Tag: M.W=200-250

Castro, David J.; Gomez-Altuve, Andreina; Reina, Jose Carlos; Rodriguez, Miguel; Sampedro, Inmaculada; Llamas, Inmaculada; Martinez-Checa, Fernando published the artcile< Roseovarius bejariae sp. nov., a moderately halophilic bacterium isolated from a hypersaline steep-sided river bed>, Related Products of 87-73-0, the main research area is hypersaline steep sided river bed halophilic bacterium Roseovarius bejariae; Roseovarius bejariae sp. nov.; halophilic bacteria; polyphasic taxonomy; saline soil.

An aerobic, Gram-stain-neg. ovoid, designated as strain A21T, was isolated using the dilution-to-extinction method from a soil sample taken from Rambla Salada, an athalassohaline habitat located in Murcia (south-eastern Spain). Strain A21T is nonmotile, has a respiratory metabolism and grows at NaCl concentrations within the range 0.5-15% (w/v) [optimum, 5% (w/v)], at 5-35°C (optimum, 28°C) and at pH 6-8 (optimum, pH 7.0). This strain is pos. for catalase activity, oxidase activity and nitrate reduction The 16S rRNA gene sequence indicates that it belongs to the genus Roseovarius in the class Alphaproteobacteria. The most closely related species are Roseovarius pacificus and Roseovarius halotolerans to which the strain A21T shows 16S rRNA gene sequence similarity values of 98.06 and 97.7%, resp. The average nucleotide identity in blast and digital DNA-DNA hybridization values between strain A21T and R. pacificus LMG 24575T are 76.8 and 21%, resp. The DNA G+C content based on the genome is 61.28mol%. The major fatty acids (>5% of the total fatty acids) of strain A21T are C18:1ω7c/C18:1ω and C18:1. The only detected isoprenoid quinone in strain A21T is ubiquinone 10 (Q-10). The polar lipid profile contains phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol and three unidentified polar lipids. Based on the phylogenetic, genotypic, phenotypic and chemotaxonomic data, the strain represents a novel species of the genus Roseovarius, for which the name Roseovarius bejariae sp. nov. is proposed. Strain A21T (=CECT 9817T =LMG 31311T) is the type strain.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sattarinezhad, A.; Roozbeh, J.; Shirazi Yeganeh, B.; Omrani, G. R.; Shams, M. published the artcile< Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial>, SDS of cas: 501-36-0 , the main research area is resveratrol antioxidant albuminuria diabetic nephropathy; Albuminuria; Diabetes complications; Diabetes mellitus; Diabetic nephropathy; Resveratrol.

Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN.In this randomized, double-blind, placebo-controlled clin. trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500 mg/day) or placebo for 90 days. Losartan (12.5 mg/day) was also administered to all participants. Primary outcomes were urinary albumin/creatinine ratio, estimated glomerular filtration rate (eGFR) and serum creatinine levels. Secondary outcomes were oxidative stress markers, and anthropometric and biochem. measures. Mean urine albumin/creatinine ratio was significantly reduced in the resveratrol group vs placebo (-46.4 mg/g, 95% CI: -64.5 to -28.3 vs 29.9 mg/g, 95% CI: 4.9 to 54.9; P < 0.001), whereas eGFR (1.7 mL/min/1.73 m2, 95% CI: -3.4 to 6.8 vs -4.0, 95% CI: -8.2 to 0.2; P = 0.08) and serum creatinine (-0.3 mg/dL, 95% CI: -0.1 to 0.1 vs 0.1 mg/dL, 95% CI: -0.0 to 0.1; P = 0.13) were unchanged. Serum antioxidant enzymes were significantly increased with resveratrol. After adjusting for confounding variables, the effect of resveratrol in reducing urinary albumin excretion was still significant (P < 0.001). Regression anal. revealed that every 1-cm decrease in waist circumference and 1-μmol/L increase in nitric oxide (NO) was associated with 9.4 mg/g and 4.0 mg/g reductions, resp., of urine albumin/creatinine ratio. This clin. trial has shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN (ClinicalTrials.gov: NCT02704494). Diabetes & Metabolism published new progress about Albuminuria. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hou, Chih-Yao; Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung published the artcile< The effects of resveratrol in the treatment of metabolic syndrome>, Reference of 501-36-0 , the main research area is resveratrol metabolic syndrome review; high-fat diet; metabolic syndrome; resveratrol; resveratrol derivatives.

A review. Resveratrol, also known as 3,5,4′-trihydroxystilbene, is a natural polyphenol that occurs as a phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, peanuts, and other oilseeds. This compound has a variety of effects on human health and diseases. This review summarizes the mounting evidence that resveratrol is helpful in treating metabolic syndrome and related disorders. Resveratrol can be provided either early as a reprogramming agent or later as part of treatment. A few of the main mechanisms underlying the beneficial effects of resveratrol on metabolic syndrome are outlined. This review also discusses the potential of resveratrol derivatives as a complementary or alternative medicine. In conclusion, resveratrol could be a useful regimen for the prevention and treatment of metabolic syndrome and its related conditions.

International Journal of Molecular Sciences published new progress about Cardiovascular disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeandet, Philippe; Clement, Christophe; Cordelier, Sylvain published the artcile< Regulation of resveratrol biosynthesis in grapevine: new approaches for disease resistance?>, Related Products of 501-36-0 , the main research area is review phytoalexin resveratrol disease resistance.

A review. Transcription factors are key components in the regulation of metabolic pathways underlying numerous plant functions. Jiang et al. (2019) showed that the WRKY8 transcription factor fine-tunes biosynthesis of the phytoalexin resveratrol in grapevine through neg. regulation of the stilbene synthase gene. This paves the way for new approaches in our understanding of the regulation of phytoalexin biosynthesis in plants and, through this, improved phytoalexin production in engineered disease resistance.

Journal of Experimental Botany published new progress about Disease resistance, plant. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simental-Mendia, Luis E.; Guerrero-Romero, Fernando published the artcile< Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial>, HPLC of Formula: 501-36-0 , the main research area is dyslipidemia lipid lowering agent resveratrol; Dyslipidemia; Lipid profile; Lipids; Randomized controlled trial; Resveratrol.

Objectives: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. Methods: Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alc. intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400mg/dL, low-d. lipoprotein cholesterol levels ≥190mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. Results: Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 vs. 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 vs. 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-d. lipoprotein cholesterol and low-d. lipoprotein cholesterol levels. Conclusion: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.

Nutrition (New York, NY, United States) published new progress about Dyslipidemia. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Killiny, Nabil; Nehela, Yasser; George, Justin; Rashidi, Mahnaz; Stelinski, Lukasz L.; Lapointe, Stephen L. published the artcile< Phytoene desaturase-silenced citrus as a trap crop with multiple cues to attract Diaphorina citri, the vector of Huanglongbing>, Quality Control of 87-73-0, the main research area is phytoene desaturase citrus Diaphorina citri HLB infection; Attract and kill; Carotenoids; Citrus; Diaphorina citri; Electrical Penetration Graph; Phytoene desaturase; Trap crop.

Huanglongbing (HLB) is one of the most destructive diseases in citrus worldwide. Unfortunately, HLB has no cure and management relies on insecticides to reduce populations of the vector, Diaphorina citri Kuwayama (Hemiptera: Liviidae). We propose an attract-and-kill strategy using a trap crop as an alternative to vector control to reduce transmission of the pathogen, ‘Candidatus Liberibacter asiaticus’. We evaluated vector response to phytoene desaturase-silenced citrus trees using virus-induced gene silencing technol. Citrus tristeza virus (CTV) was used to produce a phytoene desaturase-silenced citrus (CTV-tPDS) that expresses visual, olfactory, and gustatory cues to attract D. citri. We found that D. citri were more attracted to CTV-tPDS plants with noticeably better fecundity and overall population fitness than on control plants. Moreover, rearing D. citri on CTV-tPDS plants significantly increased their survival probability compared with those reared on control plants. CTV-tPDS plants possessed reduced content of both carotenoid and chlorophyll pigments resulting in a consistent photobleached phenotype on citrus leaves which provided a sufficient close-range visual attractant to stimulate D. citri landing. Addnl., CTV-tPDS plants exhibited an enriched profile of volatile organic compounds (VOCs), which offered adequate olfactory cues to attract psyllid from long-range. Finally, CTV-tPDS plants exhibited an enriched metabolite content of phloem sap and leaves which offered appropriate gustatory cues that influenced probing/feeding behavior. We believe that introducing CTV-tPDS plants (as a trap crop) to D. citri-infested orchards will attract and congregate psyllids to facilitate their removal from the target crop with insecticides or by other means. This new strategy could be deployed relatively quickly and economically to HLB-impacted citrus industries. Moreover, it is an eco-friendly strategy because it should partially reduce the input of chem. insecticides ameliorating the indirect cost of HLB infection.

Plant Science (Shannon, Ireland) published new progress about Aversive behavior, taste aversion. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Boxu; Kwah, Marabeth Xin-Yi; Liu, Cuiliu; Ma, Zhaowu; Shanmugam, Muthu K.; Ding, Lingwen; Xiang, Xiaoqiang; Ho, Paul Chi-Lui; Wang, Lingzhi; Ong, Pei Shi; Goh, Boon Cher published the artcile< Resveratrol for cancer therapy: Challenges and future perspectives>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review cancer resveratrol therapy; Cancer treatment; Pharmacodynamics; Pharmacokinetics; Resveratrol; Toxicity.

A review. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclin. studies on the anticancer activity of resveratrol, little progress has been made in translational research and clin. trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogs of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy.

Cancer Letters (New York, NY, United States) published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Killiny, Nabil; Nehela, Yasser; George, Justin; Rashidi, Mahnaz; Stelinski, Lukasz L.; Lapointe, Stephen L. published the artcile< Phytoene desaturase-silenced citrus as a trap crop with multiple cues to attract Diaphorina citri, the vector of Huanglongbing>, Quality Control of 87-73-0, the main research area is phytoene desaturase citrus Diaphorina citri HLB infection; Attract and kill; Carotenoids; Citrus; Diaphorina citri; Electrical Penetration Graph; Phytoene desaturase; Trap crop.

Huanglongbing (HLB) is one of the most destructive diseases in citrus worldwide. Unfortunately, HLB has no cure and management relies on insecticides to reduce populations of the vector, Diaphorina citri Kuwayama (Hemiptera: Liviidae). We propose an attract-and-kill strategy using a trap crop as an alternative to vector control to reduce transmission of the pathogen, ‘Candidatus Liberibacter asiaticus’. We evaluated vector response to phytoene desaturase-silenced citrus trees using virus-induced gene silencing technol. Citrus tristeza virus (CTV) was used to produce a phytoene desaturase-silenced citrus (CTV-tPDS) that expresses visual, olfactory, and gustatory cues to attract D. citri. We found that D. citri were more attracted to CTV-tPDS plants with noticeably better fecundity and overall population fitness than on control plants. Moreover, rearing D. citri on CTV-tPDS plants significantly increased their survival probability compared with those reared on control plants. CTV-tPDS plants possessed reduced content of both carotenoid and chlorophyll pigments resulting in a consistent photobleached phenotype on citrus leaves which provided a sufficient close-range visual attractant to stimulate D. citri landing. Addnl., CTV-tPDS plants exhibited an enriched profile of volatile organic compounds (VOCs), which offered adequate olfactory cues to attract psyllid from long-range. Finally, CTV-tPDS plants exhibited an enriched metabolite content of phloem sap and leaves which offered appropriate gustatory cues that influenced probing/feeding behavior. We believe that introducing CTV-tPDS plants (as a trap crop) to D. citri-infested orchards will attract and congregate psyllids to facilitate their removal from the target crop with insecticides or by other means. This new strategy could be deployed relatively quickly and economically to HLB-impacted citrus industries. Moreover, it is an eco-friendly strategy because it should partially reduce the input of chem. insecticides ameliorating the indirect cost of HLB infection.

Plant Science (Shannon, Ireland) published new progress about Aversive behavior, taste aversion. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sato, Tomonori; Kawasaki, Yoshihide; Maekawa, Masamitsu; Takasaki, Shinya; Saigusa, Daisuke; Ota, Hideki; Shimada, Shuichi; Yamashita, Shinichi; Mitsuzuka, Koji; Yamaguchi, Hiroaki; Ito, Akihiro; Kinoshita, Kengo; Koshiba, Seizo; Mano, Nariyasu; Arai, Yoichi published the artcile< Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma>, Quality Control of 87-73-0, the main research area is metabolomics diagnosis renal carcinoma; biomarker; clinicopathological factor; diagnosis; global metabolomics; renal cell carcinoma.

Renal cell carcinoma (RCC) is a malignant tumor that currently lacks clin. useful biomarkers indicative of early diagnosis or disease status. RCC has commonly been diagnosed based on imaging results. Metabolomics offers a potential technol. for discovering biomarkers and therapeutic targets by comprehensive screening of metabolites from patients with various cancers. We aimed to identify metabolites associated with early diagnosis and clinicopathol. factors in RCC using global metabolomics (G-Met). Tumor and nontumor tissues were sampled from 20 cases of surgically resected clear cell RCC. G-Met was performed by liquid chromatog. mass spectrometry and important metabolites specific to RCC were analyzed by multivariate statistical anal. for cancer diagnostic ability based on area under the curve (AUC) and clinicopathol. factors (tumor volume, pathol. T stage, Fuhrman grade, presence of coagulation necrosis and distant metastasis). We identified 58 metabolites showing significantly increased levels in tumor tissues, 34 of which showed potential early diagnostic ability (AUC >0.8), but 24 did not discriminate between tumor and nontumor tissues (AUC ≤0.8). We recognized 6 pathways from 9 metabolites with AUC >0.8 and 7 pathways from 10 metabolites with AUC ≤0.8 about malignant status. Clinicopathol. factors involving malignant status correlated significantly with metabolites showing AUC ≤0.8 (p = 0.0279). The tricarboxylic acid cycle (TCA) cycle, TCA cycle intermediates, nucleotide sugar pathway and inositol pathway were characteristic pathways for the malignant status of RCC. In conclusion, our study found that metabolites and their pathways allowed discrimination between early diagnosis and malignant status in RCC according to our G-Met protocol.

International Journal of Cancer published new progress about Diagnosis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vekariya, Rakesh H.; Lei, Wei; Ray, Abhisek; Saini, Surendra K.; Zhang, Sixue; Molnar, Gabriella; Barlow, Deborah; Karlage, Kelly L.; Bilsky, Edward J.; Houseknecht, Karen L.; Largent-Milnes, Tally M.; Streicher, John M.; Ananthan, Subramaniam published the artcile< Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects>, Safety of 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is MOR agonist DOR antagonist antinociceptive SAR side effects.

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed μ opioid receptor (MOR) agonist and δ/κ opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this mol. gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20(I) (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression vs. morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects.

Journal of Medicinal Chemistry published new progress about Analgesics. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Safety of 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts