Tag: M.W=150-200

Zhu, Yibo published the artcileSporulation and spore stability of Bacillus megaterium enhance Ketogulonigenium vulgare propagation and 2-keto-L-gulonic acid biosynthesis, Product Details of C6H10O7, the publication is Bioresource Technology (2012), 399-404, database is CAplus and MEDLINE.

Bacillus spp. is widely used as the companion bacterium in the two-step biosynthesis of 2-keto-L-gulonic acid (2-KLG), which is the direct precursor in the production of vitamin C by Ketogulonigenium vulgare. To understand the effects of sporulation and spore stability on 2-KLG production, the spo0A and spoVFA deletion mutants of Bacillus megaterium were constructed. The sorbose conversion rates of spo0A and spoVFA mutant co-culture systems were 33% and 70% lower, resp., than that of the wild-type co-culture system. In addition, K. vulgare cell numbers in the two mutant systems declined by 15% and 49%, resp., compared to the value in the wild-type system. Correlation anal. indicated that the 2-KLG concentration is pos. related to sorbose dehydrogenase activity and the K. vulgare cell number This study demonstrated that sporulation and spore stability of the wild-type companion play key roles in the enhancement of K. vulgare propagation and 2-KLG biosynthesis.

Bioresource Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C38H74Cl2N2O4, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zou, Wei published the artcileReview on the application of genome-based approaches on the vitamin C producing industrial strains, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Jiyinzuxue Yu Yingyong Shengwuxue (2012), 31(5), 513-521, database is CAplus.

A review with 40 references Vitamin C is one of the main fermentation products in China and its annual production accounts for more than 80% of total yields in the world. It is manufactured by a two-step fermentation process, which uses two fermentation steps to transform L-sorbose into 2-keto-L-gulonic acid, the precursor of vitamin C. This paper reviews the latest progress that has been achieved to study the key problems existing in the two-step fermentation process with emphasis on the important role played by the genome-based system biol. approaches during this process. Further, certain suggestions on how to improve the productivity of other fermentation products are also provided in this paper.

Jiyinzuxue Yu Yingyong Shengwuxue published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H17FO4S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Xiaowei published the artcileSugar and organic acid availability modulate soil diazotroph community assembly and species co-occurrence patterns on the Tibetan Plateau, Related Products of alcohols-buliding-blocks, the publication is Applied Microbiology and Biotechnology (2021), 105(21-22), 8545-8560, database is CAplus and MEDLINE.

Metabolites can mediate species interactions and the assembly of microbial communities. However, how these chems. relate to the assembly processes and co-occurrence patterns of diazotrophic assemblages in root-associated soils remains largely unknown. Here, we examined the diversity and assembly of diazotrophic communities and further deciphered their links with metabolites on Tibetan Plateau. We found that the distribution of sugars and organic acids in the root-associated soils was significantly correlated with the richness of diazotrophs. The presence of these two soil metabolites explains the variability in diazotrophic community compositions The differential concentrations of these metabolites were significantly linked with the distinctive abundances of diazotrophic taxa in same land types dominated by different plants or dissimilar soils by same plants. The assembly of diazotrophic communities is subject to deterministic ecol. processes, which are widely modulated by the variety and amount of sugars and organic acids. Organic acids, for instance, 3-(4-hydroxyphenyl)propionic acid and citric acid, were effective predictors of the characteristics of diazotrophic assemblages across desert habitats. Diazotrophic co-occurrence networks tended to be more complex and connected within different land types covered by the same plant species. The concentrations of multiple sugars and organic acids were coupled significantly with the distribution of keystone species, such as Azotobacter, Azospirillum, Bradyrhizobium, and Mesorhizobium, in the co-occurrence network. These findings provide new insights into the assembly mechanisms of root-associated diazotrophic communities across the desert ecosystems of the Tibetan Plateau.

Applied Microbiology and Biotechnology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Cai-Yun published the artcileIdentification and validation of four novel promoters for gene engineering with broad suitability across species, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Microbiology and Biotechnology (2021), 31(8), 1154-1162, database is CAplus and MEDLINE.

The transcriptional capacities of target genes are strongly influenced by promoters, whereas few studies have focused on the development of robust, high-performance and cross-species promoters for wide application in different bacteria. In this work, four novel promoters (Pk.rtufB, Pk.r1, Pk.r2, and Pk.r3) were predicted from Ketogulonicigenium robustum and their inconsistency in the -10 and -35 region nucleotide sequences indicated they were different promoters. Their activities were evaluated by using green fluorescent protein (gfp) as a reporter in different species of bacteria, including K. vulgare SPU B805, Pseudomonas putida KT2440, Paracoccus denitrificans PD1222, Bacillus licheniformis and Raoultella ornithinolytica, due to their importance in metabolic engineering. Our results showed that the four promoters had different activities, with Pk.r1 showing the strongest activity in almost all of the exptl. bacteria. By comparison with the commonly used promoters of E. coli (tufB, lac, lacUV5), K. vulgare (Psdh, Psndh) and P. putida KT2440 (JE111411), the four promoters showed significant differences due to only 12.62% nucleotide similarities, and relatively higher ability in regulating target gene expression. Further validation experiments confirmed their ability in initiating the target minCD cassette because of the shape changes under the promoter regulation. The overexpression of sorbose dehydrogenase and cytochrome c551 by Pk.r1 and Pk.r2 resulted in a 22.75% enhancement of 2-KGA yield, indicating their potential for practical application in metabolic engineering. This study demonstrates an example of applying bioinformatics to find new biol. components for gene operation and provides four novel promoters with broad suitability, which enriches the usable range of promoters to realize accurate regulation in different genetic backgrounds.xxxxxxxxxxxxx.

Journal of Microbiology and Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C12H10O4S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zou, Wei published the artcileStructure, mechanism and regulation of an artificial microbial ecosystem for vitamin C production, COA of Formula: C6H10O7, the publication is Critical Reviews in Microbiology (2013), 39(3), 247-255, database is CAplus and MEDLINE.

A review. At present, the modern two-step fermentation process is one of the major approaches for the industrial production of vitamin C. The key step in this process is the conversion of L-sorbose to 2-keto-L-gulonic acid (2-KLG), the vitamin C precursor, which is accomplished by an artificial microbial ecosystem consisting of Ketogulonicigenium vulgare and Bacillus megaterium. This review describes current progress in understanding this ecosystem, not only the individual physiol. characteristics of the two strains, but also the interactions between them. Special emphasis is placed on recent systems biol. studies of the ecosystem. We also discuss the regulation and improvement of this ecosystem, including anal. of the fermentation medium components and genetic engineering and optimum fermentative strategies. Finally, perspectives on the knowledge and engineering of this important artificial microbial ecosystem are discussed.

Critical Reviews in Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H17FO4S, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bouchet, Samuel published the artcileExtending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling, Related Products of alcohols-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2019), 10(6), 863-868, database is CAplus and MEDLINE.

Dissym. cross metathesis of alkenes as a convergent and general synthetic strategy allowed for the preparation of a new small series of human histone deacetylases (HDAC) inhibitors. Alkenes bearing Boc-protected hydroxamic acid and benzamide and trityl-protected thiols were used to provide the zinc binding groups and were reacted with alkenes bearing aromatic cap groups. One compound was identified as a selective HDAC6 inhibitor lead. Addnl. biol. evaluation in cancer cell lines demonstrated its ability to stimulate the expression of the epithelial marker E-cadherin and tumor suppressor genes like SEMA3F and p21, suggesting a potential use of this compound for lung cancer treatment. Mol. docking on all 11 HDAC isoforms was used to rationalize the observed biol. results.

ACS Medicinal Chemistry Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jiukai published the artcileVolatolomics approach for authentication of not-from-concentrate (NFC) orange juice based on characteristic volatile markers using headspace solid phase microextraction (HS-SPME) combined with GC-MS, COA of Formula: C10H18O, the publication is Food Control (2022), 108856, database is CAplus.

The not-from-concentrate (NFC) juice is gradually becoming popular with consumers. However, adulteration of NFC juice with low-priced from-concentrate (FC) juice has been a long-lasting concern. In the present study, a volatolomics approach for authentication of NFC orange juice based on volatile organic compounds (VOCs) was established. A total of 107 VOCs were identified by solid phase microextraction (SPME) GC-Q-Exactive Orbitrap. Discrimination of NFC and FC orange juice could be accomplished by orthogonal partial least squares discriminant anal. (OPLS-DA). Furthermore, 10 VOCs were selected as potential characteristic markers in different juices, including 4 esters, 5 alcs. and 1 ketone. In addition, 13 VOCs with significant quant. difference was also screened. A partial least squares discriminant anal. (PLS-DA) model based on the above 23 VOCs achieved accuracy of 100% and 95.6% for calibration and prediction set, resp. These results suggested that the volatolomics approach has great potential for authentication of NFC juice.

Food Control published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C30H40N2O4, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Hai-hua published the artcileCatalytic asymmetric intramolecular hydroarylations of ω-aryloxy- and arylamino-tethered α,β-unsaturated aldehydes, Recommanded Product: 3-Morpholinophenol, the publication is Chemistry – A European Journal (2009), 15(12), 2742-2746, database is CAplus and MEDLINE.

The first organocatalytic asym. intramol. hydroarylation of phenol- and aniline-derived enals I (X = O, NMe, NCH₂Ph, NBoc, etc.; R¹ = H, Me, NMe₂, 1-pyrrolidinyl, 4-morpholinyl, etc.; R² = H, Me, OMe, OEt) offers one of the most straightforward and atom-economic approaches to enantioenriched chromans and tetrahydroquinolines II with up to 96% ee.

Chemistry – A European Journal published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bajkacz, Sylwia published the artcileSeparation and Determination of Chemopreventive Phytochemicals of Flavonoids from Brassicaceae Plants, Quality Control of 621-37-4, the publication is Molecules (2021), 26(16), 4734, database is CAplus and MEDLINE.

The main aim of this study was to develop a method for the isolation and determination of polyphenols-in particular, flavonoids present in various morphol. parts of plants belonging to the cabbage family (Brassicaceae). Therefore, a procedure consisting of maceration, acid hydrolysis and measurement of the total antioxidant capacity of plant extracts (using DPPH assay) was conducted. Qual. anal. was performed employing thin-layer chromatog. (TLC), which was presented to be a suitable methodol. for the separation and determination of chemopreventive phytochems. from plants belonging to the cabbage family. The study involved the anal. of 25 vegetal samples, including radish, broccoli, Brussels sprouts, kale, canola, kohlrabi, cabbage, Chinese cabbage, red cabbage, pak choi and cauliflower. In addition, selected flavonoids content in free form and bonded to glycosides was determined by using an RP-UHPLC-ESI-MS/MS method.

Molecules published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Hsuan-Ju published the artcileSolid- and vapour-phase antifungal activities of six essential oils and their applications in postharvest fungal control of peach (Prunus persica L. Batsch), Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is LWT–Food Science and Technology (2022), 113031, database is CAplus.

Plant-based essential oils (EOs) possess versatile antimicrobial effects, and these render EOs a potent, sustainable antimicrobial candidate for postharvest loss control. In this study, generally recognized as safe EOs of lavender, rosewood, dill weed and fennel were investigated with the benchmark thyme red EO, for their antifungal activity against six peach spoilage fungi. We further determined their chem. compositions, as well as monitored the effect of the EOs in the phys. parameters of peaches during the storage period. Most EOs exhibited antifungal activity in the solid phase against the peach spoilage fungi, while some EOs failed to do so in the vapor phase. Rosewood (RO), thyme red (TR) and fennel (FO) EOs could inhibit mycelia growth and spore germination in a dose-dependent manner. GC-MS anal. indicated that the dominant compounds for TR, RO and FO were thymol (53.03%), linalool (77.09%) and trans-anethole (82.35%), resp. The storage tests indicated that the peach treated with RO in the vapor phase exhibited a reduced decay and maintained weight loss and total soluble solids at the room and refrigerator temperatures Moreover, the Mucor nidicola-infected peaches treated with RO exhibited significantly smaller lesion diameters and lower disease incidence relative to that by the control peaches.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts