Tag: M.W=150-200

Mengozzi, Luca published the artcilePhenoxyaluminum(salophen) Scaffolds: Synthesis, Electrochemical Properties, and Self-Assembly at Surfaces of Multifunctional Systems, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry – A European Journal (2018), 24(46), 11954-11960, database is CAplus and MEDLINE.

Salophens and Salens are Schiff bases generated through the condensation of two equivalent of salicylaldehyde with either 1,2-phenylenediamines or aliphatic diamines, resp. Both ligands have been extensively exploited as key building blocks in coordination chem. and catalysis. In particular, their metal complexes have been widely used for various catalytic transformations with high yield and selectivity. Through the modification of the phenol unit it is possible to tune the steric hindrance and electronic properties of Salophen and Salen. The introduction of long aliphatic chains in salicylaldehydes can be used to promote their self-assembly into ordered supramol. structures on solid surfaces. Herein, the authors report a novel method towards the facile synthesis of robust and air-stable [Al(Salophen)] derivatives capable of undergoing spontaneous self-assembly at the graphite/solution interface forming highly-ordered nanopatterns. The new synthetic approach relies on the use of [MeAl^III(Salophen)] as a building unit to introduce, via a simple acid/base reaction with functionalized acidic phenol derivatives, selected frameworks integrating multiple functions for efficient surface decoration. STM imaging at the solid/liquid interface made it possible to monitor the formation of ordered supramol. structures. In addition, the redox properties of the Salophen derivatives functionalized with ferrocene units in solution and on surface were unraveled by cyclic voltammetry. The use of a five-coordinate aluminum alkyl Salophen precursor enables the tailoring of new Salophen mols. capable of undergoing controlled self-assembly on HOPG, and thereby it can be exploited to introduce multiple functionalities with subnanometer precision at surfaces, ultimately forming ordered functional patterns.

Chemistry – A European Journal published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cai, Kun published the artcileChanges in Phenolic Profiles and Inhibition Potential of Macrophage Foam Cell Formation during Noni (Morinda citrifolia Linn.) Fruit Juice Fermentation, COA of Formula: C8H8O3, the publication is Fermentation (2022), 8(5), 201, database is CAplus.

The dynamic changes in phenolic composition and antioxidant activity, and the potential effect on foam cell formation and cholesterol efflux during noni (Morinda citrifolia Linn.) fruit juice fermentation were investigated in this study. The composition of phenolic compounds was significantly different at various fermentation times. Rutin, quercetin, and isoquercitrin were the major phenolics in fermented noni fruit juice based on a quant. anal. of representative phenolics. The contents of caffeic acid, 2,4-dihydroxybenzoic acid, p-coumaric acid, rutin, and quercetin tended to increase, while those of isoquercitrin decreased during the fermentation process. Fermented noni juice extracts showed high antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), hydroxyl radical scavenging activity, and ferric reducing antioxidant power. Notably, the highest antioxidant activity was observed after 28 days of fermentation Furthermore, the treatment of fermented noni juice extracts was shown to reduce foam cell formation, intracellular cholesterol level, and the cholesterol esterification ratio. A correlation anal. indicated a strong pos. relationship between the phenolic composition, antioxidant activity, and the ratio of cholesterol ester and total cholesterol. This study may provide a theor. basis for the quality improvement and standardized production of fermented noni fruit juice, thus promoting the development of the noni food industry.

Fermentation published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tai, Benjamin C. U. published the artcileSynthetic Poly(Vinylalcohol)-Based Membranes for Cartilage Surgery and Repair, Quality Control of 6346-09-4, the publication is Biotechnology Journal (2017), 12(12), n/a, database is CAplus and MEDLINE.

Cell-based therapies for cartilage repair are continually being developed to treat osteoarthritis. The cells are either introduced directly by intra-articular injection or via a cell-seeded matrix scaffold. Here, poly(vinylalc.)-based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochem. properties such as porosity, mech. strength, and permeability, and a unique self-sealing property. The membranes possess a bilayer structure with a less porous layer providing mech. strength and selective permeability, exhibit an elastic modulus of between 0.3 and 0.9 MPa, and are permeable to mols. <40 kDa, which is in the range of cartilage permeability. Three different peptide ligands with the sequences Ac-GCGYGRGDSPG, Ac-GCG(OPG)4REGOFG(OPG)4, and Ac-GCG(OPG)7, resp., are conjugated to the membranes and subject to in vitro cell adhesion and differentiation assays. Col I/Col II gene expression ratios indicated that the collagen-mimetic peptide, Ac-GCG(OPG)7, best supported mesenchymal stem cell differentiation into the chondrogenic lineage. Although low retention of the membrane is observed in vivo in a rabbit knee model, results suggest that the membrane was able to facilitate mesenchymal stem cell implantation and differentiation to chondrocytes. These PVA-based membranes provide a feasible, synthetic, off-the-shelf material for the delivery of stem cells, and can be modified for other surgical applications.

Biotechnology Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C19H21N3O3S, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jingwen published the artcileMetabolic engineering of microorganisms for vitamin C production, Computed Properties of 526-98-7, the publication is Subcellular Biochemistry (2012), 241-259, database is CAplus and MEDLINE.

A review. Vitamin C, an important organic acid, is widely used in the industries of pharmaceuticals, cosmetics, food, beverage and feed additives. Compared with the Reichstein method, biotechnol. production of vitamin C is an attractive approach due to the low cost and high product quality. In this chapter, biosynthesis of vitamin C, including one-step fermentation processes and two-step fermentation processes are discussed and compared. Furthermore, the prospects of the biotechnol. production of vitamin C are also presented.

Subcellular Biochemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C17H19N3O6, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Yun-Xing published the artcileSynthesis and binding of 6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine and related ring-opened analogs at central nicotinic receptors, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is European Journal of Medicinal Chemistry (1999), 34(2), 177-190, database is CAplus.

6,7,8,9-Tetrahydro-5H-pyrido[3,4-d]azepine (I) and its N₇-Me derivative were synthesized and evaluated as potential nicotinic acetylcholinergic receptor (nAChR) ligands. On the basis that 6,7,8,9-tetrahydro-5H-pyrido[3,4-c]azepine, which binds to nAChR with low affinity (K_i = 1100 nM), possesses an inter-nitrogen distance (4.6 Å) that may be less than optimal, I was designed due to its similar shape but longer inter-nitrogen distance (5.5 Å). Compound I (K_i = 46 nM) was found to bind with enhanced affinity. However, unlike what is seen with nornicotine/nicotine, N-methylation of I reduced affinity (K_i = 268 nM) rather than enhancing it. The results suggest that the title compounds may interact at nicotine receptors in a manner that is somewhat different from that of nicotine. Ring-opening of the pyrido[3,4-d]azepine ring led to a series of 3-(2-aminoethyl)pyridines that retained the affinity of the cyclic compound Subsequent modification, including further chain lengthening (e.g. (aminopropyl)pyridine derivatives) and introduction of unsaturation, ultimately led to the development of a series of 3-(2-aminoethoxy)pyridine derivatives Simple N-substituted derivatives of 3-(2-aminoethoxy)pyridine were found to bind with K_i values of 20 to 35 nM. Because parallel structural changes in several series of related compounds did not result in parallel shifts in nAChR affinity, it is unlikely that all the investigated compounds bind in a similar fashion at these receptors. Nevertheless, some of these compounds represent novel classes of nAChR ligands.

European Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaser, Hans-Ulrich published the artcileNo Stirring Necessary: Parallel Carbonylation of Aryl Halides with CO and Various Alcohols under Pressure, HPLC of Formula: 27292-49-5, the publication is Journal of Organic Chemistry (2003), 68(9), 3725-3728, database is CAplus and MEDLINE.

The parallel carbonylation of aryl and heteroaryl halides R¹X (R¹ = 4-MeCOC₆H₄, X = Br; R¹ = 2-pyridyl, X = Cl) with 6-25 bar of CO in 1-mL vials in a standard autoclave in the presence of an O-nucleophile R²OH (R² = Bu, PhCH₂, cyclopentyl, etc.) to give the corresponding esters R¹CO₂R² was investigated. With 2-chloropyridine as a model substrate, 102 different O-nucleophiles (primary and secondary alcs., phenols) were studied. No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functionalities were usually tolerated. The new method is suitable for screening and small scale synthesis.

Journal of Organic Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, HPLC of Formula: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuandi published the artcileCharacteristics of the microbiota and metabolic profile of high-temperature Daqu with different grades, Application of 2-Hydroxy-2-phenylacetic acid, the publication is World Journal of Microbiology & Biotechnology (2022), 38(8), 137, database is CAplus and MEDLINE.

The superior grade Daqu (S_Daqu) and normal grade Daqu (N_Daqu) have obvious differences in flavor, fracture surface, appearance, etc., which can be accurately grouped by well-trained panel based on their sensory properties. However, the differences in microbial community diversity and metabolites between the S_Daqu and N_Daqu were still unclear. The culture-dependent method, the third generation Pacific Biosciences (PacBio) single-mol., real-time (SMRT) sequencing technol., and NMR (NMR) were combined to show the characteristics in microorganisms and metabolites. This showed that the fungal counts were higher in N_Daqu while the richness of bacterial communities was higher in S_Daqu (P < 0.05). Lentibacillus, Burkholderia, Saccharopolyspora, Thermoascus, and Rasamsonia were the dominant genera of S_Daqu while Staphylococcus, Scopulibacillus, and Chromocleista were the dominant genera in N_Daqu. The content of differential acids, amino acids, and alcs. including fumarate, glucuronate, glycine, 4-carboxyglutamate, and myo-inositol in S_Daqu was higher than that in N_Daqu by 1H NMR coupled with multivariate statistical anal. The network anal. regarding microbes and metabolites suggested that Saccharopolyspora showed a strong pos. correlation with 4-carboxyglutamate while Thermoascus and Chromocleista were highly neg. correlated with alanine and isobutyrate, resp. Linear Discriminant Anal. (LDA) Effect Size (LEfSe) revealed that Macrococcus and Caulobacter were regarded as bacterial biomarkers in the S_Daqu while Chromocleista was the key fungal genera in N_Daqu. Functionality prediction indicated that the bacteria in S_Daqu were largely involved in more metabolic activities including biosynthesis, degradation, detoxification, and generation of precursor metabolite and energy.

World Journal of Microbiology & Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C9H9F5Si, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, En-Xu published the artcileReorganization of a synthetic microbial consortium for one-step vitamin C fermentation, Product Details of C6H10O7, the publication is Microbial Cell Factories (2016), 21/1-21/11, database is CAplus and MEDLINE.

Background: In the industry, the conventional two-step fermentation method was used to produce 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C, by three strains, namely, Gluconobacter oxydans, Bacillus spp. and Ketogulonicigenium vulgare. Despite its high production efficiency, the long incubation period and an addnl. second sterilization process inhibit the further development. Therefore, we aimed to reorganize a synthetic consortium of G. oxydans and K. vulgare for one-step fermentation of 2-KGA and enhance the symbiotic interaction between microorganisms to perform better. Results: During the fermentation, competition for sorbose of G. oxydans arose when co-cultured with K. vulgare. In this study, the competition between the two microbes was alleviated and their mutualism was enhanced by deleting genes involved in sorbose metabolism of G. oxydans. In the engineered synthetic consortium (H₆ + Kv), the yield of 2-KGA (mol/mol) against d-sorbitol reached 89.7 % within 36 h, increased by 29.6 %. Furthermore, metabolomic anal. was used to verify the enhancement of the symbiotic relationship and to provide us potential strategies for improving the synthetic consortium. Addnl., a significant redistribution of metabolism occurred by co-culturing the K. vulgare with the engineered G. oxydans, mainly reflected in the increased TCA cycle, purine, and fatty acid metabolism Conclusions: We reorganized and optimized a synthetic consortium of G. oxydans and K. vulgare to produce 2-KGA directly from d-sorbitol. The yield of 2-KGA was comparable to that of the conventional two-step fermentation The metabolic interaction between the strains was further investigated by metabolomics, which verified the enhancement of the mutualism between the microbes and gave us a better understanding of the synthetic consortium.

Microbial Cell Factories published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C10H2F12NiO4, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barber, Amelia Moreno published the artcileSolid-phase synthesis of novel inhibitors of farnesyl transferase, Safety of (4-Butoxyphenyl)methanol, the main research area is hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor.

A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group, has been employed as the template in the solid-phase synthesis of novel farnesyl transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor 1-farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene displayed an IC50 of 6.3 μM vs. farnesyl transferase.

Bioorganic & Medicinal Chemistry Letters published new progress about hydroxynitrotrifluorophenyl ether preparation farnesyl transferase inhibitor. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Safety of (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abramovitch, Rudolph A. published the artcileSolution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides. Sultam, pyrindine, and azepine formation, SDS of cas: 93427-13-5, the main research area is pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine.

The solution and flash-vacuum pyrolyzes of azides I (R = Me, Cl, MeO, CF3) are reported. When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the sultam (II, R = R1 = Me). A new product, pyridine III, is observed, and a modification is proposed in the mechanism proposed earlier to account for the FVP of β-arylethanesulfonyl azides. No dihydropyrindine, which would have required a Me migration, is observed When R = Cl, migration of Cl does occur and a mixture of 5H- and 7H-1-pyrindines is obtained, together with other products. When R = MeO, some MeO migration occurs on FVP to give 6,7-dihydro-3,5-dimethoxy-5H-1-pyrindine. Monodemethoxylation to give II (R = MeO, R1 = H) also takes place, and a possible mechanism is proposed. When R = CF3 the main product on FVP at 300° is the fused azepine IV in respectable yield. This is the first example of the isolation of an N-sulfonylazepine from the intramol. reaction of a sulfonylnitrene and from a FVP.

Journal of Organic Chemistry published new progress about pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, SDS of cas: 93427-13-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts