Tag: M.W=150-200

Yang, Jing published the artcileMetabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is International Journal of Food Science and Technology (2021), 56(10), 5168-5177, database is CAplus.

Raspberry leaves, byproducts in raspberry production, are also a rich source of bioactive phytochems. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS anal. and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has pos. effects on gut microbiota and potential value of maintaining intestinal health.

International Journal of Food Science and Technology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C15H20O6, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pitcher, Noel P. published the artcileDevelopment of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract, Name: 3-Hydroxyphenylacetic acid, the publication is ACS Omega (2022), 7(8), 6737-6759, database is CAplus and MEDLINE.

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents.

ACS Omega published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al Farraj, Dunia A. published the artcileCharacterization of pyrene and chrysene degradation by halophilic Hortaea sp. B15, SDS of cas: 86-48-6, the publication is Bioprocess and Biosystems Engineering (2019), 42(6), 963-969, database is CAplus and MEDLINE.

Polycyclic aromatics hydrocarbons (PAHs) are ubiquitous and toxic pollutants that are dangerous to humans and living organism in aquatic environment. Normally, PAHs has lower mol. weight such as phenanthrene and naphthalene that are easy and efficient to degrade, but high-mol.-weight PAHs such as chrysene and pyrene are difficult to be biodegraded by common microorganism. This study investigated the isolation and characterization of a potential halophilic bacterium capable of utilizing two high-mol.-weight PAHs. At the end of the experiment (25-30 days of incubation), bacterial counts have reached a maximum level (over 40 × 10¹⁶ CFU/mL). The highest biodegradation rate of 77% of chrysene in 20 days and 92% of pyrene in 25 days was obtained at pH 7, temperature 25°C, agitation of 150 rpm and Tween 80 surfactant showing to be the most impressive parameters for HMWPAHs biodegradation in this research. The metabolism of initial compounds revealed that Hortaea sp. B15 utilized pyrene to form phthalic acid while chrysene was metabolized to form 1-hydroxy-2-naphthoic acid. The result showed that Hortaea sp. B15 can be promoted for the study of in situ biodegradation of high mol. weight PAH.

Bioprocess and Biosystems Engineering published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Caiping published the artcileDiscovery of Salidroside Glycoside Analogs as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia, Name: 3-Hydroxyphenylacetic acid, the publication is Journal of Medicinal Chemistry (2022), 65(1), 135-162, database is CAplus and MEDLINE.

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-mol. drugs capable of inducing it at the clin. level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and drug angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and non-diabetic HLI mice. Together, this study offers a novel, promising small-mol.-based therapeutic strategy for treating HLI.

Journal of Medicinal Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeon, Mina published the artcileTransformation of Silanes into Silanols using Water and Recyclable Metal Nanoparticle Catalysts, Category: alcohols-buliding-blocks, the publication is ChemCatChem (2012), 4(4), 521-524, database is CAplus.

The highly selective and efficient transformation of organosilanes into silanols was achieved using readily available heterogeneous metal nanoparticle catalysts on an Al oxyhydroxide support [M/AlO(OH), M = Pd, Au, Rh, Ru, and Cu]. The transformation was performed under ambient conditions with H₂O. Among the catalysts studied, the Pd catalyst showed the highest activity; it was highly recyclable and applicable for large-scale reactions. The Pd catalyst was effective for a wide range of silanes, although small amounts of hydrogenated side products were formed in some cases for alkynyl silanes. The hydrogenation reaction was suppressed by using an O atm. or by using a gold catalyst. The Au catalyst could be reused at least ten times without any loss in activity.

ChemCatChem published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, W. published the artcileSpaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis, Formula: C6H10O7, the publication is Letters in Applied Microbiology (2013), 57(1), 54-62, database is CAplus and MEDLINE.

Two bacterial strains used for industrial production of 2-keto-L-gulonic acid (2-KLG), Ketogulonigenium vulgare 2 and Bacillus thuringiensis 1514, were loaded onto the spacecraft Shenzhou VII and exposed to space conditions for 68 h in an attempt to increase their fermentation productivities of 2-KLG. An optimal combination of mutants B. thuringiensis 320 and K. vulgare 2194 (KB2194-320) was identified by systematically screening the pH and 2-KLG production of 16 000 colonies. Compared with the coculture of parent strains, the conversion rate of L-sorbose to 2-KLG by KB2194-320 in shake flask fermentation was increased significantly from 82·7% to 95·0%. Furthermore, a conversion rate of 94·5% and 2-KLG productivity of 1·88 g l^-1 h^-1 were achieved with KB2194-320 in industrial-scale fermentation (260 m³ fermentor). An observed increase in cell number of K2194 (increased by 47·8%) during the exponential phase and decrease in 2-KLG reductase activity (decreased by 46·0%) were assumed to explain the enhanced 2-KLG production The results suggested that the mutants KB2194-320 could be ideal substitutes for the currently employed strains in the 2-KLG fermentation process and demonstrated the feasibility of using spaceflight to breed high-yielding 2-KLG-producing strains for vitamin C production Significance and Impact of the Study : KB2194-320, a combination of two bacterial strains bred by spaceflight mutation, exhibited significantly improved 2-KLG productivity and hence could potentially increase the efficiency and reduce the cost of vitamin C production by the two-step fermentation process. In addition, a new pH indicator method was applied for rational screening of K2, which dramatically improved the efficiency of screening.

Letters in Applied Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C18H23N3O4S, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Weichao published the artcileA plate method for rapid screening of Ketogulonicigenium vulgare mutants for enhanced 2-keto-L-gulonic acid production, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Brazilian Journal of Microbiology (2017), 48(3), 397-402, database is CAplus and MEDLINE.

A new plate method was developed for rapid screening of Ketogulonicigenium vulgare mutants overproducing 2-keto-L-gulonic acid (2-KLG). The screening methodol. took the advantage of the acidity caused by 2-KLG, which changes the color of bromothymol blue (pH indicator) from blue to yellow. Using the proposed method, a mutant, K. vulgare 65, was selected from 20,000 colonies produced by a strain subjected to spaceflight mutagenesis. When co-cultured with Bacillus megaterium 2980 in 20-L fermenters, K. vulgare 65 showed a high conversion rate (94.45%) of l-sorbose to 2-KLG. In contrast to the traditional screening method, this one significantly improved the frequency of obtaining pos. mutants. Theproposed plate screening method is cost-effective and easy to run and is thus useful for the isolation and screening of K. vulgare mutants overproducing 2-KLG.

Brazilian Journal of Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H5F3N4, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xianxian published the artcileExtraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity, SDS of cas: 90-64-2, the publication is Natural Product Research, database is CAplus and MEDLINE.

Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds from four traditional Chinese medicine extracts and evaluated their antifungal activities in vitro and in vivo. In vitro, honokiol extracted from Artemisia argyi showed broad-spectrum antimicrobial and mycelial inhibitory activity with EC50 in the range 3.56 – 33.85 μg/mL against eight plant pathogens. q-PCR indicated that honokiol might induce cell cancerisation and inhibit cellular respiration, which provided significant insights into honokiol function in tobacco resistance to mol. mechanisms of the phytopathogenic fungus Phytophthora nicotianae. In vivo, honokiol significantly decreased the rate of fungal infection in eggplants, potatoes, grapes, cherry tomatoes, and cucumbers, and enhanced disease resistance in tobacco. Overall, our results indicate that honokiol has the potential to control a variety of fungal and oomycete diseases, and A. argyi could be a source of honokiol.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C20H21ClN4O4, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Jing-jing published the artcileSimultaneous determination of dissolved 1-methylphenanthrene and its metabolites by derivative synchronous fluorescence spectrometry with double scans method, Computed Properties of 86-48-6, the publication is Fenxi Huaxue (2021), 49(4), 636-641, database is CAplus.

Derivative synchronous fluorescence spectrometry with double scans method was established to simultaneously determine the dissolved 1-methylphenanthrene (1-MP) and its metabolites such as 1-hydroxy-2-naphthoic acid (1H2NA) and salicylic acid (SA). With this method, the linear ranges for determination of 1-MP, 1H2NA and SA were 0.02-1.30 μmol/L, 0.02-7.60 μmol/L and 0.01-5.20 μmol/L, the detection limits (LODs) of 1-MP, 1H2NA and SA were 0.11, 0.33 and 2.90 nmol/L, the relative standard deviations (RSD) were less than 2%, and the recoveries were 97.4%-108.6%. This method was suitable for the simultaneous determination of 1-MP, 1H2NA and SA in the dissolved 1-MP microbial degradation process under the laboratory simulation condition, showing practical application potential in investigation of 1-MP degradation process and mechanism in situ.

Fenxi Huaxue published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Jiaxin published the artcileFood Waste Management Employing UV-Induced Black Soldier Flies: Metabolomic Analysis of Bioactive Components, Antioxidant Properties, and Antibacterial Potential, Synthetic Route of 90-64-2, the publication is International Journal of Environmental Research and Public Health (2022), 19(11), 6614, database is CAplus and MEDLINE.

Food waste, as a major part of municipal solid waste, has been increasingly generated worldwide. Efficient and feasible utilization of this waste material for biomanufg. is crucial to improving economic and environmental sustainability. In the present study, black soldier flies (BSF) larvae were used as carriers to treat and upcycle food waste. Larvae of the BSF were incubated with UV light for 10, 20, and 30 min at a wavelength of 257.3 nm and an intensity of 8 W. The food waste utilization efficiency, antioxidant assays, antibacterial activity, and bioactive metabolites without and with UV treatment were determined and compared. This showed that the BSF larvae feed utilization rate was around 75.6%, 77.7%, and 71.2% after UV treatment for 10, 20, and 30 min resp., contrasting with the non-UV induced group (73.7%). In addition, it was perceived that the UV exposure enhanced antioxidant and antimicrobial properties of BSF extracts, and the maximum values were observed after 20 min UV induction time. Moreover, UV-induced BSF extracts showed an improved metabolic profile than the control group, with a change in the amino acids, peptides, organic acids, lipids, organic oxides, and other derivatives This change in metabolomics profile boosted environmental signaling, degradation of starch, amino acids, sugars, and peptide metabolism It was concluded that the bioconversion of food wastes using UV-induced BSF larvae can enhance the generation of a variety of functional proteins and bioactive compounds with potent antioxidant and antimicrobial activity. However, more studies are required to exploit the efficiency of UV treatment in improving BSF′s potential for upcycling of food wastes.

International Journal of Environmental Research and Public Health published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts