Tag: M.W=200-250

Wollenburg, Marco; Moock, Daniel; Glorius, Frank published the artcile< Hydrogenation of Borylated Arenes>, Recommanded Product: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is hydrogenation stereoselective borylated arene rhodium catalyst; crystal structure mol boronic acid ester preparation; arene hydrogenation; boronic esters; cycloalkanes; heterocycles; synthetic building blocks.

A cis-selective hydrogenation of abundant aryl boronic acids and their derivatives catalyzed by rhodium cyclic (alkyl)(amino)carbene (Rh-CAAC) is reported. The reaction tolerates a variety of boron-protecting groups and provides direct access to a broad scope of saturated, borylated carbo- and heterocycles with various functional groups. The transformation is strategically important because the versatile saturated boronate products are difficult to prepare by other methods. The utility of the saturated cyclic building blocks was demonstrated by post-functionalization of the boron group.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (borylated). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Recommanded Product: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carr, Georgina; Haslam, Iain S.; Simmons, Nicholas L. published the artcile< Voltage Dependence of Transepithelial Guanidine Permeation Across Caco-2 Epithelia Allows Determination of the Paracellular Flux Component>, COA of Formula: C7H18ClNO5, the main research area is guanidine organic cation paracellular permeation intestine Caco2 cell.

The aim of this study was to investigate transepithelial ionic permeation via the paracellular pathway of human Caco-2 epithelial monolayers and its contribution to absorption of the base guanidine. Confluent monolayers of Caco-2 epithelial cells were mounted in Ussing chambers and the transepithelial conductance and elec. p.d. determined after NaCl dilution or medium Na substitution (bi-ionic conditions). Guanidine absorption (Ja-b) was measured ± transepithelial potential gradients using bi-ionic p.d.’s. Basal NaCl replacement with mannitol gives a transepithelial dilution p.d. of 28.0 ± 3.1 mV basal solution electropos. (PCl/PNa = 0.34). Bi-ionic p.d.’s (basal replacements) indicate a cation selectivity of NH4+ > K+∼Cs+ > Na+ > Li+ > tetraethylammonium+ > N-methyl-d-glucamine+∼choline+. Transepithelial conductances show good correspondence with bi-ionic potential data. Guanidine Ja-b was markedly sensitive to imposed transepithelial p.d. The ratio of guanidine to mannitol permeability (measured simultaneously) increased from 3.6 in the absence of an imposed p.d. to 13.8 (basolateral neg. p.d.). Hydrated monovalent ions preferentially permeate the paracellular pathway (Eisenman sequence 2 or 3). Guanidine may access the paracellular pathway because absorptive flux is sensitive to the transepithelial p.d. An alternative method to assess paracellular-mediated flux of charged organic mols. is suggested.

Pharmaceutical Research published new progress about Biological permeation (transepithelial ionic). 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, COA of Formula: C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdelgawad, Ibrahim Y.; Grant, Marianne K. O.; Zordoky, Beshay N. published the artcile< Leveraging the cardio-protective and anticancer properties of resveratrol in cardio-oncology>, SDS of cas: 501-36-0 , the main research area is review cardioncol cardiprotection resveratrol anticancer; anthracycline; cancer; cardio-oncology; cardiotoxicity; cardiovascular; resveratrol.

A review. Cardio-oncol. is a clin./scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. A major challenge for such interventions is to protect the cardiovascular system without compromising the therapeutic benefit of anticancer medications. Intriguingly, the polyphenolic natural compound resveratrol and its analogs have been shown in preclin. studies to protect against cancer treatment-induced cardiovascular toxicity. They have also been shown to possess significant anticancer properties on their own, and to enhance the anticancer effect of other cancer treatments. Thus, they hold significant promise to protect the cardiovascular system and fight the cancer at the same time. In this review, we will discuss the current knowledge regarding the cardio-protective and the anticancer properties of resveratrol and its analogs. Thereafter, we will discuss the challenges that face the clin. application of these agents. To conclude, we will highlight important gaps of knowledge and future research directions to accelerate the translation of these exciting preclin. findings to cancer patient care.

Nutrients published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Divya, Indira S.; Amrutha, Surendran; SeethaLekshmi, Sunil; Varughese, Sunil published the artcile< Molecular salts of quinine: a crystal engineering route to enhance the aqueous solubility>, Category: alcohols-buliding-blocks, the main research area is quinine mol salt crystal engineering aqueous solubility.

The antimalarial drug quinine (QUN) has poor aqueous solubility and belongs to Biopharmaceutical Classification System (BCS) Class-II. We report 12 novel mol. salts of QUN with α,ω-aliphatic dicarboxylic acids and aromatic coformers. The high basicity of QUN and ΔpKa of ~5 make the complexes ionic, and most of them are hydrates. The solid forms showed enhanced aqueous solubility compared to the pristine QUN. The single-crystal and powder X-ray diffraction, thermal, and microscopy data provide structural, compositional, and stability profiles of the salts. The calculated Full Interaction Maps (FIMs) provide statistical insights into the salt formation and high probability of hydration in QUN. Though with prospective torsional freedom, QUN in most complexes adopts a unique conformation; this indicates that the structure class has a higher statistical probability and belongs to a relatively deep potential energy trough in the vast crystal landscape.

CrystEngComm published new progress about Aliphatic dicarboxylic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wan, Qijuan; Wu, Liqun; Yang, Qiuhua; Lin, Mao; Guo, Songlin published the artcile< First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata) cultivated in freshwater>, Name: D-Glucosaccharic acid, the main research area is Anguilla rostrata disease freshwater Vibrio harveyi isolation pathogenicity.

Diseases caused by Vibrio harveyi in marine organisms have been generally reported in aquaculture, but there has been no reported V. harveyi infection in fish cultivated in freshwater. Herein, we isolated 3 strains of V. harveyi from diseased American eels (Anguilla rostrata) cultivated in freshwater and subsequently confirmed the virulence of V. harveyi and the extracellular product (ECP). The three isolates were identified as V. harveyi based on phenotypic features and homol. of 16S rDNA and 3 house-keeping genes (HKGs). Exptl. infection revealed that V. harveyi and ECP were highly pathogenic to American eels, and the median LDs (LD50) were 1.67 x 103 cfu/g and 7.29μg/g body weight, resp. Moreover, our antibiotic susceptibility test showed that V. harveyi was susceptible to 16 of 20 antibiotics using the VITEK system of Merieux. Furthermore, liver and kidney samples were collected for paraffin sectioning, stained with haematoxylin-eosin (H & E) and Periodic Acid-Schiff (PAS). H & E staining results revealed hepatocyte atrophy and necrosis, hepatic intercellular hemorrhage and intrahepatic venous thrombosis, while the kidney was characterized by renal tubular epithelial cell swelling and renal interstitial haematopoietic cell loss. Interestingly, glycogen deposition was more obvious in the kidney compared with the liver after PAS staining. Cultivated eel infected by V. harveyii was reported for the first time, and the results of this study provide a valuable reference for further prevention and control of fish diseases caused by V. harveyi.

Aquaculture Research published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Knoefel, Peter K.; Kraft, Robert P. Jr.; Knight, Robert D.; Moore, Susan K. published the artcile< Sodium versus mmeglumine diatrizoate in excretory urography>, Formula: C7H18ClNO5, the main research area is urinary excretion sodium meglumine diatrizoate; electrolyte excretion urine diatrizoate.

The i.v. injection of mannitol [69-65-8], Na diatrizoate (I) [737-31-5] meglumine diatrizoate (II) [131-49-7] or meglumine hydrochloride [35564-86-4] produced diuresis approaching a steady-state in anesthetized dogs. During this period the apparent volumes of distribution of meglumine and diatrizoate were similar and were greater than that of insulin. The plasma concentration, renal clearance, and the rate of urinary excretion were the same for meglumine and diatrizoate. Excretion of urine and urinary electrolytes was greater after II than I or meglumine-HCl. Urinary concentration of diatrizoate was greater after I than II. This difference appears to result from the influence of the 2 impermeant ions on the excretion of other ions. Single-dose experiments revealed no such difference between I and II due to errors arising from collection of urine from the bladder.

Investigative Radiology published new progress about Urinary system. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Formula: C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Dan-Dan; Shi, Guangjiang; Jiang, Yaping; Yao, Chao; Zhu, Chuanlin published the artcile< A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications>, Electric Literature of 501-36-0, the main research area is review resveratrol antidiabetic agent diabetes mellitus; Anti-diabetes; Anti-inflammatory; Anti-oxidant; Diabetic complications; Hypoglycemic effect; Resveratrol.

A review. Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clin. complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer mols. from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochem. and physiol. actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising mol. for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mortezaee, Keywan; Najafi, Masoud; Farhood, Bagher; Ahmadi, Amirhossein; Shabeeb, Dheyauldeen; Musa, Ahmed E. published the artcile< Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol anticancer agent cancer; Resveratrol; chemotherapy; molecular targeted therapy; neoplasm; radiation; radiotherapy; tumor microenvironment..

A review. Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clin. studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clin. studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clin. translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

Current Cancer Drug Targets published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Xiang-tao; Li, Xi; Xie, Ming-ling; Huang, Zhen; Huang, Yong-xiu; Wu, Gui-xian; Peng, Zhi-rong; Sun, Yan-ni; Ming, Qian-liang; Liu, Yan-xia; Chen, Jie-ping; Xu, Shuang-nian published the artcile< Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics>, Reference of 501-36-0 , the main research area is review resveratrol antileukemia agent pharmacokinetics leukemia; Anti-Leukemia; Drug candidate; Resveratrol.

A review. Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacol. effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied extensively via its effects on a variety of biol. processes involving cell proliferation, apoptosis, autophagy. Current treatments of leukemia mainly rely on intensive chemotherapy or hematopoietic stem cell transplantation, however, these treatments are still with poor survival and high treatment-related mortality. Therefore, it is extremely needed to find relatively non-toxic medicines with minimal side effects but sufficient therapeutic efficacy. Resveratrol is one such potential candidate owing to its reported anti-leukemia effect. In this review, we summarized resveratrol’s discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resveratrol as a potential drug candidate for anti-leukemia.

Chemico-Biological Interactions published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hua; Bo, Yang; Liu, Yang; Xu, Ming; Cai, Kaimin; Wang, Ruibo; Cheng, Jianjun published the artcile< In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction>, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride, the main research area is cancer targeting glycopolyester nanoparticle metabolic cell labeling; Cancer targeting; Cell labeling; Click chemistry; Drug design; Sugar.

We developed glycopolyesters (GPs) via azido-sugar initiated ring-opening polymerization of O-carboxyanhydrides (OCAs) and achieved efficient in vivo cancer targeting via GP-nanoparticle (GP-NP) mediated metabolic cell labeling followed by Click reaction. GP-NP shows controlled release of azido-sugars and can efficiently label LS174T colon cancer cells with azido groups in tumor-bearing mice. The exogenously introduced azido groups render excellent in vivo cancer targeting and retention of dibenzocyclooctyne-Cy5 (DBCO-Cy5) with an increasing tumor retention enhancement over time (68% at 6 h, 105% at 24 h, and 191% at 48 h) compared to control mice without azido labeling. The tumor accumulation of DBCO-doxorubicin is also significantly enhanced in GP-NP pretreated mice, resulting in improved in vivo anticancer efficacy. This study, for the first time, proposes the use of azido-sugar initiated polymerization of OCAs to form sugar delivery vehicles with high stability and controlled release, and demonstrates the increasing tumor targeting effect of DBCO-cargo over time by azido-modified tumor cells.

Biomaterials published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts