Tag: M.W=200-250

Bahramrezaie, Mojdeh; Amidi, Fardin; Aleyasin, Ashraf; Saremi, AboTaleb; Aghahoseini, Marzieh; Brenjian, Samaneh; Khodarahmian, Mahshad; Pooladi, Arash published the artcile< Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial.>, Category: alcohols-buliding-blocks, the main research area is HIF1 gene; Hormones; Intracytoplasmic sperm injection; Polycystic ovary syndrome; Resveratrol; VEGF gene.

OBJECTIVES: Management options for PCOS, as the most prevalent endocrine disorder in women of reproductive age, using natural supplements have a high priority for physicians, especially based on the etiological pathways. Therefore, this study was conducted to describe the effect of resveratrol on the angiogenesis pathway, for management of PCOS through assessing VEGF, HIF1 gene expression, and laboratory parameters. METHODS: In this triple-blind RCT, PCOS was confirmed in ICSI candidates based on the Rotterdam criteria. Sixty-two patients that met the inclusion criteria were randomly assigned to two groups. All patients took resveratrol 800 mg/day or placebo for 40 days orally from the beginning of their previous menstruation cycle until the oocyte retrieval day. The serum levels of different hormones were measured, and the expression of HIF1 & VEGF genes was quantified by real-time PCR. RESULTS: As for the laboratory hormone assay in 61 PCOS patients, a significant mean difference was seen in the FSH, LH, TSH, and testosterone between the two groups (P < 0.05). The results showed a reduction in the expression of VEGF & HIF1 genes under the effect of resveratrol in the granulosa cells (P = 0.0001). The number of mature oocytes, cleavage rate, fertilization rate, and fertility rate were not significantly different between the two groups (P > 0.05), but the high-quality oocyte rate and high-quality embryo rate were higher in the resveratrol group (P < 0.05). CONCLUSIONS: Based on the results, resveratrol may improve some outcomes of PCOS patients, probably through changing the serum levels of some sex hormones and expression of VEGF & HIF1 genes in the angiogenesis pathway of granulosa cells. Journal of assisted reproduction and genetics published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kutyna, Dariusz R.; Onetto, Cristobal A.; Williams, Thomas C.; Goold, Hugh D.; Paulsen, Ian T.; Pretorius, Isak S.; Johnson, Daniel L.; Borneman, Anthony R. published the artcile< Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome>, Name: D-Glucosaccharic acid, the main research area is Saccharomyces pan genome neo chromosome genetic diversity phenotypic plasticity.

The Synthetic Yeast Genome Project (Sc2.0) represents the first foray into eukaryotic genome engineering and a framework for designing and building the next generation of industrial microbes. However, the laboratory strain S288c used lacks many of the genes that provide phenotypic diversity to industrial and environmental isolates. To address this shortcoming, we have designed and constructed a neo-chromosome that contains many of these diverse pan-genomic elements and which is compatible with the Sc2.0 design and test framework. The presence of this neo-chromosome provides phenotypic plasticity to the Sc2.0 parent strain, including expanding the range of utilizable carbon sources. We also demonstrate that the induction of programmable structural variation (SCRaMbLE) provides genetic diversity on which further adaptive gains could be selected. The presence of this neo-chromosome within the Sc2.0 backbone may therefore provide the means to adapt synthetic strains to a wider variety of environments, a process which will be vital to transitioning Sc2.0 from the laboratory into industrial applications.

Nature Communications published new progress about Biofuels. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Zhixiang; Xu, Xiangxiang; O’Laoi, Ruadhan; Ma, Haikuo; Zheng, Jiyue; Chen, Shuaishuai; Luo, Lusong; Hu, Zhilin; He, Sudan; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu published the artcile< Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold>, Formula: C12H18BNO2, the main research area is Wnt3A inhibitor amide scaffold; Antagonist; Cancer therapy; Porcupine; Scaffold hybridization; Wnt signaling pathway.

The Wnt signaling pathway is an essential signal transduction pathway which leads to the regulation of cellular processes such as proliferation, differentiation and migration. Aberrant Wnt signaling is known to have an association with multiple cancers. Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Here the authors report the synthesis and structure-activity-relationship of the novel porcupine inhibitors based on a ‘reversed’ amide scaffold. The leading compound I was as potent as the clin. compound LGK974 in a cell based STF reporter gene assay. Compound I potently inhibited the secretion of Wnt3A, therefore was confirmed to be a porcupine inhibitor. Furthermore, compound I showed excellent chem. and plasma stabilities. However, the clearance of compound I in liver microsomal tests was moderate to high, and the solubility of compound I was suboptimal. Collective efforts toward further optimization of this novel tricyclic template to develop better porcupine inhibitors will be subsequently undertaken and reported in due course.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Formula: C12H18BNO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gianchecchi, Elena; Fierabracci, Alessandra published the artcile< Insights on the effects of resveratrol and some of its derivatives in cancer and autoimmunity: a molecule with a dual activity>, COA of Formula: C14H12O3, the main research area is review cancer autoimmunity type 1 diabetes resveratrol; autoimmunity; cancer; resveratrol.

A review. In recent years, the interest in natural compounds exerting immunoregulatory effects has enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods and beverages, including red grapes and red wine, has been demonstrated to exert both in vitro and in vivo biol. activities. More specifically, it has antiaging, cardioprotective, antioxidant, immunomodulatory, anti-inflammatory and chemopreventive activities. Due to its anti-proliferative, pro-apoptotic and immunoregulatory effects, resveratrol has gained substantial attention for the treatment of cancer or autoimmunity, which represent frequently diagnosed diseases with important consequences for the health of the patients affected. The aim of the present review is to focus on the role of resveratrol in the modulation of cancer as well as of several organ-specific or systemic autoimmune diseases, including autoimmune hepatitis, type 1 diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis.

Antioxidants published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Atanasov, Kostadin Evgeniev; Galbis, David Minana; Gallego, Julia; Serpico, Annabel; Bosch, Montserrat; Altabella, Teresa; Ferrer, Albert published the artcile< Pseudomonas germanica sp. nov., isolated from Iris germanica rhizomes>, Related Products of 87-73-0, the main research area is rhizome Pseudomonas germanica iris plant; Iris germanica; Pseudomonas; average nucleotide identity; digital DNA–DNA hybridization; endophyte; multilocus sequence analysis; type-strain.

Through bacterial plant-endophyte extraction from rhizomes of Iris germanica plant, a Gram-stain-neg., aerobic, catalaseand oxidase-pos. gammaproteobacterial strain, referred to as FIT28T, was isolated. FIT28T shows vigorous growth on nutrient rich media within the temperature range of 4-35°C, with optimal growth at 28°C, a wide pH tolerance from pH 5 to 11, and salt tolerance up to 6% (w/v) NaCl. Colonies are white-yellow and quickly become mucoid. The results of anal. of the 16S rRNA gene sequence placed the strain within the genus Pseudomonas, and multilocus sequence anal. (MLSA) using 16S rRNA, rpoB, gyrB and rpoD concatenated sequences revealed that the closest relatives of FIT28T are Pseudomonas zeae OE48.2T, ‘Pseudomonas crudilactis’ UCMA 17988, Pseudomonas tensinigenes ZA5.3T, Pseudomonas helmanticensis OHA11T , Pseudomonas baetica a390T, Pseudomonas iridis P42T, Pseudomonas atagonensis PS14T and Pseudomonas koreensis Ps 9-14T, within the Pseudomonas koreensis subgroup of the Pseudomonas fluorescens lineage. The genome size of FIT28T is about 6.7Mb with 59.09 mol% DNA G+C content. Average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values calculated from the genomic sequences of FIT28T, and the closely related P. zeae OE48.2T are 95.23 and 63.4%, resp. Biochem., metabolic and chemotaxonomic studies further support our proposal that Pseudomonas germanica sp. nov., should be considered a novel species of the genus Pseudomonas. Hence, the type strain FIT28T (=LMG 32353T =DSM 112698T) has been deposited in public cell-type culture centers.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arias, Pedro L.; Cecilia, Juan A.; Gandarias, Inaki; Iglesias, Jose; Lopez Granados, Manuel; Mariscal, Rafael; Morales, Gabriel; Moreno-Tost, Ramon; Maireles-Torres, Pedro published the artcile< Oxidation of lignocellulosic platform molecules to value-added chemicals using heterogeneous catalytic technologies>, Application of C6H10O8, the main research area is review lignocellulosic platform mol oxidation heterogeneous catalyst.

A review. Currently, much attention is being paid to the development of sustainable catalytic processes for the production of chems. (biofuels, bioproducts, and so on) from lignocellulosic biomass. This minireview pursues to give an exhaustive overview about the heterogeneous catalytic technologies proposed for the oxidation of four key platform mols. (glucose, 5-hydroxymethylfurfural, furfural and levulinic acid) into important chems., such as gluconic acid and gluconates, glucaric and formic acids, 2-diformylfuran, 2,5-furandicarboxylic acid, maleic acid and anhydride, succinic acid, furanones, furoic acid, alkyl furoates, furan-2-acrolein, succinic acid, butanone and 3-hydroxypropanoic acid. The different mechanistic pathways will be highlighted, as well as the requirements in terms of catalytic sites and catalyst stability. The challenges and opportunities will be put forward for each type of oxidation process.

Catalysis Science & Technology published new progress about Heterogeneous catalysis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhatta, Rimsha; Han, Joonsu; Zhou, Jingyi; Li, Haoyu; Wang, Hua published the artcile< Recyclable cell-surface chemical tags for repetitive cancer targeting>, Application of C6H14ClNO5, the main research area is recyclable cell surface chem tag repetitive cancer targeting; Cell targeting; Chemotherapy; Click chemistry; Metabolic glycan labeling; cancer.

Metabolic glycan labeling provides a facile yet powerful tool to install chem. tags to the cell membrane via metabolic glycoengineering processes of unnatural sugars. These cell-surface chem. tags can then mediate targeted conjugation of therapeutic agents via efficient chemistries, which has been extensively explored for cancer-targeted treatment. However, the commonly used in vivo chemistries such as azide-cyclooctyne and tetrazine-cyclooctene chemistries only allow for one-time use of cell-surface chem. tags, posing a challenge for long-term, continuous cell targeting. Here we show that cell-surface ketone groups can be recycled back to the cell membrane after covalent conjugation with hydrazide-bearing mols., enabling repetitive targeting of hydrazide-bearing agents. Upon conjugation to ketone-labeled cancer cells via a pH-responsive hydrazone linkage, Alexa Fluor 488-hydrazide became internalized and entered endosomes/lysosomes where ketone-sugars can be released and recycled. The recycled ketone groups could then mediate targeted conjugation of Alexa Fluor 647-hydrazide. We also showed that doxorubicin-hydrazide can be targeted to ketone-labeled cancer cells for enhanced cancer cell killing. This study validates the recyclability of cell-surface chem. tags for repetitive targeting of cancer cells with the use of a reversible chem., which will greatly facilitate future development of potent cancer-targeted therapies based on metabolic glycan labeling.

Journal of Controlled Release published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Application of C6H14ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Tiantian; Xiao, Dingfu; Muhammed, Arowolo; Deng, Juying; Chen, Liang; He, Jianhua published the artcile< Anti-inflammatory action and mechanisms of resveratrol>, COA of Formula: C14H12O3, the main research area is review anti inflammation resveratrol mechanism; absorption and metabolism; anti-inflammation; antioxidant; mechanism; resveratrol.

A review. Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits antioxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined Multiple exptl. studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

Molecules published new progress about Absorption. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moons, Sam J.; Rossing, Emiel; Heming, Jurriaan J. A.; Janssen, Mathilde A. C. H.; van Scherpenzeel, Monique; Lefeber, Dirk J.; de Jonge, Marien I.; Langereis, Jeroen D.; Boltje, Thomas J. published the artcile< Structure-Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation>, Synthetic Route of 5505-63-5, the main research area is mannosamine fluorosialic acid synthesis antibacterial SAR Haemophilus influenzae sialylation.

Bacterial pathogens such as Nontypeable Haemophilus influenzae (NTHi) can evade the immune system by taking up and presenting host-derived sialic acids. Herein, we report a detailed structure-activity relationship of sialic acid-based inhibitors that prevent the transfer of host sialic acids to NTHi. We report the synthesis and biol. evaluation of C-5, C-8, and C-9 derivatives of the parent compound 3-fluorosialic acid (SiaNFAc). Small modifications are tolerated at the C-5 and C-9 positions, while the C-8 position does not allow for modification. These structure-activity relationships define the chem. space available to develop selective bacterial sialylation inhibitors.

Bioconjugate Chemistry published new progress about Antibacterial agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Synthetic Route of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kamatsuka, Takuto; Shinokubo, Hiroshi; Miyake, Yoshihiro published the artcile< Design and synthesis of tunable ligands with 4,4'-bipyridyl as an electron-accepting unit and their rhenium complexes>, Electric Literature of 660867-80-1, the main research area is rhenium bipyridine pendant amine phosphine complex preparation reduction catalyst; carbon dioxide reduction photocatalyst rhenium bipyridine carbonyl complex; crystal structure rhenium bipyridine pendant amine complex; mol structure rhenium bipyridine pendant amine complex.

We have designed and prepared a series of rhenium complexes with 4,4′-bipyridyl, [(2-R1-6-R2-2′-CH2Q-4,4′-bpy)ReCl(CO)3] (2a-i, Q = NEt2, PtBu2, POtBu2; R1, R2 = H, Me, Cl, Br) as an electron-accepting unit. Electrochem. studies revealed that oxidation and reduction of these complexes occurred on the rhenium center and the 4,4′-bipyridyl skeleton, resp. The redox potentials of the rhenium complexes are controllable by tuning the substituents on the 4,4′-bipyridyl skeleton and the coordinating groups to the rhenium center. We have also examined the reactivity of the rhenium complexes in electrochem. and photochem. CO2 reduction

Organometallics published new progress about Crystal structure. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Electric Literature of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts