Tag: M.W=150-200

Tabarsa, Mehdi published the artcileIsolation, structural elucidation and immuno-stimulatory properties of polysaccharides from Cuminum cyminum, HPLC of Formula: 59-23-4, the main research area is Cuminum polysaccharide structure mol weight immunostimulation signaling cytokine; Immuno-stimulatory effect; Molecular weight; Polysaccharides; Signaling pathways; Structure.

The aim of the present study was to evaluate the effect of water-soluble polysaccharides from Cuminum cyminum to induce inflammatory response in immune cells and understand their underlying mechanisms. Weight average mol. weight (Mw) of polysaccharides varied between 191.4-512.2 × 103 g/mol. Polysaccharides induced RAW264.7 cells to release nitric oxide and express TNF-α, IL-1β, IL-6 and IL-12 inflammatory cytokines. Polysaccharides activated NK-92 cells to produce TNF-α, IFN-γ, perforin, granzyme B, NKG2D and FasL. Activations of RAW264.7 and NK-92 cells were through NF-κB and MAPKs signal pathways indicated by the presence of phosphorylated NF-κB, ERK, JNK and p38 proteins. The polysaccharide structure was mainly constituted of â†?)-Galp-(1â†? â†?)-Galp-(1â†? â†?)-Arap-(1â†?and â†?)-Arap-(1â†?glycosidic linkages. Overall results suggested that polysaccharides from C. cyminum possessing lower MW and greater expanded conformation more effectively stimulate RAW264.7 and NK-92 cells and thus could be considered for further studies on their biomedical applications.

Carbohydrate Polymers published new progress about Conformation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Misharina, T. A. published the artcileInhibition of Autoxidation of Polyunsaturated Fatty Acids by Clove and Oregano Essential Oils, SDS of cas: 124-76-5, the main research area is Eugenia Origanum essential oil synergism polyunsaturated fatty acid autoxidation.

Abstract: Inhibition of the autoxidation of polyunsaturated fatty acid Me esters isolated from fish oil by essential oils of clove, oregano and their mixture has been studied. Their content was determined after 1-6 mo of autoxidation by capillary gas chromatog. to assess antioxidant efficiency. It has been shown that the essential oils of clove and oregano and their combination effectively inhibited the autoxidation of polyunsaturated fatty acids. The degree of this inhibition depended on the structure of fatty acids and the composition of their mixtures, as well as on the essential oil content and duration of autoxidation It was shown that an increase in the number of double bonds in unsaturated acid mols. resulted in a decreased resistance of their esters to oxidation In the control, 97% of monounsaturated acids and only 9% of docosahexaenoic acid remained after 3 mo of autoxidation Clove essential oils at concentrations of 2 and 4% inhibited oxidation with equal efficiency; after 3 mo, 86-91% of esters of acids with five and six double bonds remained. Oregano essential oil was less effective as an antioxidant than the clove. Thus, up to 79% of Me eicosapentaenoate and 73% of Me docosahexaenoate remained after 3 mo of autoxidation in its presence. After 6 mo of autoxidation, the Me eicosapentaenoate and docosahexaenoate contents were 67 and 54% in the presence of 4% clove oil and only 11 and 7%, resp., with 1% oil. The inhibitory activity of 4% oregano oil and 2% clove oil turned out to be almost the same, and a similar content of all unoxidized acids was observed in the presence of 1% oils. A mixture of clove and oregano essential oils showed an additive antioxidant effect on arachidonic and eicosapentaenoic acids esters and a synergistic effect on docosahexaenoic acid ester.

Applied Biochemistry and Microbiology published new progress about Autoxidation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kotidis, Pavlos published the artcileModel-based optimization of antibody galactosylation in CHO cell culture, Computed Properties of 59-23-4, the main research area is ovary cellular growth antibody galactosylation optimization math modeling; Chinese hamster ovary (CHO) cells; antibody glycosylation; galactosylation; mathematical modeling; nucleotide sugars; process optimization.

Exerting control over the glycan moieties of antibody therapeutics is highly desirable from a product safety and batch-to-batch consistency perspective. Strategies to improve antibody productivity may compromise quality, while interventions for improving glycoform distribution can adversely affect cell growth and productivity. Process design therefore needs to consider the trade-off between preserving cellular health and productivity while enhancing antibody quality. In this work, we present a modeling platform that quantifies the impact of glycosylation precursor feeding – specifically that of galactose and uridine – on cellular growth, metabolism as well as antibody productivity and glycoform distribution. The platform has been parameterized using an initial training data set yielding an accuracy of ±5% with respect to glycoform distribution. It was then used to design an optimized feeding strategy that enhances the final concentration of galactosylated antibody in the supernatant by over 90% compared with the control without compromising the integral of viable cell d. or final antibody titer. This work supports the implementation of Quality by Design towards higher-performing bioprocesses.

Biotechnology and Bioengineering published new progress about Cell density. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Mo published the artcileStructural, rheological properties and antioxidant activities of polysaccharides from mulberry fruits (Murus alba L.) based on different extraction techniques with superfine grinding pretreatment, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Murus uronic acid mannose rhamnose polysaccharide protein antioxidant rheol; Antioxidant activities; Extraction method; Mulberry fruits polysaccharides; Rheological properties.

The structural characteristics and biol. activity of polysaccharides were influenced by different extraction methods. In this study, polysaccharides from mulberry fruits (Murus alba L., which were pre-treated with superfine grinding process) (MFP) were exacted using hot-water extraction (HWE), enzyme-assisted hot water extraction (EAHE), ultrasonic-assisted hot water extraction (UAHE), and high-speed shear homogenization-assisted hot water extraction (HSEHE). The extraction yield, structure, rheol. properties and antioxidant activities of MFPs were investigated. MFP extracted using the HSEHE method have the highest extraction yields than other extraction methods. The smaller particle size of mulberry powder was found to improve the extraction yields. The MFPs were obtained by the combination between different extraction methods and superfine grinding pretreatment (through 100 mesh sieve) (MFP-HWE100, MFP-EAHE100, MFP-UAHE100, MFP-HSEHE100) showed the same levels of monosaccharide compositions and glycosyl linkages, However, these methods can produce MFP with different monosaccharide proportions, branching degree, different mol. weight, particle size and microstructure. MFP-HSEHE100 achieved the lowest mol. weight and particle size, which exhibited better thixotropy and antioxidant activities than other MFPs. This study identified that HSEHE was the most suitable extraction method for MFP.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Heng published the artcileSulfated modification, characterization, antioxidant and hypoglycemic activities of polysaccharides from Sargassum pallidum, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Sargassum liver cancer polysaccharide antioxidant hypoglycemia sulfated modification; Antioxidant; Hypoglycemic activity; Polysaccharides; Sargassum pallidum; Sulfation modification.

The aim of this study was to investigate the effect of sulfated modification on the in vitro antioxidant and hypoglycemic activities of Sargassum pallidum polysaccharides (SPP). Three sulfated derivatives (S-SPP1-4, S-SPP1-6 and S-SPP1-8) were prepared using chlorosulfonic acid-pyridine method under different reaction conditions. Physicochem. characterization indicated that sulfated modification had successfully occurred. The degrees of substitution (DS) of S-SPP1-4, S-SPP1-6 and S-SPP1-8 were determined to be ranging from 0.85 to 1.19. Sulfated modification resulted in some changes in chem. component, mol. weight and monosaccharide composition of SPP. Among these sulfated polysaccharides, S-SPP1-4 exhibited the best DPPH and ABTS radical scavenging activities, while S-SPP1-8 exhibited the best α-glucosidase inhibitory activity and promoting-effect on glucose consumption in insulin resistant (IR)-HepG2 cells. Furthermore, all the sulfated derivatives exhibited better hypoglycemic ability than native SPP. These results suggest that appropriately sulfated modification could enhance the antioxidant and hypoglycemic activities of S. pallidum polysaccharides, which might be used as an alternative derivative of natural antioxidant and hypoglycemic agent.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jian published the artcilePhysicochemical properties, antioxidant and antiproliferative activities of polysaccharides from Morinda citrifolia L. (Noni) based on different extraction methods, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Morinda polysaccharide extraction antioxidant antiproliferative physicochem property; Antioxidant activity; Antiproliferative ability; Different extraction methods; Noni polysaccharide; Physicochemical properties.

The influences of different extraction methods on the yields, physicochem. properties, antioxidant activities and antiproliferative abilities of polysaccharides from Morinda citrifolia L. (Noni) were investigated and compared. Three extraction methods were applied to extract Noni polysaccharides (NP), which include hot water extraction (HWE), pulsed elec. field-assisted extraction (PEFAE) and ultrasonic-assisted extraction (UAE). The extraction yields, sugar contents, uronic acid contents, mol. weights, monosaccharide proportions, antioxidant activities and antiproliferative abilities of three NP samples were significantly different. However, their preliminary structural characteristics and monosaccharide types were similar. More specifically, UAE-NP had the highest extraction yield, the smallest mol. weight and the best antioxidant activities. Especially, UAE-NP showed excellent antiproliferative abilities. Compared with HWE-NP and PEFAE-NP, the IC50 value of UAE-NP on HepG2 cells reduced by 45.45% and 33.14%, resp. The highest antioxidant activities of the UAE-NP might be attributed to its smaller mol. weight, lower Gal content and higher Fuc content. The strongest antiproliferative effects of the UAE-NP might be related to the low mol. weight Overall, UAE could be a potential technique for the extraction of high-quality NP due to its high yield, high efficiency and notable bioactivities.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Xiaoyi published the artcilePhysicochemical properties, antioxidant activity and immunological effects in vitro of polysaccharides from Schisandra sphenanthera and Schisandra chinensis, HPLC of Formula: 59-23-4, the main research area is polysaccharide Schisandra antioxidant immunomodulatory agent; Antioxidant activity; Immunomodulatory effect; Physicochemical properties; S. chinensis polysaccharide; S. sphenanthera polysaccharide.

Schisandra sphenanthera and Schisandra chinensis are widely consumed either as food or for medicinal purposes. Nevertheless, no detailed comparative assessments of their physicochem. properties and biol. activity have been reported. In this paper, using hot-water extraction, alc. precipitation, and deproteinization, we obtained polysaccharidic extracts from Schisandra sphenanthera and Schisandra chinensis (denoted as SSP and SCP, resp.) and investigated their antioxidant and immunol. activities. The extracts were different from each other with regard to sugar, protein, and uronic acid contents. Both extracts were mainly composed of arabinose, glucose, and galactose, but their contents varied greatly; SSP had more galacturonic acid. Compared with SCP, SSP had stronger free radical scavenging ability, protective effects on biomols., cellular antioxidant activity, owing to its higher protein (35.35 ± 1.73%) and uronic acid (12.81 ± 1.15%) contents. With respect to cell viability, neutral red phagocytosis, NO production, and acid phosphatase activity, SCP had stronger effects than SSP; this was largely due to its high levels of mannose, galactose, arabinose, and glucose. These results provide evidence to support the use Schisandra-derived polysaccharides for several purposes, including clin., agricultural, and industrial applications.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Yuyang published the artcileMicrowave-assisted aqueous two-phase extraction of diverse polysaccharides from Lentinus edodes: Process optimization, structure characterization and antioxidant activity, Quality Control of 59-23-4, the main research area is polysaccharide Lentinus edode twophase extraction microwave antioxidant activity structure; Antioxidant activity; Lentinus edodes; Microwave-assisted aqueous two-phase extraction; Polysaccharides; Structure characterization.

Microwave-assisted aqueous two-phase extraction (MAATPE) was applied to simultaneous extraction of diverse polysaccharides from Lentinus edodes with aqueous two-phase extraction system (ATPS) of ethanol/ammonium sulfate as the biphasic extractant. Key factors in MAATPE process were optimized by response surface methodol., and the optimum conditions were concluded as follows: the ATPS composition of ethanol concentration 26.0% (weight/weight) and (NH4)2SO4 concentration 19.58% (weight/weight), extraction temperature 78.7°C, extraction time 19.55 min and solid-to-solvent ratio 1:50. The extraction yields of the polysaccharides from the top phase (PTP) and the bottom phase (PBP) were 2.12 ± 0.21% and 11.16 ± 0.28%, resp. By means of FT-IR, HPGPC and HPLC anal., PTP and PBP were different from each other in chem. structure, their average mol. weight (MW) were resp. 119,533 Da and 3906 Da. Also, the mechanism of MAATPE process was explored by composition anal. and SEM. Both polysaccharides exhibited stronger antioxidant activities, EC50 values of scavenging DPPH, hydroxyl and superoxide radicals for PBP achieved 580 ± 3, 83.1 ± 3.6 and 91.1 ± 0.5 ug/mL as against 560 ± 4, 76.3 ± 2.2 and 89.3 ± 2.4 ug/mL of PTP, resp. Compared with conventional methods using a mono-phase solvent, MAATPE can not only greatly improve extraction efficiency, but also selectively extract diverse polysaccharides.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mei, Xinya published the artcileThe antioxidant activities of balsam pear polysaccharide, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is balsam pear polysaccharide antioxidant gel permeation chromatog; Antioxidant activities; Balsam pear polysaccharide; Structural characterization.

The antioxidant activities of polysaccharide from balsam pear were studied. It was determined by gel permeation chromatog. that the mol. weight distribution of purified polysaccharide was concentrated near 33582 Da. It indicated that the monosaccharide components were rhamnose, galacturonic acid, galactose, xylose and arabinose. Fourier transform IR spectroscopy, NMR and Congo red experiments showed that there are C1, C2, C3, C5 links, and stable β-triple helix conformation in aqueous solution It was found that polysaccharide had good scavenging effect on free radicals. So, balsam pear polysaccharide should be a potential antioxidant.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Wenwei published the artcileOptimization of ultrasonic-assisted enzymatic extraction of polysaccharides from thick-shell mussel (Mytilus coruscus) and their antioxidant activities, Product Details of C6H12O6, the main research area is Mytilus polysaccharide ultrasonic assisted enzymic extraction antioxidant activity; Antioxidant activity; Mytilus coruscus; Polysaccharide; Ultrasonic-assisted enzymatic extraction.

This study aimed to obtain the purified fractions of Mytilus coruscus polysaccharides (MCPs) and investigate their antioxidant activities. MCPs were prepared through ultrasonic-assisted enzymic extraction optimized by employing the response surface methodol. A single-factor experiment was conducted using the Box-Behnken design to determine the optimum extraction conditions of MCPs. The ultrasonic power was 60 W, liquid-to-material ratio was 30 mL/g, extraction time was 36 min, extraction temperature was 64°C, enzyme concentration was 3.2%, and polysaccharide extraction yield was 12.86% ± 0.12%. A novel polysaccharide (MCP1-2) was obtained after the purification with AB-8 macroporous resin, DEAE Sepharose Fast Flow, and Sepharose CL-6B column. The mol. weight of MCP1-2 was estimated to be 134.9 kDa according to high-performance gel permeation chromatog. High-pressure liquid-phase chromatog. results showed that MCP1-2 contained mannose, rhamnose, glucuronic acid, glucose, galactose, and L-Fuc at a molar ratio of 1.53:1:4.83:81.82:2.36:1.51. IR and NMR spectroscopies confirmed that MCP1-2 possessed α- and β- configurations. The antioxidant activities of MCP1-2 were investigated in vitro, and the results showed that MCP1-2 had good antioxidant activity and can be used as a natural antioxidant in food.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts