Tag: M.W=150-200

Benny, Anju; Thomas, Jaya published the artcile< Essential Oils as Treatment Strategy for Alzheimer's Disease: Current and Future Perspectives>, Reference of 78-70-6, the main research area is review Salvia Melissa Alzheimers disease essential oil therapeutics linalool.

A review. Alzheimer’s disease is a multifarious neurodegenerative disease that causes cognitive impairment and gradual memory loss. Several hypotheses have been put forward to postulate its pathophysiol. Currently, few drugs are available for the management of Alzheimer’s disease and the treatment provides only symptomatic relief. Our aim is to review the relevant in vitro, in vivo, and clin. studies focused toward the potential uses of essential oils in the treatment of Alzheimer’s disease. Scientific databases such as PubMed, ScienceDirect, Scopus, and Google Scholar from Apr. 1998 to June 2018 were explored to collect data. We have conducted wide search on various essential oils used in different models of Alzheimer’s disease. Out of 55 essential oils identified for Alzheimer’s intervention, 28 have been included in the present review. A short description of in vivostudies of 13 essential oils together with clin. trial data of Salvia officinalis, Salvia lavandulifolia, Melissa officinalis, Lavandula angustifolia, and Rosmarinus officinalishave been highlighted. In vitrostudies of remaining essential oils that possess antioxidant and anticholinesterase potential are also mentioned. Our literary survey revealed encouraging results regarding the various essential oils being studied in preclin. and clin. studies of Alzheimer’s disease with significant effects in modulating the pathol. through anti-amyloid, antioxidants, anticholinesterase, and memory-enhancement activity.

Planta Medica published new progress about Alzheimer disease. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rasouli, Mohsen; Zolfigol, Mohammad Ali; Moslemin, Mohammad Hossien; Mohebat, Razieh; Chehardoli, Gholamabbas published the artcile< H2O2 as a green and environmentally benign reagent for the oxidation of sulfides in the presence of {[K.18-Crown-6]X3}n (X=Br, I) compared with some other organic tribromides>, Category: alcohols-buliding-blocks, the main research area is sulfoxide preparation green chem; sulfide oxidation hydrogen peroxide crown ether trihalide.

In the presence of {[K.18-Crown-6]X3}n (X = Br, I)-as interesting trihalide reagents, organic sulfides were oxidized to their corresponding sulfoxides using H2O2 as a green reagent. {[K.18-Crown-6]X3}n activates H2O2 via in situ generation of HOX and variously substituted sulfides were selectively transformed into the corresponding sulfoxides. The obtained results of {[K.18-Crown-6]X3}n with some other organic tribromides have been compared. Unexpectedly, in most cases, the results were similar.

Eurasian Chemical Communications published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iftikhar, Rabeeya; Ansari, Asma; Siddiqui, Nadir Naveed; Hussain, Fayaz; Aman, Afsheen published the artcile< Structural elucidation and cytotoxic analysis of a fructan based biopolymer produced extracellularly by Zymomonas mobilis KIBGE-IB14>, Synthetic Route of 492-62-6, the main research area is Zymomonas levan cytotoxicity fibroblast biomedical application; Chemical characterization; Cytotoxicity; Exopolysaccharide; Levan; NIH/3T3 Cell line.

Fructan based biopolymers have been extensively characterized and explored for their potential applications. Linear chained biopolymers, like levan-type fructan, have gained attention because they have exhibited unconventional stretchable and unbendable properties along with biodegradable and biocompatible nature. Current study deals with the chem. characterization and cytotoxic anal. of fructose based exopolysaccharide that was extracellularly produced by an indigenously isolated bacterial species (Zymomonas mobilis KIBGE-IB14). Maximum yield of exopolysaccharide (44.7 gL-1) was attained after 72 h of incubation at 30°C under shaking conditions (180 rpm) when the culture medium was supplemented with 150.0 gL-1 of sucrose as a sole carbon source. This exopolysaccharide displayed high water solubility index (96.0%) with low water holding capacity (17.0%) and an intrinsic viscosity of about 0.447 dL g-1. This biopolymer exhibited a characteristic linear homopolysaccharide structure of levan when characterized using Fourier Transform IR (FTIR), NMR (NMR) spectroscopy (1H, 13C, TOCSY and NOESY) while, Atomic Force Microscopy (AFM) revealed its pointed and thorny structure. The decomposition temperature of levan was approx. 245°C as revealed by Thermal Gravimetric Anal. (TGA). X-Ray Diffraction (XRD) results revealed its amorphous nature with crystalline phase. Cytotoxicity of different concentrations of levan was investigated against mouse fibroblast cell lines by measuring their cellular metabolic activity and it was noticed that a higher concentration of levan (2.0 mg ml-1) permitted the normal cell growth of NIH/3T3 cell lines. This non-cytotoxic and biocompatible nature suggests that this levan has the capability to be utilized in food and drug-based formulations as it exhibited biomedical potential.

Carbohydrate Research published new progress about Biocompatibility. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Rohit; Abbat, Sheenu; Mudududdla, Ramesh; Vishwakarma, Ram A.; Bharatam, Prasad V.; Bharate, Sandip B. published the artcile< ortho-Quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes>, Formula: C8H6O5, the main research area is quinone methide TFA generation water trapping lactam styrene.

A simple and efficient trifluoroacetic acid mediated protocol for ortho-amidomethylation of phenols in aqueous medium was described. Developed protocol has a good substrate scope, involves mild reaction conditions, and products are obtained in good yields. The quantum chem. calculations were performed in implicit solvent (water) conditions, which helped in tracing the reaction mechanism and getting insights on the possible reaction pathway, which involves the N-C bond formation and simultaneous hydrogen transfer to give final product. The applicability of this protocol for 1-pot synthesis of flavans from phenols, formaldehyde and styrene also was demonstrated.

Tetrahedron Letters published new progress about Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Caijuan; Li, Guoxun; Mu, Yu; Wu, Wenxi; Cao, Bixuan; Wang, Zixuan; Yu, Hainan; Guan, Peipei; Han, Li; Li, Liya; Huang, Xueshi published the artcile< Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones>, Name: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is jamunone analog preparation antitumor triple neg breast cancer.

Twenty-three natural jamunone analogs along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the Me group on chromanone affected the selectivity of mols. against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (I; JM) was screened as the most effective anti-triple-neg. breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Name: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhunia, Subhajit; Molla, Rostam Ali; Kumari, Vandana; Islam, Sk. Manirul; Bhaumik, Asim published the artcile< Zn(II) assisted synthesis of porous salen as an efficient heterogeneous scaffold for capture and conversion of CO2>, Safety of 2,4,6-Trihydroxyisophthalaldehyde, the main research area is zinc salphen functionalized porous polymer preparation heterogeneous catalyst; carbon dioxide cyclization epoxide zinc salphen polymer heterogeneous catalyst; dioxolanone derivative preparation.

The authors have designed a unique strategy to obtain a Zn-salphen functionalized porous polymer (Zn@SBMMP) with high Zn content (15.3%) by an easy one-step, cost effective and scalable process, from the solvothermal reaction of 3,3′-diaminobenzidine, phloroglucinoldialdehyde, and zinc acetate in DMF under N2, which shows unprecedented catalytic efficiency in the CO2 fixation reaction via cycloaddition of CO2 with epoxides. The authors hypothesize that a high d. of Zn-Schiff base/salphen units present in the porous polymer network is responsible for the exceptionally high catalytic performance of Zn@SBMMP.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carbon sequestration. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Safety of 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hongyan; Xie, Wancui; Sun, Haihong; Cao, Kewei; Yang, Xihong published the artcile< Effect of the structural characterization of the fungal polysaccharides on their immunomodulatory activity>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is immunomodulatory agent extracellular polysaccharide Aspergillus Sanguisorba Rumia Zizania; Extracellular polysaccharide; Fungus; Immunomodulatory activity; Structural characterization.

The immunomodulatory effects of the four extracellular polysaccharides, namely WPA, WPB, AP2A, and TP1A, which were isolated from the fermented broth of Aspergillus aculeatus, A. terreus and Trichoderma sp. KK19L1, were investigated in vitro. WPA, WPB, AP2A, and TP1A were not toxic to RAW264.7 cells. These polysaccharides enhanced cell viability. WPA, WPB, AP2A, and TP1A showed increased immunomodulatory effect by strengthening the phagocytic activity and enhancing the release of NO, TNF-α and IL-6 from RAW264.7 cells. WPA, WPB, AP2A, and TP1A exhibited different immunomodulatory activity in vitro due to their different structural characterizations, and their immunoregulatory effects decreased successively in the following order: WPA, WPB, AP2A, and TP1A. The extracellular polysaccharides WPA, WPB, AP2A, and TP1A had potent immunomodulatory effects and could be used as potential immunomodulatory agents in the fields of functional food and medicine.

International Journal of Biological Macromolecules published new progress about Animal gene, TNFA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhenming; Zhao, Conghui; Zhang, Guihua; Da Silva, Jaime A. Teixeira; Duan, Jun published the artcile< Genome-wide identification and expression profile of TPS Gene family in Dendrobium officinale and the role of DoTPS10 in linalool biosynthesis>, Application of C10H18O, the main research area is tps10 tps linalool gene expression Dendrobium; abiotic stress; methyl jasmonate; orchids; terpene synthase; terpenes.

Terpene synthase (TPS) is a critical enzyme responsible for the biosynthesis of terpenes, which possess diverse roles in plant growth and development. Although many terpenes have been reported in orchids, limited information is available regarding the genome-wide identification and characterization of the TPS family in the orchid, Dendrobium officinale. By integrating the D. officinale genome and transcriptional data, 34 TPS genes were found in D. officinale. These were divided into four subfamilies (TPS-a, TPS-b, TPS-c, and TPS-e/f). Distinct tempospatial expression profiles of DoTPS genes were observed in 10 organs of D. officinale. Most DoTPS genes were predominantly expressed in flowers, followed by roots and stems. Expression of the majority of DoTPS genes was enhanced following exposure to cold and osmotic stresses. Recombinant DoTPS10 protein, located in chloroplasts, uniquely converted geranyl diphosphate to linalool in vitro. The DoTPS10 gene, which resulted in linalool formation, was highly expressed during all flower developmental stages. Me jasmonate significantly up-regulated DoTPS10 expression and linalool accumulation. These results simultaneously provide valuable insight into understanding the roles of the TPS family and lay a basis for further studies on the regulation of terpenoid biosynthesis by DoTPS in D. officinale.

International Journal of Molecular Sciences published new progress about Abies grandis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohamadi Alasti, Fariba; Asefi, Narmela; Maleki, Ramin; SeiiedlouHeris, Seiied Sadegh published the artcile< Investigating the flavor compounds in the cocoa powder production process>, Computed Properties of 78-70-6, the main research area is flavor cocoa powder potassium carbonate gas chromatog; mass spectrometry; Alkalization; cocoa powder; gas chromatography; roasting; volatile flavor compounds.

Flavor is one of the most important quality properties of cacao beans, playing a key role in the admissibility of cocoa products, such as cocoa powder. This study examined the industrial processes influencing the flavor of cacao beans. The Ivory Coast cacao beans were used after their alk. treatment with potassium carbonate (up to pH 7.5-8) and being roasted at 115-120°C for 60-70 min. The volatile components were extracted using Likens-Nickerson simultaneous distillation-extraction (SDE) apparatus The volatile compound profiles were identified by means of gas chromatog.-mass spectrometry (GC-MS), as a result of which several compounds (alcs., carboxylic acids, aldehydes, ketones, esters, and pyrazines) were recognized. Alkalization and roasting were shown to be two important steps in the cacao beans processing that can affect the final cocoa powder flavor. In addition, pyrazines and esters were two major groups of flavor compounds formed during the roasting stage by the Maillard reaction. The percentage of 2,3,5,6-tetramethylpyrazine was detected in the cacao beans equal to 0.5%. After the liquor pressing stage, tetramethylpyrazine increased to its highest amount (3%) in cocoa powder. It was found that the cocoa powder contained 2.69% of tetramethylpyrazine, 3.22% iso-Bu benzoate, and 1.38% linalool. The highest percentage of increase in the mean amounts of 2,3,5,6-tetramethylpyrazine, iso-Bu benzoate, and linalool were observed in the roasting stage, after which the percentages diminished.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Alcohols Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Singh, Inder Pal published the artcile< A two-step biomimetic synthesis of antimalarial robustadials A and B>, HPLC of Formula: 4396-13-8, the main research area is phloroglucinol Vilsmeier Haak formylation; diformylphloroglucinol preparation isobutanal pinene Knoevenagel condensation Diels Alder cycloaddition; robustadial A B asym synthesis.

The antimalarial robustadials A and B have been synthesized in two steps starting from com. available phloroglucinol comprising a key biomimetic three-component reaction that involves in situ generation of an o-quinone methide via Knoevenagel condensation and subsequent Diels-Alder cycloaddition with (-)-β-pinene.

Tetrahedron Letters published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, HPLC of Formula: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts