Tag: M.W=150-200

Gyorgy, Zsuzsanna published the artcileDifferentiating Thymus vulgaris chemotypes with ISSR molecular markers, HPLC of Formula: 124-76-5, the main research area is ISSR mol marker thymus vulgaris chemotype genetic diversity.

Common thyme (Thymus vulgaris L.) is a Mediterranean evergreen shrub of the Lamiaceae that shows chem. polymorphism in its natural populations. In Mediterranean habitats six basic chemotypes have been described according to the main component in its essential oil: thymol, carvacrol, linalool, geraniol, α-terpineol, thuyanol-4, of which the thymol chemotype is widely used in cultivation and as a spice. In this study ten selected clones were analyzed in terms of chem. composition of the volatile oil and genetic fingerprint. The study question was whether individual chemotypes can be distinguished by mol. markers. Chem. composition was analyzed by GC-MS, and for assessing the genetic polymorphism ISSR marker system was chosen as it is reliable and easy to use even in case of less studied species. The studied T. vulgaris clones represented five different chemotypes and could be distinguished using 12 ISSR primers. Clones belonging to the thymol chemotype showed the most distinct separation The study shows the potential of using mol. markers in breeding and selection of T. vulgaris, being able to differentiate different chemotypes.

Biochemical Systematics and Ecology published new progress about Animal breeding. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yap, Chew Pheng published the artcileMetal-free catalytic hydrogen production from a polymethylhydrosilane-water mixture, Quality Control of 17877-23-5, the publication is RSC Advances (2016), 6(7), 5903-5906, database is CAplus.

Hydrogen gas is the most promising carbon-free energy carrier although its on-demand generation remains a formidable challenge. One of the potential pathways for generating hydrogen is through hydrolytic oxidation of organosilanes. Here, we demonstrate that the hydroxide ion OH^– serves as a potent room-temperature metal-free catalyst in the hydrolytic oxidation of polymethylhydrosilane, PMHS to hydrogen gas and the corresponding silanol with a turnover number and turnover frequency in excess of 200 and 8 min^-1 resp. Kinetic studies suggest the hydrogen generation rate is first order with respect to PMHS and OH^– but zero order with respect to water. The first step of the reaction, where the Si center of PMHS is attacked by the OH^– ion, is believed to be the rate-determining step.

RSC Advances published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C12H25Br, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Igielska-Kalwat, Joanna published the artcileThe use of Dalmatian pyrethrum daisy and an excipient in the treatment of seborrheic dermatitis, Synthetic Route of 90-64-2, the publication is Acta Biochimica Polonica (2022), 69(1), 123-129, database is CAplus and MEDLINE.

The active ingredients of the Pyretrin-D trichol. cosmetic series, namely benzyl benzoate, Dalmatian pyrethrum daisy, Cistus incanus, tea tree oil and geranium oil, almond acid and arginine were tested in respect to the treatment of seborrheic dermatitis. The paper describes the application of Dalmatian pyrethrum daisy and the excipient. Methods and devices used to confirm the effectiveness of the tested formulations included the TrichoScope Polarizer Dino-Lite (MEDL4HM) and the scanning electron microscope (SEM).

Acta Biochimica Polonica published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taeufer, Tobias published the artcilePalladium-Catalyzed Synthesis of N,N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates, Product Details of C10H9NO, the publication is Journal of Organic Chemistry (2020), 85(11), 7097-7111, database is CAplus and MEDLINE.

This work delineates the synthesis of N,N-dimethylaniline derivatives from dimethylamines and aryl triflates. The palladium-catalyzed C-N bond formation proceeds in excellent yields, using an unsophisticated catalytic system, a mild base, and triflates as electrophiles, which are readily available from inexpensive phenols. N,N-Dimethylanilines are multifunctional reaction partners and represent useful but underutilized building blocks in organic synthesis.

Journal of Organic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C14H17BF2O2, Product Details of C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michnova, Hana published the artcileBioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: comparative molecular surface analysis, Product Details of C11H8O3, the publication is Molecules (2019), 24(16), 2991, database is CAplus and MEDLINE.

A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-carboxanilides was prepared and characterized as potential anti-invasive agents. The mol. structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analyzed compounds were tested against the reference strain Staphylococcus aureus and three clin. isolates of methicillin-resistant S. aureus as well as against Mycobacterium tuberculosis and M. kansasii. In addition, the inhibitory profile of photosynthetic electron transport in spinach (Spinacia oleracea L.) chloroplasts was specified. In vitro cytotoxicity of the most effective compounds was tested on the human monocytic leukemia THP-1 cell line. The activities of N-(3,5-dimethylphenyl)-, N-(3-fluoro-5-methoxy-phenyl)- and N-(3,5-dimethoxyphenyl)-1-hydroxynaphthalene-2-carbox-amide were comparable with or even better than the commonly used standards ampicillin and isoniazid. All promising compounds did not show any cytotoxic effect at the concentration >30 μM. Moreover, an in silico evaluation of clogP features was performed for the entire set of the carboxamides using a range of software lipophilicity predictors, and cross-comparison with the exptl. determined lipophilicity (log k), in consensus lipophilicity estimation, was conducted as well. Principal component anal. was employed to illustrate noticeable variations with respect to the mol. lipophilicity (theor./exptl.) and rule-of-five violations. Addnl., ligand-oriented studies for the assessment of the three-dimensional quant. structure-activity relationship profile were carried out with the comparative mol. surface anal. to determine electron and/or steric factors that potentially contribute to the biol. activities of the investigated compounds

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dias, Patricia published the artcile3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite, HPLC of Formula: 621-37-4, the publication is Nutrients (2022), 14(2), 328, database is CAplus and MEDLINE.

Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previously reported to exert vasorelaxant effects ex vivo. The aim of this study was to shed more light on this effect in vivo, and to elucidate the mechanism of action. 3-HPAA gave rise to a dose-dependent decrease in arterial blood pressure when administered i.v. both as a bolus and infusion to spontaneously hypertensive rats. In contrast, no significant changes in heart rate were observed In ex vivo experiments, where porcine hearts from a slaughterhouse were used to decrease the need for laboratory animals, 3-HPAA relaxed precontracted porcine coronary artery segments via a mechanism partially dependent on endothelium integrity. This relaxation was significantly impaired after endothelial nitric oxide synthase inhibition. In contrast, the blockade of SKCa or IKCa channels, or muscarinic receptors, did not affect 3-HPAA relaxation. Similarly, no effects of 3-HPAA on cyclooxygenase nor L-type calcium channels were observed Thus, 3-HPAA decreases blood pressure in vivo via vessel relaxation, and this mechanism might be based on the release of nitric oxide by the endothelial layer.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lowenthal, Mark S. published the artcileDeveloping qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials, HPLC of Formula: 526-98-7, the publication is Analytical and Bioanalytical Chemistry (2013), 405(13), 4451-4465, database is CAplus and MEDLINE.

Standard Reference Materials (SRMs) offer the scientific community a stable and homogeneous source of material that holds countless application possibilities. Traditionally, the National Institute of Standards and Technol. (NIST) has provided SRMs with associated quant. information (certified values) for a select group of targeted analytes as measured in a solution or complex matrix. While the current needs of the SRM community are expanding to include non-quant. data, NIST is attempting to broaden the scope of how and what information is offered to the SRM community by providing qual. information about biomaterials, such as chromatog. fingerprints and profiles of untargeted identifications. In this work, metabolomic and proteomic profiling efforts were employed to characterize a suite of six Vaccinium berry SRMs. In the discovery phase, liquid chromatog.-tandem mass spectrometry (LC-MS/MS) data was matched to mass spectral libraries; a subsequent validation phase based on multiple-reaction monitoring LC-MS/MS relied on both retention time matching of authentic standards along with fragmentation data for a qual. overview of the most prominent organic compounds present. Definitive and putative identifications were determined for over 70 metabolites based on reporting guidelines set forth by the Metabolomics Standards Initiative (Metabolomics 3(3):211-221, 2007), and the capability of electrospray ionization mass spectrometry (ESI-MS) to profile untargeted metabolites within a complex matrix using mass spectral matching is demonstrated. Bottom-up proteomic analyses were possible using peptide databases translated from expressed sequence tags (ESTs). Homol. searches provided identification of novel Vaccinium proteins based on homol. to related genera. Chromatog. fingerprints of these berry materials were acquired for supplemental qual. information to be provided to users of these SRMs. An unbounded set of qual. data about a biomaterial is a valuable complement to quant. information traditionally provided in NIST Certificates of Anal.

Analytical and Bioanalytical Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Uroz, Stephane published the artcileDual transcriptomics and proteomics analyses of the early stage of interaction between Caballeronia mineralivorans PML1(12) and mineral, Computed Properties of 526-98-7, the publication is Environmental Microbiology (2020), 22(9), 3838-3862, database is CAplus and MEDLINE.

Summary : Minerals and rocks represent essential reservoirs of nutritive elements for the long-lasting functioning of forest ecosystems developed on nutrient-poor soils. While the presence of effective mineral weathering bacteria was evidenced in the rhizosphere of different plants, the mol. mechanisms involved remain uncharacterized. To fill this gap, we combined transcriptomic, proteomics, geo-chem. and physiol. analyses to decipher the potential mol. mechanisms explaining the mineral weathering effectiveness of strain PML1(12) of Caballeronia mineralivorans. Considering the early-stage of the interaction between mineral and bacteria, we identified the genes and proteins differentially expressed when: (i) the environment is depleted of certain essential nutrients (i.e., Mg and Fe), (ii) a mineral is added and (iii) the carbon source (i.e., glucose vs mannitol) differs. The integration of these data demonstrates that strain PML1(12) is capable of (i) mobilizing iron through the production of a non-ribosomal peptide synthetase-independent siderophore, (ii) inducing chemotaxis and motility in response to nutrient availability and (iii) strongly acidifying its environment in the presence of glucose using a suite of GMC oxidoreductases to weather mineral. These results provide new insights into the mol. mechanisms involved in mineral weathering and their regulation and highlight the complex sequence of events triggered by bacteria to weather minerals.

Environmental Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sokolova, Daria published the artcileEnantioselective Tail-to-Head Terpene Cyclizations by Optically Active Hexameric Resorcin[4]arene Capsule Derivatives, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Angewandte Chemie, International Edition (2022), 61(25), e202203384, database is CAplus and MEDLINE.

Mol. capsules enabled the conversion of substrates inside a closed cavity, mimicking to some extent enzymic catalysis. Chirality transfer from the mol. capsule onto the encapsulated substrate was only studied in a few cases. Here the chirality transfer was possible inside a rather large mol. container of approx. 1400 S3 was demonstrated. Specifically, the first examples of optically active hexameric resorcin[4]arene capsules such as I [R = Et, n-Pr, n-Bu], their ability to enantioselectively catalyze tail-to-head terpene cyclizations, and the surprisingly high sensitivity of enantioselectivity on the structural modifications was presented.

Angewandte Chemie, International Edition published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C7H6O3, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kelemen, Vanja published the artcileBrown rice proteins as delivery system of phenolic and volatile compounds of raspberry juice, Related Products of alcohols-buliding-blocks, the publication is International Journal of Food Science and Technology (2022), 57(4), 1866-1874, database is CAplus.

Development of novel food ingredients with health benefits as well as desired sensory attributes is of great importance for food industry. For that purpose, complexes (BRP/R) between brown rice proteins (amounts varied; 2%, 6% and 10%) and raspberry juice were prepared Obtained complexes were evaluated for the amount of volatile compounds, phenolic content, anthocyanin content and antioxidant activity. Those parameters depended on proteins amount The highest adsorption of total phenolics and anthocyanins (18.18 mg g^-1 and 4.59 mg g^-1, resp.) was observed on complexes obtained with the lowest amount of proteins (2%). Regarding volatiles, dominant flavor note in raspberry juice was berry (40% of overall flavor), followed by citrus and woody notes (each around 18%), while dominant flavor note on complexes was citrus note (60%) followed by green note (15%). These results suggest an efficient plant-based approach to produce value-added protein-based complexes with possible utility as food colorant and flavoring.

International Journal of Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts