Tag: M.W=200-250

Cheng, Chak Kwong; Luo, Jiang-Yun; Lau, Chi Wai; Chen, Zhen-Yu; Tian, Xiao Yu; Huang, Yu published the artcile< Pharmacological basis and new insights of resveratrol action in the cardiovascular system>, Formula: C14H12O3, the main research area is .

Resveratrol (trans-3,4′,5-trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti-inflammatory, anti-proliferative, and angio-regulatory effects against atherosclerosis, ischemia, and cardiomyopathy. This article critically reviews the current findings on the mol. basis of resveratrol-mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition In addition, this article also provides an update, both preclinically and clin., on resveratrol-induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclin. and clin. studies. Although resveratrol has been claimed as a master anti-aging agent against several age-associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.

British Journal of Pharmacology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pannu, Naveet; Bhatnagar, Archana published the artcile< Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases>, Product Details of C14H12O3, the main research area is review antioxidative antiinflammatory immunomodulating resveratrol bioavailability; Biosynthesis; Cardiovascular diseases; Diabetes; Neurological diseases; Pharmacokinetics; Resveratrol.

A review. Resveratrol, a phytoalexin with a wide range of pharmacol. properties is synthesized by plants in response to stress, injury, infection or UV radiations. As it is a secondary metabolite with many health promoting properties, various methods employing microorganisms and genetic manipulation of different synthetic enzymes, have been comprehensively studied to increase its production This flavonoid is extensively researched due to its pharmacol. properties such as anti-oxidative, anti-inflammatory and immuno-modulating effects. Knowledge of these properties of resveratrol has led to elaborate studies on its effect on diabetes, neurodegenerative diseases, cancer, ageing, obesity and cardiovascular diseases. At mol. level it targets sirtuin, adenosine monophosphate kinase, nuclear Factor-κB, inflammatory cytokines, anti-oxidant enzymes along with cellular processes such as angiogenesis, apoptosis, mitochondrial biogenesis, gluconeogenesis and lipid metabolism This discusses the properties of resveratrol and the different approaches of addressing the unfavorable synthesis and pharmacokinetics of this stilbene. Pre-clin. evaluations of resveratrol on diabetes mellitus, cardiovascular and neurol. diseases are elaborately discussed and the underlying pathways involved in its therapeutic activity have been given paramount importance. Following the pre-clin. studies, clin. trials on the same reveal the efficacy of resveratrol in the effective management of these diseases. This provides an intricate insight on resveratrol’s significance from a dietary component to a therapeutic agent.

Biomedicine & Pharmacotherapy published new progress about Aging, animal. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thapa, Samir Bahadur; Pandey, Ramesh Prasad; Park, Yong Il; Sohng, Jae Kyung published the artcile< Biotechnological advances in resveratrol production and its chemical diversity>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is chemical diversity; metabolic engineering; microbial production; resveratrol.

The very well-known bioactive natural product, resveratrol (3,5,4′-trihydroxystilbene), is a highly studied secondary metabolite produced by several plants, particularly grapes, passion fruit, white tea, and berries. It is in high demand not only because of its wide range of biol. activities against various kinds of cardiovascular and nerve-related diseases, but also as important ingredients in pharmaceuticals and nutritional supplements. Due to its very low content in plants, multi-step isolation and purification processes, and environmental and chem. hazards issues, resveratrol extraction from plants is difficult, time consuming, impracticable, and unsustainable. Therefore, microbial hosts, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, are commonly used as an alternative production source by improvising resveratrol biosynthetic genes in them. The biosynthesis genes are rewired applying combinatorial biosynthetic systems, including metabolic engineering and synthetic biol., while optimizing the various production processes. The native biosynthesis of resveratrol is not present in microbes, which are easy to manipulate genetically, so the use of microbial hosts is increasing these days. This review will mainly focus on the recent biotechnol. advances for the production of resveratrol, including the various strategies used to produce its chem. diverse derivatives

Molecules published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duman, Muhammed; Mulet, Magdalena; Altun, Soner; Saticioglu, Izzet Burcin; Gomila, Margarita; Lalucat, Jorge; Garcia-Valdes, Elena published the artcile< Pseudomonas piscium sp. nov., Pseudomonas pisciculturae sp. nov., Pseudomonas mucoides sp. nov. and Pseudomonas neuropathica sp. nov. isolated from rainbow trout>, Product Details of C6H10O8, the main research area is Pseudomonas species isolation rainbow trout; Pseudomonas; aquaculture; genome analysis; multi-locus sequence analysis; rainbow trout.

Six Gram neg., motile bacteria were isolated from rainbow trout (Oncorhynchus mykiss). The 16S rRNA sequence similarity values grouped them in the Pseudomonas mandelii (strains P49, P50T, 154aT and P154b), Pseudomonas fluorescens (strain P115T) and Pseudomonas koreensis (strain P155T) phylogenetic subgroups in the genus Pseudomonas. The DNA G + C content ranged from 58.5 to 60 mol%. The strains were characterized phenotypically using API 20NE and Biolog GENIII tests, and chemotaxonomically by their whole-cell MALDI-TOF MS protein profiles and fatty acid contents. Multi-locus sequence anal. with four housekeeping gene sequences (rpoD, rpoB, gyrB and 16S rRNA) together with genome comparisons by average nucleotide identity and genome-to-genome distance calculations were performed. Results showed that the similarity values of these strains to known species type strains were lower than the thresholds established for species in the genus Pseudomonas. Based on these data, we concluded that strains P49, P50T, P115T, P154aT, P154b and P155T belonged to four novel species. The names proposed are: Pseudomonas piscium sp. nov. for strains P49 and P50T with P50T (= CECT 30175T = CCUG 74871T) as the type strain; Pseudomonas pisciculturae sp. nov. for strain P115T (CECT 30173T = CCUG 74873T); Pseudomonas mucoides sp. nov. for strains P154aT and P154b with P154aT (= CECT 30177T = CCUG 74874T) as the type strain; and Pseudomonas neuropathica sp. nov. for strain P155T (= CECT 30178T = CCUG 74875T).

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Application of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.

Biotechnology Advances published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sandu, Mariya P.; Sidelnikov, Vladimir S.; Geraskin, Andrej A.; Chernyavskii, Aleksandr V.; Kurzina, Irina A. published the artcile< Influence of the method of preparation of the Pd-Bi/Al2O3 catalyst on catalytic properties in the reaction of liquid-phase oxidation of glucose into gluconic acid>, Related Products of 87-73-0, the main research area is palladium bismuth alumina catalyst liquid oxidation glucose gluconic acid.

Gluconic acid and its derivatives are extensively used in pharmaceutical, food, textile, and pulp and paper branches of industry during production of food additives, cleansers, medicinal drugs, stabilizers, etc. To obtain gluconic acid, the method of conversion of glucose into gluconic acid by mol. oxygen in the presence of solid catalysts is promising. The process of obtaining Pd and bimetallic nanoparticles Pd-Bi, coated on Al2O3, has been considered in the work. Samples were prepared by combined and successive impregnation of the Al2O3 support using metalloorg. precursors Pd(acac)2, Bi(ac)3, and dissolved in an organic solvent (acetic acid), followed by the removal of excess solvent. To achieve the formation of Pd and bimetallic nanoparticles Pd-Bi on the substrate surface, the synthesized samples were subjected to thermal decomposition sequentially in the atm. of Ar, O2, and H2. The surface of the obtained catalysts was studied by a combination of physicochem. methods of anal. The catalysts were analyzed in the reaction of liquid phase oxidation of glucose. The best results are achieved in the presence of the catalyst obtained by combined impregnation.

Catalysts published new progress about Binding energy. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fogacci, Federica; Tocci, Giuliano; Presta, Vivianne; Fratter, Andrea; Borghi, Claudio; Cicero, Arrigo F. G. published the artcile< Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials>, Reference of 501-36-0 , the main research area is Resveratrol; blood pressure; meta-analysis; metaregression; type 2 diabetes.

Results of previous clin. trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial. We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-anal. of available randomized, controlled clin. trials (RCTs). Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th Oct. 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials. Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression anal. revealed a pos. association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials. The favorable effect of resveratrol emerging from the current meta-anal. suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients.

Critical Reviews in Food Science and Nutrition published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Siliang; Luo, Huaiyong; Chen, Haiwen; Guo, Jianbin; Yu, Bolun; Zhang, Huan; Li, Weitao; Chen, Weigang; Zhou, Xiaojin; Huang, Li; Liu, Nian; Lei, Yong; Liao, Boshou; Jiang, Huifang published the artcile< Optimization of extraction of total trans-resveratrol from peanut seeds and its determination by HPLC>, HPLC of Formula: 501-36-0 , the main research area is tran resveratrol peanut extraction optimization; high performance liquid chromatography; peanut seed; response surface methodology; trans-resveratrol.

Resveratrol, a stilbene phytoalexin in plants, is believed to benefit human health. In this study, an optimized enzyme-assisted method was developed to extract the total content of trans-resveratrol (free or combined with glucose) in peanut seeds, followed by detection using high-performance liquid chromatog. The extraction process was optimized by Box-Behnken design and response surface methodol. The optimized enzyme concentration, digestion time, pH, and temperature were 3.02 g/L, 57.06 min, 5.88, and 51.05°C, resp. Validation tests indicated that the exptl. yield of trans-resveratrol was 0.183 ± 0.007μg/g with a relative standard deviation of 3.87% (n = 5) under the optimal condition, which was closely agreed with the predicted value (0.182μg/g). The recoveries obtained from the spiked samples were varied from 89.4 to 103.9%. Therefore, this study will provide a useful method for quantification of total trans-resveratrol in peanut seeds.

Journal of Separation Science published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohd, Azirah; Zainal, Nurhafiza; Tan, Kim-Kee; AbuBakar, Sazaly published the artcile< Resveratrol affects Zika virus replication in vitro>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol phytoalexin antiviral agent zika virus infection.

Here, a plant-secreted phytoalexin, resveratrol (RES), was investigated for its ability to inhibit ZIKV replication in vitro. Several RES treatment regimens were used. The ZIKV titers of mock- and RES-treated infected cell cultures were determined using the focus-forming assay and the Zika mRNA copy number as determined using qRT-PCR. Our results suggested that RES treatment reduced ZIKV titers in a dose-dependent manner. A reduction of >90% of virus titer and ZIKV mRNA copy number was achieved when infected cells were treated with 80μM of RES post-infection. Pre-incubation of the virus with 80μM RES showed >30% reduction in ZIKV titers and ZIKV mRNA copy number, implying potential direct virucidal effects of RES against the virus. The RES treatment reduced >70% virus titer in the anti-adsorption assay, suggesting the possibility that RES also interferes with ZIKV binding. However, there was no significant decrease in ZIKV titer when a short-period of RES treatment was applied to cells before ZIKV infection (pre-infection) and after the virus bound to the cells (virus internalization inhibition), implying that RES acts through its continuous presence in the cell cultures after virus infection. Overall, our results suggested that RES exhibited direct virucidal activity against ZIKV and possessed anti-ZIKV replication properties, highlighting the need for further exploration of RES as a potential antiviral mol. against ZIKV infection.

Scientific Reports published new progress about Antiviral agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Leskow, Carla Coluccio; Conte, Mariana; del Pozo, Talia; Bermudez, Luisa; Lira, Bruno Silvestre; Gramegna, Giovanna; Baroli, Irene; Burgos, Estanislao; Zavallo, Diego; Kamenetzky, Laura; Asis, Ramon; Gonzalez, Mauricio; Fernie, Alisdair Robert; Rossi, Magdalena; Osorio, Sonia; Carrari, Fernando published the artcile< The cytosolic invertase NI6 affects vegetative growth, flowering, fruit set, and yield in tomato>, Formula: C6H10O8, the main research area is Solanum invertase vegetative growth flowering fruit yield; Carbon partitioning; cytosolic invertase; signaling; sucrose metabolism; tomato.

Sucrose metabolism is important for most plants, both as the main source of carbon and via signaling mechanisms that have been proposed for this mol. A cleaving enzyme, invertase (INV) channels sucrose into sink metabolism Although acid soluble and insoluble invertases have been largely investigated, studies on the role of neutral invertases (A/N-INV) have lagged behind. Here, we identified a tomato A/N-INV encoding gene (NI6) co-localizing with a previously reported quant. trait locus (QTL) largely affecting primary carbon metabolism in tomato. Of the eight A/N-INV genes identified in the tomato genome, NI6 mRNA is present in all organs, but its expression was higher in sink tissues (mainly roots and fruits). A NI6-GFP fusion protein localized to the cytosol of mesophyll cells. Tomato NI6-silenced plants showed impaired growth phenotype, delayed flowering and a dramatic reduction in fruit set. Global gene expression and metabolite profile analyses of these plants revealed that NI6 is not only essential for sugar metabolism, but also plays a signaling role in stress adaptation. We also identified major hubs, whose expression patterns were greatly affected by NI6 silencing; these hubs were within the signaling cascade that coordinates carbohydrate metabolism with growth and development in tomato.

Journal of Experimental Botany published new progress about Arabidopsis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts