Tag: M.W=150-200

Chen, Yuqing; Liu, Dan; Wang, Dingyi; Lai, Shanshan; Zhong, Ruting; Liu, Yuanyuan; Yang, Chengfeng; Liu, Bin; Sarker, Moklesur Rahman; Zhao, Chao published the artcile< Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice>, Related Products of 3458-28-4, the main research area is Grifola polysaccharide type 2 diabetes gut microbiota regulation hypoglycemia; Grifola frondosa polysaccharide; Hypoglycemic; Intestinal microflora; Purification; Single-molecule real-time sequencing.

GFP-N, a novel heteropolysaccharide with a mol. weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatog. on a DEAE cellulose-52 column and gel-filtration chromatog. on a Sephadex G-100 column. Its structure was characterized by Fourier transform IR spectroscopy and one-dimensional (1H- and 13C-) NMR spectra, 1H-1H correlation spectroscopy, and 1H-13C heteronuclear single-quantum coherence spectroscopy. The structure of GFP-N consisted of L-arabinose, D-mannose and D-glucose and mainly contained three kinds of linkage type units as( →2,6)-a-D-Manp-(1 → 4, a-L-Araf-C1→, and →3,6)-β-D-Glcp-(1 →). GFP-N could activate insulin receptor substrate 1, phosphatidylinositol-3-kinase, and glucose transporter 4 and inhibit c-Jun N-terminal kinase 1/2 for hypoglycemic effects in diabetic mouse livers. This is also the first report of the regulatory efficacy of Grifola frondosa polysaccharide on intestinal microflora in vivo using single-mol. real-time sequencing. These results indicated that polysaccharide from maitake mushroom could be as an enhancer to improve type 2 diabetes and a healthy food option to help regulate gut microbiota in diabetic individuals.

Food and Chemical Toxicology published new progress about Actinobacteria. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Lin-Fang; Shang, Zhi-Chun; Sun, Fu-Juan; Zhu, Pan-Hu; Yin, Yong; Kong, Ling-Yi; Yang, Ming-Hua published the artcile< Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is formyl phloroglucinol meroterpenoid preparation anticandidal antibiofilm; Antibiofilm activity; Anticandidal activity; Essential oil; Formyl phloroglucinol meroterpenoids.

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Cedartriol B (I) showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the I treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound I is a promising candidate for further antifungal-based structure modification.

Bioorganic Chemistry published new progress about [4+2] Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yunusoglu, Oruc published the artcile< Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice>, Computed Properties of 78-70-6, the main research area is Nicotine addiction; acquisition; extinction; linalool; reinstatement.

Background: Nicotine is the addictive agent in tobacco products. The monoterpene linalool is the main ingredient in the essential oils of various aromatic plants. It has previously been demonstrated that linalool has beneficial effects on some mechanisms that are important in drug addiction. Objectives: The goal of the current study was to investigate the effect of linalool on nicotine-induced conditioned place preference (CPP) in male mice. Methods: CPP was induced by administering i.p. (i.p.) injection of nicotine (0.5 mg/kg) during the conditioning phase. The effects of nicotinic acetylcholine receptor partial agonist varenicline and linalool on the rewarding characteristics of nicotine were tested in mice with administration of linalool (12.5, 25, and 50 mg/kg, i.p.), varenicline (2 mg/kg, i.p.) or saline 30 min before nicotine injection. CPP was extinguished by repeated testing, during which conditioned mice were administered varenicline and linalool every day. One day after the last extinction trial, mice that received linalool, varenicline or saline 30 min before a priming injection of nicotine (0.1 mg/kg, i.p.) were immediately tested for reinstatement of CPP. Results: Linalool attenuated nicotine acquisition (50 mg/kg, p < .01) and reinstatement (25 and 50 mg/kg, resp. p < .05, p < .01) and accelerated the extinction of nicotine-induced CPP (50 mg/kg, p < .05). Linalool exhibited similar effects on the reference drug varenicline in the CPP phases. Conclusion: These results suggest that linalool may be helpful as an adjuvant for the treatment of nicotine use disorder. American Journal of Drug and Alcohol Abuse published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Ximeng; Ji, Xiaolong; Wang, Min; Yin, Sheng; Peng, Qiang published the artcile< An alkali-extracted polysaccharide from Zizyphus jujuba cv. Muzao: Structural characterizations and antioxidant activities>, Product Details of C6H12O6, the main research area is Zizyphus fruit acidic polysaccharide antioxidant; Acidic polysaccharide; Alkaline extraction; Antioxidant activities; Structural characterization; Ziziphus jujuba cv, Muzao.

An acidic polysaccharide (SAZMP3) was isolated from jujube fruit residues by alk. extraction and purified with DEAE-Sepharose Fast Flow and Sephacryl S-300 column chromatog. The structural characterizations of SAZMP3 were determined by high-performance gelpermeation chromatog., gas chromatog., Fourier transform IR spectroscopy, methylation anal., NMR spectroscopy, SEM, and at. force microscopy. The results determined SAZMP3 was an acidic polysaccharide mainly contained rhamnose, galactose, and galacturonic acid with a mol. weight of 9.37 kDa and its backbone might mainly be composed of 1,4-α-D-GalAp with side chains of 1,3-β-D-Galp, 1,3,5-linked Araf, 1,2,4-α-L-Rhap and terminals of 1-linked Araf, 1-linked Rhap, 1-linked Galp by methylation and NMR anal. Besides, SAZMP3 has shown potential antioxidant activity in scavenging free radicals suggesting that it is an antioxidant agent, which might contribute to the functional food qualities of jujube fruit.

International Journal of Biological Macromolecules published new progress about Acidic polysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziemniak, Marcin; Pawledzio, Sylwia; Zawadzka-Kazmierczuk, Anna; Dominiak, Paulina M.; Trzybinski, Damian; Kozminski, Wiktor; Zielinski, Rafal; Fokt, Izabela; Priebe, Waldemar; Wozniak, Krzysztof; Pajak, Beata published the artcile< X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-D-glucose in solid state and solution>, Quality Control of 492-62-6, the main research area is deoxyglucose conformation electron density hydrogen bond supramol self assembly.

The structural studies on two bromo-substituted derivatives of 2-deoxy-D-glucose (2-DG), namely 2-deoxy-2-bromo-D-glucose (2-BG) and 2-deoxy-2-bromo-D-mannose (2-BM) are described. 2-DG itself is an inhibitor of hexokinase, the first enzyme in the glycolysis process, playing a vital role in both cancer cell metabolism and viral replication in host cells. Because of that, 2-DG derivatives are considered as potential anti-cancer and anti-viral drugs. An X-ray quantum crystallog. approach allowed us to obtain more accurate positions of hydrogen atoms by applying Hirshfeld atom refinement, providing a better description of hydrogen bonding even in the case of data from routine X-ray experiments Obtained structures showed that the introduction of bromine at the C2 position in the pyranose ring has a minor influence on its conformation but still, it has a noticeable effect on the crystal structure. Bromine imposes the formation of a layered supramol. landscape containing hydrogen bonds, which involves the bromine atom. Periodic DFT calculations of cohesive and interaction energies (at the B3LYP level of theory) have supported these findings and highlighted energetic changes upon bromine substitution. Based on mol. wavefunction from the refinement, we calculated the electrostatic potential, Laplacian, and ELI-D, and applied them to charge-d. studies, which confirmed the geometry of hydrogen bonding and involvement of the bromine atom with these intermol. interactions. NMR studies in the solution show that both compounds do not display significant differences in their anomeric equilibrium compared to 2-DG, and the pyranose ring puckering is similar in both aqueous and solid state.

RSC Advances published new progress about Bader electron density. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xuegui; Bian, Jun; Li, Danqi; Liu, Changfeng; Xu, Shuangshuang; Zhang, Gongling; Zhang, Lixin; Gao, Pinyi published the artcile< Structural features, antioxidant and acetylcholinesterase inhibitory activities of polysaccharides from stem of Physalis alkekengi L.>, Formula: C6H12O6, the main research area is Physalis stem polysaccharide antioxidant acetylcholinesterase structural property.

Physalis alkekengi L.(P. alkekengi) is an important medicinal plant in China. In this study, two polysaccharides (SPAP-1 and SPAP-2) were isolated from the stem of P. alkekengi using hot water extraction method. The extract was further purified by DEAE-cellulose and Sephadex G-200 chromatog. The chem. characteristics, surface features and thermal stability of SPAP-1 and SPAP-2 were evaluated. For the first time, high-performance liquid chromatog. with refractive index detection and amino column (without sample derivatization) was performed to analyze the monosaccharide composition of polysaccharides obtained from the stem of P. alkekengi. As a result, SPAP-1 (Mw = 9.1 kDa) consisted of rhamnose, arabinose, galacturonic acid, mannose, and glucose in the ratio of 1.0:1.5:1.9:29.1:1.03, while SPAP-2 (Mw = 13.5 kDa) comprised of rhamnose, xylose, arabinose, mannose and glucose in the ratio of 31.8:14.8:1.0:6.5:22.6. Addnl., the antioxidant effects of SPAP-1 and SPAP-2 were evaluated by ferric reducing power, 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonate acid) (ABTS) and 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. The results showed that the purified polysaccharides exerted significant scavenging activities. Subsequently, acetylcholinesterase inhibitory effects in vitro of the polysaccharides were investigated, which showed that, SPAP-1 and SPAP-2 showed moderate acetylcholinesterase inhibitory activities. Thus, the polysaccharide content in P. alkekengi stem as promising source of natural products possess good antioxidant activities and may exert beneficial effects on cognitive function.

Industrial Crops and Products published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fan, Yiqing; Zhang, Yongjie; Liu, Yan; Jiang, Hongyu; Zhou, Ying; Tang, Chunlei; Fan, Weizheng published the artcile< Pyrazolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: design, synthesis and biological evaluation>, Synthetic Route of 167938-56-9, the main research area is pyrazolopyrimidine macrocyclic preparation tropomyosin receptor kinase inhibition docking; Antitumor; Design and synthesis; High selectivity; The next-generation Trk inhibitor; Tropomyosin receptor kinase.

A series of pyrazolo[1,5-a]pyrimidine derivatives I [R = H, F, Cl; X1 = (CH2)2, CH2CMe2, (R)-CHMeCH2, (S)-CHMeCH2; X2 = (CH2)2, (CH2)3, (R)-CHMeCH2, (S)-CHMeCH2, (S)-CH2CHMe, (R)-CH2CHMe] was synthesized and evaluated the their biol. activity as the second-generation Trk inhibitors. The best compounds I [R = F; X1 = CH2CMe2; X2 = (R)-CHMeCH2] (IC50 = 1.40 and 1.80 nM, against TrkA, TrkAG595R, resp.) and I [R = F; X1 = (S)-CHMeCH2; X2 = (R)-CHMeCH2] (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, resp.) showed a kinase activity comparable to TPX-0005, and I [R = F; X1 = (S)-CHMeCH2; X2 = (R)-CHMeCH2] (IC50 = 350 nM against ALK) had a higher selectivity of Trk inhibition than TPX-0005, which was of great significance for reducing toxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Synthetic Route of 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modak, Arindam; Nandi, Mahasweta; Bhaumik, Asim published the artcile< Titanium containing periodic mesoporous organosilica as an efficient catalyst for the epoxidation of alkenes>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is titanium periodic mesoporous organosilica catalyst epoxidation alkene.

A new class of titanium containing organic-inorganic hybrid periodic mesoporous organosilica (Ti-LHMS-3) has been synthesized, which contain bis(propyliminomethyl)-phloroglucinol moiety in the pore-wall. The precursor organosilane compound is obtained by Vilsmeier-Haack formylation of phloroglucinol followed by its Schiff base condensation with 3-aminopropyl-triethoxysilane (APTES). The hybrid titananosilicate is finally obtained through in situ condensation of this as-prepared organosilane precursor and tetraethylorthosilicate with titanium isopropoxide under hydrothermal conditions. The material has been thoroughly characterized by using powder X-ray diffraction (PXRD), nitrogen adsorption/desorption, transmission and scanning electron microscopic, and FTIR spectroscopic tools. This hybrid mesoporous titanosilicate material showed excellent catalytic activity in the epoxidation of alkenes under mild liquid phase reaction conditions using tert-Bu hydroperoxide (TBHP) as the oxidant.

Catalysis Today published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bayat, Yadollah; Shirini, Farhad; Goli-Jolodar, Omid published the artcile< Selective oxidation of sulfides to sulfoxides using novel nano Bronsted dicationic ionic liquid as effective reagent under grinding conditions>, SDS of cas: 699-12-7, the main research area is sulfoxide preparation green chem; sulfide selective oxidation nano bronsted dicationic ionic liquid.

In this work, 1,1′-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octane-1,4-diium) bis(hydrogen sulfate) dinitrate ([C4(DABCO-H)2]·[HSO4]2[NO3]2) as a novel Bronsted dicationic ionic liquid was prepared with available starting materials, and characterized by FT-IR, 1H NMR, 13C NMR, TGA, DSC, SEM and FESEM techniques. This nano-sized regent was efficiently employed in selective oxidation of sulfides to sulfoxides at room temperature, under grinding and solvent-free condition. A simple method, short reaction times, high yields, green and easy work-up of the products, use of com. cheap starting materials and excellent selectivity are attractive features of the present method.

Journal of Molecular Liquids published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, SDS of cas: 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Zewei; Huang, Lianfang; Cui, Liao; Zhu, Xiao published the artcile< Mannose: Good player and assister in pharmacotherapy>, Synthetic Route of 3458-28-4, the main research area is review mannose anticancer agent cancer; Cancer; Mannose; Medicinal function; Nanovaccine; Photodynamic therapy.

A review. Mannose is a monosaccharide widely distributed in body fluids and tissues, especially in the nerve, skin, testicles, retina, liver and intestines. It is used to synthesize glycoproteins and participate in immune regulation. In recent years, mannose has been applied more and more widely in the biomedical context as people have a deeper understanding of its biol. effects. This review introduces the use of mannose in treating various diseases (including cancer, urinary tract infections, type 1 diabetes, and diabetic wounds), preventing pancreatic fistula, and improving magnetic resonance imaging for acute pancreatitis. We also demonstrate that mannose has the potential for clin. applications.

Biomedicine & Pharmacotherapy published new progress about Acute pancreatitis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts