Tag: M.W=200-250

Fonseca-Santos, Bruno; Chorilli, Marlus published the artcile< The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems>, Synthetic Route of 501-36-0 , the main research area is review resveratrol neurol disease nanotechnol; Blood–brain barrier; Brain; Nanocarriers; Nanomedicines; Nasal drug delivery; Resveratrol.

A review. Neurol. disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biol. activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurol. disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnol.-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacol. and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clin. trials for some neurol. diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurol. diseases. Thus, the use of this nutraceutical has shown true for neurol. diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Central nervous system agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amrina, Rosyada Amran; Furusawa, Go; Lau, Nyok-Sean published the artcile< Saccharobesus litoralis gen. nov., sp. nov., a novel alginate-degrading bacterium isolated from the surface of intertidal algal turf>, HPLC of Formula: 87-73-0, the main research area is Saccharobesus alginate degrading bacterium phospholipid glycolipid fatty acid; Alteromonadaceae; agar degradation; alginate.

A novel rod-shaped, Gram-stain-neg., strictly aerobic and alginate-degrading marine bacterium, designated CCB-QB4T, was isolated from a surface of algal turf collected from a coastal area of Penang, Malaysia. The cells showed motility by a lateral flagellum. The rod-shaped cells formed long chains end-to- end. Phylogenetic anal. based on the 16S rRNA gene sequence of strain CCB-QB4T showed 94.07, 92.69, 91.52 and 90.90% sequence similarity to Algibacillus agarilyticus RQJ05T, Catenovulum maritimum Q1T, Catenovulum agarivorans YM01T and Catenovulum sediminis D2T, resp. Strain CCB-QB4T formed a cluster with A. agarilyticus RQJ05T. Strain CCB-QB4T was catalase-neg., oxidase-pos., and degraded agar, alginate, and starch. Cell growth was observed at 15-40°C, at pH 7.0-10.0 and in the presence of 1-6% (w/v) NaCl and glucose. The major fatty acids were summed feature 3 (C16:1 ω7c/iso-C15:0 2-OH), C16:0 and C18:1 ω7c. The polar lipids were phosphatidylethanolamine, two unidentified aminolipids, two unidentified glycolipids, an unidentified phospholipid and unidentified lipid. The major respiratory quinone was ubiquinone-8. The genomic DNA G+C content was 46.7 mol%. Based on the phenotypic, chemotaxonomic and phylogenetic data, strain CCB-BQ4T represents a novel species in a new genus, for which the name Saccharobesus litoralis gen. nov., sp. nov. is proposed. The type strain is CCB-QB4T (=JCM 33513T=-MBL 5008T).

International Journal of Systematic and Evolutionary Microbiology published new progress about Algibacillus agarilyticus. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, HPLC of Formula: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chinoy, Zoeisha S.; Bodineau, Clement; Favre, Camille; Moremen, Kelley W.; Duran, Raul V.; Friscourt, Frederic published the artcile< Selective Engineering of Linkage-Specific α2,6-N-Linked Sialoproteins Using Sydnone-Modified Sialic Acid Bioorthogonal Reporters>, Electric Literature of 5505-63-5, the main research area is sialoprotein engineering sydnone sialic acid bioorthogonal chem; click chemistry; enzymes; fluorescent probes; glycobiology; sialic acids.

The metabolic oligosaccharide engineering (MOE) strategy using unnatural sialic acids has recently enabled the visualization of the sialome in living systems. However, MOE only reports on global sialylation and dissected information regarding subsets of sialosides is missing. Described here is the synthesis and utilization of sialic acids modified with a sydnone reporter for the metabolic labeling of sialoconjugates. The positioning of the reporter on the sugar significantly altered its metabolic fate. Further in vitro enzymic assays revealed that the 9-modified neuraminic acid is preferentially accepted by the sialyltransferase ST6Gal-I over ST3Gal-IV, leading to the favored incorporation of the reporter into linkage-specific α2,6-N-linked sialoproteins. This sydnone sugar presents the possibility of investigating the roles of specific sialosides.

Angewandte Chemie, International Edition published new progress about Bioorthogonal reaction. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Electric Literature of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moggia, Giulia; Schalck, Jonathan; Daems, Nick; Breugelmans, Tom published the artcile< Two-steps synthesis of D-glucaric acid via D-gluconic acid by electrocatalytic oxidation of D-glucose on gold electrode: Influence of operational parameters>, Electric Literature of 87-73-0, the main research area is synthesis glucaric gluconic acid electrocatalysis oxidation glucose gold electrode.

Glucose electrooxidation to glucaric acid, a highly valuable platform chem., was conducted, for the 1st time, in two consecutive steps employing a bare Au electrode in a batch reactor. The 1st step, at low potential, enabled the effective formation of the intermediate, gluconic acid, promoted by the oxidation of the aldehyde group on C1. For this reaction step, except for the reaction time, all the operational parameters had a strong impact on the selectivity. At the optimal conditions of pH 11.3, 5° and 0.04M initial glucose, a maximum selectivity of 97.6% was obtained, the highest reported to date for the electrochem. process, with a conversion of 25%. At higher potential, gluconic acid was further converted to glucaric acid by the oxidation of the hydroxymethyl group on C6. For this oxidation step, the variation of the operational parameters (pH, gluconic acid initial concentration, reaction temperature and time) had no conspicuous effect on the selectivity, while the applied potential had a major role: at 1.1 VRHE, a maximum selectivity of 89.5% to glucaric acid was obtained, which is one of the highest values reported in literature so far. In all experiments, irresp. of conditions and reaction time, a maximum concentration of ∼1.2 mM of glucaric acid was achieved, and a drastic decrease of the c.d. was observed in the 1st hours of electrolysis. Addnl. control experiments revealed a poisoning process caused by glucaric acid that, once formed, remains strongly bonded to the catalyst’s active sites, thus deactivating it.

Electrochimica Acta published new progress about Cyclic voltammetry. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pesci, Pierantonio published the artcile< Involvement of chloride in the increase in proline induced by ABA and stimulated by potassium chloride in barley leaf segments>, SDS of cas: 35564-86-4, the main research area is ABA induction proline barley chloride.

Stimulation by NaCl or KCl of the ABA-induced increase in proline was synergistically enhanced by CaCl2 or MgCl2 as well as by 1,3-bis[tris(hydroxymethyl)methylamino]propane chloride (BTP-Cl), N-methyl-D-glucamine chloride (NMG-Cl), or 2-amino-2-hydroxymethyl-1,3-propandiol chloride (TRIS-Cl). This enhancing effect did not depend on the osmolarity and occurred when Cl- was higher than K+ in the incubation medium, but not vice versa. When CaCl2 or MgCl2 or NMG-Cl were added, the higher the Cl-:K+ ratio in the external solution the higher was the increase in proline. When the excess of Cl- to K+ was obtained with BTP-Cl the highest enhancing effect resulted with a Cl-:K+ ratio of 3:1 while, at a 5:1 ratio, the KCl stimulation was completely suppressed. The inhibiting effect of proline accumulation by NH4+ and 4,4′-diisothiocyano-2,2′-disulfonicacid stilbene was reversed to varying degrees depending on the magnitude of the excess of Cl- on K+ concentration in the medium. Also, the inhibition of proline accumulation obtained by tetraethylammonium chloride, monensin, and D-mannose was similarly reverted. Thus, Cl- elicits an increase in ABA-induced proline which requires the simultaneous presence of K+ (or Na+).

Plant Physiology published new progress about Barley. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, SDS of cas: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Galiniak, Sabina; Aebisher, David; Bartusik-Aebisher, Dorota published the artcile< Health benefits of resveratrol administration>, COA of Formula: C14H12O3, the main research area is review resveratrol bioavailability antiinflammatory antioxidant anticancer antidiabetic neuroprotective.

A review. Resveratrol is a polyphenol that is abundant in grape skin and seeds. Food sources of resveratrol include wine, berries, and peanuts. This compound has many properties, including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, and aging. Because resveratrol is generally well tolerated, it is believed to be a promising compound in preventing many diseases, such as diabetes and its complications. Unfortunately, this compound exhibits low bioavailability and solubility The aim of this review is to summarize the latest information on the multiple effects of resveratrol on health and the benefits of its intake, based on in vitro and in vivo studies in animals and humans.

Acta Biochimica Polonica published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Dan-Dan; Shi, Guangjiang; Jiang, Yaping; Yao, Chao; Zhu, Chuanlin published the artcile< A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol antidiabetic agent diabetes mellitus; Anti-diabetes; Anti-inflammatory; Anti-oxidant; Diabetic complications; Hypoglycemic effect; Resveratrol.

A review. Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clin. complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer mols. from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochem. and physiol. actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising mol. for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vezina, Ben; Judd, Louise M.; McDougall, Fiona K.; Boardman, Wayne S. J.; Power, Michelle L.; Hawkey, Jane; Brisse, Sylvain; Monk, Jonathan M.; Holt, Kathryn E.; Wyres, Kelly L. published the artcile< Transmission of Klebsiella strains and plasmids within and between grey-headed flying fox colonies>, Related Products of 87-73-0, the main research area is plasmid transmission Klebsiella Pteropus.

The gray-headed flying fox (Pteropus poliocephalus) is an endemic Australian fruit bat, known to carry zoonotic pathogens. We recently showed they harbor bacterial pathogen Klebsiella pneumoniae and closely related species in the K. pneumoniae species complex (KpSC); however, the dynamics of KpSC transmission and gene flow within flying fox colonies are poorly understood. High-resolution genome comparisons of 39 KpSC isolates from gray-headed flying foxes identified five putative strain transmission clusters (four intra- and one inter-colony). The instance of inter-colony strain transmission of K. africana was found between two flying fox populations within flying distance, indicating either direct or indirect transmission through a common food/water source. All 11 plasmids identified within the KpSC isolates showed 73% coverage (mean) and ≥95% identity to human-associated KpSC plasmids, indicating gene flow between human clin. and gray-headed flying fox isolates. Along with strain transmission, inter-species horizontal plasmid transmission between K. pneumoniae and Klebsiella africana was also identified within a flying fox colony. Finally, genome-scale metabolic models were generated to predict and compare substrate usage to previously published KpSC models, from human and environmental sources. These models indicated no distinction on the basis of metabolic capabilities. Instead, metabolic capabilities were consistent with population structure and ST/lineage.

Environmental Microbiology published new progress about Food. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malaguarnera, Lucia published the artcile< Influence of resveratrol on the immune response>, Synthetic Route of 501-36-0, the main research area is review resveratrol immune response; B lymphocytes; T lymphocytes; immune response; macrophages; natural killer; resveratrol.

A review. Resveratrol is the most well-known polyphenolic stilbenoid, present in grapes, mulberries, peanuts, rhubarb, and in several other plants. Resveratrol can play a beneficial role in the prevention and in the progression of chronic diseases related to inflammation such as diabetes, obesity, cardiovascular diseases, neurodegeneration, and cancers among other conditions. Moreover, resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. At the mol. level, it targets sirtuin, adenosine monophosphate kinase, nuclear factor- κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as gluconeogenesis, lipid metabolism, mitochondrial biogenesis, angiogenesis, and apoptosis. Resveratrol can suppress the toll-like receptor (TLR) and pro-inflammatory genes’ expression. The antioxidant activity of resveratrol and the ability to inhibit enzymes involved in the production of eicosanoids contribute to its anti-inflammation properties. The effects of this biol. active compound on the immune system are associated with widespread health benefits for different autoimmune and chronic inflammatory diseases. This review offers a systematic understanding of how resveratrol targets multiple inflammatory components and exerts immune-regulatory effects on immune cells.

Nutrients published new progress about B cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Santos, Ana Claudia; Pereira, Irina; Pereira-Silva, Miguel; Ferreira, Laura; Caldas, Mariana; Collado-Gonzalez, Mar; Magalhaes, Mariana; Figueiras, Ana; Ribeiro, Antonio J.; Veiga, Francisco published the artcile< Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity>, Computed Properties of 501-36-0 , the main research area is review resveratrol nanoformulation bioavailability nanocarrier; Bioactivity; Bioavailability; In vivo; Nanocarriers; Nanoencapsulation; Nanoformulations; Nanoparticles; Nanotechnology; Resveratrol.

A review. Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biol. activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnol. appeared as a potential strategy to circumvent RES physicochem. and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnol.-based carriers, contemplating their pharmacokinetics effectiveness.

Colloids and Surfaces, B: Biointerfaces published new progress about Drug bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts