Tag: M.W=150-200

Shimizu, Kuniaki published the artcileReductive cleavage reaction of N,N’-, N,O- and N,S-linked alkylidene compounds by sodium borohydride, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1974), 22(6), 1256-60, database is CAplus.

NaBH4 reduction was undertaken with a variety of N,n’-, N,O-, and N,S-linked alkylidene compounds (e.g. I-III) in aqueous ethanolic medium at room temperature Reductive cleavage of one of these two alkylidene carbon-heteroatom bonds is generally effected in this reduction The alkylidene bond initially cleaved when the two bonds were different was also determined

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C14H12O2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, M. B. published the artcileSynthesis of 4-(dibromomethyl)benzenecarbaldehyde and its reactions with N- and O-nucleophiles, Product Details of C8H19NO2, the publication is Russian Chemical Bulletin (2016), 65(1), 191-194, database is CAplus.

4-(Dibromomethyl)benzenecarbaldehyde (4-Br₂CHC₆H₄CHO, I) was prepared chemoselectively by debromination of 1,4-bis(dibromomethylbenzene) with tri-Me phosphate; reaction with primary amines RNH₂ [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂] yielded benzaldimines 4-Br₂CHC₆H₄CH:NR [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂], while reaction with tri-Me and tri-Et orthoformates in the presence of H₂SO₄ yielded the acetals 4-Br₂CHC₆H₄CH(OR¹)₂ (R¹ = Me, Et).

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, M. B. published the artcile4-(Dibromomethyl)benzaldehyde and its reactions with primary amines, Synthetic Route of 6346-09-4, the publication is Russian Journal of General Chemistry (2015), 85(9), 2209-2211, database is CAplus.

The title compound, 4-Br₂CHC₆H₄CHO (1) was prepared by reaction of 1,4-(Br₂CH)₂C₆H₄ with tri-Me phosphate with 42% yield, the side product being di-Me phosphorobromidate (MeO)₂P(O)Br. The process shows advantages over usual acid hydrolysis, being selective and leaving less aggressive hydrogen bromide waste. The aldehyde 1 reacts with primary amines RNH₂, giving aldimines 4-Br₂CHC₆H₄CH:NR [13a–d; R = ⁱPr, 4-MeOC₆H₄, CH₂CH(OEt)₂, (CH₂)₃CH(OEt)₂].

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileSynthesis and properties of 4-(dibromomethyl)benzenecarbaldehyde, SDS of cas: 6346-09-4, the publication is Tetrahedron Letters (2016), 57(2), 210-212, database is CAplus.

The 4-(dibromomethyl)benzenecarbaldehyde was synthesized for the first time using a new method, which also allowed the co-preparation of terephthalic aldehyde. The reaction of this aldehyde with primary amines RNH₂ [R = CH(CH₃)₂, 4-OCH₃C₆H₄, CH₂CH(O(C₂H₅)₂), etc.] resulted in the formation of imines RN=CHC₆H₄CHBr₂, including those containing an addnl. acetal group, while the reaction with trialkyl orthoformates HC(OR¹)₃ (R¹ = Me, Et) led to the formation of acetals R¹O(OR¹)CHC₆H₄CHBr₂. The latter compounds were transformed into 4-(dibromomethyl)-substituted benzenes containing a phosphorus functional group in the side chain via consecutive reactions with phosphorus trichloride and the esters of P(III) acids.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shibanuma, Tadao published the artcileSynthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nicardipine), HPLC of Formula: 101-98-4, the publication is Chemical & Pharmaceutical Bulletin (1980), 28(9), 2809-12, database is CAplus and MEDLINE.

(+)- And (-)-nicardipine (I) were prepared from (-)- and (+)-1-ethoxymethyl-5-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (II). Resolution of II was carried out using cinchonidine and cinchonine. The vertebral vasodilating activity of (+)-I.HCl was about 3 times that of (-)-I.HCl.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H6BrFO2, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileHighly selective synthesis of hydrosiloxanes by Au-catalyzed dehydrogenative cross-coupling reaction of silanols with hydrosilanes, Computed Properties of 17877-23-5, the publication is ACS Catalysis (2017), 7(3), 1836-1840, database is CAplus.

We report a highly selective synthesis of siloxane building blocks containing SiH₂or SiH functionalities. The system AuCl(PPh₃)/PPh₃ or AuCl(PPh₃)/PBu₃ catalyzed the reaction of trihydrosilanes with silanols giving SiH₂-containing siloxanes exclusively. On the other hand, a highly selective reaction of dihydrosilanes with silanols to afford SiH-containing siloxanes was achieved by simply changing the phosphine ligand to a bidentate one, xantphos. Usefulness of SiH₂-containing siloxanes was demonstrated by the synthesis of a trisiloxane, Et₃SiOSi(Ph)(H)OSi^tBuMe₂, and a pentasiloxane, Ph₂Si(OSiHPhOSiEt₃)₂, bearing SiH functionalities.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Winstein, S. published the artcileThe role of neighboring groups in replacement reactions. XVIII. Migration of the methoxyl group, Safety of 2-Methyl-3-bromo-2-butanol, the publication is Journal of the American Chemical Society (1952), 1160-4, database is CAplus.

cf. C.A. 45, 4661f. A result of participation of a functional neighboring group in a replacement process is migration of the neighboring group. Such a migration of a MeO group occurs in the solvolysis of Me₂C(OMe)CHBrMe (I), which solvolyzes to give Me₂C(OH)CH(OMe)Me (II). EtMe₂COH with H₂SO₄ yielded Me₂C:CHMe (III), b₇₅₂ 38.7-8.9°, n_D²⁵ 1.3845. III (175 cc.) added dropwise to 224 g. N-bromosuccinimide (IV) in 2 1. MeOH, the mixture let stand overnight, added to 2 1. saturated NaCl, and the oil extracted with Et₂O yielded 227 g. I, b₄₀ 69-9.5°, n_D²⁵ 1.4533, d₂₅ 1.2632. MR_D is given for the compounds prepared Me₂CHCH(OH)Me, b₇₆₀ 111.8-11.9°, and 6.9 g. Na refluxed in 250 cc. petr. ether (b. 150-90°), the solution treated with 42.5 g. MeI and refluxed 1 h. yielded 13.9 g. 3-methoxy-2-methylbutane, b₇₆₀ 83-3.5°, n_D²⁰ 1.3838, n_D²⁵ 1.3812, d₂₅ 0.7542. I (36.2 g.), 250 cc. MeOH, 10 g. Pd-CaCO₃, and 17 g. KOH shaken 24 h. with H at 1 atm., the solution filtered, added to 250 cc. water, and extracted with petr. ether yielded 10.6 g. Me₂C(OMe)Et, b₇₆₀ 85-6.5°, n_D²⁰ 1.3885. III (230 cc.) added dropwise during 20 min. to 270 g. IV in 21. water, the mixture stirred 1 h., and extracted the next day with Et₂O, yielded 81.1 g. 2,3-epoxy-2-methylbutane (V), b₇₆₀ 73-3.3°, n_D²⁵ 1.3822, d₂₅ 0.8000. MeCH(OMe)CO₂Me, b₇₄₇ 129-30°, n_D²⁵ 1.3957, d₂₅ 0.9948, (0.45 mol) with 1 mol Me Grignard reagent yielded 21.8 g. II, b₇₅₂ 129.5-30°, n_D²⁵ 1.4100, d₂₅ 0.8877; V with Na yielded 53% II. V (33.2 g.) in 155 cc. MeOH treated with 2 drops H₂SO₄ yielded 34.6 g. 3-methyl-3-methoxy-2-butanol (VI), b₇₆₀ 143-4°, n_D²⁵ 1.4193, 0.9151. I (90.5 g.), 30 g. CaCO₃, and 400 cc. water treated dropwise during 20 min. with 95 g. AgNO₃, the mixture stirred 4 h. and extracted with Et₂O yielded 35.3 g. II, and 6.4 g. Me₂CHCOMe, b₇₆₀ 92-5° (2,4-dinitrophenylhydrazone, m. 122-2.5°); VI gave 80% recovered alc., b₇₆₀ 141-4°, and II gave 80.6% recovered alc., b₇₆₀ 129-30°. I (90.5 g.), 92 g. AgNO₃, and 500 cc. AcOH stirred 1 h. at 90-110°, the mixture filtered, and the filtrate neutralized with 6N KOH under Et₂O yielded 16.8 g. II, b₇₅₂ 129.5-30°. VI (20 g.), 20 g. Ac₂O, and 50 cc. pyridine refluxed 1 h. yielded 22 g. acetate, b₅₀ 85°, n_D²⁵ 1.4122, d₂₅ 0.9456. VI (32.1 g.) and 6.25 g. Na dissolved in 250 cc. refluxing petr. ether (b. 230-60°) and the solution treated with 39 g. MeI in 100 cc. Et₂O and refluxed 30 min. yielded 17.3 g. 2,3-dimethoxy-2-methylbutane (VII), b₇₆₀ 125-5.5°, n_D²⁵ 1.4026, d₂₅ 0.8571. I (95.5 g.) in 500 cc. MeOH refluxed 2 h. with 70 g. Ag₂O yielded 44.8 g. VII, b₇₆₀ 125-6°, n_D²⁵ 1.4018. III (53 cc.), 89 g. IV, and 1.5 1. water stirred 1.5 h. in an ice bath, the mixture saturated with NaCl, and extracted with Et₂O, yielded 67.33 g. trimethylethylene bromohydrin (Me₂C(OH)CHBrMe) (VIII), b₁₀ 48-51°, n_D²⁵ 1.4712. AgNO₃ (9.35 g.) in 200 cc. water added dropwise to 88.5 g. VIII and 84 g. NaHCO₃ in 300 cc. water during 1 h., the mixture stirred 1 h., extracted with Et₂O, the Et₂O partially distilled, the residue shaken with 42 g. NaHCO₃ and 47 g. AgNO₃ in 200 cc. water extracted with Et₂O, and the extract distilled, yielded 21.90 g. V, b₇₆₀ 72-3°, n_D²⁵ 1.3826, and 1.95 g. Me₂CHCOMe, b₇₆₉ 90-6° (2,4-dinitrophenylhydrazone, m. 122-2.5°).

Journal of the American Chemical Society published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C10H15BO4, Safety of 2-Methyl-3-bromo-2-butanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kobayashi, Takashi published the artcileNovel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-position, COA of Formula: C10H15NO, the publication is Chemical & Pharmaceutical Bulletin (1995), 43(5), 797-817, database is CAplus and MEDLINE.

Novel 2-amino-1,4-dihydropyridine derivatives, e.g. I (R¹ and R² = N,N-dialkylaminoalkyl, 1-benzylpiperidin-3-yl, 1-benzhydrylazetidin-3-yl, Me, iso-Pr, R³ = 3-NO₂C₆H₄, 2,3-Cl₂C₆H₃, 3-CF₃C₆H₄, R⁴= NH₂, CH₃) were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- and 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chem. modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. CS-905, I (R¹ = 1-benzhydrylazetidin-3-yl, R² = iso-Pr, R³ = 3-NO₂C₆H₄, R⁴ = NH₂) exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, COA of Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kobayashi, Takashi published the artcileNovel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxyalkoxycarbonyl groups at 3- and/or 5-position, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1995), 43(5), 788-96, database is CAplus and MEDLINE.

Novel 2-amino-1,4-dihydropyridine derivatives, e.g. I (R¹ and R² = nitroxyalkyl, alkyl, N-methyl-N-benzylaminoethyl, R³ = 2- or 3-NO₂C₆H₄, 2,3-Cl₂C₆H₃, 2- or 3-CF₃C₆H₄) were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lou, Sunqi published the artcileIn Situ Growth of CsPbBr₃ Perovskite Nanocrystals in Lead-Based Matrix toward Significantly Enhanced Water/Photo Stabilities, Name: 2-Hydroxy-2-phenylacetic acid, the publication is Advanced Optical Materials (2022), 10(1), 2101448, database is CAplus.

Perovskite nanocrystals (NCs) are considered as the next-generation platforms for optoelectronic applications, but their poor stability greatly restricts their development. Here, we present a facile composite strategy to synthesize highly stable CsPbBr₃/Pb-MA composite by in situ embedding the CsPbBr₃ NCs in a C₁₆H₁₄Br₂O₆Pb₂ (Pb-MA) organometallic compound (MOC). The CsPbBr₃/Pb-MA composite powders show intense green emission at 519 nm, with a photoluminescence quantum yield of about 48.5% and a full width at half-maximum of about 17 nm. More interestingly, benefitted from the protection of MOC, the CsPbBr₃/Pb-MA composites can maintain 43% and 83% of initial intensity after being illuminated under blue light for 36 h and being immersed in water for 192 h, resp. Compared to the original CsPbBr₃ NCs, the light/water stability of CsPbBr₃/Pb-MA composites is enhanced by about 40 and 700 times (the PL intensities maintain at about 60% of the initial one), resp. As a proof-of-concept, the as-fabricated devices exhibit a wide color gamut, 97.7% and 98.2% of Rec. 2020 for white light-emitting diodes and laser diodes, resp. These findings demonstrate that the combination of MOC and perovskite NCs is an optimized strategy for the exploitation of high-performance perovskite composites for their future optoelectronic applications.

Advanced Optical Materials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Name: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts