Tag: M.W=200-250

Bueno Duarte, Gustavo Henrique; de Piloto Fernandes, Anna Maria Alves; Silva, Alex Aparecido Rosini; Zamora-Obando, Hans R.; Amaral, Alan Goncalves; de Sousa Mesquita, Alessandra; Schmidt-Filho, Jayr; Cordeiro de Lima, Vladmir C.; D’Almeida Costa, Felipe; Andrade, Victor Piana; Porcari, Andreia M.; Eberlin, Marcos Nogueira; Simionato, Ana Valeria Colnaghi published the artcile< Gas chromatography-mass spectrometry untargeted profiling of non-Hodgkin's lymphoma urinary metabolite markers>, Formula: C6H10O8, the main research area is gas chromatog mass spectrometry non Hodgkin lymphoma metabolomic biomarker; Biomarkers; Gas chromatography-mass spectrometry; Metabolomics; Non-Hodgkin’s lymphoma.

Abstract: Non-Hodgkin’s lymphoma (NHL) is a cancer of the lymphatic system where the lymphoid and hematopoietic tissues are infiltrated by malignant neoplasms of B, T, and natural killer lymphocytes. Effective and less invasive methods for NHL screening are urgently needed. Herein, we report an untargeted gas chromatog.-mass spectrometry (GC-MS) method to investigate metabolic changes in non-volatile derivatized compounds from urine samples of NHL patients (N = 15) and compare them to healthy controls (N = 34). Uni- and multivariate data anal. showed 18 endogenous metabolites, including amino acids and their metabolites, sugars, small organic acids, and vitamins, as statistically significant for group differentiation. A receiver operating characteristic curve (ROC) generated from a support vector machine (SVM) algorithm-based model achieved 0.998 of predictive accuracy, displaying the potential and relevance of GC-MS-detected urinary non-volatile compounds for predictive purposes. Furthermore, a specific panel of key metabolites was also evaluated, showing similar results. All in all, our results indicate that this robust GC-MS method is an effective screening tool for NHL diagnosis and it is able to highlight different pathways of the disease.

Analytical and Bioanalytical Chemistry published new progress about Cancer diagnosis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Youngjin; Jo, HyunA; Cho, Jae Hyun; Dhanasekaran, Danny N.; Song, Yong Sang published the artcile< Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer>, Electric Literature of 501-36-0, the main research area is review resveratrol anticancer tumor microenvironment hypoxia oxidative stress cancer; cancer; chemoresistance; metastasis; resveratrol; tumor microenvironment.

A review. Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

International Journal of Molecular Sciences published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Armstrong, R. D.; Hirayama, J.; Knight, D. W.; Hutchings, G. J. published the artcile< Quantitative Determination of Pt- Catalyzed D-Glucose Oxidation Products Using 2D NMR>, Safety of D-Glucosaccharic acid, the main research area is platinum catalyzed glucose oxidation 2D NMR.

Quant. correlative 1H-13C NMR has long been discussed as a potential method for quantifying the components of complex reaction mixtures Here, we show that quant. HMBC NMR can be applied to understand the complexity of the catalytic oxidation of glucose to glucaric acid, which is a promising bio-derived precursor to adipic acid, under aqueous aerobic conditions. It is shown through 2D NMR anal. that the product streams of this increasingly studied reaction contain lactone and dilactone derivatives of acid products, including glucaric acid, which are not observable/quantifiable using traditional chromatog. techniques. At 98% glucose conversion, total C6 lactone yield reaches 44%. Furthermore, a study of catalyst stability shows that all Pt catalysts undergo product-mediated chem. leaching. Through catalyst development studies, it is shown that sequestration of leached Pt can be achieved through use of carbon supports.

ACS Catalysis published new progress about Catalyst supports. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Safety of D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Tiantian; Xiao, Dingfu; Muhammed, Arowolo; Deng, Juying; Chen, Liang; He, Jianhua published the artcile< Anti-inflammatory action and mechanisms of resveratrol>, Quality Control of 501-36-0, the main research area is review anti inflammation resveratrol mechanism; absorption and metabolism; anti-inflammation; antioxidant; mechanism; resveratrol.

A review. Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits antioxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined Multiple exptl. studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

Molecules published new progress about Absorption. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Huawei; Umar, Shahid; Liu, Zhenhua; Bukowski, Michael R. published the artcile< Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet>, Application of C6H10O8, the main research area is azoxymethane plasma metabolome dihydrocholesterol cholesterol; aberrant crypt foci; azoxymethane; colon cancer; high-fat diet; inflammation; metabolome; obesity.

Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat vs. 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a mouse cancer model. However, the underlying metabolic basis remains to be determined In the present study, we hypothesize that AOM treatment results in different plasma metabolomic responses in diet-induced obese mice. An untargeted metabolomic anal. was performed on the plasma samples by gas chromatog. time-of-flight mass spectrometry (GC-TOF-MS). We found that 53 of 144 identified metabolites were different between the 4 groups of mice (AIN, AIN + AOM, HFD, HFD + AOM), and sparse partial least-squares discriminant anal. showed a separation between the HFD and HFD + AOM groups but not the AIN and AIN + AOM groups. Moreover, the concentrations of dihydrocholesterol and cholesterol were inversely associated with AOM-induced colonic ACF formation. Functional pathway analyses indicated that diets and AOM-induced colonic ACF modulated five metabolic pathways. Collectively, in addition to differential plasma metabolomic responses, AOM treatment decreases dihydrocholesterol and cholesterol levels and alters the composition of plasma metabolome to a greater extent in mice fed a HFD compared to the AIN.

Metabolites published new progress about Aberrant crypt foci. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Li; Zhou, Mengmeng; Huang, Dawei; Wasan, Harpreet S.; Zhang, Kai; Sun, Leitao; Huang, Hong; Ma, Shenglin; Shen, Minhe; Ruan, Shanming published the artcile< Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial- mesenchymal transition via the AKT/GSK-3beta/Snail signaling pathway>, Application In Synthesis of 501-36-0 , the main research area is resveratrol AKT GSK Snail colon cancer EMT signaling pathway.

The identification of safe and effective drugs that inhibit tumor invasion and metastasis is required to improve the clin. outcome of patients with colon cancer. The present study aimed to investigate the inhibitory effects and possible mechanisms of action of resveratrol against the invasion and metastasis of colon cancer. AKT1-knockdown SW480 and SW620 colon cancer cells were used to detect the effects of resveratrol on cell invasion and metastasis, as well as changes in the expression of epithelial-mesenchymal transition (EMT) markers and serine/threonine kinase (AKT)/glycogen synthase kinase (GSK)-3beta/Snail signaling pathway-related mols. in vitro. Furthermore, nude mice were inoculated with SW480 cells in the tail vein to establish an in vivo lung metastasis model of colon cancer, to investigate the effects of resveratrol on lung metastasis in colon cancer. The results revealed that resveratrol treatment and AKT1 knockdown significantly inhibited cell migration and invasion in colon cancer, and markedly increased E-cadherin expression and decreased that of N-cadherin, phospho (p)-AKT1, p-GSK-3beta, and Snail in colon cancer both in vitro and in vivo. Furthermore, the effects of resveratrol were significantly weaker in the AKT1-knockdown cells. In conclusion, resveratrol may suppress the invasion and metastasis of colon cancer through reversal of EMT via the AKT/GSK-3beta/Snail signaling pathway.

Molecular Medicine Reports published new progress about Cadherin CDH1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Berretta, Massimiliano; Bignucolo, Alessia; Francia, Raffaele Di; Comello, Francesco; Facchini, Gaetano; Ceccarelli, Manuela; Iaffaioli, Rosario Vincenzo; Quagliariello, Vincenzo; Maurea, Nicola published the artcile< Resveratrol in cancer patients: from bench to bedside>, Electric Literature of 501-36-0, the main research area is review pharmacokinetics resveratrol cardioprotectant anticancer agent cardiovascular disease cancer; cancer; complementary medicines; cytochrome P450; food-drug; inflammation; personalized medicine; pharmacodynamic; pharmacokinetic; resveratrol.

A review. Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive mol. and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biol. targets, cardiovascular outcomes, physico-chem. and pharmacokinetic properties of resveratrol in preclin. and clin. models implementing its potential use in cancer patients.

International Journal of Molecular Sciences published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paschalidis, Leandros; Beer, Barbara; Sutiono, Samuel; Sieber, Volker; Burger, Jakob published the artcile< Design of enzymatic cascade reactors through multi-objective dynamic optimization>, Name: D-Glucosaccharic acid, the main research area is enzymic cascade reactor multiobjective dynamic optimization.

Multi-enzymic cascade reactions have gathered a lot of interest lately because of their potential for sustainable production of chems. In this paper, model-based, multi-objective, dynamic optimization is applied to the design of an enzymic cascade reactor that produces α-ketoglutarate. Pareto-optimal process schedules, which are best compromises between space-time yield, enzyme consumption and cofactor consumption, are determined and visualized. Depending on the importance of the individual objectives, the optimal process schedules vary. It is demonstrated, that multi-objective optimization is a valuable tool for the development of enzymic cascades. It provides decision support for making further experiments, finding bottlenecks in the cascade, and choosing an optimal process schedule for the production

Biochemical Engineering Journal published new progress about Biochemical cofactors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scelfo, Simone; Geobaldo, Francesco; Pirone, Raffaele; Russo, Nunzio published the artcile< Catalytic wet air oxidation of D-glucose by perovskite type oxides (Fe, Co, Mn) for the synthesis of value-added chemicals>, Electric Literature of 87-73-0, the main research area is glucose wet air oxidation organic acid perovskite oxide catalyst; CWAO; Lactic acid; Levulinic acid; Perovskites; d-glucose; d-saccharic acid.

The conversion of common biomasses derived, as D-glucose, into value-added chems. has received highest attention in the last few years. Among all processes, the catalytic wet air oxidation (CWAO) of derived biomasses using noble metal-based heterogeneous catalytic systems has been investigated. Nevertheless, the redox effect of such catalysts on such bio-compounds has still to be investigated in detail. In the present work, the activity for the conversion of D-glucose into C6 aldaric acid, lactic acid and levulinic acid of some perovskite type oxides (LaBO3; B: Fe, Co, Mn) characterized by noticeable catalytic properties and stability under hydrothermal conditions, have been investigated. The influence of the reaction temperature and the effect of the catalytic properties on the distribution of the liquid products have been studied. In the best conditions, 50.3 mol.% and 69.5 mol.% of lactic and levulinic acid have been obtained by using LaCoO3 and LaMnO3, resp. Apart from the oxidative effect, the affinity hydrogen allowed the catalytic conversion of some key intermediates, such as pyruvic aldehyde and hydroxymethylfurfural, into the desired products. LaMnO3, which has resulted to be the most oxidizable/reducible catalyst at low temperatures, has shown the best catalytic activity among the studied catalysts, promoting the conversion of hydroxymethylfurfural to levulinic acid and giving overall the highest yield.

Carbohydrate Research published new progress about Biomass. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thapa, Samir Bahadur; Pandey, Ramesh Prasad; Park, Yong Il; Sohng, Jae Kyung published the artcile< Biotechnological advances in resveratrol production and its chemical diversity>, SDS of cas: 501-36-0 , the main research area is chemical diversity; metabolic engineering; microbial production; resveratrol.

The very well-known bioactive natural product, resveratrol (3,5,4′-trihydroxystilbene), is a highly studied secondary metabolite produced by several plants, particularly grapes, passion fruit, white tea, and berries. It is in high demand not only because of its wide range of biol. activities against various kinds of cardiovascular and nerve-related diseases, but also as important ingredients in pharmaceuticals and nutritional supplements. Due to its very low content in plants, multi-step isolation and purification processes, and environmental and chem. hazards issues, resveratrol extraction from plants is difficult, time consuming, impracticable, and unsustainable. Therefore, microbial hosts, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, are commonly used as an alternative production source by improvising resveratrol biosynthetic genes in them. The biosynthesis genes are rewired applying combinatorial biosynthetic systems, including metabolic engineering and synthetic biol., while optimizing the various production processes. The native biosynthesis of resveratrol is not present in microbes, which are easy to manipulate genetically, so the use of microbial hosts is increasing these days. This review will mainly focus on the recent biotechnol. advances for the production of resveratrol, including the various strategies used to produce its chem. diverse derivatives

Molecules published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts