD (0.15 mL; 0.78 mmol). Subsequently, the resulting mixture was stirred at RT overnight, and concentrated in vacuo. Subsequently, the reaction mixture was partitioned between 5% aqueous NaHC03 solution and EtOAc. The layers were separated and the organic layer was dried (Na2S04), filtered, and concentrated. The residue was purified by column chromatography (S1O2, Et20: hexanes 1:2) to afford the product (174 mg, 52%). Rt 1.59 min (System B), [M+H]+ 542.0.

With the rapid development of chemical substances, we look forward to future research findings about 217479-60-2.

Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
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Reference of 53463-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10-Bromodecan-1-ol (0.24 g, 1.0 mmol) in dry THF (1mL) was mixed with 3,4-dihydro-2H-pyran (0.11 g, 1.25 mmol) and iodine (0,05 g, 0.2 mmol). The mixture was added to a 50 mL conical flask, and a small funnel was placed over it to reduce possible evaporation of solvent. The flask was irradiated in microwave oven at 600 MW power for 3min. On cooling, the reaction mixture was diluted with chloroform (30 mL) and washed with 10percent aq. sodium thiosulphate solution (2 x 5 mL), water (2 x 5 mL), brine and dried. Evaporation of the solvent under reduced pressure and purification by silica gel column chromatography (1:9 ethyl acetate: n-hexane) furnished 10-bromo-1-tetrahydropyranyloxydecane (0.30 g, 94percent) as a colourless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 53463-68-6, 10-Bromodecanol.

Reference:
Article; Kaur, Jasamrit; Kaur, Irvinder; Jindal, Gitanjali; Manhas, Priya; Gupta, Neeru; Singh, Jasvinder; Journal of Chemical Research; vol. 39; 4; (2015); p. 230 – 232;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate

Step b: The crude product from step a (40.23 g, 0.157 mol) was dissolved in 50 mL pyridine, cooled to 0 C., and Ts-Cl (32.92 g, 0.173 mol) was added slowly. The flask containing the reaction mixture was sealed and placed in a refrigerator at 0 C. for 24 h. The reaction mixture was poured into ice/H2O, and the aqueous layer was extracted with CH2Cl2 (3×100 mL). The combined organic layers were washed with 2% HOAc in H2O, and dried over anhydrous MgSO4. The solvent was removed under vacuum to yield the tosylate as colorless oil. The oil was dried under vacuum (52.97 g, mol, 78%). HPLC: tR=13.0 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate.

Reference:
Patent; Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng; US2006/228325; (2006); A1;,
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Electric Literature of 2615-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, molecular weight is 282.33, as common compound, the synthetic route is as follows.

j00346j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (5 g, 1.70 mmol) in THF (100 mL) was charged with tosyl chloride (10.1 g, 5.30 mmol) and solution of potassium hydroxide (5.9 g, 5.30 mmol) in H20 (100 mL) at room temperature. The resulting solution was heated to 60 C for 5 h then cooled to room temperature and evaporated in vacuo. Theresidue obtained was diluted with DCM (100 mL) and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCM to obtain 8 g, 76% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.94 Hz, 4H), 7.48 (d, J= 8.38 Hz, 4H), 4.08-4.13 (m, 4H), 3.54-3.59 (m, 4H), 3.43 -3.50 (m, 16H), 2.42 (s, 6H).

Statistics shows that 2615-15-8 is playing an increasingly important role. we look forward to future research findings about 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Electric Literature of 162744-59-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.

To a solution of (4-bromo-2,6-difluorophenyl)methanol (2 g, 8.97 mmol) in DCM (80 inL) was added tribromophosphine (2.91 g, 10.76 mmol) at 0 C. The resulting mixture was stirred at rt. After LCMS analysis showed the starting material had disappeared, the mixture was washed with aqueous NaHC03 (40 inL) and brine (30 mL). The organic layer was dried over NaaSOzi, filtered and concentrated. The crude material was purified by silica column chromatography (PE/EA = 5/1) to yield a colorless oil of 5-bromo-2-(bromomethyl)-l,3-difluorobenzene (1.6 g, 5.48 mmol, 61.2% yield): lH NMR (400 MHz, CD3OD) delta 7.12 (d, J= 6.8 Hz, 2H), 4.47 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 162744-59-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; EIDAM, Hilary Schenck; DEMARTINO, Michael P.; GONG, Zhen; GUAN, Amy Huiping; RAHA, Kaushik; WU, Chengde; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; CHEUNG, Mui; WO2014/141187; (2014); A1;,
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Synthetic Route of 7541-49-3, Adding some certain compound to certain chemical reactions, such as: 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol,molecular formula is C20H40O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7541-49-3.

A mixture of 48.6 mmol (15.02 g) of (E, Z)-(all-rac)-phytol (E/Z = 72/28), 51.1 mmol (11.56 g) of benzoic anhydride and 2.4 mmol (0.30 g) OF N, N-DIMETHYLAMINOPYRIDINE in 30 mL of hexane was stirred at 23 to 24C for 20 hours. Then 50 ml of water were added and the organic phase was extracted thrice with 50 mL of diethyl ether. The combined or- ganic phases were washed thrice with an aqueous solution of HCl (10% by weight), neu- tralised with 50 mL of a saturated solution OF NAHC03, washed with 50 mL of a saturated solution of NaCl and with 50 mL of water and dried over NA2SO4. AFTER FILTRATION, the sol- vent was evaporated in vacuo to afford a colorless oil and a white precipitate. This crude material was purified by column chromatography over silica gel using a mixture of ethyl acetate and hexane (v/v = 5: 95) as eluent. 37.2 mmol (14. 80 g) of (E,Z)-(all-rac)-phytyl benzoate were isolated as a colorless oil (E/Z = 68/32; yield: 76% based on (all-rac)-phytol ; purity: 99. 5%-GC area).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DSM IP ASSETS B.V.; WO2005/26142; (2005); A2;,
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Reference of 53463-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10-Bromodecan-1-ol (0.24 g, 1.0 mmol) in dry THF (1mL) was mixed with 3,4-dihydro-2H-pyran (0.11 g, 1.25 mmol) and iodine (0,05 g, 0.2 mmol). The mixture was added to a 50 mL conical flask, and a small funnel was placed over it to reduce possible evaporation of solvent. The flask was irradiated in microwave oven at 600 MW power for 3min. On cooling, the reaction mixture was diluted with chloroform (30 mL) and washed with 10percent aq. sodium thiosulphate solution (2 x 5 mL), water (2 x 5 mL), brine and dried. Evaporation of the solvent under reduced pressure and purification by silica gel column chromatography (1:9 ethyl acetate: n-hexane) furnished 10-bromo-1-tetrahydropyranyloxydecane (0.30 g, 94percent) as a colourless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 53463-68-6, 10-Bromodecanol.

Reference:
Article; Kaur, Jasamrit; Kaur, Irvinder; Jindal, Gitanjali; Manhas, Priya; Gupta, Neeru; Singh, Jasvinder; Journal of Chemical Research; vol. 39; 4; (2015); p. 230 – 232;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate

Step b: The crude product from step a (40.23 g, 0.157 mol) was dissolved in 50 mL pyridine, cooled to 0 C., and Ts-Cl (32.92 g, 0.173 mol) was added slowly. The flask containing the reaction mixture was sealed and placed in a refrigerator at 0 C. for 24 h. The reaction mixture was poured into ice/H2O, and the aqueous layer was extracted with CH2Cl2 (3×100 mL). The combined organic layers were washed with 2% HOAc in H2O, and dried over anhydrous MgSO4. The solvent was removed under vacuum to yield the tosylate as colorless oil. The oil was dried under vacuum (52.97 g, mol, 78%). HPLC: tR=13.0 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate.

Reference:
Patent; Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng; US2006/228325; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 2615-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, molecular weight is 282.33, as common compound, the synthetic route is as follows.

j00346j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (5 g, 1.70 mmol) in THF (100 mL) was charged with tosyl chloride (10.1 g, 5.30 mmol) and solution of potassium hydroxide (5.9 g, 5.30 mmol) in H20 (100 mL) at room temperature. The resulting solution was heated to 60 C for 5 h then cooled to room temperature and evaporated in vacuo. Theresidue obtained was diluted with DCM (100 mL) and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCM to obtain 8 g, 76% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.94 Hz, 4H), 7.48 (d, J= 8.38 Hz, 4H), 4.08-4.13 (m, 4H), 3.54-3.59 (m, 4H), 3.43 -3.50 (m, 16H), 2.42 (s, 6H).

Statistics shows that 2615-15-8 is playing an increasingly important role. we look forward to future research findings about 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Electric Literature of 162744-59-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.

To a solution of (4-bromo-2,6-difluorophenyl)methanol (2 g, 8.97 mmol) in DCM (80 inL) was added tribromophosphine (2.91 g, 10.76 mmol) at 0 C. The resulting mixture was stirred at rt. After LCMS analysis showed the starting material had disappeared, the mixture was washed with aqueous NaHC03 (40 inL) and brine (30 mL). The organic layer was dried over NaaSOzi, filtered and concentrated. The crude material was purified by silica column chromatography (PE/EA = 5/1) to yield a colorless oil of 5-bromo-2-(bromomethyl)-l,3-difluorobenzene (1.6 g, 5.48 mmol, 61.2% yield): lH NMR (400 MHz, CD3OD) delta 7.12 (d, J= 6.8 Hz, 2H), 4.47 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 162744-59-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; EIDAM, Hilary Schenck; DEMARTINO, Michael P.; GONG, Zhen; GUAN, Amy Huiping; RAHA, Kaushik; WU, Chengde; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; CHEUNG, Mui; WO2014/141187; (2014); A1;,
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