Tag: M.W=150-200

Feng, Simin; Luan, Di; Ning, Ke; Shao, Ping; Sun, Peilong published the artcile< Ultrafiltration isolation, hypoglycemic activity analysis and structural characterization of polysaccharides from Brasenia schreberi>, Application In Synthesis of 3458-28-4, the main research area is Brasenia hypoglycemic structural characterization; Brasenia schreberi; Hypoglycemic; Molecular conformation; Polysaccharides.

Brasenia schreberi (B. schreberi) is a rare and precious vegetable, which coat with a gelatinous mucilage. This study is aiming to investigate the relationship between structural characteristics and hypoglycemic activities of polysaccharides with different mol. weight (Mw) range. Three polysaccharides fractions, namely BSP-U100 (50-100 kDa), BSP-U50 (10-50 kDa) and BSP-U10 (<10 kDa), were isolated from B. schreberi mucilage using ultrafiltration method. Compared to other polysaccharide samples, only BSP-U100 had a triple helix structure and existed as the ordered structure in aqueous solution Furthermore, BSP-U100 exhibited higher α-amylase (IC50 = 0.4414 mg/mL) and α-glucosidase (IC50 = 0.5993 mg/mL) inhibitory activity. A heteropolysaccharide BSP-1a, which average Mw was 83.98 kDa, was purified from BSP-U100 by DEAE Sepharose Fast Flow and Sephadex G-75 column. D-galactose (66.85%), D-glucose (2.05%) and D-mannose (1.65%) were three main monosaccharides of BSP-1a. Structural characterization of BSP-1a showed that BSP-1a might be a kind of L-D-pyranose type galactose and mainly composed of α-1 → 6-linked Galp, α-1 → 3-linked Manp and α-1 → 4-linked Glcp. This study provided a theor. basis for the development and application of B. schreberi polysaccharides as a potential anti-diabetic supplement. International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Bin; Elder, W. Zachary; Miyake, Garret M. published the artcile< Scalable and Phosphine-Free Conversion of Alcohols to Carbon-Heteroatom Bonds through Blue-Light Promoted Iodination Reaction>, Reference of 699-12-7, the main research area is alc scalable carbon heteroatom bond blue light iodination.

A simple route toward the diverse conversion of alcs. via an SN2 pathway, in which blue light promoted iodination is used to form alkyl iodide intermediates from simple unreactive alcs. ROH [R = hex-5-yn-1-yl, 2-(1H-indol-3-yl)ethyl, cyclopentyl, etc.] was reported. The scope of the process tolerates a range of nucleophiles R1H [R1 = CN, (4-bromophenyl)carbonyloxidanyl, quinolin-6-yloxidanyl, (furan-2-yl)carbonyloxy, etc.] to construct C-N, C-O, C-S, and C-C bonds. Furthermore, this method can be used for the preparation and late stage functionalization of pharmaceuticals, as highlighted by the synthesis of thiocarlide, butoxycaine, and pramoxine.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Reference of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlomagno, C.; Banfi, P. I.; Gualerzi, A.; Picciolini, S.; Volpato, E.; Meloni, M.; Lax, A.; Colombo, E.; Ticozzi, N.; Verde, F.; Silani, V.; Bedoni, M. published the artcile< Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis>, Application of C6H12O6, the main research area is human amyotrophic lateral sclerosis saliva Raman fingerprint biomarker diagnosis.

Abstract: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to progressive and irreversible muscle atrophy. The diagnosis of ALS is time-consuming and complex, with the clin. and neurophysiol. evaluation accompanied by monitoring of progression and a long procedure for the discrimination of similar neurodegenerative diseases. The delayed diagnosis strongly slows the potential development of adequate therapies and the time frame for a prompt intervention. The discovery of new biomarkers could improve the disease diagnosis, as well as the therapeutic and rehabilitative effectiveness and monitoring of the pathol. progression. In this work saliva collected from 19 patients with ALS, 10 affected by Parkinson’s disease, 10 affected by Alzheimer’s disease and 10 healthy subjects, was analyzed using Raman spectroscopy, optimizing the parameters for detailed and reproducible spectra. The statistical multivariate anal. of the data revealed a significant difference between the groups, allowing the discrimination of the disease onset. Correlation of Raman data revealed a direct relationship with paraclin. scores, identifying multifactorial biochem. modifications related to the pathol. The proposed approach showed a promising accuracy in ALS onset discrimination, using a fast and sensitive procedure that can make more efficient the diagnostic procedure and the monitoring of therapeutic and rehabilitative processes in ALS.

Scientific Reports published new progress about Alzheimer disease. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sundar, Smrithi; Sandilya, Avilasha A.; Priya, M. Hamsa published the artcile< Unraveling the Influence of Osmolytes on Water Hydrogen-Bond Network: From Local Structure to Graph Theory Analysis>, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is osmolyte water hydrogen bond network MD simulations graph theory; protein conformation water osmolyte MD simulation graph theory.

Water structure in aqueous osmolyte solutions, deduced from the slight alteration in the water-water radial distribution function, the decrease in water-water hydrogen bonding, and tetrahedral ordering based only on the orientation of nearest water mols. derived from the mol. dynamics simulations, appears to have been perturbed. A careful anal., however, reveals that the hydrogen bonding and the tetrahedral ordering around a water mol. in binary solutions remain intact as in neat water when the contribution of osmolyte-water interactions is appropriately incorporated. Furthermore, the distribution of the water binding energies and the water excess chem. potential of solvation in solutions are also pretty much the same as in neat water. Osmolytes are, therefore, well integrated into the hydrogen-bond network of water. Indeed, osmolytes tend to preferentially hydrogen bond with water mols. and their interaction energies are strongly correlated to their hydrogen-bonding capability. The graph network anal., further, illustrates that osmolytes act as hubs in the percolated hydrogen-bond network of solutions The degree of hydrogen bonding of osmolytes predominantly determines all of the network properties. Osmolytes like ethanol that form fewer hydrogen bonds than a water mol. disrupt the water hydrogen-bond network, while other osmolytes that form more hydrogen bonds effectively increase the connectivity among water mols. Our observation of minimal variation in the local structure and the vitality of osmolyte-water hydrogen bonds on the solution network properties clearly imply that the direct interaction between protein and osmolytes is solely responsible for the protein stability. Further, the relevance of hydrogen bonds on solution properties suggests that the hydrogen-bonding interaction among protein, water, and osmolyte could be the key determinant of the protein conformation in solutions

Journal of Chemical Information and Modeling published new progress about Binding energy (of water mols.). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pacheco-Hernandez, Yesenia; Sanchez-Hernandez, Gloria Rubi; Reyes-Cervantes, Eric; Romero-Arenas, Omar; Perez-Xochipa, Ivonne; Villa-Ruano, Nemesio published the artcile< Chemical Variation and Pharmacological Properties of Dyssodia decipiens Essential Oil>, Product Details of C10H18O, the main research area is verbenone limonene beta caryophyllene linalool essential oil Dyssodia; Dyssodia decipiens; bioactive compounds; biological activity; flavor and fragrances; volatile profiling.

Dyssodia decipiens is one of the seven recognized species within the Dyssodia genus, which has economic and social relevance in Mexico. Herein, we report on the volatile characterization and pharmacol. activity of D. decipiens. The essential oils (2017-2019) contained verbenone (30.8-60.9%), limonene (5.6-35.5%), β-caryophyllene (7.8-19.8%) and linalool (4.5-12.4%) as major constituents along the studied years. Antifungal properties were probed on Candida albicans ATCC 90028, ATCC 10231 (fluconazole resistant) and five clin. isolates (IS1-IS5). Flower essential oils had the best anti-C. albicans activity (MIC 59.2-93.5μg mL-1), and limonene (MIC 125.5-188.4μg mL-1) and β-caryophyllene (MIC 104.3-184.2μg mL-1) were involved in this effect. SEM examination revealed that D. decipiens essential oils produced an evident lysis on the fungus. Mosquito repellent activity was demonstrated on Aedes aegypti, a vector of dengue, chikungunya and zika viruses. The repellent activity of leaf essential oils (20%) was effective within 1-5 h post-treatment (>90%) and it was stronger (p<0.01) than that of com. DEET. The evaluation of the four major volatiles (10% each) produced similar results to those of essential oils. Finally, leaf essential oils showed a moderate antiproliferative activity on the lines OVCAR-3 (LD50 56.5-85.7μg mL-1), and verbenone (LD50 65.3μg mL-1) and β-caryophyllene (LD50 43.6μg mL-1) were linked to this effect. Chemistry & Biodiversity published new progress about Aedes aegypti. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zohrevandi, Mina; Mozafari, Roya; Ghadermazi, Mohammad published the artcile< A nickel nanoparticle engineered CoFe2O4/SiO2-NH2@carboxamide composite as a novel scaffold for the oxidation of sulfides and oxidative coupling of thiols>, Electric Literature of 699-12-7, the main research area is nickel carboxamide complex supported cobalt ferrite nanoparticle catalyst preparation; sulfoxide green preparation; sulfide oxidation nickel carboxamide complex catalyst; disulfide green preparation; thiol oxidative coupling nickel carboxamide complex catalyst.

A new Ni-carboxamide complex supported on CoFe2O4 nanoparticles (CoFe2O4/SiO2-NH2@carboxamide-Ni) was prepared The carboxamide host material unit generated cavities that stabilized the nickel nanoparticles effectively and prevented the aggregation and separation of these particles on the surface. This compound was appropriately characterized using FT-IR spectroscopy, FE-SEM, ICP-OES, EDX, XRD, TGA anal., VSM and X-ray at. mapping. The catalytic oxidation of sulfides to give sulfoxides RS=OR1 [R = Ph, 4-BrC6H4, Bn, etc.; R1 = H, Me, Ph, etc.] and oxidative coupling of thiols to give disulfides R2S-SR2 [R2 = Ph, 4-MeC6H4, Bn, etc.] in the presence of the designed catalyst was explored as a highly selective catalyst using hydrogen peroxide as a green oxidant. The easy separation, simple workup, excellent stability of the nanocatalyst, short reaction times, non-explosive materials as well as appropriate yields of the products were some outstanding advantages of this protocol.

RSC Advances published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Electric Literature of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Mudududdla, Ramesh; Bharate, Jaideep B.; Battini, Narsaiah; Battula, Satyanarayana; Yadav, Rammohan R.; Singh, Baldev; Vishwakarma, Ram A. published the artcile< Tandem one-pot synthesis of flavans by recyclable silica-HClO4 catalyzed Knoevenagel condensation and [4 + 2]-Diels-Alder cycloaddition>, Product Details of C8H6O5, the main research area is flavan preparation Knoevenagel condensation Diels Alder silica perchloric acid.

An efficient one-pot multi-component synthesis of flavans, e.g., I, using perchloric acid supported on silica as a recyclable heterogeneous catalyst has been described. This is the first report of direct one-step construction of a flavan skeleton from a phenolic precursor, e.g., II. The method involves a Knoevenagel-type condensation leading to in situ formation of transient O-quinone methide which further undergoes [4 + 2]-Diels-Alder cycloaddition with styrene, e.g., 4-H2C:CHC6H4CMe3, to yield a flavan skeleton. The method provides easy access to a wide range of bio-active natural products viz. flavonoids, anthocyanins and catechins.

Organic & Biomolecular Chemistry published new progress about Diels-Alder reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Product Details of C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Chunyu; Shin, Myeongcheol; Park, Youngjae; Choi, Byoungyun; Jang, Seokhui; Lim, Chaejin; Yun, Hye Sup; Lee, Im-Soon; Won, So-Yoon; Cho, Kyoung Sang published the artcile< Linalool alleviates Aβ42-induced neurodegeneration via suppressing ROS production and inflammation in fly and rat models of Alzheimer's disease>, Product Details of C10H18O, the main research area is .

Terpenes are vital metabolites found in various plants and animals and known to be beneficial in the treatment of various diseases. Previously, our group identified terpenes that increased the survival of Alzheimer’s disease (AD) model flies expressing human amyloid β (Aβ) and identified linalool as a neuroprotective terpene against Aβ toxicity. Linalool is a monoterpene that is commonly present as a constituent in essential oils from aromatic plants and is known to have anti-inflammatory, anticancer, antihyperlipidemia, antibacterial, and neuroprotective properties. Although several studies have shown the beneficial effect of linalool in AD animal models, the mechanisms underlying the beneficial effect of linalool on AD are yet to be elucidated. In the present study, we showed that linalool intake increased the survival of the AD model flies during development in a dosedependent manner, while the survival of wild-type flies was not affected even at high linalool concentrations Linalool also decreases Aβ-induced apoptosis in eye disks as well as the larval brain. Moreover, linalool intake was found to reduce neurodegeneration in the brain of adult AD model flies. However, linalool did not affect the total amount of Aβ42 protein or Aβ42 aggregation. Rather, linalool decreased Aβ-induced ROS levels, oxidative stress, and inflammatory response in the brains of AD model flies. Furthermore, linalool attenuated the induction of oxidative stress and gliosis by Aβ1-42 treatment in the rat hippocampus. Taken together, our data suggest that linalool exerts its beneficial effects on AD by reducing Aβ42-induced oxidative stress and inflammatory reactions.

Oxidative Medicine and Cellular Longevity published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Li-Chao; Zhu, Yong-Ming; Zhu, Zhen-Yuan; Xue, Wei; Liu, Chun-Yu; Sun, Hui-Qing; Yue-Yin published the artcile< Chemical structure and effects of antioxidation and against α-glucosidase of natural polysaccharide from Glycyrrhiza inflata Batalin>, Related Products of 3458-28-4, the main research area is Glycyrrhiza antioxidant alpha glucosidase natural polysaccharide free radical scavenger; Antioxidant activity; Glycyrrhiza inflata Batalin; Polysaccharide; Structural characterization; Surface plasmon resonance; α-Glucosidase inhibition.

GIBP, a homogeneous polysaccharide extracted from Glycyrrhiza inflata Batalin with a mol. weight 1.96 x 103 kDa, had a triple helix structure, smooth and sheet-like structure. Comprehensive anal. showed that the main chain of GIBP was composed of α-D-1,4 linked glucose, branch points were composed of α-D-1,3,6 and α-D-1,2,3,6 linked glucoses, and side chains were composed of α-D-1,3 and β-D-1,6 linked galactose, β-L-1,2 linked arabinose, α-D-1,3 and β-D-1,3 mannose. The scavenging abilities of GIBP (3 mg/mL) against DPPH· radical, ·OH radical, O2-· radical and ABTS were 50.75 ± 0.13% and 52.32 ± 0.13, 25.84 ± 0.35% and 44.57 ± 0.15% and it also demonstrated an obvious dose-effect relationship. The inhibitory activity of α-glucosidase showed that the inhibitory effect of GIBP was enhanced with the increase of concentration When the concentration reached 6 mg/mL, the inhibition rate of α-glucosidase activity reached 64.77%. And the ka, kd and KD were 6.472 x 104 1/Ms., 2.934 x 10-3 1/s and 4.534 x 10-8 M.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Sinuo; Yan, Sen; Meng, Zhiyuan; Huang, Shiran; Sun, Wei; Jia, Ming; Teng, Miaomiao; Zhou, Zhiqiang; Zhu, Wentao published the artcile< New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1>, Application In Synthesis of 492-62-6, the main research area is metabolome bisphenol tetrabromobisphenol cannabinoid CB1 receptor obesity Danio; Bisphenols; Metabolomic modulations; Molecular structure; PCR array; Zebrafish.

Bisphenols (BPs), as widely used plastic additives, penetrate into our daily lives. BPs are considered endocrine disruptors and could potentially induce obesity. In this study, the effects of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) on food intake and lipid metabolism in zebrafish were determined Moreover, the impact of BPA and TBBPA on the endocannabinoid system (ECS) of zebrafish was further explored by metabolomics, transcriptomics, and mol. docking anal. Here we show that exposure to BPA and TBBPA at concentrations commonly found in the environment (20, 100, and 500μg/L) led to hyperphagia and obesity in adult male zebrafish. Metabolomics and histopathol. anal. revealed significant lipid accumulation in the liver of zebrafish exposed to BPA and TBBPA. The expression of ECS-related genes, in conjunction with RNA-Seq results, further indicated that BPA and TBBPA increased appetite and induced obesity by activating cannabinoid receptor type 1(CB1). Furthermore, mol. docking revealed that six representative BPs including BPA and TBBPA could bind to the CB1 receptor. Collectively, these findings indicate that CB1 may be a potential target for BPs to induce obesity.

Journal of Hazardous Materials published new progress about Adult, nonmammalian. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts