Tag: M.W=150-200

Smolobochkin, A. V. published the artcileSynthesis of novel 2-arylpyrrolidines by the reaction of 1-(4,4-diethoxybutyl)urea with resorcinols, Name: 4,4-Diethoxybutan-1-amine, the publication is Russian Chemical Bulletin (2014), 63(1), 284-285, database is CAplus.

Reaction of 1-(4,4-diethoxybutyl)urea with resorcinol, 2-methylresorcinol, and pyrogallol in chloroform in the presence of trifluoroacetic acid affords new 2,2′-(1,3-phenylene)bis(pyrrolidine-1-carboxamides).

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C24H29N5O3, Name: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey published the artcileSynthesis of novel 2-(het)arylpyrrolidine derivatives and evaluation of their anticancer and anti-biofilm activity, Quality Control of 6346-09-4, the publication is Molecules (2019), 24(17), 3086pp., database is CAplus and MEDLINE.

A library of novel 2-(het)arylpyrrolidine-1-carboxamides I [R = H, n-hexyl, 4-MeOC₆H₄, etc.; Ar = 4-hydroxy-6-methyl-pyran-2-one-3-yl, 4-hydroxycoumarin-3-yl, 1,3-benzodioxol-5-ol-6-yl, 6-chloro-4-((4-yl-3-hydroxyphenyl)amino)-5-nitrobenzo[c][1,2,5]oxadiazole 1-oxide] was obtained via a modular approach based on the intramol. cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds toward M-Hela tumor cell lines was twice that of reference drug tamoxifen, whereas cytotoxicity toward normal Chang liver cell did not exceed tamoxifen toxicity. In vivo studies showed that the number of surviving animals on day 60 of observation was up to 83% and increased life span (ILS) was up to 447%. Addnl., some pyrrolidine-1-carboxamides possessing a benzofuroxan moiety obtained were found to effectively suppress bacterial biofilm growth. Thus, these compounds were promising candidates for further development both as anti-cancer and anti-bacterial agents.

Molecules published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C21H37BO, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileCyclization of 1-(4,4-diethoxybutyl)-3-arylureas: a case study, Synthetic Route of 6346-09-4, the publication is Monatshefte fuer Chemie (2018), 149(3), 535-541, database is CAplus.

The study on the reaction of (4,4-diethoxybutyl)ureas with nucleophilic aromatics was reported herein. It was found that the structure of the products mainly depends on the strength of the acid used as catalyst as well as aromatic nucleophile nature and its concentration Either 2-arylpyrrolidines e.g., (R,S)-2,2′-(4,6-Dihydroxy-5-methyl-1,3-phenylene)bis[N-(naphthalen-1-yl)pyrrolidine-1-carboxamide], diarylbutanes, 1-[4,4-Bis(5-chloro-2,4-dihydroxyphenyl)butyl]-3-(naphthalen-1-yl)urea, bispyrrole derivatives, N-(Naphthalen-1-yl)-4-[1-(naphthalen-1-ylcarbamoyl)pyrrolidin-2-yl]-2,3-dihydro-1H-pyrrole-1-carboxamide, or pyrrolidinequinazolinones can be synthesized via variation of these factors. The proposed mechanism of the reaction is discussed.

Monatshefte fuer Chemie published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H11NO4, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileAcid-catalyzed reaction of phenols with N-(4,4-diethoxybutyl)sulfonamides – a new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2017), 53(2), 161-166, database is CAplus.

A new method for the synthesis of 2-aryl-1-sulfonylpyrrolidines I (R = Me, Et, Ph, p-tolyl; R¹ = 5-chloro-2,4-dihydroxyphenyl, 2-hydroxynaphthalen-1-yl, 2,7-dihydroxynaphthalen-1-yl) on the basis of reactions between various phenols ArH and N-(4,4-diethoxybutyl)sulfonamides RS(O)₂NH(CH₂)₃CH(OEt)₂ in the presence of trifluoroacetic acid has been developed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H16O2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khairullin, R. A. published the artcileSynthesis of O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates and their reactions with N-nucleophiles, Related Products of alcohols-buliding-blocks, the publication is Doklady Chemistry (2016), 467(2), 131-135, database is CAplus.

O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates, 2-(dialkoxythiophosphorylthio)-substituted aldehydes with branched carbon groups, were obtained by hydrolysis of phosphoryl-containing iminium salts. The reaction with primary amines results in imines containing acetal group in different positions. Tri- and tetra-substituted perhydro-1,3-diazoles and oxazoles containing a phosphorus atom in the side chain were prepared by reacting the aldehydes with O,Nand N,N-dinucleophiles.

Doklady Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiong, Xionghua published the artcileExpression, purification and characterization of a quinoprotein L-sorbose dehydrogenase from Ketogulonicigenium vulgare Y25, Category: alcohols-buliding-blocks, the publication is African Journal of Microbiology Research (2013), 7(24), 3117-3124, database is CAplus.

It is well known that Ketogulonicigenium vulgare Y25 could effectively oxidize L-sorbose to 2-keto-L-gulonic acid (2KGA), an industrial precursor of vitamin C. There in, L-sorbose dehydrogenase is one of the key enzymes responsible for the production of 2KGA. From this organism, the coding region of sdh gene was cloned into pET22b plasmid and its transcription product was overexpressed. This procedure allowed purification of L-sorbose dehydrogenase and production of polyclonal antibodies. In Western blot assays, the antibodies gave a pos. reaction against bacteria protein extract and purified L-sorbose dehydrogenase. The mol. mass of the enzyme was 60532 Da and the N-terminal amino acid sequence was determined to be QTAIT. The Native-PAGE and resting-cell reaction assay showed that purified L-sorbose dehydrogenase could convert L-sorbose to 2KGA and PQQ was found to be indispensable for its activity as prosthetic group. The enzyme showed broad substrates specificity and the K_m value for -sorbose and 1-propanol was 21.9 mM and 0.13 mM, resp. The optimum pH of the enzyme activity was 8.0 and the optimum temperature was 35°C. The activity of the L-sorbose dehydrogenase was greatly stimulated by Ca²⁺ and strongly inhibited by Co²⁺ and Cu²⁺. The results obtained from the present study showed that a PQQ-dependent L-sorbose dehydrogenase could oxidize -sorbose into 2-keto-L-gulonic acid in vitro.

African Journal of Microbiology Research published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C11H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Shanghua published the artcileCopper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions, Name: 4-(1H-Pyrrol-1-yl)phenol, the publication is Journal of the American Chemical Society (2016), 138(41), 13493-13496, database is CAplus and MEDLINE.

In the presence of Cu(acac)₂ and N,N’-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide, aryl and heteroaryl chlorides, bromides, and iodides underwent hydroxylation reactions in DMSO/H₂O to yield phenols and aryl and heteroaryl alcs. A wide range of aryl and heteroaryl chlorides bearing either electron-donating or electron-withdrawing groups underwent hydroxylation at 130 °C to provide the corresponding phenols and hydroxylated heteroarenes in 52-96% yields. When more reactive aryl and heteroaryl bromides and iodides were employed, the hydroxylation reactions could be performed at 80° and 60°, resp., using 0.5 mol% of Cu(acac)₂.

Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C12H14BNO2, Name: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Akondi, Srirama Murthy published the artcileAerobic, Diselenide-Catalyzed Redox Dehydration: Amides and Peptides, Name: 4,4-Diethoxybutan-1-amine, the publication is Organic Letters (2018), 20(3), 538-541, database is CAplus and MEDLINE.

At 2.5 mol % loadings using reaction temperatures between 30-55 °C, ortho-functionalized diaryl diselenides are highly effective organocatalytic oxidants for aerobic redox dehydrative amidic and peptidic bond formation using tri-Et phosphite as a simple terminal reductant. This simple-to-perform organocatalytic reaction relies on the ability of selenols to react directly with dioxygen in air without recourse to metal catalysts. It represents an important step toward the development of a general, economical, and benign catalytic redox dehydration protocol.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Name: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barik, Chandan Kr published the artcileRuthenacyclic Carbamoyl Complexes: Highly Efficient Catalysts for Organosilane Hydrolysis, Recommanded Product: Triisopropylsilanol, the publication is European Journal of Inorganic Chemistry (2018), 2018(46), 4982-4986, database is CAplus.

The ruthenacyclic carbamoyl complexes [RuX{2-NHC(O)C₅H₃NR}(CO)₂(NCMe)] (R = H and Me; X = Br and SC₆H₃-o,o-Me₂) are excellent catalysts for the hydrolysis of organosilanes, particularly towards primary silanes, generating H under ambient conditions within seconds. These complexes are structural mimics of the [Fe]-hydrogenase active site and like the natural enzyme, a labile ligand at the 6th coordination site is essential to the catalytic activity.

European Journal of Inorganic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Lijuan published the artcileCharacterization of the key aroma-active compounds in high-grade Dianhong tea using GC-MS and GC-O combined with sensory-directed flavor analysis, Related Products of alcohols-buliding-blocks, the publication is Food Chemistry (2022), 132058, database is CAplus and MEDLINE.

Dianhong tea (DHT) is popular for its pleasant caramel-like aroma. In this study, the aroma profile of high-grade DHT have been studied using gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O) combined with headspace solid phase microextraction (HS-SPME). A total of 52 aroma-active compounds were identified by GC-O coupled with aroma extract dilution anal. (AEDA) and odor specific magnitude estimation (Osme). Among them, quantification of 21 aroma-active compounds indicated that the content of linalool (5928μg/kg) was the highest in high-grade DHT, followed by phenylethanol (3923μg/kg) and phenylacetaldehyde (1801μg/kg). Sensory-directed aroma recombination and omission tests further verified that phenylacetaldehyde, linalool, geraniol and 3-ethyl-2,5-dimethylpyrazine were important contributors to the overall sensory characteristics of high-grade DHT which dominated mainly by floral, sweet and caramel-like odors. This work will provide a theor. reference for comprehensively understanding the aroma characteristic of DHT.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts