Tag: M.W=200-250

Ashrafizadeh, Milad; Ahmadi, Zahra; Farkhondeh, Tahereh; Samarghandian, Saeed published the artcile< Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities>, Product Details of C14H12O3, the main research area is Wnt signaling pathway; cancer therapy; medicinal plants; resveratrol.

Wingless-type MMTV integration site (Wnt) signaling pathway is considered as an important pathway regulating a variety of biol. processes such as tissue formation and homeostasis, cell proliferation, cell migration, cell differentiation, and embryogenesis. Impairment in the Wnt signaling pathway is associated with pathol. conditions, particularly cancer. So, modulation of this pathway can be considered as a promising strategy and several drugs have been developed in line with this strategy. Resveratrol (Res) is a naturally occurring nutraceutical compound exclusively found in different fruits and nuts such as grape, peanut, and pistachio. This compound has favorable biol. and therapeutic activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, cardioprotective, and antidiabetic. At the present review, we demonstrate how Res modulates Wnt signaling pathway to exert its pharmacol. effects.

Journal of Cellular Physiology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Lianyu; Jiao, Lu; Ju, Jiasheng; Ma, Xuelan published the artcile< Effect of Sodium Selenite on the Metabolite Profile of Epichloe sp. Mycelia from Festuca sinensis in Solid Culture>, Formula: C6H10O8, the main research area is Epichloe Festuca sinensis sodium selenite metabolite mycelia solid culture; Culture time; Epichloë sp. from Festuca sinensis; Metabolite analysis; Selenium.

Selenium (Se) is an essential micronutrient with many beneficial effects for humans and other living organisms. Numerous microorganisms in culture systems enrich and convert inorganic selenium to organic selenium. In this study, Epichloe sp. from Festuca sinensis was exposed to increasing Na2SeO3 concentrations (0, 0.1, 0.2, 0.3, and 0.4 mmol/L) in Petri dishes with potato dextrose agar (PDA) for 8 wk. Epichloe sp. mycelia were immediately collected after mycelial diameters were measured at 4, 5, 6, 7, and 8 wk of cultivation, resp. Gas chromatog.-mass spectrometer (GC-MS) anal. was performed on different groups of Epichloe sp. mycelia. Different changes were observed as Epichloe sp. was exposed to different selenite conditions and cultivation time. The colony diameter of Epichloe sp. decreased in response to increased selenite concentrations, whereas the inhibitory effects diminished over time. Seventy-two of the 203 identified metabolites did not differ significantly across selenite treatments within the same time point, while 82 compounds did not differ significantly between multiple time points of the same Se concentration However, the relative levels of 122 metabolites increased the most under selenite conditions. Specifically, between the 4th and 8th weeks, there were increases in 2-keto-isovaleric acid, uridine, and maltose in selenite treatments compared to controls. Selenium increased glutathione levels and exhibited antioxidant properties in weeks 4, 5, and 7. Addnl., we observed that different doses of selenite could promote the production of carbohydrates such as isomaltose, cellobiose, and sucrose; fatty acids such as palmitoleic acid, palmitic acid, and stearic acid; and amino acids such as lysine and tyrosine in Epichloe sp. mycelia. Therefore, Epichloe sp. exposed to selenite stress may benefit from increased levels of some metabolite compounds

Biological Trace Element Research published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Huai-Wei; Wu, Jia-Xue; Huang, Xian-Qiang; Li, Da-Cheng; Wang, Su-Na; Lu, Yi; Dou, Jian-Min published the artcile< RhIII-Catalyzed C-H N-Heteroarylation and Esterification Cascade of Carboxylic Acid with Organoboron Reagents and 1,2-Dichloroethane in One-Pot Synthesis>, Application of C12H18BNO2, the main research area is aryl carboxylic acid heteroaromatic boronate heteroarylation esterification cascade rhodium.

A RhIII-catalyzed C(sp2)-H N-heteroarylation and esterification cascade of aryl carboxylic acids with N-heteroaromatic boronates and 1,2-dichloroethane in a one-pot synthesis has been disclosed. The strong coordinating ability of ortho- and meta-substituted pyridine boronates and pyrazoles as well as unsubstituted pyrimidine allows them to serve as the coupling partners. This protocol allows late-stage modification of the key precursor of roflumilast and compounds of pharmaceutical interest, which highlights the potential application of this synthetic method.

Organic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Application of C12H18BNO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Canellas, Natalia O. A.; Olivares, Fabio L.; Canellas, Luciano P. published the artcile< Metabolite fingerprints of maize and sugarcane seedlings: searching for markers after inoculation with plant growth-promoting bacteria in humic acids>, Category: alcohols-buliding-blocks, the main research area is metabolite fingerprint biostimulant seedling Zea Saccharum.

Background: The neg. consequences of industrial agriculture greatly affect human health and the environment. Debating our dietary requirements and challenging the means of food production are necessary. In the first years of transitioning to agroecol. production, crop yields normally decrease. Humic acids and beneficial bacteria used as plant growth promoters can be helpful during this stressful time. Metabolite target identification will aid in increasing plant responses to these agents. Materials: We evaluated the metabolite fingerprints of maize and sugarcane seedlings after 5 days of treatment with like-humic acids isolated from vermicompost coupled with a combined Herbaspirillum seropedicae and Gluconacetobacter diazotrophicus application. The hydromethanolic foliar extracts were submitted for 1H NMR anal., and the data were explored using chemometrics procedures. After the preliminary screening, the extracts were analyzed by gas chromatog. coupled to time of flight mass spectrometry to identify metabolite targets. Results: The biostimulant significantly changed the metabolic fingerprints independent of the plant species. The main proton spectral regions changed by biostimulant use were from 0 to 2.5 ppm and 3.5 to 5 ppm, as revealed by a principal component anal. The main signals corresponded to amino acid, sugar and organic acid chem. shifts. Aspartic acid was the amino acid present in greatest amounts in both leaf extracts A significant change occurred in the region normally attributed to (CHn)-protons bound to electron-withdrawing groups, such as carboxyls from mucic, ribonic and saccharic acids derived from sugars and aromatic structures from shikimic acid, 4-hydroxybenzoate and 3,4-dihydroxycinnamic acid. The main organic acids altered by the biostimulant were representatives of the tricarboxylic acid cycle (citric, isocitric, aconitic, malic and fumaric acids). Linoleic and myristic acids, 1-mono palmitin and tocopherol were the major lipid components found at greater levels in the treated leaf extracts Compounds from the oxidative end products of ascorbic acid metabolism, like threonic, isothreonic and oxalic acids, are putative biomarkers of the biostimulant as are the cyclic polyol identified as quinic acid and trehalose, a disaccharide involved in plant stress responses. Conclusion: The biostimulant induced significant changes in the metabolite fingerprints of maize and sugarcane seedlings as revealed by NMR. Both primary and secondary metabolisms were affected, and 22 putative biomarkers associated with the biostimulant-treated plant phenotype were identified. This agrees with previous work indicating that the stimulation of primary and secondary metabolisms was partially responsible for biostimulant effects on non-leguminous plants. Moreover, these metabolite targets could be used to genetically manipulate metabolic pathways to aid Poaceae breeding programs in increasing biostimulative responses.

Chemical and Biological Technologies in Agriculture published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brigante, Federico I.; Lucini Mas, Agustin; Erban, Alexander; Fehrle, Ines; Martinez-Seidel, Federico; Kopka, Joachim; Wunderlin, Daniel A.; Baroni, Maria V. published the artcile< Authenticity assessment of commercial bakery products with chia, flax and sesame seeds: Application of targeted and untargeted metabolomics results from seeds and lab-scale cookies>, Application In Synthesis of 87-73-0, the main research area is bakery products chia flax sesame seeds metabolomics cookies.

Usually the investigations in food authenticity focus on the discovery of new markers in laboratory-made products. However, tests in com. products are indispensable yet rarely performed. This work presents the application of the discovered markers of chia, flax and sesame seeds in two previous studies carried out by HPLC-MS/MS and GC-MS. A set of com. bakery products was analyzed by the same workflows to assess their authenticity regarding the declaration of the seeds in the ingredients list and the package. Presence or absence of the seeds was determined by evaluation of the corresponding markers in the products. All the bakery products passed the evaluation process and were declared as authentic by both anal. techniques. Markers coming from both techniques for each of the seeds were complementary since using them as groups represents a major advantage when studying food adulteration.

Food Control published new progress about Bakery products. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Zhaohan; Zhang, Xiaoqiong; Yong, Tuying; Bie, Nana; Zhan, Guiting; Li, Xin; Liang, Qingle; Li, Jianye; Yu, Jingjing; Huang, Gang; Yan, Yuchen; Zhang, Zelong; Zhang, Bixiang; Gan, Lu; Huang, Bo; Yang, Xiangliang published the artcile< Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles>, Application In Synthesis of 5505-63-5, the main research area is metformin programmed cell death therapy macrophage microparticle.

The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive microenvironment, and the inadequate tumor accumulation and penetration of anti-PD-1/PD-L1 antibody. Resetting tumor-associated macrophages (TAMs) is a promising strategy to enhance T-cell antitumor immunity and ameliorate tumor immunosuppression. Here, mannose-modified macrophage-derived microparticles (Man-MPs) loading metformin (Met@Man-MPs) are developed to efficiently target to M2-like TAMs to repolarize into M1-like phenotype. Met@Man-MPs-reset TAMs remodel the tumor immune microenvironment by increasing the recruitment of CD8+ T cells into tumor tissues and decreasing immunosuppressive infiltration of myeloid-derived suppressor cells and regulatory T cells. More importantly, the collagen-degrading capacity of Man-MPs contributes to the infiltration of CD8+ T cells into tumor interiors and enhances tumor accumulation and penetration of anti-PD-1 antibody. These unique features of Met@Man-MPs contribute to boost anti-PD-1 antibody therapy, improving anticancer efficacy and long-term memory immunity after combination treatment. Our results support Met@Man-MPs as a potential drug to improve tumor resistance to anti-PD-1 therapy.

Nature Communications published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Application In Synthesis of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahman, Habibur Md.; Akter, Rokeya; Bhattacharya, Tanima; Abdel-Daim, Mohamed M.; Alkahtani, Saad; Arafah, Mohammed W.; Al-Johani, Norah S.; Alhoshani, Norah M.; Alkeraishan, Nora; Alhenaky, Alhanof; Abd-Elkader, Omar H.; El-Seedi, Hesham R.; Kaushik, Deepak; Mittal, Vineet published the artcile< Resveratrol and neuroprotection: impact and its therapeutic potential in Alzheimer's disease>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol neuroprotection Alzheimer disease; Alzheimer’s disease; bioavailability; neuroprotective; oxidative stress; resveratrol; therapeutic agent.

A review. Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most exptl. research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol’s effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective mol. mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.

Frontiers in Pharmacology published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sadler, Scott A.; Tajuddin, Hazmi; Mkhalid, Ibraheem A. I.; Batsanov, Andrei S.; Albesa-Jove, David; Cheung, Man Sing; Maxwell, Aoife C.; Shukla, Lena; Roberts, Bryan; Blakemore, David C.; Lin, Zhenyang; Marder, Todd B.; Steel, Patrick G. published the artcile< Iridium-catalyzed C-H borylation of pyridines>, Computed Properties of 660867-80-1, the main research area is iridium catalyzed carbon hydrogen borylation pyridine; crystal mol structure boryl pyridine.

The iridium-catalyzed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodol. for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring.

Organic & Biomolecular Chemistry published new progress about Borylation. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Computed Properties of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Badaoui, Antoine published the artcile< Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol Scutellaria root extract cosmetic product allergic contact dermatitis; Scutellaria baicalensis; CAS no 94279-99-9; CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; eczema; patch test; resveratrol.

Authors report the second case of allergic contact dermatitis caused by resveratrol (CAS number 501-36-0), and Scutellaria baicalensis root extract (CAS no 94279-99-9), both antioxidants, contained in the same cosmetic. A 37-yr-old woman with no past medical history, reported a papular and vesicular eruption of the face and neck, with itchy sensations, 48 h after the application of a new facial cream: Resveratrol BE cream (Skinceuticals). Patch tests were performed with the European baseline and cosmetic series (Chemotechnique Diagnostics), and with the Resveratrol BE cream ‘as is’. Patch test chambers used were IQ ultra (Chemotechnique Diagnostics), fixed with Hypafix (BSN Medical) for 48 h. Patch tests with resveratrol 1% aqueous and S. baicalensis root extract 0.5% aqueous were subsequently performed in four control healthy volunteers and were neg. until D7. Both resveratrol 1% aqueous and S. baicalensis 0.5% aqueous have been tested in healthy patients and showed no pos. reaction, confirming the absence of irritation when tested at these concentrations This case highlights this importance of patch testing all the cosmetics in question brought by the patient, and in case of a pos. reaction, to perform an addnl. patch test with the resp. ingredients, in order to identify new emerging allergens.

Contact Dermatitis published new progress about Allergic contact dermatitis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Lu-Zhou; Huang, Si-Ling; Hou, Jin; Guo, Xue-Ping; Wang, Feng-Shan; Sheng, Ju-Zheng published the artcile< Cell-based and cell-free biocatalysis for the production of D-glucaric acid>, Synthetic Route of 87-73-0, the main research area is review Escherichia coli yeast glucaric acid biosensor enzyme catalysis; Biosensor; Cell-free synthetic biology; D-Glucaric acid; Escherichia coli; Metabolic engineering; Yeast.

A review. D-Glucaric acid (GA) is a value-added chem. produced from biomass, and has potential applications as a versatile platform chem., food additive, metal sequestering agent, and therapeutic agent. Marketed GA is currently produced chem., but increasing demand is driving the search for eco-friendlier and more efficient production approaches. Cell-based production of GA represents an alternative strategy for GA production A series of synthetic pathways for GA have been ported into Escherichia coli, Saccharomyces cerevisiae and Pichia pastoris, resp., and these engineered cells show the ability to synthesize GA de novo. Optimization of the GA metabolic pathways in host cells has leapt forward, and the titer and yield have increased rapidly. Meanwhile, cell-free multi-enzyme catalysis, in which the desired pathway is constructed in vitro from enzymes and cofactors involved in GA biosynthesis, has also realized efficient GA bioconversion. This review presents an overview of studies of the development of cell-based GA production, followed by a brief discussion of potential applications of biosensors that respond to GA in these biosynthesis routes.

Biotechnology for Biofuels published new progress about Biocatalysis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts