Tag: M.W=150-200

Hu, Huigang published the artcilePolysaccharides from pineapple pomace: new insight into ultrasonic-cellulase synergistic extraction and hypoglycemic activities, SDS of cas: 59-23-4, the main research area is Ananas polysaccharide ultrasonic cellulase extraction hypoglycemic activity; Characterization; Hypoglycemic activity; Pineapple pomace polysaccharides; Response surface methodology; Ultrasonic-cellulase extraction.

This study determined the optimal extraction conditions for ultrasonic-cellulase synergistic extraction of polysaccharides from pineapple pomace (PPP) using Plackett-Burman design and response surface methodol. The optimal hydrolysis temperature, ratio of material to water, pH value, hydrolysis time, ultrasonic power and the additive quantity of cellulase were 50 °C, 1:45 g/mL, 6.0, 100 min, 160 W and 2.0%, resp., giving a extraction yield of 1.10 ± 0.03%. PPP was further isolated and purified by DEAE-52 cellulose and Sephadex G-100 chromatog. columns, revealing four main elution peaks, named PPF0, PPF1, PPP2 and PPF3, were obtained. The mol. weight, monosaccharide compositions, structural features and appearance morphol. of polysaccharide fractions (PPFs) were analyzed by high-performance liquid chromatog. (HPLC), gel permeation chromatog. (GPC), UV spectroscopy, fourier transform IR spectroscopy (FT-IR), and SEM (SEM). Furthermore, the hypoglycemic activities of PPFs with different concentrations were also investigated by insulin resistance HepG2 cells model in vitro. Results showed that PPF0, PPF1, PPF2 and PPF3 were composed of mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, xylose, arabinose and fucose with mol. weight of 6.71 × 104, 1.11 × 104, 2.22 × 104 and 5.1 × 103 Da, resp. All of them could alleviate the development of insulin resistance HepG2 cells with a dose-dependent relationship. The glucose consumption increased 46.4%, 50.5%, 82.1% and 53.6%; 86.8%, 81.6%, 86.8% and 84.2% at the concentration of 20 μg/mL, resp., without or with insulin. These results suggested that PPFs can be explored as a potential hypoglycemic agent in biomedical and functional food.

International Journal of Biological Macromolecules published new progress about Ananas comosus. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Remigante, Alessia published the artcileD-galactose decreases anion exchange capability through band 3 protein in human erythrocytes, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is anion exchange capability D galactose band 3 protein; Band 3 protein; SO42− uptake; anion exchange; d-Galactose; glycation; oxidative stress.

D-Galactose (D-Gal), when abnormally accumulated in the plasma, results in oxidative stress production, and may alter the homeostasis of erythrocytes, which are particularly exposed to oxidants driven by the blood stream. In the present investigation, the effect of D-Gal (0.1 and 10 mM, for 3 and 24 h incubation), known to induce oxidative stress, has been assayed on human erythrocytes by determining the rate constant of SO42- uptake through the anion exchanger Band 3 protein (B3p), essential to erythrocytes homeostasis. Moreover, lipid peroxidation, membrane sulfhydryl groups oxidation, glycated Hb (% A1c), metHb levels (% MetHb), and expression levels of B3p have been verified. Our results show that D-Gal reduces anion exchange capability of B3p, involving neither lipid peroxidation, nor oxidation of sulfhydryl membrane groups, nor MetHb formation, nor altered expression levels of B3p. D-Gal-induced %A1c, known to crosslink with B3p, could be responsible for rate of anion exchange alteration. The present findings confirm that erythrocytes are a suitable model to study the impact of high sugar concentrations on cell homeostasis; show the first in vitro effect of D-Gal on B3p, contributing to the understanding of mechanisms underlying an in vitro model of aging; demonstrate that the first impact of D-Gal on B3p is mediated by early Hb glycation, rather than by oxidative stress, which may be involved on a later stage, possibly adding more knowledge about the consequences of D-Gal accumulation.

Antioxidants published new progress about Anion exchange. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rozi, Parhat published the artcileSequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk, Application In Synthesis of 59-23-4, the main research area is Fritillaria polysaccharide extraction antioxidant activity property; Antioxidant activity; Characterization; Fritillaria pallidiflora schrenk; Polysaccharide.

In this paper, Fritillaria pallidiflora schrenk polysaccharides were extracted with different methods and isolated by anion-exchange and gel-permeation chromatog. Physicochem. properties, structural characteristics and antioxidant activities were investigated for the first time. The polysaccharides composed of glucose, galactose, arabinose, xylose, mannose and rhamnose with different molar ratio and mol. weight Fourier transform IR spectroscopy and NMR anal. exhibited the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different fractions. The thermogravimetric anal. manifested the thermal stability of polysaccharides. The reducing power and antioxidant activities of polysaccharides were evaluated in vitro. Among them, the acidic fraction FPSP-H2-1 has a strong antioxidant effect against DPPH, hydroxyl and ABTS free radicals. The results revealed the polysaccharide’s important role as potential natural antioxidant agents during the investigation and application of bioactive polysaccharide.

International Journal of Biological Macromolecules published new progress about Anion exchange. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maertens, Christophe published the artcileSynthesis and characterization of end-functionalized oligo(vinylthiophenes) with liquid crystal properties, Computed Properties of 6214-45-5, the main research area is end functionalized vinylthiophene liquid crystal property.

A general scheme for the synthesis of end-functionalized conjugated (E)-vinylthiophene oligomers with liquid crystal and potential 2nd-order nonlinear optical properties is described. These push-pull thiophene-containing aromatic mols. show mesogenic properties over different temperature ranges depending on the chain length and the functional end-groups.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johansson, Gary published the artcileMolecular recognition directed self-assembly of tubular liquid crystalline and crystalline supramolecular architectures from Taper Shaped (15-crown-5)methyl 3,4,5-tris(p-alkyloxybenzyloxy)benzoates and (15-crown-5)methyl 3,4,5-tris(p-dodecyloxy)benzoate, Computed Properties of 6214-45-5, the main research area is crown ether hydroxymethyl benzoate derivative; liquid crystalline hydroxymethyl crown benzoate; supramol architecture hydroxymethyl crown benzoate; mol recognition hydroxymethyl crown benzoate.

The syntheses and characterization of title crown ether derivatives I [R = p-Me(CH2)nOC6H4CH2, where n = 3, 5, or 11 (27); R = Me(CH2)11 (28)] are described. Complexation of the crown ether endo-receptor with CF3SO3Na destabilizes the crystalline phase of I and induces for the case of 27 and 28 the self-assembly of a supramol. cylindrical channel-like architecture which displays a thermotropic hexagonal columnar (Φh) mesophase. Most remarkably, in the crystalline phase of the complexes of 27 with CF3SO3Na the cylindrical structure of the Φh mesophase is maintained. Characterization of these supramol. architectures was performed by a combination of differential scanning calorimetry, thermal optical polarized microscopy, X-ray scattering and mol. modeling. A model is proposed in which a stratum of the column is formed by six mols. of 27 and 28 with the crown ether receptors residing in the column center and the alkyl tails radiating toward the column periphery. Endo-Recognition generated via the (15-crown-5)methyl receptor upon complexation, and exo-recognition provided by the tapered 3,4,5-tris(p-dodecyloxybenzyloxy)benzoate and 3,4,5-tris(p-dodecyloxy)benzoate fragments of 27 and 28 provide the driving force for the self-assembly of this cylindrical supramol.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verhertbruggen, Yves published the artcileChallenging the putative structure of mannan in wheat (Triticum aestivum) endosperm, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Triticum endosperm mannan; Cell wall; Cereal; Grain; Hemicellulose; Mannan; Mannose.

In wheat endosperm, mannan, is poorly documented. Nevertheless, this hemicellulosic polysaccharide might have a determinant role in wheat grain development since, in Arabidopsis thaliana, mutants with a reduced amount of mannan show an altered seed development. In order to gain knowledge about mannan in wheat, we have determined its biochem. structure in wheat endosperm where mannose content is about 0.2% (dry weight basis). We developed a method of enzymic fingerprinting and isolated mannan-enriched fractions to decipher its fine structure. Although it is widely accepted that the class of mannan present in grass cell walls is glucomannan, our data indicate that, in wheat endosperm, this hemicellulose is only represented by short unsubstituted chains of 1,4 linked D-mannose residues and is slightly acetylated. Our study provides information regarding the interactions of mannan with other cell wall components and help to progress towards the understanding of monocot cell wall architecture and the mannan synthesis in wheat endosperm.

Carbohydrate Polymers published new progress about Seed, endosperm. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Misselwitz, Benjamin published the artcileUpdate on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management, Computed Properties of 59-23-4, the main research area is lactose malabsorption intolerance pathogenesis diagnosis; diet; functional bowel disorder; hydrogen breath tests; lactase; malabsorption.

Lactose is the main source of calories in milk, an essential nutriedigestion, patients with visceral hypersensitivity nt in infancy and a key part of the diet in populations that maintain the ability to digest this disaccharide in adulthood. Lactase deficiency (LD) is the failure to express the enzyme that hydrolyzes lactose into galactose and glucose in the small intestine. The genetic mechanism of lactase persistence in adult Caucasians is mediated by a single C→T nucleotide polymorphism at the LCTbo -13’910 locus on chromosome-2. Lactose malabsorption (LM) refers to any cause of failure to digest and/or absorb lactose in the small intestine. This includes primary genetic and also secondary LD due to infection or other conditions that affect the mucosal integrity of the small bowel. Lactose intolerance (LI) is defined as the onset of abdominal symptoms such as abdominal pain, bloating and diarrhea after lactose ingestion by an individual with LM. The likelihood of LI depends on the lactose dose, lactase expression and the intestinal microbiome. Independent of lactose digestion, patients with visceral hypersensitivity associated with anxiety or the Irritable Bowel Syndrome (IBS) are at increased risk of the condition. Diagnostic investigations available to diagnose LM and LI include genetic, endoscopic and physiol. tests. The association between self-reported LI, objective findings and clin. outcome of dietary intervention is variable. Treatment of LI can include low-lactose diet, lactase supplementation and, potentially, colonic adaptation by prebiotics. The clin. outcome of these treatments is modest, because lactose is just one of a number of poorly absorbed carbohydrates which can cause symptoms by similar mechanisms.

Gut published new progress about Abdominal pain. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Brijesh published the artcileIn Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19, Application In Synthesis of 124-76-5, the main research area is COVID traditional Indian spices antiviral effect; 6LXT; 6YNQ; 6YOR; COVID-19; isovitexin; myricetin; spices.; spike protein.

The global health emergency due to SARS-CoV-2 causing the COVID-19 pandemic emphasized the scientific community to intensify their research work for its therapeutic solution In this study, Indian traditional spices owing to various medicinal properties were tested in silico for their inhibitory activity against SARS-CoV-2 proteins. SARS-CoV-2 spike proteins (SP) and main proteases (Mpro) play a significant role in infection development were considered as potential drug targets. A total of 75 phytochems. present in traditional Indian spices retrieved from the published literature and Dr. Duke’s Phytochem. and Ethnobotanical Database, were docked with Mpro (PDB IDs: 6YNQ), and the SP (PDB IDs: 6LXT and 6YOR). Through the screening process, 75 retrieved phytochems. were docked with spike protein (PDB IDs: 6LXT and 6YOR) and main protease (PDB ID: 6YNQ) of SARS-CoV-2. Among them, myricetin, a flavonoid (rank score: 6LXT: -11.72383; 6YOR: -9.87943; 6YNQ: -11.68164) from Allium sativum L and Isovitexin, an example of flavone (rank score: 6LXT: -12.14922; 6YOR: -10.19443; 6YNQ: -12.60603) from Pimpinella anisumL were the most potent ligands against SP and Mpro of SARS-CoV-2. Whereas, Astragalin from Crocus sativus L.; Rutin from Illicium verum, Oxyguttiferone from Garcinia cambogia; Scopolin from Apium graveolens L, Luteolin from Salvia officinalis, Emodin, Aloe-emodin from Cinnamomum zeylanicium and Apigenin from Allium sativum L showed better inhibition against Mpro than SP of SARS-CoV-2. The amino acid residues like SER, LYS, ASP and TYR were found playing important role in protein-ligand interactions via hydrogen bonding and Vander Waals forces. Optimal use of traditional spices in our daily meals may help fight against COVID-19. This study also paves the path for herbal drug formulation against SARS-CoV-2 after wet lab validation.

Current Pharmaceutical Design published new progress about Acorus calamus. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Ding-Tao published the artcileIn vitro simulated digestion and fecal fermentation of polysaccharides from loquat leaves: Dynamic changes in physicochemical properties and impacts on human gut microbiota, Category: alcohols-buliding-blocks, the main research area is loquat leaf polysaccharide fecal fermentation digestion gut microbiota human; Fecal fermentation; Gut microbiota; Loquat polysaccharides; Structural characteristic; in vitro digestion.

The aim of this study was to well understand the dynamic changes of physicochem. properties of polysaccharides from loquat leaves (LLP) during in vitro simulated saliva-gastrointestinal digestion and fecal fermentation and its related impacts on human gut microbiota. Results showed that the contents of reducing sugar of LLP slightly increased during the gastrointestinal digestion, and its mol. weight also slightly decreased, suggesting that LLP could be slightly degraded under the gastrointestinal digestion conditions. Moreover, during the fecal fermentation, the mol. weight of the indigestible LLP (LLP-I) significantly decreased, and the molar ratio of constituent monosaccharides of LLP-I, such as glucuronic acid, galacturonic acid, galactose, and arabinose, significantly changed, indicating that LLP-I could be degraded and consumed by human gut microbiota. Indeed, some beneficial bacteria such as Megasphaera, Megamonas, Bifidobacterium, Phascolarctobacterium, and Desulfovibrio significantly increased, suggesting that LLP-I could change the composition and abundance of gut microbiota. LLP-I could also promote the production of health-promoting short chain fatty acids. Results from this study are benefical to well understand the in vitro digestion and fecal fermentation behaviors of LLP, and LLP can be developed as a potential prebiotic in the functional food industry.

International Journal of Biological Macromolecules published new progress about Actinobacteria. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arulprakasam, Karthick Raja published the artcileGenome mining of biosynthetic gene clusters intended for secondary metabolites conservation in actinobacteria, Category: alcohols-buliding-blocks, the main research area is genome mining secondary metabolite actinobacteria; Anti-microbial resistance; Biosynthetic gene cluster; Genome mining; Non-ribosomal peptide synthetases; Polyketide synthases; Secondary metabolites.

Evolution of genome sequencing technol., on the one hand, and advancement of computational genome mining tools, on the other hand, paves way for improvement in predicting secondary metabolites. In past, numerous efforts were made concerning genome mining for recognizing secondary metabolites within the genus, but only a negligible quantity of comparative genomic reports had carried out among species of different genera. In this study, we explored potential of 24 actinobacteria species belonging to the genera, including Streptomyces, Nocardia, Micromonospora, and Saccharomonospora, to traverse diversity and distribution of Biosynthetic Gene Clusters (BGCs). Investigating results obtained from antiSMASH (Antibiotics and Secondary Metabolites Anal. Shell), NaPDoS (Natural Product Domain Seeker), and NP.searcher revealed conservation of genus-specific gene clusters among various species. E.g., NAGGN (n-acetyl glutaminyl glutamine amide) is present in Micromonospora, furan in Nocardia, melanin, and lassopeptide occur in Streptomyces. Bioactive compounds like alkyl-O-dihydro geranyl methoxy hydroquinone, SapB, desferrioxamine E, 2-Methylisoborneol, mayamycin, cyclodipeptide synthase, diisonitrile, salinichelin, hopene, ectoine and isorenieratene are highly conserved among diverse genera. Furthermore, pharmacol. activity of actinobacterial derived metabolites against bacterial and fungal pathogens were illustrated. We need to accomplish large-scale anal. of natural products, including various genera of actinobacteria to deliver comprehensive intuition to overcome antibiotic resistance.

Microbial Pathogenesis published new progress about Actinobacteria. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts