Tag: M.W=200-250

Mortezaee, Keywan; Najafi, Masoud; Farhood, Bagher; Ahmadi, Amirhossein; Shabeeb, Dheyauldeen; Musa, Ahmed E. published the artcile< Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol anticancer agent cancer; Resveratrol; chemotherapy; molecular targeted therapy; neoplasm; radiation; radiotherapy; tumor microenvironment..

A review. Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clin. studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clin. studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clin. translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

Current Cancer Drug Targets published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iyer, Gayatri R.; Wigginton, Janis; Duren, William; LaBarre, Jennifer L.; Brandenburg, Marci; Burant, Charles; Michailidis, George; Karnovsky, Alla published the artcile< Application of differential network enrichment analysis for deciphering metabolic alterations>, Related Products of 87-73-0, the main research area is metabolome glutathione type 1 2 diabetes pregnancy; differential networks; enrichment analysis; metabolic disorders; metabolomics and lipidomics; partial correlation networks.

Modern anal. methods allow for the simultaneous detection of hundreds of metabolites, generating increasingly large and complex data sets. The anal. of metabolomics data is a multi-step process that involves data processing and normalization, followed by statistical anal. One of the biggest challenges in metabolomics is linking alterations in metabolite levels to specific biol. processes that are disrupted, contributing to the development of disease or reflecting the disease state. A common approach to accomplishing this goal involves pathway mapping and enrichment anal., which assesses the relative importance of predefined metabolic pathways or other biol. categories. However, traditional knowledge-based enrichment anal. has limitations when it comes to the anal. of metabolomics and lipidomics data. We present a Java-based, user-friendly bioinformatics tool named Filigree that provides a primarily data-driven alternative to the existing knowledge-based enrichment anal. methods. Filigree is based on our previously published differential network enrichment anal. (DNEA) methodol. To demonstrate the utility of the tool, we applied it to previously published studies analyzing the metabolome in the context of metabolic disorders (type 1 and 2 diabetes) and the maternal and infant lipidome during pregnancy.

Metabolites published new progress about Alditols, esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Lichen; Semba, Kazuhiko; Nakao, Yoshiaki published the artcile< para-Selective C-H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis>, Reference of 660867-80-1, the main research area is selective carbon hydrogen bond activation borylation benzamide pyridine; iridium complex aluminum Lewis acid catalyst benzamide borylation; C-H activation; Lewis acids; boronate esters; iridium; regioselectivity.

Para-Selective C-H borylation of benzamides and pyridines was achieved by cooperative Ir/Al catalysis. A combination of Ir catalysts commonly employed for arene C-H borylation and bulky Al-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C-H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (multi-substituted). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Reference of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schaarschmidt, Stephanie; Glaubitz, Ulrike; Erban, Alexander; Kopka, Joachim; Zuther, Ellen published the artcile< Differentiation of the High Night Temperature Response in Leaf Segments of Rice Cultivars with Contrasting Tolerance>, SDS of cas: 87-73-0, the main research area is Oryza cultivar leaf segment high night temperature; RNA-Seq; high night temperature; leaf segments; metabolomics; rice cultivars; sheath.

High night temperatures (HNT) affect rice yield in the field and induce chlorosis symptoms in leaves in controlled chamber experiments However, little is known about mol. changes in leaf segments under these conditions. Transcript and metabolite profiling were performed for leaf segments of six rice cultivars with different HNT sensitivity. The metabolite profile of the sheath revealed a lower metabolite abundance compared to segments of the leaf blade. Furthermore, pre-adaptation to stress under control conditions was detected in the sheath, whereas this segment was only slightly affected by HNT. No unique significant transcriptomic changes were observed in the leaf base, including the basal growth zone at HNT conditions. Instead, selected metabolites showed correlations with HNT sensitivity in the base. The middle part and the tip were most highly affected by HNT in sensitive cultivars on the transcriptomic level with higher expression of jasmonic acid signaling related genes, genes encoding enzymes involved in flavonoid metabolism and a gene encoding galactinol synthase. In addition, gene expression of expansins known to improve stress tolerance increased in tolerant and sensitive cultivars. The investigation of the different leaf segments indicated highly segment specific responses to HNT. Mol. key players for HNT sensitivity were identified.

International Journal of Molecular Sciences published new progress about Chlorosis (plant). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Li; Cai, Kaimin; Yu, Jin; Cheng, Jianjun published the artcile< Novel Liposomal Azido Mannosamine Lipids on Metabolic Cell Labeling and Imaging via Cu-Free Click Chemistry>, Reference of 5505-63-5, the main research area is liposomal azido mannosamine lipid metabolic cell labeling imaging.

In comparison with the popular Ac4ManNAz applied as cell labels via Cu-free click chem., two novel azido mannosamine lipids with C6 and C12 esters on anomeric hydroxyl groups were prepared and encapsulated in a liposome delivery system, which enhanced chem. stabilities and showed good cell-metabolizable labeling efficiency on MDA-MB-231 cells with strong fluorescence after the treatment of DBCO-Cy5 by triazole formation via click chem.

Bioconjugate Chemistry published new progress about Confocal microscopy. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Reference of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Repossi, Gaston; Das, Undurti N.; Eynard, Aldo Renato published the artcile< Molecular Basis of the Beneficial Actions of Resveratrol>, Electric Literature of 501-36-0 , the main research area is review resveratrol gut microbiota transcription factor inflammation; Brain-derived neurotrophic factor; Cancer; Cytotoxic; Lipoxin A4; Metabolic syndrome; Polyunsaturated fatty acids; Resveratrol.

A review. Resveratrol modulates the transcription factor NF-κB, cytochrome P 450 isoenzyme CYP1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. CAMP, in turn, activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway that facilitates increased oxidation of fatty acids, mitochondrial respiration and their biogenesis and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17) and other pro-inflammatory mols. and inhibits expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin. Thus, there is an overlap in the beneficial actions of resveratrol, PUFAs and BDNF suggesting that these mols. may interact and augment synthesis and action of each other. Since resveratrol is not easily absorbed from the gut it is likely that it may act on endocannabinoid and light, odor, and taste receptors located in the gut, which, in turn, convey their messages to the various organs via vagus nerve.

Archives of Medical Research published new progress about AMP-activated protein kinase activators. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Degraeuwe, Alexia; Jacobs, Marie-Claude; Herman, Anne published the artcile< Allergic contact dermatitis caused by resveratrol in a cosmetic cream.>, HPLC of Formula: 501-36-0 , the main research area is CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; resveratrol.

There is no abstract available for this document.

Contact dermatitis published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Dan; Wang, Gangcheng; Jin, Guoguo; Yao, Ke; Zhao, Zhenjiang; Bie, Liangyu; Guo, Yongjun; Li, Ning; Deng, Wenying; Chen, Xiaobin; Chen, Beibei; Liu, Yuanyuan; Luo, Suxia; Guo, Zhiping published the artcile< Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway>, HPLC of Formula: 501-36-0, the main research area is resveratrol anticancer cell growth AKT STAT3 signaling colon cancer.

Colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer-related deaths. Although surgical techniques and treatment strategies for colon cancer have advanced over the past two decades, the prognosis has not improved considerably. Resveratrol, a natural stilbene compound, possesses antioxidant, cardioprotective and anticancer properties. However, the role of resveratrol in colon cancer has not been fully elucidated. The present study demonstrated that resveratrol inhibited cell proliferation and colony growth in DLD1 and HCT15 colon cancer cells, but did not affect normal colon epithelial cells. The resveratrol-mediated inhibition of cell proliferation correlated with an induction of apoptosis and with G1 phase cell cycle arrest in colon cancer cells. Addnl., resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol. Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol. The present study confirmed that resveratrol bound to AKT1 and AKT2 with a pull-down assay. Furthermore, knockdown of AKT1 and AKT2 inhibited cell proliferation and colony growth, by attenuating cell cycle progression and increasing apoptosis in colon cancer cells, effects that were similar to those caused by resveratrol treatment. Taken together, the present results suggest that the targeting effects of resveratrol to AKT1 and AKT2 may be a potent strategy for chemoprevention or therapy for colon cancer.

International Journal of Molecular Medicine published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Ji-Sheng; Feng, Jun-Long; Dai, Heng-Heng; Chen, Zi-Long; Li, Xiao; Bao, Bing-Hao; Deng, Sheng; Meng, Fan-Chao; Zhao, Qi; Xu, Hong-Sheng; Wang, Bin; Li, Hai-Song published the artcile< Potential mechanism of Achyranthis bidentatae radix plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology>, Computed Properties of 87-73-0, the main research area is Achyranthis bidentatae semen vaccariae granule DMED treatment network pharmacol; Endocrine diseases; biological network; penis; traditional Chinese medicine.

Achyranthes bidentata Blume (Amaranthaceae) (ABR) and semen vaccariae (SV) are used commonly in the clin. treatment of erectile dysfunction in males with diabetes mellitus (DMED) to strengthen the kidney and promote blood circulation, and often achieve good curative effects. Explore mechanistic details of ABR + SV treatment against DMED. Prediction of key targets by network pharmacol. A rat model of DM was established by streptozotocin injection (55 mg/kg). Apomorphine (100μg/kg) was injected into rats to screen the DMED model. Group C (n = 6) and group M (n = 6) were gavaged with deionized water; group T (n = 6) was given Achyranthis bidentatae radix-semen vaccariae granule suspension (2.5 g/kg). It lasted 8 wk. Real-time reverse transcription-quant. polymerase chain reaction (RT-qPCR) and western blotting (WB) were used to measure the expression of tissue-related proteins and mRNA. The predicted key targets are albumin (ALB), caspase-3 (CASP3), vascular endothelial growth factor A (VEGFA), angiotensin-converting enzyme (ACE), and endothelial nitric oxide synthase (eNOS). Compared with the M group (0.52 ± 0.04; 0.50 ± 0.03; 0.49 ± 0.02; 0.23 ± 0.03), CASP3, VEGFA, and ACE protein expression reduced in the T group (0.39 ± 0.06; 0.34 ± 0.03; 0.39 ± 0.03), and eNOS protein expression increased (0.34 ± 0.03). ABR + SV can improve erectile function in DMED rats. This study provides a potential mechanism for the treatment of DMED with ABR + SV and can benefit from more patients.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Achyranthes bidentata. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bennouna, Djawed; Tourniaire, Franck; Durand, Thierry; Galano, Jean-Marie; Fine, Frederic; Fraser, Karl; Benatia, Sheherazade; Rosique, Clement; Pau, Charlotte; Couturier, Charlene; Pontet, Celia; Vigor, Claire; Landrier, Jean-Francois; Martin, Jean-Charles published the artcile< The Brassica napus (oilseed rape) seeds bioactive health effects are modulated by agronomical traits as assessed by a multi-scale omics approach in the metabolically impaired ob-mouse>, SDS of cas: 87-73-0, the main research area is Brassica seed inflammation uridine asparagine mannitol valine; Bioactives; Brassica; Metabolomics; Phytochemicals; Transcriptomics.

Beside oil, oilseed rape (Brassica napus) seeds contains nutritional bioactives such as polyphenols and glucosinolates. However, to date their nutritional properties have been overlooked in the new “”double zero”” breeds. Seed alc. extracts from two B. napus cultivars most contrasting in their phytochem. contents as measured by mass-spectrometry were given to ob-mice. Biol. outcomes including clin. metrics, gut and plasma metabolomes, liver transcriptome and metabolome were compared to ob-mice given a similar broccoli extract (Brassica oleracea).One B. napus extract induced a reduction of the oxidative stress indicated by the decrease of plasma isoprostanoids. This was associated to the regulation of the antioxidant stress defense Nrf2 pathway, to omic oxidative stress functions, metabolic and cell process regulations, and the metabolomics microbiota profile.Extracts of B. napus seeds demonstrated health effects that may be improved by selecting appropriate agronomical traits, highlighting the potential benefits of better utilizing agronomy for improved human and animal nutrition

Food Chemistry: Molecular Sciences published new progress about Antioxidants. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts