Tag: M.W=150-200

Yang, Zhongzhou; Li, Yueqing; Gao, Fengzhan; Jin, Wei; Li, Shuying; Kimani, Shadrack; Yang, Song; Bao, Tingting; Gao, Xiang; Wang, Li published the artcile< MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flwers of Freesia hybrida and Arabidopsis thaliana>, SDS of cas: 78-70-6, the main research area is terpene synthase gene Freesia hybrida Arabidopsis thaliana MYB21 MYC2; Freesia hybrida ; Arabidopsis; MYB–bHLH complex; flower scents; linalool; terpene synthase; transcription factor.

Previously, linalool was found to be the most abundant component among the cocktail of volatiles released from flwers of Freesia hybrida. Linalool formation is catalyzed by monoterpene synthase TPS1. However, the regulatory network developmentally modulating the expression of the TPS1 gene in Freesia hybrida remains unexplored. In this study, three regulatory genes, FhMYB21L1, FhMYB21L2, and FhMYC2, were screened from 52 candidates. Two MYB transcription factor genes were synchronously expressed with FhTPS1 and could activate its expression significantly when overexpressed, and the binding of FhMYB21L2 to the MYBCORE sites in the FhTPS1 promoter was further con firmed, indicating a direct role in activation. FhMYC2 showed an inverse expression pattern compared with FhTPS1; its expression led to a decreased binding of FhMYB21 to the FhTPS1 promoter to reduce its activation capacity when co-expressed, suggesting a role for an MYB-bHLH complex in the regulation of the FhTPS1 gene. In Arabidopsis, both MYB21 and MYC2 regulators were shown to activate the expression of sesquiterpene synthase genes, and the regu latory roles of AtMYB21 and AtMYC2 in the expression of the linalool synthase gene were also confirmed, implying conserved functions of the MYB-bHLH complex in these two evolutionarily divergent plants. Moreover, the expression ratio between MYB21 and MYC2 orthologues might be a determinant factor in floral linalool emission.

Journal of Experimental Botany published new progress about Arabidopsis thaliana. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jian; Li, Hui; Fang, Daqing; Liu, Lingjun; Han, Xu; Sun, Jina; Li, Chunpu; Zhou, Yu; Ye, Deju; Liu, Hong published the artcile< Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines>, Product Details of C8H10OS, the main research area is fused tetracyclic indeno benzothiazine preparation; sulfoximide diazo indandione carbon hydrogen activation intramol annulation cascade.

A facile access to highly fused tetracyclic indeno-1,2-benzothiazines has been established via a Rh(III)-catalyzed C-H bond activation and intramol. annulation cascade between sulfoximides and all-carbon diazo indandiones. This strategy is characterized by the fact that the diazo coupling partners do not require preactivation, along with its high efficiency, broad substrate generality, and facile transformation. Particularly, the highly conjugated tetracyclic products demonstrate good optical properties and can easily enter cells to emit bright fluorescence for live cell imaging.

Journal of Organic Chemistry published new progress about Benzothiazines Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takeuchi, Hironori; Fujimori, Yusuke; Ueda, Yoshihiro; Shibayama, Hiromitsu; Nagaishi, Masaru; Yoshimura, Tomoyuki; Sasamori, Takahiro; Tokitoh, Norihiro; Furuta, Takumi; Kawabata, Takeo published the artcile< Solvent-Dependent Mechanism and Stereochemistry of Mitsunobu Glycosylation with Unprotected Pyranoses>, Application of C6H12O6, the main research area is unprotected pyranose stereoselective Mitsunobu glycosylation mechanism solvent effect.

An SN2 mechanism was proposed for highly stereoselective glycosylation of benzoic acid with unprotected α-D-glucose under Mitsunobu conditions in dioxane, while an SN1 mechanism was indicated for nonstereoselective glycosylation in DMF. The SN2-type stereoselective Mitsunobu glycosylation is generally applicable to various unprotected pyranoses as glycosyl donors in combination with a wide range of acidic glycosyl acceptors such as carboxylic acids, phenols, and imides, retaining its high stereoselectivity (33 examples). Glycosylation of a carboxylic acid with unprotected α-D-mannose proceeded also in an SN2 manner to directly afford a usually less accessible 1,2-cis-mannoside. One- or two-step total syntheses of five simple natural glycosides were performed using the glycosylation strategy presented here using unprotected α-D-glucose.

Organic Letters published new progress about Absolute configuration. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghorbani-Choghamarani, Arash; Sahraei, Rokhsareh; Taherinia, Zahra; Mohammadi, Masoud published the artcile< Cu(I)@Isatin-Glycine-Boehmite nanoparticles: as novel heterogeneous catalyst for the synthesis and selective oxidation of sulfides>, Application of C8H10OS, the main research area is copper immobilized modified boehmite nanoparticle preparation thermal stability; haloarene thiourea copper nanocatalyst cross coupling reaction green chem; diaryl sulfide preparation; thioether hydrogen peroxide copper nanocatalyst oxidation green chem; sulfoxide preparation.

This work presented the synthesis of Cu (I) immobilized on modified boehmite nanoparticles as an environmentally friendly heterogeneous catalyst for the synthesis of sulfides and their oxidation to the corresponding sulfoxides in good to excellent yields. The structure of the catalyst was studied by SEM, X-ray diffraction, thermogravimetric, inductively coupled plasma at. emission spectroscopy, and Brunauer-Emmett-Teller techniques. The use of this heterogeneous nanocatalyst in mentioned organic reactions allowed achieving good results such as the excellent stability, high efficiency, low cost, easy recovery, and reusability of catalyst for four continuous cycles.

Journal of the Iranian Chemical Society published new progress about Cross-coupling reaction. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tran, Duc N.; Cramer, Nicolai published the artcile< Biomimetic Synthesis of (+)-Ledene, (+)-Viridiflorol, (-)-Palustrol, (+)-Spathulenol, and Psiguadial A, C, and D via the Platform Terpene (+)-Bicyclogermacrene>, Quality Control of 4396-13-8, the main research area is biomimetic synthesis ledene viridiflorol palustrol spathulenol psiguadial ACD sesquiterpene; bicyclogermacrene enantioselective synthesis; bicyclogermacrene; biomimetic synthesis; cyclization; natural products; terpenes.

(+)-Bicyclogermacrene (I) is a strained bicyclic and common sesquiterpene found in several essential oils. A short and good yielding synthesis of bicyclogermacrene proceeding in seven steps is reported. This terpene is used as key platform intermediate for a biomimetic access to several aromadendrene sesquiterpenoids, such as ledene, viridiflorol, palustrol, and spathulenol. Furthermore, bicyclogermacrene is shown to be the terpene component in the synthesis of the meroterpenoids psiguadial A, C, and D.

Chemistry – A European Journal published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; Antti, Henrik; Iglesias-Gato, Diego; Flores-Morales, Amilcar; Bergh, Anders; Wikstroem, Pernilla; Groebner, Gerhard published the artcile< Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status>, Category: alcohols-buliding-blocks, the main research area is proteome metabolome TMPRSS2 ERG phosphocholine hypoxanthine prostate cancer progression; 1H HRMAS NMR; Gleason score; Metabolomics; Prostate cancer; TMPRSS2-ERG.

Abstract: Background: Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic mols. is of fundamental importance for developing more effective therapies and diagnostics. Here, we carried out an extensive anal. of prostate tissue samples to reveal metabolic alterations during PC development and disease progression and furthermore between TMPRSS2-ERG rearrangement-pos. and -neg. PC subclasses. Methods: Comprehensive metabolomics anal. of prostate tissue samples was performed by non-destructive high-resolution magic angle spinning NMR (1H HR MAS NMR). Subsequently, samples underwent moderate extraction, leaving tissue morphol. intact for histopathol. characterization. Metabolites in tissue extracts were identified by 1H/31P NMR and liquid chromatog.-mass spectrometry (LC-MS). These metabolomics profiles were analyzed by chemometric tools and the outcome was further validated using proteomic data from a sep. sample cohort. Results: The obtained metabolite patterns significantly differed between PC and benign tissue and between samples with high and low Gleason score (GS). Five key metabolites (phosphocholine, glutamate, hypoxanthine, arginine and α-glucose) were identified, who were sufficient to differentiate between cancer and benign tissue and between high to low GS. In ERG-pos. PC, the anal. revealed several acylcarnitines among the increased metabolites together with decreased levels of proteins involved in β-oxidation; indicating decreased acyl-CoAs oxidation in ERG-pos. tumors. The ERG-pos. group also showed increased levels of metabolites and proteins involved in purine catabolism; a potential sign of increased DNA damage and oxidative stress. Conclusions: Our comprehensive metabolomic anal. strongly indicates that ERG-pos. PC and ERG-neg. PC should be considered as different subtypes of PC; a fact requiring different, sub-type specific treatment strategies for affected patients.

BMC Cancer published new progress about Acylcarnitines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jianfei; Huang, Jiaqi; Guo, Huanyu; Jiang, Shaoming; Zhang, Jing; Ning, Yuchen; Fang, Mudannan; Liu, Shijie published the artcile< Optimization of immobilization conditions for Lactobacillus penntosus cells>, Product Details of C6H12O6, the main research area is immobilization lactic acid fermentation Lactobacillus penntosus; Fermentation; Immobilization; Lactic acid; Lactobacillus pentosus.

Abstract: In this study, the immobilization technol. was used to improve the LA yield and shorten the fermentation time. The optimum conditions to immobilize Lactobacillus pentosus ATCC 8041 cell were determined by Taguchi design L16 (45). The immobilized L. pentosus ATCC 8041 cells prepared by 2% sodium alginate (SA) and 6% polyvinyl alc. (PVA) with the immobilization process by 0.10 M calcium chloride (CaCl2) and 2.5% boric acid (H3BO3) had the best performance of LA yield at the temperature of 35°C, which is significantly higher than that of L. pentosus ATCC 8041 free cells. These cells maintained the stable and efficient performance in 15 repeated batch fermentation, and they also have excellent mech. strength to keep from breakage caused by cell growth and agitation.

Bioprocess and Biosystems Engineering published new progress about Fermentation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghlissi, Zohra; Kallel, Rim; Krichen, Fatma; Hakim, Ahmed; Zeghal, Khaled; Boudawara, Tahiya; Bougatef, Ali; Sahnoun, Zouheir published the artcile< Polysaccharide from Pimpinella anisum seeds: Structural characterization, anti-inflammatory and laser burn wound healing in mice>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Staphylococcus Pimpinella laser burn wound healing seed polysaccharide antiinflammatory; Anti-inflammatory activity; Laser burn; Pimpinella anisum; Polysaccharide; Wound healing.

The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated and characterized to evaluate its laser burn wound-healing and anti-inflammatory activities in mice. The structure characterization of PAP by Infra-red spectrometry (IR), NMR (NMR), Gas chromatogram-Mass spectrometer (GC-MS) and colorimetric methods revealed an optimum yield of 8.84%, a high quantity of carbohydrate (64.75%) and low levels of lipids, protein and sulfate. Galactose (33.47%), β-D-Glucose (26.71%) and a-D-Mannose (18.21%) were the major monosaccharides components presenting in PAP, and a smaller amounts of β-D-Galactose, D-Fructose, a-D-Glucose, a-L-Galactose and arabinose were detected. PAP showed noticeable antioxidant and antibacterial properties. The anti-inflammatory activity of PAP in the carrageenan-induced paw edema model in mice, demonstrated by reduced edema and cellular infiltration, and oxidative stress markers in muscle tissue. A beneficial wound healing effect was also revealed. The topical application of PAP based gel on laser burn lesions accelerates wound contraction, the re-epithelization and remodeling phases after seven days of treatment. The results demonstrated that PAP is a novel promising source of natural wound healing and anti-inflammatory drugs. The high content and varied PAP monosaccharides seem to be responsible for the observed biol. activities.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Klare, Juliane; Rurik, Marc; Rottmann, Eric; Bollen, Anke; Kohlbacher, Oliver; Fischer, Markus; Hackl, Thomas published the artcile< Determination of the Geographical Origin of Asparagus officinalis L. by 1H NMR Spectroscopy>, Computed Properties of 492-62-6, the main research area is Asparagus geog NMR spectroscopy; NMR; asparagus; food fraud; geographical origin; support vector machine.

Food authenticity concerning the geog. origin becomes increasingly important for consumers, food industries, and food authorities. In this study, nontargeted1H NMR metabolomics combined with machine learning methodologies was applied to successfully distinguish the geog. origin of 237 samples of white asparagus from Germany, Poland, The Netherlands, Spain, Greece, and Peru. Support vector classification of the geog. origin achieved an accuracy of 91.5% for the entire sample set and 87.8% after undersampling the majority class. Important regions of the spectra could be identified and assigned to potential chem. markers. A subset of samples was compared to isotope-ratio mass spectrometry (IRMS), an established method for the determination of origin of white asparagus in Germany. Here, SVM classification led to accuracies of 79.4% for NMR and 70.9% for IRMS. Finally, the classification of asparagus from different German regions was evaluated, and the influence of year and variety was analyzed.

Journal of Agricultural and Food Chemistry published new progress about Asparagus. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Nifei; Zhang, Xiaojun; Wang, Shaowei; Guo, Qingbin; Li, Zhenjing; Liu, Huanhuan; Wang, Changlu published the artcile< Structural characterisation and immunomodulatory activity of polysaccharides from white asparagus skin>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is immunomodulatory polysaccharide asparagus skin; Immunomodulatory; NMR; Pectin; Polysaccharide; Structure; White asparagus skin.

The physicochem. properties, structural features and immunomodulatory effects of the white asparagus (Asparagus officinalis L.) skin polysaccharides (WASP) were systematically studied. WASP showed a pectic-like structure with a relatively low degree of esterification (DE, 18%); the weight-average mol. weight (Mw) and intrinsic viscosity were 76.1 kDa and 13 mL/g, resp. Structurally, the dominated sugar residue of WASP was 4-α-D-GalpA (39.7 mol%), while other residues including α-L-Araf, 3-α-L-Rhap, 2,4-α-L-Rhap, and 4-β-D-Galp were also detected with a comparable amount A proposed structure of WASP was also presented. Physiol., WASP could modulate the immune response of RAW 264.7 macrophages through increasing the release of immune factors (IL-6, TNF-α and IL-10) and improving the expression of mRNA. To conclude, the pectic-like polysaccharides from white asparagus (Asparagus officinalis L.) skin could be potentially used as an immunomodulatory agent in functional food.

Carbohydrate Polymers published new progress about Asparagus (white). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts