Tag: M.W=200-250

Shen, Li; Cai, Kaimin; Yu, Jin; Cheng, Jianjun published the artcile< Facile Click-Mediated Cell Imaging Strategy of Liposomal Azido Mannosamine Lipids via Metabolic or Nonmetabolic Glycoengineering>, Reference of 5505-63-5, the main research area is fluorescence imaging liposome azido mannosamine lipid.

Two Ac4ManNAz (AAM) derivatives with octadecanoic ester (C18 ester) and octadecyl ether (C18 ether) attached to the anomeric hydroxyl groups were synthesized and used in preparation of liposomes. Both liposomes show strong cell-labeling efficiencies on MDA-MB-231 cancer cells. The cell surface-anchored azide group can react with DBCO-Cy5 via Cu-free click chem. The two liposomes exhibit different azide placement mechanisms; C18-ether-AAM-treated cells have azido placement through direct insertion, while C18-ester-AAM-treated cells express azido more through metabolic glycoengineering.

ACS Omega published new progress about Confocal laser scanning microscopy. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Reference of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xingru; Guo, Rui; Zhao, Yaxuan; Liu, Danping; Chen, Jing; Miao, Ningning; Gao, Shujuan; Guo, Jixun; Zhang, Tao; Shi, Lianxuan published the artcile< Wild soybean resists the stress of low phosphorus by increasing nutrient reuse between the young and old leaves>, Product Details of C6H10O8, the main research area is Glycine leaf age nutrient phosphorus deficiency metabolomics.

Screening and identification of plant resources with high quality and multi resistance is important for crop breeding. In this study, ion content was determined by ion chromatog. and at. absorption spectrophotometer, and gas chromatog.-mass spectrometry (GC-MS)-based metabolomic anal. was carried out. Then metabolic pathways were constructed using the Kyoto Encyclopedia of Genes and Genomes and the MetaboAnalyst website to compare the changes and differences of young and old leaves of two wild soybean lines with different stress tolerance under low-phosphorus (LP) stress. The aim was to reveal the mechanism of wild soybean resistance to LP stress from insights concerning nutrient accumulation and mobilization. The results showed that in LP-tolerant wild soybean, Ca2+ accumulated and TCA, amino acid and organic acid metabolisms were enhanced in young and old leaves; disaccharide and trisaccharide metabolism was enhanced and phosphohexose metabolism was inhibited in old leaves; Mg2+, disaccharide and trisaccharide contents increased in young leaves, while inorganic P was relatively stable. Our experiment highlighted that LP-tolerant wild soybean adapted to LP stress by enhancing energy and material metabolisms and maintaining the growth and development of young leaves at the expense of old leaves, which is of great significance for the development and utilization of germplasm resources and the breeding of LP-tolerant soybean.

Plant Growth Regulation published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chimento, Adele; De Amicis, Francesca; Sirianni, Rosa; Sinicropi, Maria Stefania; Puoci, Francesco; Casaburi, Ivan; Saturnino, Carmela; Pezzi, Vincenzo published the artcile< Progress to improve oral bioavailability and beneficial effects of resveratrol>, Application In Synthesis of 501-36-0, the main research area is review resveratrol oral bioavailability beneficial effect; resveratrol; resveratrol bioavailability; resveratrol delivery systems; resveratrol derivatives.

A review. Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro and in vivo studies have shown that in addition to antioxidant, anti-inflammatory, cardioprotective and neuroprotective actions, it exhibits antitumor properties. In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its poor bioavailability, various methodol. approaches and different synthetic derivatives have been developed. In this review, we will describe the strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV. These methodol. approaches include RSV nanoencapsulation in lipid nanocarriers or liposomes, nanoemulsions, micelles, insertion into polymeric particles, solid dispersions, and nanocrystals. Moreover, the biol. results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described. Results reported in the literature are encouraging but require addnl. in vivo studies, to support clin. applications.

International Journal of Molecular Sciences published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Bin; Wang, Sijia; Wang, Yakun; Ke, Songze; Jin, Weihua; Chen, Jianwei; Zhang, Huawei; Sun, Jiadong; Henning, Susanne M.; Wang, Jian; Wang, Hong published the artcile< Gut microbiota-mediated xanthine metabolism is associated with resistance to high-fat diet-induced obesity>, Name: D-Glucosaccharic acid, the main research area is gut microbiota xanthine metabolism high fat diet induced obesity; 16S rRNA sequencing; Gut microbiome; High-fat diet resistance; Host-microbial co-metabolism; Metabolomics; Obesity.

Resistance to high-fat diet-induced obesity (DIR) has been observed in mice fed a high-fat diet and may provide a potential approach for anti-obesity drug discovery. However, the metabolic status, gut microbiota composition, and its associations with DIR are still unclear. Here, ultraperformance liquid chromatog.-tandem mass spectrometry-based urinary metabolomic and 16S rRNA gene sequencing-based fecal microbiome analyses were conducted to investigate the relationship between metabolic profile, gut microbiota composition, and body weight of C57BL/6J mice on chow or a high-fat diet for 8 wk. PICRUSt anal. of 16S rRNA gene sequences predicted the functional metagenomes of gut bacteria. The results demonstrated that feeding a high-fat diet increased body weight and fasting blood glucose of high-fat diet-induced obesity (DIO) mice and altered the host-microbial co-metabolism and gut microbiota composition In DIR mice, high-fat diet did not increase body weight while fasting blood glucose was increased significantly compared to chow fed mice. In DIR mice, the urinary metabolic pattern was shifted to a distinct direction compared to DIO mice, which was mainly contributed by xanthine. Moreover, high-fat diet caused gut microbiota dysbiosis in both DIO and DIR mice, but in DIR mice, the abundance of Bifidobacteriaceae, Roseburia, and Escherichia was not affected compared to mice fed a chow diet, which played an important role in the pathway coverage of FormylTHF biosynthesis I. Meanwhile, xanthine and pathway coverage of FormylTHF biosynthesis I showed significant pos. correlations with mouse body weight These findings suggest that gut microbiota-mediated xanthine metabolism correlates with resistance to high-fat DIO.

Journal of Nutritional Biochemistry published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (gene sequencing). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Cui; He, Qian; Zeng, Linlin; Shen, Ling; Luo, Qiaomei; Zhang, Wentao; Zhou, Xia; Wan, Jun published the artcile< Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus>, Synthetic Route of 87-73-0, the main research area is digestion promotor dashanzha pill crataegi fructus; Crataegi Fructus; Dashanzha Pill; dyspepsia, gut microbiota; endoplasmic reticulum stress.

Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatog.-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathol. changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota anal. revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress.

Chemistry & Biodiversity published new progress about Akkermansia. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Wenwu; Wu, Limeng; Li, Deping; Huang, Yaoguang; Liu, Mingyue; Liu, Wenjie; Tian, Caizhi; Liu, Xin; Jiang, Xiaowen; Hu, Xiaolong; Gao, Xudong; Xu, Zihua; Lu, Hongyuan; Zhao, Qingchun published the artcile< Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property>, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is human colon lung cancer CDK9 antiproliferative anticancer tacrine derivative; AChE; CDK2; CDK9; Cancer therapeutics; Tacrine.

Tacrine was the first approved drug by the FDA for the treatment of Alzheimer′s disease (AD) but was withdrawn from the market due to its dose-dependent hepatotoxicity. Herein, we describe our efforts toward the discovery of a novel series of tacrine derivatives for cancer therapeutics. Intensive structural modifications of tacrine led to the identification of N-(4-{9-[(3S)-3-aminopyrrolidin-1-yl]-5,6,7,8-tetrahydroacridin-2-yl}pyridin-2-yl)cyclopropanecarboxamide hydrochloride ((S)-45, ZLWT-37) as a potent antiproliferative agent (GI50 = 0.029 μM for HCT116). In addition, ZLWT-37 exhibited lower inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) compared to tacrine. The in vitro studies demonstrated that ZLWT-37 could significantly induce apoptosis and arrest the cell cycle in the G2/M phase in HCT116 cells. The in vivo studies revealed that compound ZLWT-37 showed excellent antitumor efficacy in HCT116 xenograft tumor model and favorable pharmacokinetics profiles (F% = 28.70%) as well as low toxicity in the acute toxicity test with a median LD (LD50) of 380.3 mg/kg. Encouragingly, ZLWT-37 had no obvious hepatotoxicity, nephrotoxicity, and hematol. toxicity. Kinase assay suggested that ZLWT-37 possessed potent cyclin-dependent kinase 9 (CDK9) inhibitory activity (IC50 = 0.002 μM) and good selectivity over CDK2 (IC50 = 0.054 μM). Collectively, these findings indicate that compound ZLWT-37 is a promising anti-cancer agent that deserves further preclin. evaluation.

Bioorganic Chemistry published new progress about Antiproliferative agents. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tran, Johan M.; Farrell, Melanie A.; Fanestil, Darrell D. published the artcile< Effect of ions on binding of the thiazide-type diuretic metolazone to kidney membrane>, Synthetic Route of 35564-86-4, the main research area is kidney metolazone sodium chloride transport.

The effect of a number of ions on the binding of the thiazide-type diuretic metolazone (MTZ) to rat renal cortical membranes was studied to elucidate the mechanism of NaCl transport in the kidney distal tubule. Among the cations tested, Na+ stimulated the binding up to 2.4-fold over control. The effective concentration of Na+ that produced half-maximal stimulation was 2-17 mM. Li+, K+, NH4+, Rb+, and Cs+ produced little stimulation of binding of MTZ. Several anions including Cl- inhibited binding. The inhibition of binding of MTZ by Cl- was enhanced by Na+ and Li+. Scatchard anal. revealed that 50 mM Na+ increased the affinity for binding of MTZ from a Kd = 3.56 nM to Kd = 1.32 nM. Chloride, in the presence of 50 mM Na+, competitively inhibited binding of MTZ by suppressing the affinity to Kd = 9.27 nM without changing the maximal number of binding sites (0.733 pmol/mg). A mechanism for the MTZ-sensitive NaCl transport is proposed, in which the transporter protein possesses a binding site for Na+ and a binding site for Cl-, which is also the binding site for MTZ. Na+ binds to its site and increases the affinity for Cl-/MTZ. The binding of Cl- to the transporter enables the import of Na+ and Cl- across the tubule membrane. MTZ, however, when present competes with Cl- for the binding site on the transporter and prevents the transport of Na+ and Cl-.

American Journal of Physiology published new progress about Biological cotransport. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Degraeuwe, Alexia; Jacobs, Marie-Claude; Herman, Anne published the artcile< Allergic contact dermatitis caused by resveratrol in a cosmetic cream.>, Reference of 501-36-0, the main research area is CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; resveratrol.

There is no abstract available for this document.

Contact dermatitis published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pollastri, Sara; Delaunay, Clara; Thepaut, Michel; Fieschi, Franck; Bernardi, Anna published the artcile< Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors>, Category: alcohols-buliding-blocks, the main research area is glycomimetic ligand synthesis L SIGN SARSCoV2 coronavirus spike protein.

The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The mols. described here are the first known glycomimetic ligands of L-SIGN.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anticoronaviral agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farkhondeh, Tahereh; Folgado, Silvia Llorens; Pourbagher-Shahri, Ali Mohammad; Ashrafizadeh, Milad; Samarghandian, Saeed published the artcile< The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway>, HPLC of Formula: 501-36-0, the main research area is resveratrol therapeutic Nrf signaling pathway review; Inflammation; Nrf2; Oxidative stress; Resveratrol; Therapeutic effects.

A review. Resveratrol is a natural polyphenol derived from grapes, berries, red wine, peanuts amongst other fruits and nuts. Beneficial effects such as anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, anti-obesity, anti-diabetic, and anti-cancer of resveratrol have been demonstrated by preclin. and clin. research. A possibility is that these therapeutical effects are associated with modulation of the Nrf2 signaling pathway in the following way: resveratrol may potentiate Nrf2 signaling through blockage of Keap1, by means of changing the Nrf2 mediators, its expression and its nuclear translocation. This article reviews the evidence of the Nrf2 modulating hypothesis as a possible mol. mechanism underlying the medicinal properties of resveratrol.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts