Tag: M.W=150-200

Gu, Jinyan published the artcilePreparation, characterization and bioactivity of polysaccharide fractions from Sagittaria sagittifolia L., Formula: C6H12O6, the main research area is polysaccharide fraction Sagittaria sagittifolia antioxidant extraction; Antioxidant activity; Characterization; Fractional precipitation; Immunoactivity; Sagittaria sagittifolia L. polysaccharide; Ultrasonic assisted extraction.

To ascertain the preliminary structural characteristics and biol. activity of different fractions of polysaccharides from Sagittaria sagittifolia L. (SPCs) by ultrasonic assisted extraction (UAE), four new polysaccharides (SPC-60, SPC-70, SPC-80 and SPC-90) were successively fractionated by ethanol. The results implied that except for neutral sugar, four contained proteins and uronic acids in their structure, which were further confirmed by the UV and IR spectra. Mol. weight and monosaccharide composition anal. exhibited that SPC-60 (52.0 kDa), SPC-70 (294.9 kDa), SPC-80 (230.6 kDa) and SPC-90 (229.4 kDa) were a neutral polysaccharide composed of rhamnose, arabinose, xylose, mannose, glucose and galactose with dramatically different mole ratios. In addition, SPC-70 exhibited stronger antioxidant activity in vitro than the other three components. SPCs could significantly promote macrophage proliferation, NO release and phagocytosis. Thus, these results provided a reference for applications of S. sagittifolia L. polysaccharides which would benefit the development of industry and agriculture.

Carbohydrate Polymers published new progress about Apoptosis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Nifei published the artcileFractionation, structural characteristics and immunomodulatory activity of polysaccharide fractions from asparagus (Asparagus officinalis L.) skin, Quality Control of 59-23-4, the main research area is Asparagus polysaccharide macrophage phagocytosis physicochem property; Immunomodulatory activity; Polysaccharide fractions; Structural characterization; Structure-immunomodulatory relationship; White asparagus skin.

The physicochem. properties, structural features and structure-immunomodulatory activity relationship of pectic polysaccharides from the white asparagus (Asparagus officinalis L.) skin were systematically studied. Using sequential ethanol precipitation, five sub-fractions namely WASP-40, WASP-50, WASP-60, WASP-70 and WASP-80 with distinct degree of esterification (DE) and mol. weight (Mw) were obtained. The Mw and DE values were decreased with the increase of the ethanol concentrations Structurally, although 4-α-D-GalpA was the dominant sugar residue in all fractions, the molar ratios were decreased, whereas other sugar residues including arabinose- and mannose-based sugar residues overall increased with the increase of ethanol concentration In addition, the effects of sub-fractions on the RAW 264.7 cells indicated that pectic polysaccharides with the higher DE value showed a stronger immunomodulatory activity. Moreover, the structure-activity relationship was also discussed in this study, which extends the value-added application of asparagus and its processing byproducts.

Carbohydrate Polymers published new progress about Asparagus. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

van Vuuren, S. published the artcileIndigenous South African essential oils as potential antimicrobials to treat foot odour (bromodosis), Quality Control of 124-76-5, the main research area is foot odor therapy essential oil antimicrobial.

Foot odor, known as bromodosis, is produced as a result of a combination of exocrine secretions and bacterial growth on the feet. Several com. essential oils have demonstrated promise in inhibiting the growth of odor-causing bacteria as a novel strategy to offer relief from this dermatol. problem. South Africa harbours an abundance of diverse indigenous flora which has shown favorable antimicrobial properties. As such, the potential application of natural products against bromodosis-causing Brevibacterium species with the aim of finding cosmetically appealing and promising African sourced essential oils capable of masking foot malodour was the focus of this study. The antimicrobial activity of 41 oils were investigated using the microdilution assay where the min. inhibitory concentrations (MICs) were reported against Brevibacillus agri (ATCC 51663), Brevibacillus epidermidis (DSM 20660) and Brevibacillus linens (DSM 20425). Ninety-five percent of the oils tested displayed noteworthy activity (MIC ≤ 1.00 mg/mL) against B. agri with S. africana-caerulea demonstrating the highest activity (0.03 mg/mL) overall. Thirty-one essential oils displayed noteworthy activity (MIC ≤ 1.00 mg/mL) against B. epidermidis. Two essential oils (Plectranthus grandidentatus and Salvia africana-lutea) displayed noteworthy activity (MIC = 1.00 mg/mL) against B. linens. The major constituents for each oil was determined using gas chromatog. coupled to mass spectrometry and limonene appears to be the most frequent essential oil constituent (23 of the oils). The olfactory properties of the essentials oils displaying noteworthy activity were further considered. These findings presenting interesting anti-bromodosis activity hold great potential, as not only do the selected oils have antimicrobial activity, but the pleasant aroma of these aromatic botanicals can further mask and control foot odor.

South African Journal of Botany published new progress about Agathosma. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Purcaro, Giorgia published the artcileBreath metabolome of mice infected with Pseudomonas aeruginosa, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is metabolome breath volatile organic compound Pseudomonas infection; Breath; Comprehensive gas chromatography-time-of-flight mass spectrometer (GC×GC ToF MS); Pseudomonas aeruginosa; Volatile organic compounds (VOCs).

The measurement of specific volatile organic compounds in breath has been proposed as a potential diagnostic for a variety of diseases. The most well-studied bacterial lung infection in the breath field is that caused by Pseudomonas aeruginosa. To determine a discriminatory core of mols. in the “”breath-print”” of mice during a lung infection with four strains of P. aeruginosa (PAO1, PA14, PAK, PA7). Furthermore, we attempted to extrapolate a strain-specific “”breath-print”” signature to investigate the possibility of recapitulating the genetic phylogenetic groups (Stewart et al. Pathog Dis 71(1), 20-25, 2014. https://doi.org/10.1111/2049-632X.12107). Breath was collected into a Tedlar bag and shortly after drawn into a thermal desorption tube. The latter was then analyzed into a comprehensive multidimensional gas chromatog. coupled with a time-of-flight mass spectrometer. Random forest algorithm was used for selecting the most discriminatory features and creating a prediction model. Three hundred and one mols. were significantly different between animals infected with P. aeruginosa, and those given a sham infection (PBS) or inoculated with UV-killed P. aeruginosa. Of those, nine metabolites could be used to discriminate between the three groups with an accuracy of 81%. Hierarchical clustering showed that the signature from breath was due to a specific response to live bacteria instead of a generic infection response. Furthermore, we identified ten addnl. volatile metabolites that could differentiate mice infected with different strains of P. aeruginosa. A phylogram generated from the ten metabolites showed that PAO1 and PA7 were the most distinct group, while PAK and PA14 were interspersed between the former two groups. To the best of our knowledge, this is the first study to report on a core murine breath print, as well as, strain level differences between the compounds in breath. We provide identifications (by running com. available anal. standards) to five breath compounds that are predictive of P. aeruginosa infection.

Metabolomics published new progress about Algorithm. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chinuki, Yuko published the artcileAlpha-Gal-containing biologics and anaphylaxis, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is review; Anaphylaxis; Cetuximab; Galactose-α-1, 3-galactose; Red meat allergy; Tick bites.

Cetuximab, the IgG1 subclass chimeric mouse-human monoclonal antibody biol. that targets the epidermal growth factor receptor (EGFR), is used worldwide for the treatment of EGFR-pos. unresectable progressive/recurrent colorectal cancer and head and neck cancer. Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti oligosaccharide IgE antibodies specific for galactose-α-1,3-galactose (α-Gal) oligosaccharide present on the mouse-derived Fab portion of the cetuximab heavy chain. Furthermore, it has been revealed that patients who are allergic to cetuximab also develop an allergic reaction to mammalian meat containing the same α-Gal oligosaccharide owing to cross-reactivity, and the presumed cause of sensitization is tick bites: Amblyomma in the United States. Investigations of cetuximab-related anaphylaxis have revealed three novel findings that improve our understanding of immediate-type allergy: 1. oligosaccharide can serve as the main IgE epitope of anaphylaxis; 2. because of the oligosaccharide epitope, a wide range of cross-reactivity with mammalian meats containing α-Gal similar to cetuximab occurs; and 3. tick bites are a crucial factor of sensitization to the oligosaccharide.

Allergology International published new progress about Amblyomma. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Byeong Wook published the artcileStructure-activity relationship (SAR) studies on the mutagenic properties of 2,7-diaminofluorene and 2,7-diaminocarbazole derivatives, Product Details of C11H16O2, the main research area is structure activity relationship mutagenic properties diaminofluorene diaminocarbazole; Ames test; Aromatic amines; HCV NS5A inhibitor.

We discovered that 2,7-diaminofluorene or 2,7-diaminocarbazole moiety can be employed as a core structure of highly effective NS5A inhibitors that are connected through amide bonds to proline-valine-carbamate motifs. Amide bonds can be easily cleaved via various metabolic pathways upon administration into the body, and metabolites containing 2,7-diaminofluorene and 2,7-diaminocarbazole core structures have been known to be strong mutagens. To avoid the mutagenesis issue of these core structures, we examined various functional groups at the C9 or N9 position of 2,7-diaminofluorene or 2,7-diaminocarbazole, resp., through the Ames test in TA98 and TA100 mutants of Salmonella typhimurium LT-2. We discovered that, through proper alkyl substitution at the C9 or N9 position, 2,7-diaminofluorene and 2,7-diaminocarbazole moieties can be successfully employed in drug discovery without necessarily causing mutagenicity problems.

Bioorganic & Medicinal Chemistry Letters published new progress about Ames test. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Nagender published the artcileNovel Chitosan-Gelatin microcapsules containing rosemary essential oil for the preparation of bioactive and protective linen, HPLC of Formula: 124-76-5, the main research area is chitosan gelatin linen fabric microcapsule rosemary essential oil.

Biomols. present in natural materials have always remained a prime choice for the development of safe, protective, and wellness-related textile products. In this study, functional microcapsules were prepared using the chitosan-gelatin complex as a shell material and rosemary essential oil as a core material. The prepared microcapsules were utilized for the development of multifunctional linen fabric. The oil release mechanism of microcapsules was studied using the Korsmeyer-Peppas model. The obtained microcapsules and finished linen fabrics were characterized using SEM-EDX anal. and ATR-FTIR anal. The durability of functionalities against repeated launderings was also studied. The microcapsules with an encapsulation efficiency of more than 70% were used to impart durable mosquito-repellency (more than 90%) against Anopheles mosquitoes, antibacterial properties against E. coli (> 93%) and S. aureus (> 95%) bacteria, significant (> 91%) antioxidant activity and a pleasant aroma. The chem. constituents of rosemary oil were also found to be responsible for imparting multifunctional properties. The novel combination of biopolymers and essential oil was explored for the development of multifunctional textiles.

Industrial Crops and Products published new progress about Anopheles. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khalil, Samah R. published the artcileRestoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is Moringa leaf extract Tilmicosin heart injury apoptosis antioxidant; Apaf-1; Apoptosis; Bcl-2; Caspase-3; Moringa oleifera; Tilmicosin.

Tilmicosin (Til), an effective macrolide antibiotic, is widely used against respiratory diseases in livestock; however, its treatment is associated with cardiac tissue impairments. In this study, the ethanolic extract of Moringa oleifera (MO) leaves was investigated at two doses (400 and 800 mg/kg body weight [bw], orally) to determine its role in counteracting the effects of Til treatment (75 mg/kg bw) on the cardiac tissue in rats, exploring the oxidative stress-mediated damage and apoptosis. A high dose of MO ethanolic extract elicits considerable changes in the body weight, reduces the mortality rate, neutralizes the impaired cardiac injury markers, improves antioxidant endpoints (total antioxidant capacity, superoxide dismutase, catalase activity, and reduced glutathione level). Also it attenuates the oxidative stress indexes (total reactive oxygen species, 8-hydroxy-2-deoxyguanosine, lipid peroxides [malondialdehyde], and protein carbonyl levels) that are associated with Til injection. The co-administration of MO ethanolic extract with Til considerably modulates the expression of apoptosis pathway-encoding genes (Bcl-2, caspase-3, Bax, p53, apoptosis-inducing factor, and Apaf-1), particularly in the high-dose group. Our results support that the concurrent administration of MO ethanolic extract with Til at a dose of 800 mg/kg bw increases the protective activity of the antioxidant system and delays or slows the pathol. development of cardiotoxicity mediated by Til injection.

Gene published new progress about Apoptosis. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hayashi, Hiroyuki published the artcileInsight into the Mechanism of the Acylation of Alcohols with Acid Anhydrides Catalyzed by Phosphoric Acid Derivatives, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is alc acylation carboxylic acid anhydride phosphoric acid derivative catalysis.

Insight into the mechanism of a safe, simple, and inexpensive phosphoric acid (H3PO4)-catalyzed acylation of alcs. with acid anhydrides is described. The corresponding in situ-generated diacylated mixed anhydrides, unlike traditionally proposed monoacylated mixed anhydrides, are proposed as the active species. In particular, the diacylated mixed anhydrides act as efficient catalytic acyl transfer reagents rather than as Bronsted acid catalysts simply activating acid anhydrides. Remarkably, highly efficient phosphoric acid (1-3 mol %)-catalyzed acylation of alcs. with acid anhydrides was achieved and a 23 g scale synthesis of an ester was demonstrated. Also, phosphoric acid catalyst was effective for synthetically useful esterification from carboxylic acids, alcs., and acid anhydride. Moreover, with regard to recent developments in chiral 1,1′-bi-2-naphthol (BINOL)-derived phosphoric acid diester catalysts toward asym. kinetic resolution of alcs. by acylation, some phosphate diesters were examined As a result, a 31P NMR study and a kinetics study strongly supported not only the acid-base cooperative mechanism as previously proposed by other researchers but also the mixed anhydride mechanism as presently proposed by us.

Journal of Organic Chemistry published new progress about Acylation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mafu, Lubabalo published the artcileSolvent-free synthesis of novel para-menthane-3,8-diol ester derivatives from citronellal using a polymer-supported scandium triflate catalyst, HPLC of Formula: 42822-86-6, the main research area is citronellal para menthane diol ester derivative solvent free synthesis; polymer supported scandium triflate catalyst acylation; PS-Sc(OTf)3; acylation; diesters; para-menthane-3,8-diol.

The use of natural resources as a chem. feedstock for the synthesis of added-value products is gaining interest; as such we report an environmentally friendly method for the synthesis of para-menthane-3,8-diol from natural citronellal oil in 96% yield, under solvent free aqueous conditions. The acylation of para-menthane-3,8-diol with various acid anhydrides over polymer-supported scandium triflate (PS-Sc(OTf)3) catalyst was subsequently developed, where both hydroxy groups of para-menthane-3,8-diol could be simultaneously acylated under mild reaction conditions to form the corresponding diesters in good yields. The advantages of this method include a simple procedure from natural resources, using solvent-free reaction conditions.

Beilstein Journal of Organic Chemistry published new progress about Acylation. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, HPLC of Formula: 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts