Tag: M.W=150-200

Liu, Jia-Jia published the artcileGC-MS profile of Hua-Feng-Dan and RNA-Seq analysis of induced adaptive responses in the liver, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Hua Feng Dan RNA sequence liver bioinformatic signaling GCMS; GC-MS; GEO database; Hua-Feng-Dan; RNA-seq; adaptation; bioinformatics.

Hua-Feng-Dan is a patent Chinese medicine for stroke recovery and various diseases. This study used GC-MS to profile its ingredients and RNA-Seq to analyze the induced adaptive response in the liver. Hua-Feng-Dan was subjected to steam distillation and solvent extraction, followed by GC-MS anal. Mice were orally administered Hua-Feng-Dan and its “”Guide drug”” Yaomu for 7 days. Liver pathol. was examined, and total RNA isolated for RNASeq, followed by bioinformatic anal. and quant. real-time PCR (qPCR). Forty-four volatile and fifty liposol. components in Hua-Feng-Dan were profiled and analyzed by the NIST library and their concentrations quantified. The major components (>1%) in volatile (5) and liposol. (10) were highlighted. HuaFeng-Dan and Yaomu at hepatoprotective doses did not produce liver toxicity as evidenced by histopathol. and serum enzyme activities. GO Enrichment revealed that Hua-Feng-Dan affected lipid homeostasis, protein folding, and cell adhesion. KEGG showed activated cholesterol metabolism, bile secretion, and PPAR signaling pathways. Differentially expressed genes (DEGs) were identified by DESeq2 with p < 0.05 compared to controls. Hua-Feng-Dan produced more DEGs than Yaomu. qPCR on selected genes largely verified RNA-Seq results. Ingenuity Pathways Anal. of the upstream regulator revealed activation of MAPK and adaptive responses by Hua-FengDan, and Yaomu was less effective. Hua-Feng-Dan-induced DEGs were highly correlated with the Gene Expression Omnibus database of chem.-induced adaptive transcriptome changes in the liver. GC-MS primarily profiled volatile and liposol. components in Hua-FengDan. Hua-Feng-Dan at the hepatoprotective dose did not produce liver pathol. changes but induced metabolic and signaling pathway activations. The effects of Hua Feng-Dan on liver transcriptome changes point toward induced adaptive responses to program the liver to produce hepatoprotective effects. Frontiers in Pharmacology published new progress about Bioinformatics. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zhangbao published the artcileCharacterization and immunological activities of polysaccharides from Polygonatum sibiricum, Product Details of C6H12O6, the main research area is Polygonatum polysaccharides cytokines immunomodulatory; Polygonatum sibiricum polysaccharide; characterization; immunological activity.

We investigated the physicochem. properties and composition of monosaccharides from Polygonatum sibiricum. Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines. The average mol. weight (Mw) of PSP was 9.514 x 104 Da. The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72:1.78:4.15:1.00:2.48. PSP increased thymus and spleen indexes, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages. Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, while blood leukocytes and platelet counts of Cy-treated mice recovered. PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-a (TNF-α) in the sera of Cy-treated mice. PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes. Addnl., PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner. Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.

Biological & Pharmaceutical Bulletin published new progress about Blood platelet. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Altassan, Ruqaiah published the artcileInternational consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management, COA of Formula: C6H12O6, the main research area is review phosphoglucomutase diagnosis protein glycosylation; d-galactose; PGM1-CDG; congenital disorder of glycosylation; management guidelines; phosphoglucomutase 1 deficiency.

Phosphoglucomutase 1 deficiency is a rare genetic disorder that affects glycogen metabolism, glycolysis, and protein glycosylation. Previously known as GSD XIV, it was recently reclassified as a congenital disorder of glycosylation, PGM1-CDG. PGM1-CDG usually manifests as a multisystem disease. Most patients present as infants with cleft palate, liver function abnormalities and hypoglycemia, but some patients present in adulthood with isolated muscle involvement. Some patients develop life-threatening cardiomyopathy. Unlike most other CDG, PGM1-CDG has an effective treatment option, -galactose, which has been shown to improve many of the patients’ symptoms. Therefore, early diagnosis and initiation of treatment for PGM1-CDG patients are crucial decisions. In this article, our group of international experts suggests diagnostic, follow-up, and management guidelines for PGM1-CDG. These guidelines are based on the best available evidence-based data and experts’ opinions aiming to provide a practical resource for health care providers to facilitate successful diagnosis and optimal management of PGM1-CDG patients.

Journal of Inherited Metabolic Disease published new progress about Cardiomyopathy. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Veeraperumal, Suresh published the artcilePolysaccharides from Gracilaria lemaneiformis promote the HaCaT keratinocytes wound healing by polarised and directional cell migration, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Gracilaria lemaneiformis wound healing promoter cell proliferation; Cell migration; Cell polarisation; Gracilaria lemaneiformis; Human keratinocyte; Wound healing.

In this study, we evaluated the wound healing activity of polysaccharides fractions from Gracilaria lemaneiformis. Three purified fractions, namely, GLP-1, GLP-2 and GLP-3 were obtained from anion-exchange chromatog. and were evaluated for their cell proliferation activity. Among the three fractions, the fraction GLP-2 promoted cell proliferation at a concentration of 100μg/mL. Further, chem. and structural anal. of GLP-2 revealed it to be a homogenous and repeating structure of alternating 4-linked 3,6-anhydro-α-L-galactopyranosyl and 3-linked β-D-galactopyranosyl units with sulfate residues. Further, we analyzed the wound healing activities of the fraction GLP-2 and its underlying mechanisms. The results showed that GLP-2 promotes cell proliferation and migration through activation of PI3 K/aPKC signaling during human keratinocytes wound healing. Based on the findings in this study, we concluded that the wound healing activities of the GLP-2 fraction can provide the scientific basis for the development of G. lemaneiformis polysaccharides based product for wound management.

Carbohydrate Polymers published new progress about Cell migration. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gomez-Ramos, M. M. published the artcileExploration of environmental contaminants in honeybees using GC-TOF-MS and GC-Orbitrap-MS, Application In Synthesis of 124-76-5, the main research area is environmental contaminant honeybee Apis GC TOF MS Orbitrap; pollutant PAH phthalate synthetic musk Apis; Environmental contaminants; GC-EI-TOF-MS; GC-Orbitrap-MS; Honeybee; Non-targeted screening.

This study reports an anal. approach by gas chromatog. and high-resolution mass spectrometry (HRMS) intended to be used for investigation of nontargeted environmental contaminants in honeybees. The approach involves a generic extraction and anal. with two GC-HRMS systems: time-of-flight and Orbitrap analyzers, GC-TOF-MS, and GC-Orbitrap-MS operated in electron-impact ionization (EI) mode. The workflow for screening of non-targeted contaminants consisted of initial peak detection by deconvolution and matching the first-stage mass spectra EI-MS with a nominal mass spectral library. To gain further confidence in the structural characterization of the contaminants under investigation, mol. formula of representative ions (mol. and fragment ions) was provided for those with an accurate mass scoring (error < 5 ppm). This methol. was applied for screening environmental contaminants in 75 samples of adult honeybee. This approach has provided the tentative identification of environmental contaminants belonging to different chem. groups, among them, PAHs, phthalates and synthetic musks. Residues of veterinary treatments used in apiculture were also detected in the honeybee samples. Science of the Total Environment published new progress about Apis mellifera. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia published the artcileChemical composition and biological activities of essential oils from peels of three Citrus species, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Citrus fruit peelessential oil chem composition phototoxicity biol activity; Citrus limon; Citrus × bergamia; Citrus × myrtifolia; eco-compatibility; essential oil; phytotoxicity.

Fruit peels are generally underutilized byproducts of the food industry, although they are valuable sources of bioactive compounds The aim of this study is to evaluate a new application for three Citrus peel EOs as bio-herbicides. After a micro-morphol. evaluation of Citrus peels by SEM anal., the phytochem. composition of the EOs of Citrus x bergamia Risso & Poit., Citrus x myrtifolia Raf., and Citruslimon (L.) Osbeck was characterized by GC/FID and GC/MS analyses. The in vitro phytotoxicity against germination and initial radical elongation of several crop and weed species was evaluated. Furthermore, the eco-compatibility of these EOs has been assessed by the brine shrimp (Artemia salina) lethality assay. SEM anal. highlighted the morphometric differences of the schizolysigenous pockets among the peels of the three Citrus species. Oxygenated monoterpenes are the main constituents in C. x bergamia (51.09%), whereas monoterpene hydrocarbons represent the most abundant compounds in C. x myrtifolia (82.15%) and C. limon (80.33%) EOs. They showed marked and selective phytotoxic activity in vitro, often at very low concentration (0.1 μg/mL) against all plant species investigated, without showing any toxicity on Artemia salina, opening the perspective of their use as safe bio-herbicides.

Molecules published new progress about Artemia salina. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miura, Patricia Tidori published the artcileStudy of the chemical composition and ecotoxicological evaluation of essential oils in Daphnia magna with potential use in aquaculture, Synthetic Route of 124-76-5, the main research area is Daphnia essential oil chem composition aquaculture ecotoxicol.

Essential oils have been used in aquaculture due to their wide range of biol. activities. However, even though they have a potentially low risk for fish, it is necessary to assess the risks to nontarget organisms to guarantee their safe use in the environment. Here, we assessed the acute toxicity on the model organism Daphniamagna of seven essential oils of interest in aquaculture (Lippiaalba, Lippiagracilis, Lippiasidoides, Menthaarvensis, Menthapiperita, Ocimumgratissimum and Pipercallosum). Furthermore, we also studied the chem. composition of essential oils using gas chromatog.-mass spectrometry (GC-MS) to relate toxicity to the chem. composition The half maximal effective concentration values during 48 h of exposure (EC50-48 h) of the essential oils for D. magna showed toxicity ranging from moderately (EC50-48 h 3.59 mg/L for L. gracilis, followed by L. sidoides, L. alba and O. gratissimum) to slightly toxic (EC50-48 h 43.74 mg/L for M. piperita as the least toxic, M. arvensis and P. callosum). Thus, for the purpose of establishing ecol. safe therapeutic protocols, the correct use of these substances in aquaculture should be considered, as the toxicity of the essential oils observed indicates potential interference with the nontarget organism D. magna.

Aquaculture Research published new progress about Acute toxicity. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tunnisa, Fitra published the artcileAntioxidant and antidiabetic compounds identification in several Indonesian underutilized Zingiberaceae spices using SPME-GC/MS-based volatilomics and in silico methods, HPLC of Formula: 124-76-5, the main research area is Zingiber eucalyptol fenchone volatiles antioxidant antidiabetic SPME GCMS Indonesia; AC, Amomum compactum Soluble ex Maton; AGI, α-glucosidase inhibitor; AM, Alpinia malaccensis (Burm.f.) Roscoe; Antioxidant; BR, Boesenbergia rotunda L. Mansf.; CA, Curcuma aeruginosa Roxb; CH, Curcuma heyneana Val. & Zijp; CP, Curcuma purpurascens Blume; CT, Curcuma petiolata Roxb; CUPRAC, Cupric ion reducing antioxidant capacity; CZ, Curcuma zedoria Roscoe; DPPH, 2,2-diphenyl-1-picrylhydrazyl; FRAP, Ferric reducing antioxidant property; GC/MS, Gas chromatography/mass spectrometry; Metabolomics; OPLS, Orthogonal projection to the least square; PCA, Principal component analysis; SPME, Solid phase micro extraction; SPME-GC/MS; TFC, Total flavonoid content; TPC, Total phenolic content; Volatiles; ZA, Zingiber aromaticum Val.; ZC, Zingiber purpureum Roscoe; ZO, Zingiber ottensii Val.; ZZ, Zingiber zerumpet L. Roscoe ex Sm.; α-Glucosidase inhibitor.

This study aimed to identify compounds in 12 minor Zingiberaceae spices grown in Indonesia linked with in vitro α-glucosidase inhibitor and antioxidant (DPPH, FRAP, CUPRAC) activities using SPME-GC/MS volatilomics. The results illustrated that Zingiber aromaticum Val., Alpinia malaccensis (Burm.f.) Roscoe, Amomum compactum Soluble ex Maton, and Zingiber purpureum Roscoe had the highest α-glucosidase inhibitor and DPPH, FRAP, CUPRAC antioxidant activities, resp. Also, the total phenolic content pos. influenced DPPH, FRAP, and CUPRAC antioxidant activities. The strongest pos. correlation with α-glucosidase inhibitor and DPPH antioxidant activities was found in eucalyptol; whereas o-cymene and terpinen-4-ol had the strongest correlations with FRAP and CUPRAC antioxidants, resp. Furthermore, the mol. docking anal. revealed that all compounds with a strong correlation with α-glucosidase inhibitor activity (based on their OPLS VIP score) had binding energies (-5.06 – -6.26 kcal/mol) close to Acarbose (-10.11 kcal/mol). Thus, this study provided vital information on the volatile compounds in underutilized spices associated with their health beneficial properties.

Food Chemistry: X published new progress about Adipose tissue. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Jing-Kun published the artcilePhysicochemical characteristics and in vitro biological activities of polysaccharides derived from raw garlic (Allium sativum L.) bulbs via three-phase partitioning combined with gradient ethanol precipitation method, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Allium polysaccharide uronic acids carbohydrates; Bioactivity; Characterization; Garlic (Allium sativum L.); Gradient ethanol precipitation; Polysaccharide; Preparation; Three-phase partitioning.

In the present study, three-phase partitioning (TPP) coupled with gradient ethanol precipitation (GEP) was developed for the first time to extract and isolate polysaccharides (GPSs) from raw garlic (Allium sativum L.) bulbs. Four kinds of fructose polymers, namely, GPS35, GPS50, GPS65, and GPS80, were obtained at the final ethanol precipitation concentrations of 35%, 50%, 65%, and 80% (volume/volume), resp., and their physicochem. characteristics and in vitro biol. activities were investigated. Results indicated that GPS80 had higher carbohydrate (86.68% ± 0.90%) and uronic acid (12.89% ± 0.09%) contents, lower weight-average mol. weight (8.93 x 103 Da), and looser surface morphol. than the other three GPSs. Furthermore, among the four GPSs, GPS80 exhibited the strongest antioxidant capacities, inhibitory effects on α-amylase and α-glycosidase, and nitric oxide stimulatory activity on RAW264.7 macrophage cells in vitro. Therefore, this study provides a simple and feasible technol. strategy for producing bioactive polysaccharides from raw Allium vegetables.

Food Chemistry published new progress about Allium sativum. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oswald, Iain W. H. published the artcileIdentification of a New Family of Prenylated Volatile Sulfur Compounds in Cannabis Revealed by Comprehensive Two-Dimensional Gas Chromatography, COA of Formula: C10H18O, the main research area is prenylated volatile sulfur compound Cannabis terpene Allium.

Cannabis sativa L. produces over 200 known secondary metabolites that contribute to its distinctive aroma. Studies on compounds traditionally associated with the scent of this plant have focused on those within the terpenoid class. These isoprene-derived compounds are ubiquitous in nature and are the major source of many plant odors. Nonetheless, there is little evidence that they provide the characteristic “”skunk-like”” aroma of cannabis. To uncover the chem. origins of this scent, we measured the aromatic properties of cannabis flowers and concentrated extracts using comprehensive two-dimensional gas chromatog. equipped with time-of-flight mass spectrometry, flame ionization detection, and sulfur chemiluminescence. We discovered a new family of volatile sulfur compounds (VSCs) containing the prenyl (3-methylbut-2-en-1-yl) functional group that is responsible for this scent. In particular, the compound 3-methyl-2-butene-1-thiol was identified as the primary odorant. We then conducted an indoor greenhouse experiment to monitor the evolution of these compounds during the plant’s lifecycle and throughout the curing process. We found that the concentrations of these compounds increase substantially during the last weeks of the flowering stage, reach a maximum during curing, and then drop after just one week of storage. These results shed light on the chem. origins of the characteristic aroma of cannabis and how volatile sulfur compound production evolves during plant growth. Furthermore, the chem. similarity between this new family of VSCs and those found in garlic (allium sativum) suggests an opportunity to also investigate their potential health benefits.

ACS Omega published new progress about Allium sativum. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts