Tag: M.W=150-200

Abdel-Razek, A. S. published the artcileBioelimination of phenanthrene using degrading bacteria isolated from petroleum soil: safe approach, Safety of 1-Hydroxy-2-naphthoic acid, the publication is Desalination and Water Treatment (2020), 131-140, database is CAplus.

Polyaromatic hydrocarbon contamination is considered as serious pollution resulted from industrial activities. Phys. or chem. methods used for remediation of hydrocarbons might cause the transfer of the remediated compounds from the polluted sites into other clean locations. Our study is concerned by the bioremediation of phenanthrene, using microbial degraders that will eventually, result in the release of non-toxic structures, as end products. Successfully, three bacterial isolates; Enterobacter cloacae, Bacillus sp. and Bacillus thuringiensis with accession numbers; MK559694, MK561601 and MK559693, resp., showed higher phenanthrene biodegradation ability. The examined conditions indicated that the isolates were active in a wide range of temperatures, pH and hydrocarbon concentrations The gas chromatog.-mass spectrum anal. of the formed byproducts showed the existence of intermediate structures with varied carbon values, ranged from C4H8O2 to C12H22O11. However, these byproducts did not show cytotoxic effect against Vero cell lines, compared with the tested undegraded phenanthrene. The obtained results revealed that these bacterial isolates can be used as potent phenanthrene degraders with safe and non-toxic end products, which allow the treated water to be used for non-potable water applications.

Desalination and Water Treatment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Safety of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qudrat-i-Khuda, M. published the artcileInvestigations on Ocimum gratissimum. II. Characterization of gratissimin and gratissimic acid, Related Products of alcohols-buliding-blocks, the publication is Sci. Res. (Dacca, Pakistan) (1965), 2(1/2), 8-10, database is CAplus.

cf. CA 62, 81191g. Reduction of gratissimum C₂₀H₂O₄ (I) with Li-AlH₄ has given a diol, C₁₈H₂₀O₂, m.p. 104 °, which forms ditoluene-p-sulfonyl derivative, m.p. 184°, confirms the mol. formula and evidence the presence of 2 COOCH₃ groups in the mol. Acetic anhydride converts gratissimic acid (II) into a crystalline anhydride, m.p. 187°. Oxidation of II with KMnO₄ has afforded a high yield of benzoic acid. Results indicate that I is dimethyl ester of α-truxillic acid (III) and II is identical with this acid, which has been confirmed by comparing these compounds with III and its dimethyl ester prepared from trans-cinnamic acid.

Sci. Res. (Dacca, Pakistan) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Omran, Anahid published the artcileSynthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D₃ receptor ligands with extended functionality for probing the secondary binding pocket, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1897-1902, database is CAplus and MEDLINE.

A series of 3-(3-hydroxyphenyl)pyrrolidine analogs which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality were synthesized and their in vitro binding affinities at human dopamine receptors were evaluated. The authors’ ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D₃ receptor. The N-alkyl analogs constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D₃ receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogs were also prepared to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogs were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.

Bioorganic & Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deldaele, Christopher published the artcileRoom-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides, Formula: C8H19NO2, the publication is ChemCatChem (2016), 8(7), 1319-1328, database is CAplus.

An efficient and highly practical procedure was reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides were readily aminated at room temperature The reaction proceeded well regardless of the electronic properties of the starting aryl iodide and the amination products were obtained without the need for purification by column chromatog. in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination was extended to the amination of complex aryl iodides at room temperature

ChemCatChem published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chams, Amani published the artcileDirect growth of polymer brushes from an electrodeposited conducting poly(dithienylpyrrole) layer functionalized with ATRP initiating moieties, Synthetic Route of 23351-09-9, the publication is Journal of Electroanalytical Chemistry (2013), 20-30, database is CAplus.

A new strategy for growing polymer brushes using surface-initiated atom transfer radical polymerization (SI-ATRP) from a thin functionalized conducting-polymer layer is reported. Three new heterocyclic monomers based on thiophene and/or pyrrole bearing an ATRP-initiator have been synthesized. Electrochem. behavior and electrodeposition of these monomers was carried out by both potentiodynamic (CV) and potentiostatic (CA) methods. Remarkably, the use of a tricyclic (2,5-dithienyl)pyrrole-based monomer allowed the formation of a conducting film at a relatively low oxidation potential (onset ∼0.65 V/SCE). Electroactivity characterization showed that conducting, stable and adherent thin polymer layer was formed. The charge-transfer agent was subsequently engaged in SI-ATRP to grow polymethacrylate brushes directly from the conducting functionalized surface. Both the functionalized conducting polymer layer and the resulting tethered polymer brushes were characterized using XPS and SEM (SEM). This study confirms that polymethacrylate brushes can efficiently grow directly from a functionalized conducting-polymer thin layer by using a conventional SI-ATRP procedure.

Journal of Electroanalytical Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Synthetic Route of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dalton, David R. published the artcileBromohydrin formation in aqueous dimethyl sulphoxide; electronic and steric effects, Application In Synthesis of 2588-77-4, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1971), 85-9, database is CAplus.

The role of electronic and steric effects in the stereospecific trans-addition of HOBr to olefins, with moist Me2SO as solvent-reactant and N-bromosuccinimide as the source of Br, was examined In the absence of severe steric restrictions, the electronic effects were observed to direct the addition in a Markovnikov sense. Highly hindered olefins and those wherein the electron d. at the C:C double bond is severely depleted by electron-withdrawing substituents fail to react. Similar systems which have shown a susceptibility to carbonium ion rearrangements in analogous reactions fail to yield, for the most part, rearranged products. The intermediate is deemed best represented by a bromonium ion, symmetrical or nonsymmetrical, depending upon the structure of the starting olefin. If the addition of HOBr is retarded owing to electronic or steric effects, considerable amounts of dibromide accompany bromohydrin.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Application In Synthesis of 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bastien, Dominic published the artcileFragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3182-3192, database is CAplus and MEDLINE.

The continuously increasing use of trimethoprim as a common antibiotic for medical use and for prophylactic application in terrestrial and aquatic animal farming has increased its prevalence in the environment. This has been accompanied by increased drug resistance, generally in the form of alterations in the drug target, dihydrofolate reductase (DHFR). The most highly resistant variants of DHFR are known as type II DHFR, among which R67 DHFR is the most broadly studied variant. We report the first attempt at designing specific inhibitors to this emerging drug target by fragment-based design. The detection of inhibition in R67 DHFR was accompanied by parallel monitoring of the human DHFR, as an assessment of compound selectivity. By those means, small aromatic mols. of 150-250 g/mol (fragments) inhibiting R67 DHFR selectively in the low millimolar range were identified. More complex, sym. bis-benzimidazoles and a bis-carboxyphenyl were then assayed as fragment-based leads, which procured selective inhibition of the target in the low micromolar range (K_i = 2-4 μM). The putative mode of inhibition is discussed according to mol. modeling supported by in vitro tests.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diez, Stefan J. published the artcileCrystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates, HPLC of Formula: 86-48-6, the publication is Crystal Growth & Design (2018), 18(6), 3263-3268, database is CAplus.

A crystal growth technique, interfacial cocrystn., is demonstrated to be a simple and effective method for preparing multi-component crystal forms. The technique is based on the generation of a liquid-liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hanack, M. published the artcileStudies on cyclopropane derivatives, SDS of cas: 50915-29-2, the publication is Angewandte Chemie (1962), 116-17, database is CAplus.

Dicyclopropylcarbinol (I) (Hart and Curtis, CA 50, 12839f) with PCl₅ or PCl₃ at — 15° gave only 1-cyclopropyl-4-chloro-1-butene (II), b₁₂ 60-2°, in 85% yield. With 3% HCl at 80° I gave 69% II and 11% cyclopropylbutadiene (III), b. 96-7°. With AcCl in Et₂O, I gave 10% acetate (IV) and 22% II. Pure IV was easily obtained with Ac₂O; alk. saponification gave only I. With PBr₃ in Et₂O or with 60% HBr at 0° I gave only 1-cyclopropyl-4-bromo-1-butene in 80% yield. Hydrolysis of II with 10% K₂CO₃ 3 hrs. at 80° gave 35% I. With Na amylate, II gave III, which easily formed a diene adduct, m. 84-5°, with maleic anhydride. Dicyclopropyl ketone (V) (Hart and C., loc. cit.) and MeMgI gave 70% dicyclopropylmethylcarbinol, b₁₅ 58°. With Na and EtOH the oxime of V easily gave the amine. Methylcyclopropylcarbinol (VI) with concentrated HCl and ZnCl₂ at 0° gave 5-chloro-2-pentene, which gave 10% VI when hydrolyzed with 10% K₂CO₃ 3 hrs. at 80°.

Angewandte Chemie published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, SDS of cas: 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rosen, G. M. published the artcileNeuromuscular blocking activity of a series of β-haloethylamines, Synthetic Route of 101-98-4, the publication is Archives Internationales de Pharmacodynamie et de Therapie (1973), 204(2), 242-51, database is CAplus and MEDLINE.

The degree of irreversible neuromuscular blockade caused by 6 β-haloethylamines that exist in equilibrium between the linear from RNMeCH2CH2Cl and the aziridinium chloride form I, depends on the stability of the aziridinium ion. Thus when the aziridinium ion is either conjugated with the aromatic ring, such as in 2-chloroethylmethylphenylamine [1669-85-8], or separated from it by methylene groups to minimize interaction with the aromatic/ring the compounds act as reversible blocking agents. Irreversible blockade is produced by compounds, such as benzyl(2-chloroethyl)methoxyethylamine [50283-06-2] in which the aziridinium ion is stabilized by interaction with the non-bonding electrons, the ether O, or with the π-electrons of the aromatic ring.

Archives Internationales de Pharmacodynamie et de Therapie published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts