Tag: M.W=150-200

Lu, Shu-xia published the artcileOptimization of medium composition for two-step fermentation of vitamin C using response surface methodology, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Shipin Kexue (Beijing, China) (2013), 34(3), 202-206, database is CAplus.

2-Keto-L-gulonic acid production during the conversion process from L-sorbose to 2-keto-L-gulonic acid in the two-step fermentation of vitamin C was improved. An efficient companion strain of Bacillus subtilis A9 that facilitates the growth of Gluconobacter oxydans and the production of acids was screened from fresh milk. Based on single factor tests, the compositions of fermentation medium were optimized by response surface methodol. The results showed that three factors including L-sorbose, corn liquor and urea revealed significant impact on the production of 2-KGA. The optimal compositions included 90 g/L L-sorbose, 14.2 g/L corn liquor, 12.2 g/L urea, 4.1 g/L CaCO₃ and 0.2 g/L MgSO₄. Under the optimal medium, the yield of 2-keto-L-gulonic acid was up to 69.74 g/L, which was close to the theor. value of 70.33 g/L with the relative error of-0.59 g/L. The established regression equation for 2-KGA revealed excellent fitting. Therefore, it is credible and can be used for practical prediction.

Shipin Kexue (Beijing, China) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Tingting published the artcileResponse surface methodology to optimize medium for 2-keto-L-gulonic acid production by new strains system in two-step vitamin C fermentation, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Weishengwuxue Zazhi (2012), 32(2), 47-53, database is CAplus.

The ability of Bacillus pumilus HJ-04 to promote the production of vitamin C (VC) precursor, 2-keto-L-gulonic acid (2-KGA), by 2-KGA-producing strain is stronger than industrial Bacillus megaterium B2980 as associated bacteria in second step of two-step VC fermentation Six factors that affected the 2-KGA production by new strains system were analyzed and optimized adopting single factor test, Plackett-Burman (PB) design, and Box-Behnken design. The results indicated that L-sorbose, urea, and corn syrup were the noticeably influencing factors. The optimum acid-producing condition was 94.95 g/L of L-sorbose, 11.99 g/L of urea, 14.13 g/L of corn syrup. The acid production increased by 12.31 mg/mL, and the production period shortened by 6 h after the optimization.

Weishengwuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H23N3O2S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Yu published the artcileOptimization of medium composition for two-step fermentation of vitamin C based on artificial neural network-genetic algorithm techniques, Computed Properties of 526-98-7, the publication is Biotechnology & Biotechnological Equipment (2015), 29(6), 1128-1134, database is CAplus.

The production of 2-keto-L-gulonic acid (2-KGA) during the conversion from L-sorbose to 2-KGA in the two-step fermentation of vitamin C can be improved by using an efficient companion strain Bacillus subtilis A9 to facilitate the growth of Ketogulonicigenium vulgare and the production of 2-KGA. Two optimization models, namely response surface methodol. (RSM) and artificial neural network (ANN), were built to optimize the medium components for mixed-culture fermentation of 2-KGA. The root mean square error, R2 and the standard error of prediction given by the ANN model were 0.13%, 0.99% and 0.21%, resp., while the RSM model gave 1.89%, 0.84% and 2.9%, resp. This indicated that the fitness and the prediction accuracy of the ANN model were higher than those of the RSM model. Furthermore, using genetic algorithm (GA), the input space of the ANN model was optimized, predicting that the maximum 2-KGA production of 72.54 g·L-1 would be obtained at the GA-optimized concentrations of the medium components (L-sorbose, 92.5 g·L-1; urea, 10.2 g·L-1; corn steep liquor, 16 g·L-1; CaCO3, 3.96 g·L-1; MgSO4, 0.28 g·L-1). The 2-KGA production exptl. obtained using the ANN-GA-designed medium was 71.21 ± 1.53 g·L-1, which was in good agreement with the predicted value. The same optimization process may be used to improve the production during bacterial mixed-cultures fermentation by changing the fermentation parameters.

Biotechnology & Biotechnological Equipment published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H8N2, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Sai published the artcileInterfacial Effects of the CuO/GO Composite to Mediate the Side Reactions of N,N-Dimethylformamide Fragments, HPLC of Formula: 23351-09-9, the publication is ACS Applied Materials & Interfaces (2014), 6(24), 22174-22182, database is CAplus and MEDLINE.

The interface between nanocatalysts and graphene oxide (GO) has been found to play a crucial role in enhancing the catalytic activity and improving the selectivity of amination reactions in N,N-dimethylformamide (DMF). The composite catalysts of CuO/GO used for the catalytic coupling of aryl halides with amines in DMF can completely inhibit the side reaction between the aryl halides and fragments of DMF. With identical amounts of Cu-catalysts, the conversion of iodobenzene and the selectivity for the target product reached 100% when CuO/GO composite catalysts were employed, while these results were 70.3 and 42.8%, resp., when CuO catalysts were used alone. Exptl. evidence confirms that the interfacial effect of CuO/GO is the origination of the improved performance of composite catalysts, which has been found to efficiently transfer fragments of DMF to GO and avoid unexpected side reactions during the catalytic process.

ACS Applied Materials & Interfaces published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xuerong published the artcileTransition Metal-Free Aerobic Oxidation of Aryl Secondary and Primary Alcohols to Carbonyl Compounds in Open Air, Synthetic Route of 90-64-2, the publication is ChemistrySelect (2022), 7(3), e202103502, database is CAplus.

Here, an efficient and practical oxidation of aryl secondary and primary alcs. R¹CH(OH)R² (R¹ = Ph, biphenyl-4-yl, 2-naphthyl, etc., R² = H, ME, Et, CO₂H, 4-ClC₆H₄, etc.) to the corresponding carbonyl compounds using NaOtBu in open air at room temperature has been developed. By utilizing NaOtBu/air/toluene, a series of ketones R¹C(O)R² or benzoic acids were obtained in high yields, resp. More importantly, most of the substrates with electron-withdrawing or electron-donating groups could be converted to the corresponding products in high to excellent yields. Furthermore, the practicality of the reaction was demonstrated through a 1.0 g-scale reaction with excellent yield.

ChemistrySelect published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C24H29N5O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Castineiras, Alfonso published the artcileMulticomponent Solids of DL-2-Hydroxy-2-phenylacetic Acid and Pyridinecarboxamides, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Crystals (2022), 12(2), 142, database is CAplus.

We prepared cocrystals of DL-2-Hydroxy-2-phenylacetic acid (D, L-H2ma) with the pyridinecarboxamide isomers, picolinamide (pic) and isonicotinamide (inam). They were characterized by elemental anal., single crystal and powder X-ray, IR spectroscopy and ¹H and ¹³C NMR. The crystal and mol. structures of (pic)-(D-H₂ma) (1), (nam)-(L-H₂ma) (2) and (inam)-(L-H₂ma) (3) were studied. The crystal packing is stabilized primarily by hydrogen bonding and in some cases through π-πstacking interactions. The anal. of crystal structures reveals the existence of the characteristic heterosynthons with the binding motif R²₂(8) (primary amide-carboxilic acid) between pyridinecarboxamide mols. and the acid. Other synthons involve hydrogen bonds such as O-H(carboxyl)···N(pyridine) and O-H(hydroxyl)···N(pyridine) depending on the isomer. The packing of 1 and 3 is formed by tetramers, for whose formation a crystallization mechanism based on two stages is proposed, involving an amide-acid (1) or amide-amide (3) mol. recognition in the first stage and the formation of others, and interdimeric hydrogen bonding interactions in the second. The thermal stability of the cocrystals was studied by differential scanning calorimetry and thermogravimetry. Further studies were conducted to evaluate other physicochem. properties of the cocrystals in comparison to the pure coformers. D.-functional theory (DFT) calculations (including NCIplot and QTAIM analyses) were performed to further characterize and rationalize the noncovalent interactions.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Yan published the artcileMetabolic profile and underlying antioxidant improvement of Ziziphi Spinosae Folium by human intestinal bacteria, Related Products of alcohols-buliding-blocks, the publication is Food Chemistry (2020), 126651, database is CAplus and MEDLINE.

Ziziphi Spinosae Folium, the leaf of Ziziphus jujuba Mill. Var. spinosa (Bunge) Hu ex H. F. Chou (LZJS), is currently used as a healthy tea in China. This study evaluated the chem. components and antioxidant activities of LZJS flavonoid (LZJSF) and fermented LZJSF (FLZJSF) using human intestinal bacteria (HIB) through dynamic fermentation Eighteen flavonoids were simultaneously identified in LZJSF using UHPLC-Q-Orbitrap-MS method, nine of which were targeted for a HIB metabolism study. Seven small phenolic acids were identified in FLZJSF. Not only at chem. level but also at PC12 cell level, FLZJSF samples fermented for 4 and 6 h showed significant pos. correlation between their activities and flavonoid aglycons, which were transformed from LZJSF. However, FLZJSF samples (8 h and longer time) mainly contained phenolic acids and indicated weak activities. Thus, LZJSF was found to result in increased antioxidant activity and could be com. utilized as a novel functional food.

Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C4HN5, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagasawa, Shota published the artcileChromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols, Product Details of C9H11NO4, the publication is Journal of Organic Chemistry (2021), 86(9), 6952-6968, database is CAplus and MEDLINE.

We describe an aerobic intramol. dearomative coupling reaction of tethered phenols such as I using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products such as II including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Journal of Organic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirose, Yuta published the artcileStereoselective synthesis of the A-ring of armatol A from a bromo-substituted chiral building block based on Ireland-Claisen rearrangement and ring-closing olefin metathesis, Product Details of C9H22OSi, the publication is Heterocycles (2015), 91(1), 76-103, database is CAplus.

The stereoselective synthesis of the A-ring (I) of armatol A, a natural polycyclic ether triterpene from the red alga Chondria armata, was achieved in a non-biomimetic way. The synthesis employed Ireland-Claisen rearrangement of an ester, prepared from a bromo-substituted chiral building block, for the construction of C6 and C7 stereocenters and a relay ring-closing olefin metathesis for the seven-membered ring formation.

Heterocycles published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayashi, Yoshiyuki published the artcilePreparation of tertiary amines having different substituents from quaternary 2-hydroxyethylammonium salts, Related Products of alcohols-buliding-blocks, the publication is Yukagaku (1987), 36(6), 409-12, database is CAplus.

N,N-Disubstituted ethanolamines readily and quant. reacted with alkyl halides to give quaternary 2-hydroxyethylammonium halides. The quaternary salts, when treated with a small excess of KOH at 120°, afforded tertiary amines in high yields, accompanied by the evolution of ethylene oxide. Thus, Me(CH₂)₉NMeCH₂CH₂OH was treated with PhCH₂Cl to give 93% PhCH₂[Me(CH₂)₉]N⁺MeCH₂CH₂OH Cl^–, which was heated at 120° with KOH to give 90% Me(CH₂)₉NMeCH₂Ph. N,N-Dimethylalkylamines were also prepared quant. in a one-pot reaction procedure from N,N-dimethylethanolamine and alkyl halides.

Yukagaku published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts