Tag: M.W=150-200

Adger, B. M. published the artcileCatalytic transfer hydrogenolysis of N-benzyl protecting groups, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Synthesis (1987), 53-5, database is CAplus.

The catalytic transfer hydrogenolysis of a number of N-benzyl compounds has been examined Of the three hydrogen donors studied, ammonium formate and hydrazine hydrate were more effective than sodium hypophosphite. In general, debenzylation of secondary and tertiary benzylamines could be readily accomplished by refluxing the substrate with an excess of the hydrogen donor in alc. solvents for a few hours using catalytic amounts of 10% palladium on carbon. The two N-benzyl heteroaromatic amines studied were stable to the above conditions.

Synthesis published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matejczyk, Marzena published the artcileThe study of biological activity of mandelic acid and its alkali metal salts in wastewaters, SDS of cas: 90-64-2, the publication is Environmental Research (2022), 112429, database is CAplus and MEDLINE.

In the present work we compared the biol. activity of mandelic acid (MA) and its Li, Na, K, Rb and Cs salts. The study also investigated the effect of raw wastewaters (RW) and treated wastewaters (TW), comparable to microbial medium (MM) on the biol. activity of the tested chem. compounds used in concentrations of 5; 2.5; 1.25; 0.625; 0.3125 mg/mL. In the present experiment the evaluation of the following parameters was performed: E. coli (ATCC 25922) cells viability, growth inhibition of E. coli (ATCC 25922), the inhibition of GFP protein, genotoxicity and ROS generation. Our results showed that three main factors differentiated the antibacterial activity of MA and its Li, Na, K, Rb and Cs salts: study environment (MM, RW, TW), metal forming salt of mandelic acid and concentration of tested compounds Addnl., raw and treated wastewater, compared to microbial medium, changes the antimicrobial activity of MA and its salts in relation to the E. coli strain. We also detected that both MA and its salts affect the GFP protein and the induction of the recA promoter (genotoxicity test). The activity of the tested salts in relation to these two parameters is strictly dependent on the type of salt-forming metal and the concentration used. The anal. of ROS synthesis suggests that in the majority of the studied mandelic acid salts, oxidative stress is the dominant mechanism of cytotoxicity and genotoxicity. We also showed that both raw wastewaters (RW) and treated wastewaters (TW), compared to microbial medium (MM), change significantly the activity of MA and its salts.

Environmental Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kinugawa, Masahiko published the artcileFacile synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetrical dicarboxylates via quaternary ammonium salts of 2-aminoethyl 1,4-dihydropyridine-3,5-dicarboxylates, COA of Formula: C10H15NO, the publication is Synthetic Communications (1997), 27(19), 3321-3331, database is CAplus.

Useful 1,4-dihydropyridine unsym. dicarboxylates nitrendipine (I, R = Et), nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and monocarboxylic acid I (R = H) were prepared from I (R = CH₂CH₂NMeCH₂Ph, N-benzyl-3-piperidinyl) via their quaternary ammonium salts, e.g., II.

Synthetic Communications published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, COA of Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hasegawa, Tadashi published the artcilePhotocyclization of (ω-dialkylamino)alkyl β-oxoesters via remote hydrogen transfer, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1990), 901-5, database is CAplus.

The (ω-dialkylamino)alkyl β-oxoesters PhCOCR₂CO₂(CH₂)_nN(CH₂R¹)CH₂R² I (n = 2, 3, 4; R = H, Me; R², R³ = H, Ph) undergo photocyclization via remote hydrogen transfer to give the medium-sized azalactones (II) and/or aminolactones III. Intramol. electron transfer from nitrogen to the excited carbonyl group of I occurs prior to the remote hydrogen transfer.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Escobedo, Ericson published the artcileActivation of hydrogen peroxide, persulfate, and free chlorine by steel anode for treatment of municipal and livestock wastewater: Unravelling the role of oxidants speciation, Recommanded Product: 2-Methyl-3-bromo-2-butanol, the publication is Water Research (2022), 118305, database is CAplus and MEDLINE.

Despite the extensive application of electrochem. advanced oxidation processes (EAOPs) in wastewater treatment, the exact speciation of oxidants and their effects on pollutants removal efficiency, byproducts formation, and effluent toxicity are largely unknown. In this study, galvanostatic steel anodes were used to drive the electrochem. activation of hydrogen peroxide (EAHP), persulfate (EAP), and free chlorine (EAFC), for industrial-scale treatment of municipal and livestock wastewater with a focus on micropollutants and transformation products (MTPs) and effluent toxicity. Response surface methodol. determined the optimized conditions for each treatment towards total organic carbon ([TOC]₀ = 180 mg/L) removal at pH 3.0: persulfate dose = 0.12 mmol/min, 26.5 mA/cm²; free chlorine dose = 0.29 mmol/min, 37.4 mA/cm²; H₂O₂ dose = 0.20 mmol/min, 45 mA/cm². Probe-compound degradation revealed that HO^•, SO^•-₄ and Fe^IVO²⁺ species were simultaneously generated in EAP, whereas HO^• and Fe^IVO²⁺ were the principal oxidants in EAHP and EAFC, resp. Samples were analyzed via liquid and gas chromatog. in non-target screening (NTS) mode to monitor the generation or removal of MTPs and byproducts including compounds that have not been reported previously. The speciation of oxidants, shifted in presence of halide ions (Cl^–, Br^–) in real wastewater samples, significantly affected the mineralization efficiency and byproduct formation. The production of halogenated byproducts in EAFC and EAP substantially increased the effluent toxicity, whereas EAHP provided non-toxic effluent and the highest mineralization efficiency (75 – 80%) to be nominated as the best strategy.

Water Research published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Recommanded Product: 2-Methyl-3-bromo-2-butanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okimoto, Mitsuhiro published the artcileElectrooxidative cyclization of hydroxy amino compounds possessing a benzyl group, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Synthesis (2012), 44(9), 1315-1322, database is CAplus.

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2-piperidinemethanols, resp., by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base.

Synthesis published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cherkasov, Rafael A. published the artcileThiophosphorylation of Pharmacophoric Phenols, Diols, and Triols, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2013), 188(1-3), 24-26, database is CAplus.

Novel organyldithiophosphonic and bis(aryldithiophosphonic) acids were obtained by the reaction of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with paracetamol, 4-(1H-pyrrol-1-yl)phenol, ethambutol dihydrochloride, vitamin B₆, and its acetonide derivatives

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shon, Jong Cheol published the artcileThe impact of phenanthrene on membrane phospholipids and its biodegradation by Sphingopyxis soli, Related Products of alcohols-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2020), 110254, database is CAplus and MEDLINE.

The direct interactions of bacterial membranes and polycyclic aromatic hydrocarbons (PAHs) strongly influence the biol. processes, such as metabolic activity and uptake of substrates due to changes in membrane lipids. However, the elucidation of adaptation mechanisms as well as membrane phospholipid alterations in the presence of phenanthrene (PHE) from α-proteobacteria has not been fully explored. This study was conducted to define the degradation efficiency of PHE by Sphingopyxis soli strain KIT-001 in a newly isolated from Jeonju river sediments and to characterize lipid profiles in the presence of PHE in comparison to cells grown on glucose using quant. lipidomic anal. This strain was able to resp. utilize 1-hydroxy-2-naphthoic acid and salicylic acid as sole carbon source and approx. 90% of PHE (50 mg/L) was rapidly degraded via naphthalene route within 1 day incubation. In the cells grown on PHE, strain KIT-001 appeared to dynamically change profiles of metabolite and lipid in comparison to cells grown on glucose. The levels of primary metabolites, phosphatidylethanolamines (PE), and phosphatidic acids (PA) were significantly decreased, whereas the levels of phosphatidylcholines (PC) and phosphatidylglycerols (PG) were significantly increased. The adaptation mechanism of Sphingopyxis sp. regarded mainly the accumulation of bilayer forming lipids and anionic lipids to adapt more quickly under restricted nutrition and toxicity condition. Hence, these findings are conceivable that strain KIT-001 has a good adaptive ability and biodegradation for PHE through the alteration of phospholipids, and will be helpful for applications for effective bioremediation of PAHs-contaminated sites.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C2H8Cl2N4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Jae Won published the artcileA Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry & Biology (Cambridge, MA, United States) (2011), 18(4), 476-484, database is CAplus and MEDLINE.

Summary: Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). We have previously shown that the hydrolytic enzyme KIAA1363 (or AADACL1) is highly elevated in aggressive cancer cells, where it plays a key role in generating the monoalkylglycerol ether (MAGE) class of NELs. Here, we use activity-based protein profiling-guided medicinal chem. to discover a highly potent and selective inhibitor of KIAA1363, the carbamate JW480. We show that JW480, and an shRNA probe that targets KIAA1363, reduce MAGEs and impair the migration, invasion, survival, and in vivo tumor growth of human prostate cancer cell lines. These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacol. probe for disrupting this pro-tumorigenic metabolic pathway.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mitsudome, Takato published the artcileSupported gold nanoparticle catalyst for the selective oxidation of silanes to silanols in water, Recommanded Product: Triisopropylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2009), 5302-5304, database is CAplus and MEDLINE.

Hydroxyapatite-supported gold nanoparticles (AuHAP) can act as highly efficient and reusable catalysts for the oxidation of diverse silanes into silanols in water; this is the first catalytic methodol. for the selective synthesis of aliphatic silanols using water under organic-solvent-free conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts