Tag: M.W=150-200

Shim, Young Key published the artcileNew synthetic route to 1,4-dihydropyridine monoacid derivatives, Quality Control of 101-98-4, the publication is Taehan Hwahakhoe Chi (1988), 32(2), 144-8, database is CAplus.

A novel synthetic route to 1,4-dihydropyridine mono carboxylic acid derivatives is described. Allyl Me 2,6-dimethyl-4-(3′-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate I (R = allyl) was treated with Pd(OAc)₂ in dioxane for 30 min at 100° C with reflux to give the mono acid I (R = H; II) in 94% yield. II was converted to Nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and its derivatives in 70∼85% yield.

Taehan Hwahakhoe Chi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H10CoF6P, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smith, Mark G. published the artcileNovel crystal forms of 4-aminoantipyrine and its derivatives: Co-crystallizing a reluctant molecule, Quality Control of 86-48-6, the publication is Journal of Molecular Structure (2019), 307-313, database is CAplus.

To the best of our knowledge, the first co-crystallization of the pharmaceutical ingredient 4-aminoantipyrine is reported with 2-aminobenzoic acid as the co-former, and the method used for its supramol. synthesis is discussed. Two mol. salts of 4-aminoantipyrine, as well as two co-crystals of a derivative of 4-aminoantipyrine were also synthesized. The complexes discussed show that careful application of synthon theory, choice of solvent and consideration of the pK_a difference between 4-aminoantipyrine and the co-former are required to successfully co-crystallize this reactive mol. In summary, the co-former must be chosen so that its functional group forms a robust heterosynthon with the reactive mol. The presence of polar solvents or large pK_a differences between 4-aminoantipyrine and its potential co-crystallizer favors salt formation, whereas a non-polar solvent and a small pK_a difference is required for the co-crystallization of 4-aminoantipyrine.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C18H28N2O7, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Lina published the artcileGold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols, Recommanded Product: Triisopropylsilanol, the publication is RSC Advances (2014), 4(13), 6807-6810, database is CAplus.

Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

RSC Advances published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Meijere, Armin published the artcileDe novo synthesis of racemic spirocyclopropane-annelated 2-deoxyhexose derivatives, Quality Control of 50915-29-2, the publication is European Journal of Organic Chemistry (2003), 472-478, database is CAplus.

High-pressure-induced inverse-electron-demand hetero-Diels-Alder reactions of Et trans-4-ethoxy-2-oxo-3-butenoate and Me trans-4-benzyloxy-2-oxo-3-butenoate with benzyl (cyclopropylidenemethyl) ether each yielded mixtures of two separable diastereomeric esters (64% and 80%, resp.) which, in three subsequent steps, led to the 3-ethylated and 3-benzylated α- and β-anomeric benzyl spiro[2-deoxy-(D,L)-arabino-hexopyranoside-2,1′-cyclopropanes] α-10a,b and β-10a,b, resp. The relative configuration of β-10a was proved by an X-ray crystal structure anal. Deprotection of β-10b was achieved by Pd-catalyzed hydrogenation in dimethylacetamide leading to spiro[2-deoxy-α/β-2-(D,L)-arabino-hexopyranoside-2,1′ -cyclopropane].

European Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Quality Control of 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Mingyu published the artcileNovel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is European Journal of Pharmaceutical Sciences (2021), 105931, database is CAplus and MEDLINE.

At present, oral chemotherapy showing the advantages of non-invasiveness, convenience, and high patient compliance, is gradually replacing traditional i.v. chemotherapy to treat patients with cancer. RA-XII, a unique natural cyclopeptide, exhibits various biol. activities, such as anti-tumor, anti-angiogenic, and anti-metastatic activities. Designing an orally available formulation of RA-XII is of great importance in the development of clin. useful anticancer agents. However, RA-XII shows low oral bioavailability in rats due to its poor solubility and low permeability. To overcome these limitations, in this work, a natural deep eutectic solvent (NADES) was designed to efficiently deliver RA-XII by oral administration. A novel NADES composed of betaine and mandelic acid in the molar ratio of 1:1 (Bet-Man NADES) was successfully prepared based on a binary phase diagram of Bet and Man. Acute toxicity studies indicated that Bet-Man NADES was well tolerated with acceptable toxicity. In Bet-Man NADES solutions, the solubility of RA-XII was increased by up to 17.54-fold, and the diffusion and permeability of RA-XII carried out in a Franz cell was also significantly improved 10.35 times. In terms of biopharmaceutical classification this is translated into a change for RA-XII from class IV to class II systems. More importantly, Bet-Man NADES was transferred into the solid formulation by the inclusion of a polymer, and amorphous solid dispersions based on Bet-Man NADES (PVP K30/NADES/RA-XII, ASDs) were successfully prepared to improve uniformity, apparent solubility, dissolution, and cytotoxicity in vitro. Consequently, the oral bioavailability of RA-XII in NADES solutions and ASDs was enhanced by approx. 11.58 and 7.56 times compared with that of pure RA-XII in 0.5% CMC-Na. Thus, it can be seen that a natural deep eutectic solvent and its modified amorphous solid dispersions are appropriate novel strategies for improving dissolution rate and bioavailability of poor soluble natural products such as RA-XII.

European Journal of Pharmaceutical Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdallah el hadj, A. published the artcileAI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Fluid Phase Equilibria (2022), 113297, database is CAplus.

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state.

Fluid Phase Equilibria published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tudorascu, Marius published the artcileEnzymes in organic syntheses. I. Olefin transformation to addition products catalyzed by chloroperoxidase, SDS of cas: 55376-31-3, the publication is Progress in Catalysis (1993), 63-70, database is CAplus.

Chloroperoxidase in free or immobilized form catalyzed the addition reactions of olefins with hypohalous acids generated from metal halides and H₂O₂. Thus, the reaction of propylene with LiBr-H₂O₂ afforded 1-bromo-2-propanol (92-3%) and 2-bromo-1-propanol.

Progress in Catalysis published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C16H14O6, SDS of cas: 55376-31-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xueyan published the artcileChiral discrimination of enantiomers based on different interactions with alterable chiral oligomer, SDS of cas: 90-64-2, the publication is Journal of Polymer Research (2021), 28(12), 486, database is CAplus.

Series of chiral oligomer ((S)-1-(S)-7)) based on the different proportions of achiral fluorophore unit (9, 9-dipropyl alkynyl fluorene (1a)) and chiral unit ((S)-2-(4-isopropyl-4, 5-dihydrooxazol-2-yl)-2-(prop-2-yn-1-yl) pent-4-ynenitrile (1b)) via Glaser coupling method were synthesized. The results showed that the fluorescent probe can be applied to the recognition of different enantiomers by changing the ratio of fluorophore to chiral group in the oligomer. The hydrogen bonding between chiral units and enantiomers in oligomers and large steric hindrance of rigid achiral units on conformation of the polymers may be the reasons for the different recognition abilities of oligomer with different ratios.

Journal of Polymer Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C6H11NO2, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Trzmiel, Simon P. O. published the artcileChromous siloxides of variable nuclearity and magnetism, SDS of cas: 17877-23-5, the publication is Dalton Transactions (2022), 51(13), 5072-5081, database is CAplus and MEDLINE.

Treatment of Cr[N(SiMe₃)₂]₂(THF)₂ with HOSiR₃ (R = Et, iPr) in THF afforded the bridged Cr^II siloxide complexes Cr₃(OSiEt₃)₂(μ-OSiEt₃)₄(THF)₂ and Cr₂(OSiiPr₃)₂(μ-OSiiPr₃)₂(THF)₂ in high yield. Exposure of these compounds to vacuum in aliphatic solvents led to the loss of coordinated THF and to the formation of the homoleptic chromous siloxides Cr₄(μ-OSiEt₃)₈ and Cr₃(OSiiPr₃)₂(μ-OSiiPr₃)₄, resp., in moderate to high yield. Use of TMEDA as a potentially bidentate donor mol. gave the monomeric cis-coordinated siloxide Cr(OSiiPr₃)₂(tmeda) (tmeda = N,N,N’,N’-tetramethylethane-1,2-diamine). Oxidation of Cr₂(OSiiPr₃)₂(μ-OSiiPr₃)₂(THF)₂ with CHI₃ and C₂Cl₆ produced the trigonal bipyramidal chromic compound Cr^III(OSiiPr)₃(THF)₂ and asym. coordinated Cr₂Cl₃(OSiiPr₃)₃(THF)₃, resp. Magnetic measurements (Evans and SQUID) hinted at (a) antiferromagnetic interactions between the Cr^II centers, (b) revealed higher effective magnetic moments (μ_eff) for cis-coordinated monomeric heteroleptic complexes compared to trans-coordinated ones, and (c) pointed out the highest (μ_eff) for the tetranuclear complex Cr₄(μ-OSiEt₃)₈ (6.26μB, SQUID, 300 K; Cr···Cr_adjacent average 2.535 Å).

Dalton Transactions published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C12H17BO4S, SDS of cas: 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Castro Dantas, T. N. published the artcilePreparation of aminoalkylphosphonium salts, Category: alcohols-buliding-blocks, the publication is Phosphorus and Sulfur and the Related Elements (1982), 13(1), 97-105, database is CAplus.

Three synthetic methods gave aminophosphonium salts Ph₃P⁺(CH₂)_nNRR¹ X^– (n = 2-4; R, R¹ = Me, Et, Me₂CH, Ph, PhCH₂). Yields are better with n = 3, but no intramol. stabilization was detected.

Phosphorus and Sulfur and the Related Elements published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts