Tag: M.W=150-200

Ghorbani-Choghamarani, Arash; Moradi, Parisa; Tahmasbi, Bahman published the artcile< Nickel(II) immobilized on dithizone-boehmite nanoparticles: as a highly efficient and recyclable nanocatalyst for the synthesis of polyhydroquinolines and sulfoxidation reaction>, Related Products of 699-12-7, the main research area is polyhydroquinoline sulfoxidation reaction nickel dithizone boehmite nanoparticle.

In this work, in the first stage, boehmite nanoparticles were easily fabricated via addition of NaOH solution to a solution of Al(NO3)3.9H2O at room temperature in water. Then, nickel-dithizone catalyst was supported on boehmite nanoparticles (Ni-dithizone@boehmite). Ni-dithizone@boehmite is a low-cost, nontoxic, and recoverable catalyst, which provides an environment friendly reaction conditions. In the second stage, catalytic activity of this catalyst was studied in the synthesis of polyhydroquinoline derivatives and selective oxidation of sulfides to sulfoxides. The reactions not require very high temperatures or inert atm. The developed heterogeneous catalyst could be easily separated by centrifugation and recycled for several runs without leaching of Nickel from the surface of the catalyst or significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Nanocatalysts. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Related Products of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Libo; Li, Tengfei; Liu, Fangcheng; Liu, Dawei; Xu, Yaqin; Yang, Yu; Zhao, Yanbo; Wei, He published the artcile< Ultrasonic-assisted enzymatic extraction and characterization of polysaccharides from dandelion (Taraxacum officinale) leaves>, Computed Properties of 3458-28-4, the main research area is polysaccharide ultrasonic enzymic extraction leaf Taraxacum; Dandelion; Polysaccharides; Simulated digestion; Structural characterization; Ultrasonic-assisted enzymatic extraction.

Ultrasonic-assisted enzymic extraction (UAEE) technol. was employed to extract the polysaccharides from dandelion leaves (DLP). The extraction conditions were optimized by response surface method (RSM) and Box-Behnken design (BBD). The polysaccharide yield (14.05 ± 0.95%), which well matched with the predicted value of 14.27%, was obtained under the optimum parameters: ultrasound power 500 W, ultrasound time 42 min, cellulase amount 4.90%, and particle size 80 mesh. After purification by AB-8 Macroporous Resin and Sephadex G-100 column, a novel polysaccharide (DLP-I) was isolated and its mol. weight was estimated to be 87,000 g/mol by high performance liquid chromatog. (HPLC). Gas chromatog. (GC) anal. showed that DLP-I was composed of rhamnose, arabinose, mannose, galactose and glucose in the molar ratio of 1.14:1.00:1.05:4.76:1.52. 1D and 2D NMR spectra confirmed that the backbone of DLP-I was mainly consisted of →4)-α-D-Galp-(1→, →4)-β-D-Manp-(1→, →4)-α-D-Glcp-(1→, →2,4)-α-L-Rhap-(1→, and α-L-Araf-(1→ with branching at O-2 and O-4 of →2,4)-α-L-Rhap-(1→. In addition, the digestion results showed DLP-I could keep its stability during the simulated digestive juices.

International Journal of Biological Macromolecules published new progress about Food processing. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Rossi, Charles; Bambino, Kathryn; Morrison, Joshua; Sakarin, Isabel; Villacorta-Martin, Carlos; Zhang, Changwen; Ellis, Jillian L.; Fiel, M. Isabel; Ybanez, Maria; Lee, Youngmin A.; Huang, Kuan-lin; Yin, Chunyue; Sakaguchi, Takuya F.; Friedman, Scott L.; Villanueva, Augusto; Chu, Jaime published the artcile< Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans>, Product Details of C6H12O6, the main research area is fibrosis hepatic stellate cell mannose phosphate isomerase.

The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis led us to explore the function of MPI and mannose metabolism in liver development and adult liver diseases. Herein, analyses of transcriptomic data from three human liver cohorts demonstrate that MPI gene expression is down-regulated proportionate to fibrosis in chronic liver diseases, including nonalcoholic fatty liver disease and hepatitis B virus. Depletion of MPI in zebrafish liver in vivo and in human hepatic stellate cell (HSC) lines in culture activates fibrotic responses, indicating that loss of MPI promotes HSC activation. We further demonstrate that mannose supplementation can attenuate HSC activation, leading to reduced fibrogenic activation in zebrafish, culture-activated HSCs, and in ethanol-activated HSCs. Conclusion: These data indicate the prospect that modulation of mannose metabolism pathways could reduce HSC activation and improve hepatic fibrosis.

Hepatology (Hoboken, NJ, United States) published new progress about Animal gene, COL1A1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cho, Soon Ok; Lim, Joo Weon; Kim, Hyeyoung published the artcile< Oxidative stress induces apoptosis via calpain- and caspase-3-mediated cleavage of ATM in pancreatic acinar cells>, HPLC of Formula: 492-62-6, the main research area is calpain caspase ATM pancreatic acinar cell oxidative stress apoptosis; Ataxia telangiectasia mutated; calpain; caspase-3; glucose/glucose oxidase; pancreatic acinar cells.

Oxidative stress-induced DNA cleavage and apoptosis in pancreatic acinar cells has been implicated in the pathogenesis of acute pancreatitis. Thus, an efficient DNA repair process is key to prevention of apoptotic pancreatic acinar cell death. Ataxia telangiectasia mutated (ATM), a sensor of DNA breaks, functions by recruiting DNA repair proteins to initiate the DNA repair process. In the present study, we investigated whether H2O2 produced by the action of glucose oxidase on α-D-glucose (G/GO) induces apoptosis in pancreatic acinar AR42J cells through an alteration of the level of ATM. As a result, G/GO induced apoptosis by promoting a loss of cell viability, increase in Bax, decrease in Bcl-2, cleavage of poly (ADP-ribose) polymerase (PARP) and fragmentation of DNA. In addition, ATM cleavage along with elevated levels of calpain and caspase-3 activity was induced by G/GO. By using ATM siRNA, we demonstrated that reduction in ATM levels enhanced G/GO-induced apoptosis. Moreover, inhibition of calpain activity by calpeptin or calpastatin, or by inhibition of caspase-3 with z-DEVD, suppressed G/GO-induced apoptosis and ATM cleavage. Collectively, these findings suggest that proteolysis of ATM is the underlying mechanism of apoptosis of pancreatic acinar cells caused by exposure to oxidative stress.

Free Radical Research published new progress about Actins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tamoradi, Taiebeh; Ghorbani-Choghamarani, Arash; Ghadermazi, Mohammad published the artcile< Immobilization of Pd(0) complex on the surface of SBA-15: A reusable catalyst for the synthesis of 5-substituted tetrazoles, sulfides and sulfoxides>, Product Details of C8H10OS, the main research area is tetrazole preparation sulfide sulfoxide preparation palladium complex catalyst.

A simple and efficient method for the synthesis of 5-substituted tetrazoles, sulfides and sulfoxides in the presence of Pd(0) complex immobilized on mesoporous SBA-15 as an efficient, recoverable and thermally stable mesostructure was reported. Also, the prepared mesostructure was characterized by Fourier transform IR spectroscopy, SEM, x-ray mapping, energy-dispersive x-ray spectroscopy, N2 adsorption and desorption, inductively coupled plasma optical emission spectroscopy and thermal gravimetric anal. Then, this mesostructured catalyst was applied in the synthesis of 5-substituted tetrazoles, sulfides and sulfoxides. The approach described here offers advantages such as short reaction times, high yield, purity yields, simple and eco- friendly, easy work-up. More importantly, this nanohybrid robust catalyst did not undergo metal leaching and applied several times without any decrease in catalytic activity.

Polyhedron published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Lanting; Xiao, Yangyang; Zhou, Xiaochen; Yu, Jizhong; Jian, Guotai; Li, Jianlong; Chen, Jiaming; Tang, Jinchi; Yang, Ziyin published the artcile< Uncovering reasons for differential accumulation of linalool in tea cultivars with different leaf area>, Application In Synthesis of 78-70-6, the main research area is Camellia Tea Aroma Linalool oxide Leaf; Aroma; Camellia sinensis; Geranyl pyrophosphate (PubChem CID: 44134732).; Leaf area; Linalool; Linalool (PubChem CID: 6549); Linalool oxide; Tea; cis-linalool oxide (furaniod) (PubChem CID: 6428573); trans-linalool oxide (furaniod) (PubChem CID: 6431475).

It is generally proposed that tea cultivars with larger leaves contain more linalool, an important tea aroma contributor, than ones with smaller leaves. The objective of this study was to confirm the trait and explore the involved reason. Investigation on ten tea cultivars with different leaf areas demonstrated a significant pos. correlation between linalool content and leaf area (R2 = 0.739, p = 0.010). Anal. of metabolite and gene expression level showed that the transform ability of linalool into linalool oxides was the key factor. Feeding experiments that supplied tea leaves of different leaf areas with [2H3]linalool under different light conditions revealed that the larger tea leaves receive more light and are less capable of transformation of linalool to linalool oxides, thus leading to linalool accumulation. This information will advance understanding of the variation of linalool content in tea varieties and will provide assistance in breeding and screening of high-linalool tea cultivars.

Food Chemistry published new progress about Camellia sinensis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhari, Anand Kumar; Singh, Vipin Kumar; Dwivedy, Abhishek Kumar; Das, Somenath; Upadhyay, Neha; Singh, Akanksha; Dkhar, Mumtaz S.; Kayang, Highland; Prakash, Bhanu; Dubey, Nawal Kishore published the artcile< Chemically characterized Pimenta dioica (L.) Merr. essential oil as a novel plant based antimicrobial against fungal and aflatoxin B1 contamination of stored maize and its possible mode of action>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Pimenta essential oil antimicrobial agent maize aflatoxin B1 contamination; Pimenta dioica essential oil; aflatoxin B1; ergosterol; lipid peroxidation; methylglyoxal; α-Terpineol.

The chem. characterization of P. dioica essential oil (PDEO) revealed the presence of 50 components, among which α-terpineol (30.31%) was the major component followed by β-linalool (6.75%) and γ-terpinene (4.64%). The oil completely inhibited the growth of aflatoxin B1-secreting strain Aspergillus flavus LHP-VS-8, and aflatoxin B1 production at 2.5 and 1.5μL/mL, resp. The oil caused dose-dependent reduction of methylglyoxal (an AFB1 inducer), enhanced leakage of Ca2+, Mg2+ and K+ ions, and significantly reduced the ergosterol content of the fungal plasma membrane. During in situ experiments, PDEO exhibited complete protection of fumigated maize cob slices from fungal infestation without affecting seed germination. The chem. characterized PDEO is recommended as a plant based preservative and shelf life enhancer of food commodities by preventing fungal growth, AFB1 production and lipid peroxidation This is the 1st report on PDEO as inhibitor of AFB1 secretion, and methylglyoxal biosynthesis.

Natural Product Research published new progress about Aspergillus flavus. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hao; Zhou, Musen; Sebastian, Jessalyn; Wu, Jianzhong; Gu, Mengyang published the artcile< Efficient force field and energy emulation through partition of permutationally equivalent atoms>, HPLC of Formula: 492-62-6, the main research area is efficient force field energy emulation partition permutationally equivalent atom.

Gaussian process (GP) emulator has been used as a surrogate model for predicting force field and mol. potential, to overcome the computational bottleneck of ab initio mol. dynamics simulation. Integrating both at. force and energy in predictions was found to be more accurate than using energy alone, yet it requires O((NM)3) computational operations for computing the likelihood function and making predictions, where N is the number of atoms and M is the number of simulated configurations in the training sample due to the inversion of a large covariance matrix. The high computational cost limits its applications to the simulation of small mols. The computational challenge of using both gradient information and function values in GPs was recently noticed in machine learning communities, whereas conventional approximation methods may not work well. Here, we introduce a new approach, the atomized force field model, that integrates both force and energy in the emulator with many fewer computational operations. The drastic reduction in computation is achieved by utilizing the naturally sparse covariance structure that satisfies the constraints of the energy conservation and permutation symmetry of atoms. The efficient machine learning algorithm extends the limits of its applications on larger mols. under the same computational budget, with nearly no loss of predictive accuracy. Furthermore, our approach contains an uncertainty assessment of predictions of at. forces and energies, useful for developing a sequential design over the chem. input space. (c) 2022 American Institute of Physics.

Journal of Chemical Physics published new progress about Algorithm. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rong, Yu; Yang, Ruili; Yang, Yuzhe; Wen, Yazhou; Liu, Sixin; Li, Congfa; Hu, Zhuoyan; Cheng, Xiangrong; Li, Wu published the artcile< Structural characterization of an active polysaccharide of longan and evaluation of immunological activity>, HPLC of Formula: 3458-28-4, the main research area is longan pulp polysaccharide structure immunomodulatory activity signaling; Immunomodulatory activities; Longan polysaccharides; Signaling pathways; Structural features.

An active polysaccharide (LPD2) was isolated from longan pulp by comparing the effects of polysaccharides on the phagocytosis of macrophages. LPD2 was composed of arabinose, mannose, glucose, and galactose in a molar ratio of 0.25:0.49:1:0.5 with average mol. weight of 9.64 × 106 Da. The main linkages of the sugar residues of LPD2 were (1→4)-β-Glc and (1→6)-β-Man. LPD2 significantly enhanced the lymphocytes proliferation, phagocytosis and NO and IL-6 secretion by macrophage. The anti-TLR2 and anti-TLR4 mAbs markedly suppressed LPD2-mediated NO and IL-6 production Furthermore, anti-TLR4 or anti-TLR2 plus anti-TLR4 treatment significantly decreased LPD2-induced increase of MyD88, IRAK4, TRAF6 and INOS mRNA expression. Moreover, western blotting anal. showed that LPD2 enhanced the expression of target proteins in MyD88/IRAK4-TRAF6- INOS pathways. These results suggested that LPD2 induced macrophage activation partly via the TLR2- and TLR4-mediated MyD88/IRAK4-TRAF6 signaling pathways. Knowing the structural features and activities of active polysaccharide of longan gives the insights into longan polysaccharide application as an immunomodulatory agent.

Carbohydrate Polymers published new progress about Cell activation. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maiti, Sudip; Li, Yingzi; Sasmal, Sheuli; Guin, Srimanta; Bhattacharya, Trisha; Lahiri, Goutam Kumar; Paton, Robert S.; Maiti, Debabrata published the artcile< Expanding chemical space by para-C-H arylation of arenes>, Application In Synthesis of 492-62-6, the main research area is biaryl scaffold preparation.

A robust catalytic system that displayed unique efficacy toward para-arylation of highly functionalized substrates such as drug entities, giving access to structurally diversified biaryl scaffolds, e.g., I was developed. This diversification process provided access to an expanded chem. space for further exploration in drug discovery. Further, the applicability of the transformation was realized through the synthesis of drug mols. bearing a biphenyl fragment. Computational and exptl. mechanistic studies further provided insight into the catalytic cycle operative in this versatile C-H arylation protocol.

Nature Communications published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts