Tag: M.W=200-250

Pasquariello, Rolando; Verdile, Nicole; Brevini, Tiziana A. L.; Gandolfi, Fulvio; Boiti, Cristiano; Zerani, Massimo; Maranesi, Margherita published the artcile< The role of resveratrol in mammalian reproduction>, Formula: C14H12O3, the main research area is review resveratrol polyphenol female male reproduction; cryopreservation; oocyte quality; ovary function; phytoestrogens; polyphenols; reproduction; sirtuin; sperm quality; spermatozoa; testis function.

A review. Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.

Molecules published new progress about Anti-apoptotic agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Hang; Song, An; Zhang, Yunjia; Shu, Linyi; Song, Guangyao; Ma, Huijuan published the artcile< Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis>, Application In Synthesis of 501-36-0 , the main research area is meta analysis resveratrol lipid type 2 diabetes.

Objective : Few studies have considered the effect of resveratrol on blood lipid levels, and the results of these studies are inconsistent. In this study, the first meta-anal. on the effect of resveratrol on blood lipid levels in patients with type 2 diabetes was conducted. Methods : This study used keywords such as type 2 diabetes, total cholesterol, triglyceride (TG), high-d. lipoprotein, low-d. lipoprotein, and resveratrol and their abbreviations, free words, and related words to search PubMed, Cochrane Library, and Embase. The Cochrane risk of bias tool was used to evaluate the risk of bias, and Review Manager 5.3 and Stata 13.0 were used for data merging and statistical anal. Results : Ten randomized controlled trials involving a total of 363 patients with type 2 diabetes were included in the anal. The results show that longer resveratrol intervention time (≥6 mo) can reduce TG levels. But resveratrol increased total cholesterol in patients within obesity range. In type 2 diabetes patients with obesity and in those who took lipid-lowering drugs, resveratrol increased low-d. lipoprotein levels. Conclusions : Resveratrol can improve TG in patients with type 2 diabetes.

Obesity published new progress about High-density lipoproteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Machado, Noelia D.; Fernandez, Mariana A.; Diaz, David Diaz published the artcile< Recent Strategies in Resveratrol Delivery Systems>, Computed Properties of 501-36-0, the main research area is review resveratrol delivery system photostability; drug delivery systems; encapsulation; nutrition; pharmaceutics; resveratrol.

A review. Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio-protective, antioxidant and anti-inflammatory activities. Trans-resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the pos. properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chem. instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

ChemPlusChem published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yanke; Yang, Sufen; Yang, Yang; Liu, Teng published the artcile< Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells>, Product Details of C14H12O3, the main research area is ovarian carcinoma resveratrol immunogenic cell death; Cytotoxic T cell; Immunogenic cell death; Ovarian carcinoma; Resveratrol.

Purpose: This study aimed to clarify whether immunogenic cell death (ICD) contributed to the anti-tumor action of resveratrol against ovarian carcinoma. Methods: Resveratrol suppressed cell proliferation and induced apoptosis in ovarian carcinoma cells. In addition, resveratrol treatment stimulated cell surface exposure of calreticulin, HMGB1 secretion and ATP release. Results: Vaccination with resveratrol-pretreated ID8 cells significantly inhibited growth of subsequent inoculated xenograft tumor. Direct administration with resveratrol suppressed tumor progression accompanied with compromised cell proliferation and enhanced cell apoptosis. We further characterized increases of both mature dendritic cells and cytotoxic T cells in xenograft tumor in response to resveratrol treatment, which also inhibited TGF-β production and stimulated both IL12p7 and IFN-γ secretion. Most importantly, we demonstrated that combination with PD-1 antibody greatly inhibited tumor growth, while depletion of CD8+ T cells by neutralizing antibody restored xenograft progression. Conclusion: Our data suggested resveratrol exerted anti-tumor action against ovarian cancer via both apoptosis and ICD pathways.

Infectious Agents and Cancer published new progress about CD8-positive T cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dull, Ana-Maria; Moga, Marius Alexandru; Dimienescu, Oana Gabriela; Sechel, Gabriela; Burtea, Victoria; Anastasiu, Costin Vlad published the artcile< Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review endometriosis resveratrol anti inflammation angiogenic therapeutics; anti-inflammatory; cytokines; endometriosis; inflammatory disease; resveratrol.

A review. Endometriosis represents a severe gynecol. pathol., defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathol. affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiol. and pathogenesis of this disease still remain not fully understood. Initially, endometriosis was related to retrograde menstruation, but new theories have been launched, suggesting that chronic inflammation can influence the development of endometriosis because inflammatory mediators have been identified elevated in patients with endometriosis, specifically in the peritoneal fluid. The importance of dietary phytochems. and their effect on different inflammatory diseases have been highlighted, and nowadays more and more studies are focused on the anal. of nutraceuticals. Resveratrol is a phytoestrogen, a natural polyphenolic compound with antiproliferative and anti-inflammatory actions, found in many dietary sources such as grapes, wine, peanuts, soy, berries, and stilbenes. Resveratrol possesses a significant anti-inflammatory effect via inhibition of prostaglandin synthesis and it has been proved that resveratrol can exhibit apoptosis-inducing activities. From the studies reviewed in this paper, it is clear that the anti-inflammatory effect of this natural compound can contribute to the prevention of endometriosis, this phenolic compound now being considered a new innovative drug in the prevention and treatment of this disease.

Molecules published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Speck, Ulrich; Siefert, Hans Martin; Klink, Gunter published the artcile< Contrast media and pain in peripheral arteriography>, Application of C7H18ClNO5, the main research area is contrast media pain arteriog.

Pain caused by x-ray contrast media in peripheral arteriog. was assessed by behavioral changes of nonanesthetized, unrestrained rats. All ionic monomeric contrast media caused severe pain in a concentration of 300 mg I/mL. Dilution of contrast media markedly reduced pain. Solutions containing Na salts were considerably more painful than solutions with meglumine salts. The i.v. cholangiog. agent meglumine iodipamide [3521-84-4] did not cause vascular pain in a concentration of 300 mg I/mL, although its systemic toxicity was high. Pain in arteriog. was attributable primarily to the high osmotic pressure of contrast media solutions rather than to their chemotoxicity.

Investigative Radiology published new progress about Artery. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Application of C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hashemi, Seirana; Razaghi-Moghadam, Zahra; Nikoloski, Zoran published the artcile< Identification of flux trade-offs in metabolic networks>, Recommanded Product: D-Glucosaccharic acid, the main research area is Arabidopsis thaliana flux trade metabolic network.

Trade-offs are inherent to biochem. networks governing diverse cellular functions, from gene expression to metabolism Yet, trade-offs between fluxes of biochem. reactions in a metabolic network have not been formally studied. Here, we introduce the concept of absolute flux trade-offs and devise a constraint-based approach, termed FluTO, to identify and enumerate flux trade-offs in a given genome-scale metabolic network. By employing the metabolic networks of Escherichia coli and Saccharomyces cerevisiae, we demonstrate that the flux trade-offs are specific to carbon sources provided but that reactions involved in the cofactor and prosthetic group biosynthesis are present in trade-offs across all carbon sources supporting growth. We also show that absolute flux trade-offs depend on the biomass reaction used to model the growth of Arabidopsis thaliana under different carbon and nitrogen conditions. The identified flux trade-offs reflect the tight coupling between nitrogen, carbon, and sulfur metabolisms in leaves of C3 plants. Altogether, FluTO provides the means to explore the space of alternative metabolic routes reflecting the constraints imposed by inherent flux trade-offs in large-scale metabolic networks.

Scientific Reports published new progress about Arabidopsis thaliana. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Filardo, Simone; Di Pietro, Marisa; Mastromarino, Paola; Sessa, Rosa published the artcile< Therapeutic potential of resveratrol against emerging respiratory viral infections>, Product Details of C14H12O3, the main research area is review resveratrol respiratory virus infection; Anti-viral mechanisms; Emerging respiratory viruses; Resveratrol.

A review. Resveratrol has been widely studied for its therapeutic potential due to its antioxidant, anti-inflammatory and anti-microbial properties. In particular, resveratrol has shown promising antiviral activity against numerous viruses responsible for severe respiratory infections. Amongst these, influenza virus, respiratory syncytial virus and the emerging SARS-cov-2 are known to cause pneumonia, acute respiratory distress syndrome or multi-organ failure, especially, in vulnerable individuals like immunocompromised patients or the elderly, leading to a considerable economic burden worldwide. In this context, resveratrol may have potential value for its anti-inflammatory activity, since most of the severe virus-associated complications are related to the overactivation of the host-immune response, leading to lung damage. Herein, we present an overview of the antiviral activity and potential mechanisms of resveratrol against the respiratory tract viruses considered as a public threat for their rapid transmission and high morbidity and mortality in the general population.

Pharmacology & Therapeutics published new progress about Drug bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farkhondeh, Tahereh; Folgado, Silvia Llorens; Pourbagher-Shahri, Ali Mohammad; Ashrafizadeh, Milad; Samarghandian, Saeed published the artcile< The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway>, Electric Literature of 501-36-0 , the main research area is resveratrol therapeutic Nrf signaling pathway review; Inflammation; Nrf2; Oxidative stress; Resveratrol; Therapeutic effects.

A review. Resveratrol is a natural polyphenol derived from grapes, berries, red wine, peanuts amongst other fruits and nuts. Beneficial effects such as anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, anti-obesity, anti-diabetic, and anti-cancer of resveratrol have been demonstrated by preclin. and clin. research. A possibility is that these therapeutical effects are associated with modulation of the Nrf2 signaling pathway in the following way: resveratrol may potentiate Nrf2 signaling through blockage of Keap1, by means of changing the Nrf2 mediators, its expression and its nuclear translocation. This article reviews the evidence of the Nrf2 modulating hypothesis as a possible mol. mechanism underlying the medicinal properties of resveratrol.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ceballos, Francisco C.; Virseda-Berdices, Ana; Resino, Salvador; Ryan, Pablo; Martinez-Gonzalez, Oscar; Perez-Garcia, Felipe; Martin-Vicente, Maria; Brochado-Kith, Oscar; Blancas, Rafael; Bartolome-Sanchez, Sofia; Vidal-Alcantara, Erick Joan; Alboniga-Diez, Oihane Elena; Cuadros-Gonzalez, Juan; Blanca-Lopez, Natalia; Martinez, Isidoro; Martinez-Acitores, Ignacio Ramirez; Barbas, Coral; Fernandez-Rodriguez, Amanda; Jimenez-Sousa, Maria Angeles published the artcile< Metabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation>, Formula: C6H10O8, the main research area is metabolic profiling COVID 19 disease severity sex specific dysregulation; COVID-19; Spanish hospitals; disease onset; metabolomics; severity; sex-specific.

Metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression. We performed a retrospective cross-sectional study in 123 COVID-19 patients which were stratified as asymptomatic/mild, moderate and severe according to the highest COVID-19 severity status, and a group of healthy controls. We performed an untargeted plasma metabolic profiling (gas chromatog. and capillary electrophoresis-mass spectrometry (GC and CE-MS)) and cytokine evaluation. After data filtering and identification we observed 105 metabolites dysregulated (66 GC-MS and 40 CE-MS) which shown different expression patterns for each COVID-19 severity status. These metabolites belonged to different metabolic pathways including amino acid, energy, and nitrogen metabolism among others. Severity-specific metabolic dysregulation was observed, as an increased transformation of L-tryptophan into L-kynurenine. Thus, metabolic profiling at hospital admission differentiate between severe and moderate patients in the later phase of worse evolution. Several plasma pro-inflammatory biomarkers showed significant correlation with deregulated metabolites, specially with L-kynurenine and L-tryptophan. Finally, we describe a strong sex-related dysregulation of metabolites, cytokines and chemokines between severe and moderate patients. In conclusion, metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the SARS-CoV-2 mol. pathogenesis. This technique makes it possible to identify metabolic phenoconversion that predicts disease progression and explains the pronounced pathogenesis differences between sexes.

Frontiers in Immunology published new progress about COVID-19. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts