Tag: M.W=150-200

Manetti, Fabrizio published the artcileParallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity, Name: (4-Butoxyphenyl)methanol, the main research area is arylthiopyrimidinone preparation HIV 1 transcriptase inhibitor.

A simple and efficient methodol. for the parallel solution-phase synthesis has been set up to obtain a series of thiouracils, in turn selectively S-benzylated under microwave irradiation to give new S-DABOs. Biol. screening led to the identification of compounds with nanomolar activity toward both the highly purified recombinant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) enzyme (wild-type and mutants) and wild-type (wt) and mutant HIV-1 strains. In particular, I was found to be the most potent S-DABO reported so far (ID50 = 26 nM toward the isolated wt enzyme) with subnanomolar activity toward both the wt and the pluriresistant virus (IRLL98) HIV-1 strain (EC50 < 0.14 nM and EC50 = 0.22 nM, resp.). Mol. modeling calculations were also performed to investigate the binding mode of such compounds onto the non-nucleoside reverse transcriptase inhibitor binding site and to rationalize the relationships between their chem. structure and activity values toward wt RT. Journal of Medicinal Chemistry published new progress about Homo sapiens. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Name: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Guijie published the artcileStructural Characterization and Immunostimulatory Activity of Heteropolysaccharides from Fuzhuan Brick Tea, Synthetic Route of 59-23-4, the main research area is immunostimulatory heteropolysaccharide Fuzhuan brick tea; Fuzhuan brick tea; immunostimulatory activity; polysaccharides; structural characterization.

Fuzhuan brick tea (FBT), one of the unique dark teas, has various health-promoting functions. In the present study, one polysaccharide fraction, namely FBTPS-2-1, was extracted and purified from FBT, and its structure and potential immunostimulatory activity were investigated. The results showed that FBTPS-2-1,one of typical heteropolysaccharides, was mainly composed of Gal, Ara, and Glc with little molar content of Man, Rha, GalA, and GlcA in molar ratio of 46.59:22.13:13.57:8.20:6.02:2.12:1.38 and mol. weight of 748 kDa. The backbone of FBTPS-2-1 contained â†?)-β-D-Galp-(1â†?)-β-D-Galp-(1â†? â†?)-β-D-Galp-(1â†?)-α-D-Glcp-(1â†? â†?)-α-D-Glcp-(1â†?)-α-D-Glcp-(1â†? â†?)-α-D-Glcp-(1â†?)-β-D-Galp-(1â†? â†?)-β-D-Galp-(1â†?)-β-D-Galp-(1â†? â†?,6)-β-D-Galp-(1â†?)-β-D-Galp-(1â†?and â†?,6)-β-D-Galp-(1â†?,6)-β-D-Galp-(1â†? The linkages of branches in FBTPS-2-1 were mainly composed of α-L-Araf-(1â†?,6)-β-D-Galp-(1â†? â†?)-α-L-Araf-(1â†?,6)-β-D-Galp-(1â†? â†?)-β-D-Galp-(1â†?,6)-β-D-Galp-(1â†? α-L-Araf-(1â†?,5)-α-L-Araf-(1â†? â†?,5)-α-L-Araf-(1â†?)-α-L-Araf-(1â†? α-D-Galp-(1â†?,5)-α-L-Araf-(1â†?and â†?)-α-L-Araf-(1â†?)-β-D-Galp-(1â†? Furthermore, FBTPS-2-1 could increase the phagocytosis of macrophages and promote the secretion of NO and a variety of inflammatory cytokines, including TNF-α, IL-1β, and IL-6, indicating noticeable immune enhancement activity. Thus, FBTPS-2-1 could serve as a potentially functional food to improve human health by modulating the host immunoreaction.

Journal of Agricultural and Food Chemistry published new progress about Homo sapiens. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pesesse, R. published the artcileMultimodal chemometric approach for the analysis of human exhaled breath in lung cancer patients by TD-GC × GC-TOFMS, Category: alcohols-buliding-blocks, the main research area is multimodal chemometrics human exhaled breath lung cancer GC TOFMS; Breath analysis; Comprehensive two-dimensional gas chromatography (GC × GC); Lung cancer; Statistics; Thermal desorption (TD); Time-of-flight mass spectrometry (TOFMS); Volatile organic compounds (VOCs).

Lung cancer is the deadliest cancer in developed countries. To reduce its mortality rate, it is important to enhance the authors’ capability to detect it at earlier stages by developing early diagnostic methods. In that context, the anal. of exhaled breath is an interesting approach because of the simplicity of the medical act and its non-invasiveness. Thermal desorption comprehensive two-dimensional gas chromatog. time of flight mass spectrometry (TD-GC × GC-TOFMS) has been used to characterize and compare the volatile content of human breath of lung cancer patients and healthy volunteers. On the sampling side, the contaminations induced by the bags membrane and further environmental migration of VOCs during and after the sampling have also been studied. Over a realistic period of 6 h, the concentration of contaminants inside the bag can increase from 2 to 3 folds based on simulated breath samples. On the data processing side, Fisher ratio (FR) and random forest (RF) approaches were applied and compared in regards to their ability to reduce the data dimensionality and to extract the significant information. Both approaches allow to efficiently smooth the background signal and extract significant features (27 for FR and 17 for RF). Principal component anal. (PCA) was used to evaluate the clustering capacity of the different models. For both approaches, a separation along PC-1 was obtained with a variance score around 35%. The combined model provides a partial separation with a PC-1 score of 52%. This proof-of-concept study further confirms the potential of breath anal. for cancer detection but also underlines the importance of quality control over the full anal. procedure, including the processing of the data.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Homo sapiens. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiao, Lili published the artcileStudy on structure characterization of pectin from the steamed ginseng and the inhibition activity of lipid accumulation in oleic acid-induced HepG2 cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is pectin steamed ginseng oleic acid lipid accumulation; HepG2 cell; Lipid accumulation; Pectin; Steamed ginseng.

Two acid polysaccharides were obtained from steamed ginseng (GPS-1 and GPS-2) through water extraction, ion-exchange chromatog. and gel chromatog. The structural features and ability of the polysaccharides to inhibit lipid accumulation in oleic acid-induced HepG2 cells were studied. GPS-1 consisted of type I arabinogalactans (AG-I), arabinogalactans-II (AG-II) and rhamnogalacturonan I (RG-I) domains. GPS-2 was a pectin-like polysaccharide consisting mainly of the homogalacturonan (HG) domain and a small amount of AG domain. Both GPS-1 and GPS-2 had branches attaching on O-3 of (16)-GalA or O-4 of (1 2)-Rha and terminated by either Ara or Gal. An in vitro experiment revealed that GPS-1 treatment at 50-400 g/mL could dose-dependently decrease intracellular lipid accumulation and cholesterol (TC) and triglycerides (TG) levels. GPS-1 exerted a more serious hypolipidemic effect than GPS-2 did. Moreover, GPS-1 considerably increased the phosphorylation of AMP-activated protein kinase (AMPK) and affected the expression of AMPK downstream targets, including the inhibition of the protein expression of sterol regulatory element-binding protein 1c (SREBP-1c) and activation of Acetyl-CoA carboxylase (ACC). Results suggest that GPS-1 could inhibit lipid accumulation via the AMPK the signalling pathway.

International Journal of Biological Macromolecules published new progress about Homo sapiens. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jayawardena, Thilina U. published the artcileIsolation and purification of fucoidan fraction in Turbinaria ornata from the Maldives; Inflammation inhibitory potential under LPS stimulated conditions in in-vitro and in-vivo models, Related Products of alcohols-buliding-blocks, the main research area is Turbinaria fucoidan inflammation sulfated polysaccharides; Anti inflammation; Brown algae; Fucoidan; Nitric oxide; RAW 264.7; Turbinaria ornata.

Fucoidan, referred to as fucose containing sulfated polysaccharides (FCSP), is a polymer from brown algae cell wall that is reported to exhibit potential anti-inflammatory activity. In the present study, the fucoidans are extracted from Turbinaria ornata (TO) from the Maldives. The method involves enzyme assisted extraction and is modified in order to improve the effectiveness and purity of final product. Purified fucoidan fraction was identified as F10, and its chem. properties were verified via FTIR, 1H NMR and monosaccharide anal. Selected inflammatory mediators were studied to evaluate the anti-inflammatory potential using RAW 264.7 macrophages. F10 successfully inhibited NO production (IC50 = 30.83 ± 1.02 μg mL-1). F10 dose-dependently down-regulated iNOS, COX-2, and pro-inflammatory cytokines including PGE2 levels. The in vivo experiments were assisted by zebrafish embryo model. This exhibited reduction in ROS, NO expression levels. To our knowledge, this is the first report to illustrate potential anti-inflammatory activity of FCSPs extracted from the brown algae T. ornata. Concisely, the results suggest that fucoidan purified from T. ornata increases the macrophage cellular and zebrafish embryo resistance against LPS-induced inflammation. Based on the observations, the fucoidans are promising candidates to be used in the pharmaceutical and cosmeceutical sectors.

International Journal of Biological Macromolecules published new progress about Inflammation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Rui published the artcilePectic polysaccharides from purple passion fruit peel: A comprehensive study in macromolecular and conformational characterizations, Quality Control of 59-23-4, the main research area is pectic polysaccharide purple passion fruit peel conformation; Conformational behavior; Macromolecular dimension; Passiflora edulis Sims f. edulis; Pectic polysaccharides; Purple passion fruit peel; Ultrasonic-aided ammonium oxalate extraction.

A polysaccharide (PFPP) from purple passion fruit peel was optimally extracted, with the highest yield (10.05%, weight/weight) obtained under 35°C extraction temperature, 240 W ultrasonic power, 65:1 mL/g liquid-to-solid ratio, 0.6% (w/v) ammonium oxalate, 30 min extraction time and pH 2.0. According to composition analyses, pectic PFPP and its fractions (PFPP-10, -15 and -20) were revealed as linear homogalacturonans interrupted by rhamnogalacturonan I in different lengths and extensities, where low esterification degrees (35.35-39.66%) were indicated via FT-IR. Furthermore, based on macromol. models, comprehensive analyses on macromol. and conformational characterizations of PFPP fractions were conducted quant. through, e.g., shape factor (1.42-1.79), Mark-Houwink-Sakurada exponent (0.55-0.74), conformational power-law exponent (0.52-0.58), fractal dimension (1.72-1.94) and persistence length (6.73-13.47 nm). Therefore, different semi-flexible coil conformations were proposed schematically, where lower mol.-weight PFPP fractions were less flexible. This could provide a mol. basis for precise re-utilizations of PFPP in food and pharmaceutical industries.

Carbohydrate Polymers published new progress about Conformation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kapur, S. published the artcileToxicology of benzyl alcohols: a QSAR analysis, Related Products of alcohols-buliding-blocks, the main research area is QSAR benzyl alc toxicity.

There is an evidence that benzyl alcs. may exhibit toxicity via a radical mechanism. To test this possibility, the authors studied the toxicity of para substituted benzyl alcs. on rapidly dividing cancer cells (L1210 leukemia). This system has previously found utility in studying the apparent radical toxicity of a variety of phenols. However, no evidence could be found for an electronic effect and the cellular toxicity was associated primarily with hydrophobicity. Comparison of this quant. structure-activity relationships (QSAR) with others for the reactions of benzyl alcs. in diverse systems provides insight into mechanisms of action. A QSAR for the interaction of benzyl alcs. with protozoa yields an equation that is dependent on both hydrophobicity and acidity of the OH group vs. a mixture of bacteria and fungi, the critical dependence on hydrophobicity prevails with a small dependence on a resonance-stabilized, radical mediated electronic effect. The chloramphenicols provide an instructive example, where the radical mediated electronic effect overshadows the hydrophobic contribution to bacterial toxicity. These various QSAR for benzyl alcs. indicate that mechanisms of growth inhibition in vitro vary depending on cell/organism type, the strength of the bond and lability of the hydrogen, and the strength of the initiating radical reagent.

Chemosphere published new progress about Cytotoxicity. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Delgado-Fernandez, Paloma published the artcileEffect of selected prebiotics on the growth of lactic acid bacteria and physicochemical properties of yoghurts, SDS of cas: 59-23-4, the main research area is prebiotics growth lactic acid bacteria yoghurt physicochem property.

The feasibility of manufacturing yoghurts with three prebiotics, i.e., fructooligosaccharides (FOS), galactooligosaccharides (GOS) or lactulose added at two concentrations (2 and 4%, w/v) was investigated. Physicochem. and microbial characterization was conducted on the effect of prebiotics on acidification, viability of Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus, lactose and prebiotic consumption and production of organic acids during fermentation (up to 6 h) and cold storage (for 28 d). GOS and FOS remained unaltered throughout fermentation and cold storage, while the viability of starter culture was similar to that observed in the control yoghurt. Yoghurts manufactured with 4% lactulose showed a significant decrease of lactulose content associated with a lower decrease of lactose relative to the control. This effect was associated with a significant increase (2.2 log10 cfu mL-1) in L. delbrueckii ssp. bulgaricus and a moderate decrease (1.0 log10 cfu mL-1) in S. thermophilus at the end of cold storage.

International Dairy Journal published new progress about Fermentation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saadi Saaidpour published the artcileUsing gas chromatography-mass spectrometry in conjunction with chemometrics technique for characterization of iranian essential oils Myrtus communis L., Computed Properties of 124-76-5, the main research area is gas chromatog mass spectrometry chemometrics iranian essential oil component.

Abstract: Myrtus communis L. essential oils were extracted by simultaneous distillation extraction method and studied with gas chromatog.-mass spectrometry (GC-MS). The obtained mass spectra were investigated by searching in NIST library, and 54 components were identified, but due to several problems such as varying baseline due to column bleed, low signal-to-noise ratio of peaks, and co-elution, some of components did not have satisfactory match factors. Chemometric resolution techniques were used to resolve these problems. The number of identified components was expanded to 67 using combination of GC-MS with resolution technique. In addition, the presence of worthful components such as α-Pinene (36.19%), 1,8-Cineole (11.44%), d-Limonene (10.04%), Linalool (7.76%), α-Terpineol (5.51%), linalyl acetate (4.19%) and α-Terpineol acetate (2.61%) in Myrtle essential oils have been verified. The results of this study indicate that joining of hyphenated chromatog. methods and multivariate curve resolution techniques can be useful for comprehensive, rapid, and accurate anal. of complex natural product such as Iranian Myrtle essential oils.

Journal of Analytical Chemistry published new progress about Chemometrics. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahmani, Zahra published the artcileOptimization of microwave-assisted extraction and structural characterization of pectin from sweet lemon peel, HPLC of Formula: 59-23-4, the main research area is sweet lemon peel pectin microwave assisted extraction structural characteristics; Monosaccharide composition; Physicochemical characterization; Sweet lemon peel pectin.

The microwave-assisted extraction of pectin from sweet lemon peel (SLP) was optimized using Box-Behnken design. The highest pectin yield (25.31%) was observed under optimal condition (microwave power of 700 W, irradiation time of 3 min and pH of 1.5). The physicochem., structural and some bioactivity of the SLP pectin isolated at optimum condition was evaluated. The SLP pectin was rich in galacturonic acid and galactose (87.2 mol%), high in mol. weight (615.836 kDa) and low in degree of esterification (1.2-35.1%). Furthermore, the SLP pectin was composed of 55.7% linear region (homogalacturonan) and 42.2% hairy region (rhamnogalacturonan-I). Also, the FT-IR and H-NMR results confirm the major presence of low methylated galacturonic acid rich structure in the isolated samples. In addition, SLP pectin showed good emulsifying and antioxidant properties. A pseudoplastic flow behavior was observed for SLP pectin solution at higher concentrations (1% w/v <). These results represent an inexpensive source for pectin extraction with high pectin yield and good properties. International Journal of Biological Macromolecules published new progress about Citrus limon. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts