Tag: M.W=150-200

Zhao, Bin published the artcileStructural characterization and antioxidant activity of oligosaccharides from Panax ginseng C. A. Meyer, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Panax ginseng oligosaccharide antioxidant activity; Antioxidant activity; Oligosaccharides; Panax ginseng.

The purpose of present work was to investigate the antioxidant activity of oligosaccharides from mountain-cultivated ginseng (MCG) and cultivated ginseng (CG). The antioxidant activity of total oligosaccharides from MCG and CG were compared preliminary. And then, the total oligosaccharides of MCG, which displayed stronger activity than that of CG, were separated by Carbon-Celite column and eluted with water and ethanol of different concentrations (30%, 50%, 70%, 95%, volume/volume). Five fractions, MCGOS-H2O, MCGOS-30, MCGOS-50, MCGOS-70, MCGOS-95, were obtained. Seven oligosaccharides were purified from MCGOS-30-MCGOS-95. The structure features of oligosaccharides (MCGO-1-MCGO-7) were characterized using high performance liquid chromatog. (HPLC), methylation and gas chromatog.-mass (GC-MS), as well as NMR spectroscopy. ABTS radical scavenging assay, DPPH radical scavenging assay as well as ferric reducing antioxidant power assay were adopted for antioxidant activity of all the different oligosaccharides sub-fraction. The result showed that the fractions of MCGOS-70 and MCGOS-95 exhibited significant radical scavenging activity with DPPH and ABTS. In conclusion, the oligosaccharides from MCG possessed the significant antioxidant activity. Therefore, we propose that the oligosaccharides from Panax ginseng can be developed as natural antioxidants in food and pharmaceutical fields.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Hua published the artcileIsolation, purification, structure and antioxidant activity of polysaccharide from pinecones of Pinus koraiensis, Formula: C6H12O6, the main research area is polysaccharide fraction rhamnose arabinose mannose glucose galactose glycosidic Pinus; PKP-E; Pinecones; Pinus koraiensis; Polysaccharide; Structure characterization.

The polysaccharides (PKP-E) extracted from the pinecones of Pinus koraiensis were studied, which was fractionated using DEAE-52 cellulose and Sephadex G-100. Four novel polysaccharide fractions were obtained, which were PKP-E-1-1, -1-2, -2-1, and -2-2, resp. The structural features were characterized using HPGPC, monosaccharide composition anal., Congo red test, periodate oxidation, Smith degradation, FTIR and NMR spectroscopy. The results showed the 4 purified fractions were non-triple helical structured heteropolysaccharides and composed of L-rhamnose, L-arabinose, D-mannose, D-glucose, and D-galactose. The fractions were mainly linked by 1â†? or 1â†?glycosidic bonds and the backbone of 4 fractions was probably composed of(â†?, 6)-β-D-Man-(1â†? and α-D-GalpA-(1â†?, which resembles pectin. Moreover, the antioxidant activities of the polysaccharides were measured by scavenging radical capacity tests. The PKP-E-2-1 was the most stable and active fraction, and the resp. IC50 for the hydroxyl and ABTS·+ radicals were 3.0 and 23.6 mg/mL.

Carbohydrate Polymers published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Shujie published the artcileExtraction, characterization and antioxidant activity evaluation of polysaccharides from Smilacina japonica, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Smilacina polysaccharide mannose glucose antioxidant; Antioxidant activity; Characterization; Smilacina japonica polysaccharide.

Three polysaccharides of uniform mol. weight designated as SJP1-1, SJP2-1, and SJP3-1 from Smilacina japonica were studied in this paper. Resp., their specific optical rotations were -45°, -75°, and -35°, their polysaccharide contents were 89.22%, 93.05%, and 59.83%, their relative average mol. weights were 1.87 × 105 Da, 1.04 × 105 Da, and 1.36 × 104 Da. Three polysaccharides were all composed mainly of the three monosaccharides mannose, glucose, and galactose, which together in SJP1-1, SJP2-1, and SJP3-1 resp. made up 96.34%, 98.23%, and 91.67% of the total polysaccharide. The polysaccharide structure was maintained mostly by β-glucose (1 â†?3), β-glucose (1 â†?4), α-mannose (1 â†?3), and α-galactose (1 â†?4) glycosidic linkages. SEM showed that SJP1-1, SJP2-1, and SJP3-1 were smooth uniform microspheres with diameters of 10-20μm that combined to form both uniformly dispersed particles and blocky structures. Finally, antioxidant assay showed that these polysaccharides all had a strong ability to scavenge ·OH and DPPH· radicals, with the effects of purified polysaccharides being greater than those of crude polysaccharides. This first report on the properties of these polysaccharides provides a basis for further studies to shed light on the medical properties of Smilacina japonica.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salarbashi, Davoud published the artcileFenugreek seed gum: Biological properties, chemical modifications, and structural analysis- A review, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is review Fenugreek seed gum physicochem functional property; Fenugreek seed gum; Functional properties; Physico-chemical properties.

Fenugreek is a leguminous plant belongs to the family Fabaceae, which is extensively cultivated as a semiarid crop in Northern Africa, the Mediterranean, India, and Canada. In the present review paper, first we summarized the extraction, purification, chem. composition, mol. structure, and rheol. behavior of the mucilages isolated from Fenugreek seeds (FSG), and then their functional properties presented to elucidate the potential application of this traditional source of hydrocolloids in food, pharmaceutical, and other industries. To date, there is no technique that can successfully remove the attached protein from FSG. From a structural point of view, galactose and mannose are the most abundant polysaccharide in FSG composition, suggesting a galactomannan-like structure. FSG is the most soluble of the seed gums. FSG solutions at various temperatures and concentrations showed a time-dependent shear thinning behavior. Furthermore, these hydrocolloids can be employed for the fabrication of eco-friendly packaging systems. Antioxidant capacity and anti-fungi activity of FSG has been proved in different studies. In conclusion, industrial applications of FSG are possible due to its strong thickening properties. Addnl., FSG has an excellent emulsification capacity, which enables its application in the food, cosmetic and/or pharmaceutical industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bensing, Barbara A. published the artcileRecognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection, Computed Properties of 59-23-4, the main research area is Streptococcus endocarditis innate immunity sialoglycan.

Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal species express a serine-rich repeat surface adhesin that mediates attachment to sialylated glycans on mucin-like glycoproteins, but the specific sialoglycan structures recognized can vary from strain to strain. Previous studies have shown that sialoglycan binding is clearly important for aortic valve infections caused by some S. gordonii, but this process did not contribute to the virulence of a strain of S. sanguinis. Here we generated isogenic strains of S. gordonii that differ only in the type and range of sialoglycan structures to which they adhere and examined whether this rendered them more or less virulent in a rat model of endocarditis. Importantly, we found that human and rat platelet GPIbα (the major receptor for S. gordonii and S. sanguinis on platelets) display similar O-glycan structures, comprised mainly of a di-sialylated core 2 hexasaccharide, although the rat GPIbα has a more heterogenous composition of modified sialic acids. The combined results suggest that streptococcal interaction with a minor O-glycan on GPIbα may be more important than the over-all affinity for GPIbα for pathogenic effects.

PLoS Pathogens published new progress about Aortic valve. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Mingrui published the artcileNatural deep eutectic solvents pretreatment as an aid for pectin extraction from apple pomace, Category: alcohols-buliding-blocks, the main research area is natural deep eutectic solvent pectin extraction apple pomace.

Three natural deep eutectic solvents (NADES; choline chloride (CC): lactic acid (LA), CC: oxalic acid (OA), CC: urea (U)) in the ratio 1:2 were tested as a pretreatment of apple pomace prior to hot water extraction of pectin. The pretreatment duration and temperature (for 0.5-2h, at 40-80°C) was adjusted to limit cell wall polysaccharides losses and degradation Extraction yields and sugar composition were used to evaluate the impact of the pretreatment on pectin extraction and the mol. weight and degree of esterification of pectin were characterized. Results showed that CC:LA and CC:U pretreatments led to close overall recovery yields with the control using water instead of NADES. Instead, CC:OA led to polysaccharides degradation and loss. The cell wall monosaccharides composition was affected after CC:LA and CC:U pretreatments at 60°C and above, while it was preserved by CC:LA pretreatments at 40°C for 1h. Moreover, CC:LA pretreatment facilitated hot water extraction of a large amount (33.1%-56.1% of uronic acid recovery) of high Mw HM pectin comparable with pectin obtained through classical method. CC:U pretreatment led to saponification and affected pectin composition by introducing choline. Thus, CC:LA pretreatment of apple pomace followed by water extraction offers a “”green”” alternative for mineral acid pectin extraction while CC:U allows functionalizing pectin in apple pomace prior to hot water extraction

Food Hydrocolloids published new progress about Apple pomace. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Agatonovic-Kustrin, Snezana published the artcileModels for skin and brain penetration of major components from essential oils used in aromatherapy for dementia patients, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is dementia skin blood brain barrier terpenoid essential oil aromatherapy; Alzheimer’s disease; QSAR; blood brain barrier; skin penetration; terpenes.

The aim of this work was to develop quant. structure activity relationships (QSARs), to predict skin and blood barrier penetrative abilities of 119 terpenoids from EOs used in aromatherapy. The first model was based on exptl. measured skin permeability for 162 mols., and the second model on BBB permeability for 138 mols. Each mol. was encoded with 63 calculated mol. descriptors and an artificial neural network was used to correlate mol. descriptors to permeabilities. Developed QSAR models confirm that EOs components penetrate through the skin and across the BBB. Some well-known descriptors, such as log P (lipophilicity), mol. size and shape, dominated the QSAR model for BBB permeability. Compounds with the highest predicted BBB penetration were hydrocarbon terpenes with the smallest mol. size and highest lipophilicity. Thus, mol. size is a limiting factor for penetration. Compounds with the highest skin permeability have slightly higher mol. size, high lipophilicity and low polarity. Our work shows that a major disadvantage of novel multitarget compounds developed for the treatment of Alzheimer’s disease is the size of mols., which cause problems in their delivery to the brain. Therefore, there is a need for smaller compounds, which possess more desirable physicochem. properties and pharmacokinetics, in addition to targeted biol. effects.

Journal of Biomolecular Structure and Dynamics published new progress about Aromatherapy. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yimeng published the artcileStructural characterization, antiproliferative and immunoregulatory activities of a polysaccharide from Boletus Leccinum rugosiceps, Computed Properties of 59-23-4, the main research area is Leccinum breast carcinoma LRP1 antiproliferative immunoregulatory activity hepatoma cell; Antitumor; Immunomodulatory; Leccinum rugosiceps; Polysaccharide; Structure.

A homogeneous water-soluble flaky polysaccharide named LRP-1 (18.82 kDa) was extracted and purified from the rare edible and medicinal fungi Leccinum rugosiceps. The structure characterization of LRP-1 was analyzed by GPC, GC, GC-MS, FT-IR, SEM, 1D/2D NMR, and its antitumor and immunoregulatory activities were determined The results show that LRP-1 is a new polysaccharide with a backbone which is mainly composed of â†?-α-D-Fucp-3â†? â†?-α-D-Rhap-3â†? â†?-β-D-Glcp-6â†? â†?-β-D-Glcp-3â†? â†?-α-D-Glcp-4â†? â†?-β-D-Galp-6 â†?and â†?-α-D-Manp-6â†? Results of MTT assay show that LRP-1 inhibit the growth of human hepatoma cells HepG-2 and human breast carcinoma MCF-7 cells in vitro. LRP-1 could also induce the secretion of NO and immune factors (IL-6 and TNF-α) of RAW264.7. This study suggests that LRP-1 has potential to be used as nutraceutical food with antitumor and immunoregulatory activities.

International Journal of Biological Macromolecules published new progress about Autoxidation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jingqin published the artcileGreen synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold nanoparticles, COA of Formula: C10H18O, the main research area is Curcuma leaf gold nanoparticle antioxidant cytotoxicity green chem.

The present work indicated the green synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of gold nanoparticles containing Curcumae Kwangsiensis Folium (Leaf) aqueous extract Characterization of gold nanoparticles was done by Field Emission SEM (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transformed IR Spectroscopy (FT-IR), and UV-Visible Spectroscopy (UV-Vis). MTT assay was used on common ovarian cancer cell lines i.e., SW-626, PA-1, and SK-OV-3 to survey the cytotoxicity and anti-ovarian cancer effects of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles. The best results of cytotoxicity and anti-ovarian cancer properties were seen in the case of gold nanoparticles. They had very low cell viability and high anti-ovarian cancer activities dose-dependently against PA-1, SW-626, and SK-OV-3 cell lines without any cytotoxicity on the normal cell line (HUVEC). For investigating the antioxidant properties of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles, the DPPH test was used in the presence of butylated hydroxytoluene as the pos. control. The best results of antioxidant properties were seen in the case of gold nanoparticles. They inhibited half of the DPPH mols. in the concentration of 153μg/mL. Maybe significant anti-human ovarian cancer potentials of gold nanoparticles synthesized by Curcumae Kwangsiensis Folium leaf aqueous extract against common human ovarian cancer cell lines are linked to their antioxidant activities.

Arabian Journal of Chemistry published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiang, Yueyue published the artcileSpatial variation of volatile organic compounds and antioxidant activity of turmeric (Curcuma longa L.) essential oils harvested from four provinces of China, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is volatile organic compound antioxidant Curcuma longa essential oil; Antioxidant activity; Curcuma longa L; DPPH; HS-SPME-GC-MS; Turmeric essential oils (TEOs).

The objective of this study was to investigate the spatial variation of volatile organic compounds and antioxidant activity of turmeric essential oils (TEOs) harvested from four provinces of China. The major chem. components of these TEOs were analyzed using headspace solid-phase micro-extraction gas chromatog.-mass spectrometry. More than forty volatile organic compounds in TEOs were identified, which accounted for 82.09-93.64% of the oil components. The relative abundances of the main volatile organic compounds in TEOs at the genus level were visualized by a heat map. The antioxidant activity of the TEOs of five different origins was characterized by the DPPH free radical scavenging activity, in which the antioxidant activity of the TEOs from Guangxi was superior to those of other sources. Furthermore, the IC50 values of the antioxidants TEOs collected from Guangxi, Sichuan, Yunnan, Changting, and Liancheng were 33.30, 42.5, 35.22, 63.27, and 39.96 mg/mL, resp., which indicated the excellent free radical scavenging activity of those TEOs. Therefore, the TEOs might be considered as a natural antioxidant with potential applications in food and pharmaceutical industries.

Current Research in Food Science published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts