Tag: M.W=200-250

Ochiai, Asako; Kuroda, Keiji published the artcile< Preconception resveratrol intake against infertility: Friend or foe>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review endometriosis infertility resveratrol; aging; assisted reproductive technology; infertility; resveratrol; sirtuin.

A review. Growing evidence indicates that resveratrol has potential therapeutic effects in infertile women with diminished ovarian function, polycystic ovary syndrome (PCOS), or endometriosis. However, only one clin. trial in women undergoing in vitro fertilization (IVF) cycles using resveratrol has ever been reported. This review focuses on the potential therapeutic effects of resveratrol on pregnancy and on its advantages and disadvantages in pregnancy outcomes during infertility treatment. Methods : We performed a literature review to describe the known impacts of resveratrol on the ovary and endometrium. Results : Resveratrol upregulates sirtuin (SIRT)1 expression in ovaries, which is associated with protection against oxidative stress. It leads to the activation of telomerase activity and mitochondrial function, improving ovarian function. In the endometrium, resveratrol downregulates the CRABP2-RAR pathway leading to suppressing decidual and senescent changes of endometrial cells, which is essential for embryo implantation and placentation. Moreover, resveratrol may also induce deacetylation of important decidual-related genes. Conclusions : Resveratrol has potential therapeutic effects for improving ovarian function; however, it also has anti-deciduogenic actions in uterine endometrium. In addition, its teratogenicity has not yet been ruled out; thus, resveratrol should be avoided during the luteal phase and pregnancy.

Reproductive Medicine and Biology published new progress about Embryo, animal, two-cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeyaraman, Maya M; Al-Yousif, Nameer S H; Singh Mann, Amrinder; Dolinsky, Vernon W; Rabbani, Rasheda; Zarychanski, Ryan; Abou-Setta, Ahmed M published the artcile< Resveratrol for adults with type 2 diabetes mellitus.>, HPLC of Formula: 501-36-0, the main research area is .

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disorder that is characterised by insulin resistance and hyperglycaemia, which over time may give rise to vascular complications. Resveratrol is a plant-derived nutritional supplement shown to have anti-diabetic properties in many animal models. Less evidence is available on its safety and efficacy in the management of T2DM in humans. OBJECTIVES: To assess the efficacy and safety of resveratrol formulations for adults with type 2 diabetes mellitus. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and International Pharmaceutical Abstracts, as well as the International Clinical Trials Registry Platform (ICTRP) Search Portal and ClinicalTrials.gov. The date of the last search was December 2018 for all databases. No language restrictions were applied. SELECTION CRITERIA: All randomised controlled trials (RCTs) comparing effects of oral resveratrol (any dose or formulation, duration, or frequency of administration) with placebo, no treatment, other anti-diabetic medications, or diet or exercise, in adults with a diagnosis of T2DM. DATA COLLECTION AND ANALYSIS: Two review authors independently identified and included RCTs, assessed risk of bias, and extracted study-level data. Study authors were contacted for any missing information or for clarification of reported data. We assessed studies for certainty of the evidence using the GRADE instrument. MAIN RESULTS: We identified three RCTs with a total of 50 participants. Oral resveratrol not combined with other plant polyphenols was administered at 10 mg, 150 mg, or 1000 mg daily for a period ranging from four weeks to five weeks. The comparator intervention was placebo. Overall, all three included studies had low risk of bias. None of the three included studies reported long-term, patient-relevant outcomes such as all-cause mortality, diabetes-related complications, diabetes-related mortality, health-related quality of life, or socioeconomic effects. All three included studies reported that no adverse events were observed, indicating that no deaths occurred (very low-quality evidence for adverse events, all-cause mortality, and diabetes-related mortality). Resveratrol versus placebo showed neutral effects for glycosylated haemoglobin A1c (HbA1c) levels (mean difference (MD) 0.1%, 95% confidence interval (CI) -0.02 to 0.2; P = 0.09; 2 studies; 31 participants; very low-certainty evidence). Due to the short follow-up period, HbA1c results have to be interpreted cautiously. Similarly, resveratrol versus placebo showed neutral effects for fasting blood glucose levels (MD 2 mg/dL, 95% CI -2 to 7; P = 0.29; 2 studies; 31 participants), and resveratrol versus placebo showed neutral effects for insulin resistance (MD -0.35, 95% CI -0.99 to 0.28; P = 0.27; 2 studies; 36 participants). We found eight ongoing RCTs with approximately 800 participants and two studies awaiting assessment, which, when published, could contribute to the findings of this review. AUTHORS’ CONCLUSIONS: Currently, research is insufficient for review authors to evaluate the safety and efficacy of resveratrol supplementation for treatment of adults with T2DM. The limited available research does not provide sufficient evidence to support any effect, beneficial or adverse, of four to five weeks of 10 mg to 1000 mg of resveratrol in adults with T2DM. Adequately powered RCTs reporting patient-relevant outcomes with long-term follow-up periods are needed to further evaluate the efficacy and safety of resveratrol supplementation in the treatment of T2DM.

The Cochrane database of systematic reviews published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Min; Li, Ni; Zhang, Xiao-Fei; Zhou, Xing-Kui; Shi, Rui; Su, Yuan-Xiao; Liu, Jian-Jin; Cao, Yi; Mo, Ming He; Ma, Li published the artcile< Sphingobacterium faecale sp. nov., a 1-aminocyclopropane-1-carboxylate deaminase producing bacterium isolated from camel faeces>, SDS of cas: 87-73-0, the main research area is Sphingobacterium fecale camel feces aminocyclopropane carboxylate deaminase bacterium; 16S rRNA gene; Sphingobacterium faecale sp. nov.; camel faeces; polyphasic taxonomic.

An investigation of the diversity of 1-aminocyclopropane-1-carboxylate deaminase producing bacteria associated with camel faeces revealed the presence of a novel bacterial strain designated C459-1T. It was Gram-stain-neg., short-rod-shaped and non-motile. Strain C459-1T was observed to grow optimally at 35°C, at pH 7.0 and in the presence of 0% NaCl on Luria-Bertani agar medium. The cells were found to be pos. for catalase and oxidase activities. The major fatty acids (>10%) were identified as iso-C15 : 0, summed feature 3 (C16 : 1 ω6c and/or C16 : 1 ω7c) and iso-C17 : 0 3-OH. The predominant menaquinone was MK-7. The major polar lipids consisted of phosphatidylethanolamine, one sphingophospholipid, two unknown aminophospholipids, three unknown glycolipids and five unknown lipids. The genomic DNA G + C content was 40.3 mol%. Phylogenetic anal. based on 16S rRNA gene sequences indicated that strain C459-1T was affiliated with the genus Sphingobacterium and had the highest sequence similarity to Sphingobacterium tabacisoli h337T (97.0%) and Sphingobacterium paucimobilis HER1398T (95.6%). The average nucleotide identity and digital DNA-DNA hybridization values between strain C459-1T and S. tabacisoli h337T were 83.8 and 33.8%, resp. Phenotypic characteristics including enzyme activities and carbon source utilization differentiated strain C459-1T from other Sphingobacterium species. Based on its phenotypic, chemotaxonomic and phylogenetic properties, strain C459-1T represents a novel species of the genus Sphingobacterium, for which the name Sphingobacterium faecale sp. nov. is proposed, with strain is C459-1T (CGMCC 1.18716T = KCTC 82381T) as the type strain.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Ji Yong; Kim, Young Joo; Lee, Ji Youn; Lee, Yun-Sang; Jeong, Jae Min published the artcile< Imaging of the third gasotransmitter hydrogen sulfide using 99mTc-labeled alpha-hydroxy acids>, SDS of cas: 87-73-0, the main research area is alpha hydroxy acid 99mTc hydrogen sulfide gasotransmitter imaging; Glucoheptonate; Gluconate; H(2)S; Hypoxia; Inflammation; Ischemia; Technetium.

Various α-hydroxy acids such as glycolate, L-lactate, D-lactate, D-gluconate, D-glucoheptonate, D-glucuronate, D-glucarate, and citrate were labeled with 99mTc in the presence of stannous chloride. The labeled compounds were incubated with 0.2 mM of NaHS, and reactive sulfur species and then analyzed by ITLC/normal saline to detect the formation of insoluble complex. Matrigels containing various concentrations of NaHS were xenografted on the shoulder of normal mice, and an imaging study was performed after i.v. injection of [99mTc]Tc-gluconate. We also obtained autoradiog. image of a rat brain with a temporary brain ischemia after i.v. injection of [99mTc]Tc-gluconate.[99mTc]Tc-gluconate showed the highest formation of insoluble complex (87.8 ± 3.6%) after incubation with 0.2 mM NaHS. The Matrigel containing 2μmol NaHS showed uptake of [99mTc]Tc-gluconate, which proved the feasibility as the specific H2S imaging agent in vivo. Temporary ischemic lesion of rat brain showed high radioactivity accumulation representing the feasibility as endogenous H2S imaging agents. We proved that 99mTc-labeled α-hydroxy acid especially [99mTc]Tc-gluconate is a novel endogenous H2S imaging agent, which might contribute to study and diagnosis of various diseases related with inflammation and hypoxia.

Nuclear Medicine and Biology published new progress about Brain. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Product Details of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.

Biotechnology Advances published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Wei; Hu, ChengXiao; Xu, JiaYang; Ming, JiaJia; Zhao, YuanYuan; Cai, MiaoMiao; Sun, XueCheng; Liu, XinWei; Zhao, XiaoHu published the artcile< Dissolved organic matter derived from rape straw pretreated with selenium in soil improves the inhibition of Sclerotinia sclerotiorum growth>, Electric Literature of 87-73-0, the main research area is DOM rape straw selenium soil Sclerotinia; Dissolved organic matter (DOM); Inhibition; Rape straw; Sclerotinia sclerotiorum; Selenium.

Sclerotinia sclerotiorum (S. sclerotiorum) is a soil-borne pathogen with broad host range. Dissolved organic matter (DOM) plays a vital role in regulating microbial activity in soil. Exogenous selenium (Se) inhibits plant pathogen growth and enhances the capacity of plants to resist disease. DOM from rape straw with Se treated in soil (RSDOMSe) was extracted, and the inhibitory effect on S. sclerotiorum growth was investigated. RSDOMSe inhibited S. sclerotiorum growth, which not only caused severe damage to S. sclerotiorum hyphae but also enhanced soluble protein leakage, thereby improving the growth inhibition ratio by 20.9%. As the action in intercellular, RSDOMSe led to a significant increase in oxalic acid and decrease in CWDE (cell wall-degrading enzyme, which helps pathogens to invade plants) activities, downregulation of Bi1 (BAX inhibitor-1, required for S. sclerotiorum virulence), Ggt1 (γ-glutamyl transpeptidase, regulates the ROS antioxidant system), CWDE2 and CWDE10 gene expression levels, compared with non-Se treated RSDOM (RSDOMN). Eight metabolites upregulated in RSDOMSe were identified by GC-TOF-MS, and among these metabolites, fumaric acid, maleic acid, malonic acid, mucic acid, saccharic acid, succunic acid and phenylacetic acid showed significant inhibition on S. sclerotiorum growth. These findings provide valuable insight into a new approach for developing eco-friendly fungicides.

Journal of Hazardous Materials published new progress about BAX inhibitor-1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murgia, Denise; Mauceri, Rodolfo; Campisi, Giuseppina; De Caro, Viviana published the artcile< Advance on resveratrol application in bone regeneration: progress and perspectives for use in oral and maxillofacial surgery>, Reference of 501-36-0, the main research area is review resveratrol chronic bone regeneration surgery; Resveratrol; alveolar bone loss; bone defect; bone-regeneration; craniofacial tissue; resveratrol scaffold.

A review of the natural polyphenol Resveratrol (RSV) claims numerous pos. effects on health due to the well documented biol. effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together exptl. findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.

Biomolecules published new progress about Bone. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hassenrueck, Jessica; Wittmann, Valentin published the artcile< Cyclopropene derivatives of aminosugars for metabolic glycoengineering>, Quality Control of 5505-63-5, the main research area is cyclopropene aminosugar metabolic glycoengineering; bioorthogonal chemistry; carbohydrates; cyclopropenes; inverse electron-demand Diels–Alder reaction; metabolic engineering.

Cyclopropenes have been proven valuable chem. reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels-Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reaction, allowing their visualization in biol. systems. Here, we present a comparative study of six cyclopropene-modified hexosamine derivatives and their suitability for MGE. Three mannosamine derivatives in which the cyclopropene moiety is attached to the sugar by either an amide or a carbamate linkage and that differ by the presence or absence of a stabilizing Me group at the double bond have been examined We determined their DAinv reaction kinetics and their labeling intensities after metabolic incorporation. To determine the efficiencies by which the derivatives are metabolized to sialic acids, we synthesized and investigated the corresponding cyclopropane derivatives because cyclopropenes are not stable under the anal. conditions. From these experiments, it became obvious that N-(cycloprop-2-en-1-ylcarbonyl)-modified (Cp-modified) mannosamine has the highest metabolic acceptance. However, carbamate-linked N-(2-methylcycloprop-2-en-1-ylmethyloxycarbonyl)-modified (Cyoc-modified) mannosamine despite its lower metabolic acceptance results in the same cell-surface labeling intensity due to its superior reactivity in the DAinv reaction. Based on the high incorporation efficiency of the Cp derivative we synthesized and investigated two new Cp-modified glucosamine and galactosamine derivatives Both compounds lead to comparable, distinct cell-surface staining after MGE. We further found that the amide-linked Cp-modified glucosamine derivative but not the Cyoc-modified glucosamine is metabolically converted to the corresponding sialic acid.

Beilstein Journal of Organic Chemistry published new progress about Amino sugars Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Quality Control of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Jieye; Oliver, Allen G.; Serianni, Anthony S. published the artcile< D-Mannosamine hydrochloride (2-amino-2-deoxy-D-mannose hydrochloride): ionic hydrogen bonding in saccharides involving chloride and aminium ions>, SDS of cas: 5505-63-5, the main research area is mannosamine hydrochloride ionic hydrogen bonding saccharide; 2-amino-2-deoxy-d-mannose hydrochloride; anomeric disorder; crystal structure; d-mannosamine hydrochloride; ionic hydrogen bonding.

D-Mannosamine hydrochloride (2-amino-2-deoxy-D-mannose hydrochloride), C6H14NO5+·Cl-, (I), crystallized from a methanol/ethyl acetate/n-hexane solvent mixture at room temperature in a 4C1 chair conformation that is slightly distorted towards the C3,O5B form. A comparison of the structural parameters of (I) with the corresponding parameters in α-D-glucosamine hydrochloride, (II), and β-D-galactosamine hydrochloride, (III)/(III’), was undertaken to evaluate the effects of ionic hydrogen bonding on structural properties. Three types of ionic hydrogen bonds are present in the crystals of (I)-(III)/(III’), i.e. N+-H···O, N+-H···Cl-, and O-H···Cl-. The exocyclic structural parameters in (I), (II), and (III)/(III’) appear to be most influenced by this bonding, especially the exocyclic hydroxy groups, which adopt eclipsed conformations enabled by ionic hydrogen bonding to the chloride anion. Anomeric disorder was observed in crystals of (I), with an α:β ratio of 37:63. However, anomeric configuration appears to exert minimal structural effects; i.e., bond lengths, bond angles, and torsion angles are essentially identical in both anomers. The observed disorder at the anomeric C atom of (I) appears to be caused by the presence of the chloride anion and atom O3 or O4 in proximal voids, which provide opportunities for hydrogen bonding to atom O1 in both axial and equatorial orientations.

Acta Crystallographica, Section C: Structural Chemistry published new progress about Crystallization. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, SDS of cas: 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molina-Menor, Esther; Vidal-Verdu, Angela; Satari, Leila; Calonge-Garcia, Alba; Pascual, Javier; Pereto, Juli; Porcar, Manuel published the artcile< Belnapia mucosa sp. nov. and Belnapia arida sp. nov., isolated from desert biocrust>, Electric Literature of 87-73-0, the main research area is Belnapia desert biocrust fatty acid phylogeny; Alphaproteobacteria; Belnapia; Tabernas Desert; biocrust; novel species.

Two novel Gram-staining-neg., aerobic, cocci-shaped, non-motile, non-spore forming, pink-pigmented bacteria designated strains T6T and T18T, were isolated from a biocrust (biol. soil crust) sample from the vicinity of the Tabernas Desert (Spain). Both strains were catalase-pos. and oxidase-neg., and grew under mesophilic, neutrophilic and non-halophilic conditions. According to the 16S rRNA gene sequences, strains T6T and T18T showed similarities with Belnapia rosea CGMCC 1.10758T and Belnapia moabensis CP2CT (98.11 and 98.55% gene sequence similarity, resp.). The DNA G + C content was 69.80 and 68.96% for strains T6T and T18T, resp.; the average nucleotide identity by blast (ANIb) and digital DNA-DNA hybridization (dDDH) values confirmed their adscription to two novel species within the genus Belnapia. The predominant fatty acids were summed feature 8 (C18 : 1ω7c/C18 : 1ω6c), C16 : 0, C18 : 1 2-OH and summed feature 3 (C16 : 1ω7c/C16 : 1ω6c). According to he results of the polyphasic study, strains T6T and T18T represent two novel species in the genus Belnapia (which currently includes only three species), for which names Belnapia mucosa sp. nov. (type strain T6T = CECT 30228T = DSM 112073T) and Belnapia arida sp. nov. (type strain T18T = CECT 30229T = DSM 112074T) are proposed, resp.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts