Tag: M.W=200-250

Zhao, Y. N.; Cao, Y. N.; Sun, J.; Liang, Z.; Wu, Q.; Cui, S. H.; Zhi, D. F.; Guo, S. T.; Zhen, Y. H.; Zhang, S. B. published the artcile< Anti-breast cancer activity of resveratrol encapsulated in liposomes>, Application In Synthesis of 501-36-0 , the main research area is breast cancer anttumor liposome resveratrol.

Resveratrol (RES) is a naturally occurring and effective drug for tumor prevention and treatment. However, its low levels of aqueous solubility, stability, and poor bioavailability limit its application, especially when used as a free drug. In this study, RES was loaded into peptide and sucrose liposomes (PSL) to enhance the physico-chem. properties of RES and exploit RES delivery mediated by liposomes to effectively treat breast cancer. RES loaded PSL (the complex: PSL@RES) were stable, had a good RES encapsulation efficiency, and prolonged RES-release in vitro. PSL@RES was exceptionally efficient for inhibiting the growth of cancer cells, as the IC50 of PSL@RES in MCF-7 cells was found to be only 20.89 μmol L-1. The therapeutic efficacy of PSL@RES was evaluated in mice bearing breast cancer. The results showed that PSL@RES at a dosage of 5 mg kg-1 was more effective than 10 mg kg-1 free RES, and PSL@RES inhibited tumor growth completely at a dosage of 10 mg kg-1. PSL@RES induced apoptosis in breast tumor by upregulation of p53 expression. This then downregulated Bcl-2 and upregulated Bax, thereby inducing Caspase-3 activation. More importantly, encapsulation of RES within peptide liposomes greatly reduced the toxicity of free RES to mice. Overall, the simple formulation of liposomal nanocarriers of RES developed in this study produces satisfactory outcomes to encourage further applications of liposomal carriers for the treatment of breast cancer.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oh, Woo Taek; Jun, Jin Woo; Giri, Sib Sankar; Yun, Saekil; Kim, Hyoun Joong; Kim, Sang Guen; Kim, Sang Wha; Kang, Jeong Woo; Han, Se Jin; Kwon, Jun; Kim, Ji Hyung; Smits, Theo H. M.; Park, Se Chang published the artcile< Pseudomonas tructae sp. nov., novel species isolated from rainbow trout kidney>, Recommanded Product: D-Glucosaccharic acid, the main research area is phosphatidylethanolamine arginine dihydrolase quinone rainbow trout kidney Pseudomonas; MLSA; Pseudomonas; rainbow trout.

This study describes the biochem. and phylogenetic characteristics of a Gram-neg. strain, SNU WT1T, isolated from rainbow trout kidney. The 16S rRNA gene sequencing indicated that strain SNU WT1T was highly similar to Pseudomonas wadenswilerensis CCOS 864T and closely related to other Pseudomonas putida-related strains. Multilocus sequence anal. of concatenated partial gyrB, rpoB and rpoD sequences revealed that strain SNU WT1T was distinct from P. putida-related strains and formed a sep. clade. The average nucleotide identity and Genome-to-Genome Distance Calculator values were 90.19 and 41.7%with its closest relativeP. wadenswilerensis CCOS 864T ; however, it was phenotypically distinct from CCOS 864T with respect to arginine dihydrolase, glucose fermentation, aesculin hydrolysis and N-acetyl-glucosamine assimilation. The major polar lipid of the strain was phosphatidylethanolamine and the major quinone was Q-9. The genome of strain SNU WT1T had 5 685 196 bp with a G+C content of 61.83 mol%. We describe a novel species of genus Pseudomonas, for which the name Pseudomonas tructae has been proposed, with SNU WT1T (= KCTC 72265 = JCM 33436) as the type strain.

International Journal of Systematic and Evolutionary Microbiology published new progress about GC content. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qu, Xianfeng; Chen, Xiao; Shi, Qingqing; Wang, Xiaofei; Wang, Dongguo; Yang, Li published the artcile< Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol beclin1 interleukin6 ischemia reperfusion injury diabetic myocardium; diabetes; ischemia/reperfusion injury; resveratrol autophagy.

The rising incidence and complications of diabetes constitutes a major public health issue. The mortality rate of diabetes-induced myocardial ischemia/reperfusion (I/R) injury is significantly elevated. Resveratrol (RSV) is a naturally occurring polyphenol considered to be a potent cardioprotective compound The aim of the present study was to explore the function and mol. mechanism of RSV on diabetes-induced myocardial I/R injury. Left anterior descending coronary artery ligation was performed to stimulate myocardial I/R injury in streptozotocin-induced diabetic rats. Heart elec. activity was monitored through an ECG to confirm successful models. The myocardial infarct volume was detected via 2,3,5-triphenyltetrazolium chloride staining. Western blotting was employed to examine the levels of autophagy markers. It was found that the injection of RSV mitigated the ischemia- or I/R injury-induced myocardial damage on hemodynamic function and infarct size, but the autophagy inhibitor 3-methyladenine significantly blocked the function of RSV. Furthermore, the application of RSV significantly enhanced the expression of Beclin-1 and LC-3II but inhibited the serum levels of tumor necrosis factor-α and interleukin-6. These findings revealed an alleviating effect of RSV on diabetes-induced myocardial I/R injury and provided new evidence for the successful application of RSV on the diabetic myocardium.

Experimental and Therapeutic Medicine published new progress about Autophagy. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hoseini, Asma; Namazi, Gholamreza; Farrokhian, Alireza; Reiner, Zeljko; Aghadavod, Esmat; Bahmani, Fereshteh; Asemi, Zatollah published the artcile< The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease>, Application of C14H12O3, the main research area is diet supplement diabetes mellitus coronary heart disease resveratrol.

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 wk. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β -1.09μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β -0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Addnl., resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β -0.21μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD. Food & Function published new progress about Acetylation. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Shu; Wang, Mengya; Qiang, Zhe; Song, Jianchun; Wang, Yue; Fan, Yuchi; You, Zhengwei; Liao, Yaozu; Zhu, Meifang; Ye, Changhuai published the artcile< Multi-functional and highly conductive textiles with ultra-high durability through 'green' fabrication process>, Computed Properties of 87-73-0, the main research area is green conductive GA chitosan polyamide SWCNT composite coated textile.

Conductive textiles with mech. flexibility, long-term durability and stability under harsh conditions are highly desired for potential applications in wearable electronics and devices. One challenge associated with the development of such materials is their fabrication method, which requires to be low-cost, scalable, and environmental-friendly. Herein, we developed a full “”green”” route to fabricate machine-washable conductive textiles by coating textiles with a novel crosslinked and conductive polymer composite coating, using single-walled carbon nanotubes (SWNTs) and bio-mass derived glucaric acid/chitosan (GA-chitosan) organic salt aqueous solution with dip-coating or spray-coating. The crosslinked SWNTs/GA-chitosan polyamide coatings exhibit a high elec. conductivity of up to 7.4 x 102 S/m and high water/organic solvents resistance. The conductive textiles can achieve an exceptional Joule heating performance driven by moderate voltage and exhibit a high electromagnetic interference shielding efficiency of approx. 30 dB at X-band under optimized formulation. The high adhesive energy between the polymer composite coatings and textile substrates enables the ultra-high durability and stability of textiles, confirmed by mech. deformation, rubbing, and washing tests. This simple and organic solvent-free processing method provides an environmentally friendly, cost-effective fabrication approach, holding great promise for large-scale production of multifunctional conductive wearable textiles for EMI shielding and/or personal heating applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Carbon nanotubes (single walled). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaito, Abdullah; Posadino, Anna Maria; Younes, Nadin; Hasan, Hiba; Halabi, Sarah; Alhababi, Dalal; Al-Mohannadi, Anjud; Abdel-Rahman, Wael M.; Eid, Ali H.; Nasrallah, Gheyath K.; Pintus, Gianfranco published the artcile< Potential adverse effects of resveratrol a literature review>, Formula: C14H12O3, the main research area is review resveratrol toxicity bioavailability stilbenoid; anticancer; antioxidant effects; biphasic; oxidative DNA damage; pro-oxidant effects; reactive oxygen species (ROS); resveratrol.

A review. Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound Ever since, several pharmacol. activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clin. trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

International Journal of Molecular Sciences published new progress about Bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lindberg, B.; Asplund, L.; Fellner-Feldegg, H.; Kelfve, P.; Siegbahn, H.; Siegbahn, K. published the artcile< ESCA applied to liquids. ESCA spectra from molecular ions in solution>, Quality Control of 35564-86-4, the main research area is ESCA spectra pyridylsulfamoylphenylazosalicylate; salicylate pyridylsulfamoylphenylazo ESCA.

The application of ESCA to the N-methylglucamine salt of 5-[p-(2-pyridylsulfamoyl)phenylazo]salicylic acid is described. By exchange of one of the ions in the solution the ESCA spectra of the individual ionic components are deduced. Broadening of N lines in the spectrum indicates different chem. forms in solution

Chemical Physics Letters published new progress about Photoelectron spectra. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Xiao-Ying; Dong, Quan-Xiu; Zhu, Jie; Sun, Xun; Zhang, Li-Fan; Qiu, Mandy; Yu, Xiao-Lin; Liu, Rui-Tian published the artcile< Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy>, COA of Formula: C14H12O3, the main research area is resveratrol tau cognitive deficit neuropathol tauopathy; Alzheimer’s disease; Resveratrol; neuroinflammation; oligomer; synapse loss; tau..

Background: Alzheimer’s Disease (AD) is characterized by the presence of extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles assembled by the microtubuleassocd. protein tau. Increasing evidence demonstrated that tau pathol. played an important role in AD progression. Resveratrol (RSV) has previously proved to exert neuroprotective effect against AD by inhibiting Aβ generation and Aβ-induced neurocytotoxicity, while its effect on tau pathol. is still unknown. Methods: The effect of RSV on tau aggregation was measured by Thioflavin T fluorescence and Transmission electron microscope imaging. The effect of RSV on tau oligomer-induced cytotoxicity was assessed by MTT assay and the uptake of extracellular tau by N2a cells was determined by immunocytochem. 6-mo-old male PS19 mice were treated with RSV or vehicle by oral administration (gavage) once a day for 5 wk. The cognitive performance was determined using Morris water maze test, object recognition test and Y-maze test. The levels of phosphorylated-tau, gliosis, proinflammatory cytokines such as TNF-α and IL-1β, and synaptic proteins including synaptophysin and PSD95 in the brains of the mice were evaluated by immunoblotting, immunostaining and ELISA, resp. Results: RSV significantly inhibited tau aggregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells. When applied to PS19 mice, RSV treatment effectively rescued cognitive deficits, reducing the levels of phosphorylated tau, neuroinflammation and synapse loss in the brains of mice. Conclusion: These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies.

Current Alzheimer Research published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Komorowska, Justyna; Wątroba, Mateusz; Szukiewicz, Dariusz published the artcile< Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease.>, COA of Formula: C14H12O3, the main research area is Alzheimer’s disease; Antioxidation; Central nervous system; Polyphenols; Resveratrol.

PURPOSE: The prevalence of Alzheimer’s Disease is rising, in part due to increase in the medium age of residents in developed countries. The aim of the study has been to determine whether resveratrol (RSV) can be effective in the prevention or treatment of Alzheimer’s Disease, providing its antioxidant, anti-inflammatory, and SIRT1-activating properties. METHODS: A systematic review of some experimental and clinical studies has been made. The eligibility criteria have comprised: maximum 10 years passed from the study publication, geographical diversity of the studies performed, and – as much as possible – pertaining of the reviewed study results both to animal models of AD, and to humans. RESULTS: After the final assessment of the eligibility criteria, 96 research studies have been included in the review. Overall results suggest that RSV can be effectively used in the prevention of AD, especially in reference to its familial forms with an early onset. At the same time, efficacy of RSV in the treatment of AD needs further studies, aimed at: improving its transport through the blood-brain barrier (BBB), performing prospective clinical in vivo trials on large groups of patients, and determining the optimal RSV dosage. DISCUSSION: Providing RSV mechanisms of action, inhibitory in reference to many pathomechanisms of AD, it seems very likely that RSV could be effective in AD prevention. The main limitations referring to such presumption include: limited permeability of BBB to RSV, and scarcity of clinical studies on RSV pertaining to large groups of humans.

Advances in medical sciences published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lv, Chunrong; Larbi, Allai; Wu, Guoquan; Hong, Qionghua; Quan, Guobo published the artcile< Improving the quality of cryopreserved goat semen with a commercial bull extender supplemented with resveratrol>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol semen extender cryopreservation goat; Antioxidant; Cryopreservation; Goats; Resveratrol; Semen.

The purpose of the current study was to evaluate the effects of resveratrol (RSV) on the quality of frozen-thawed goat sperm. Semen samples from four bucks were divided into five aliquots and diluted with a com. bull semen extender containing: no antioxidant (RSV-0, control), 10μM RSV (RSV-10), 50μM RSV (RSV-50), 100μM RSV (RSV-100) and 250μM RSV (RSV-250). After thawing, sperm motility, abnormal morphol., membrane and acrosome integrity, mitochondrial activity, phosphatidylserine (PS) distribution, and oxidative stress were evaluated. The results indicated that in comparison with the control, when the concentration of RSV was 10 or 50μM, the total motility, progressive motility, membrane and acrosome integrity, and mitochondrial activity of post-thaw spermatozoa was greater (P < 0.05). Addnl., the use of extenders containing RSV-10 or RSV-50 resulted in a greater percentage of viable spermatozoa as compared to the other groups (P < 0.05). Importantly, there were more viable spermatozoa (49.61 ± 0.61%) and less non-viable spermatozoa (49.16 ± 1.01%) in the RSV-50 group compared to the other extenders (P < 0.05). Furthermore, the use of the extenders containing RSV-10 and -50 resulted in a reduction in ROS production in frozen-thawed spermatozoa as compared to the control (P < 0.05). There, however, was no difference among extenders for abnormal morphol. and PS distribution. In conclusion, supplementation with RSV, at a concentration of 10 or 50μM in the semen extender, can improve the post-thaw goat sperm quality, which may occur as a consequence of inhibition of ROS generation. Animal Reproduction Science published new progress about Acrosome. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts