Tag: M.W=150-200

Chakrabortty, Pekham; Biswas, Surajit; Das, Anjan; Dolai, Malay; Islam, Sk Manirul published the artcile< Diformylphloroglucinol derived imine based covalent organic frameworks (PHTA) as efficient organocatalyst for conversion of isocyanates to urea derivatives>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is diformylphloroglucinol covalent organic framework preparation surface structure; aryl isocyanate organocatalyst dimerization; diaryl urea preparation.

New two-dimensional porous covalent organic frameworks (PHTA) with imine linkers was synthesized and effectively utilized as metal free catalytic system for the synthesis of urea derivatives from a wide range of isocyanates under inert atm. The material has been thoroughly characterized using powder XRD, HRTEM, FESEM, BET, FT-IR, XPS and a structure-activity relationship was established. The imine based covalent organic framework owing to its highly conjugated system permits superior conduction efficiency of carriers, thereby exhibiting better performance and exceptional reusability and selectivity (> 99%) towards generation of urea derivatives from the corresponding isocyanates. At room temperature the solvent free catalytic process under nitrogen atm. requires short range of reaction duration (2 h) to produce high yields (84-96%) of urea derivatives from resp. isocyanates. The catalytic route of urea synthesis in presence of organocatalyst PHTA was suitably described by theor. calculations (DFT) method. The heterogeneity and recyclability nature of the catalyst was checked for five cycles and the obtained result portrayed its good catalytic effectiveness.

Molecular Catalysis published new progress about Binding energy. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Juan; Ji, Hai-yu; Liu, Chao; Liu, An-jun published the artcile< The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice>, COA of Formula: C6H12O6, the main research area is Grifola hepatoma macrophage proliferation mannose glucose anticancer; Anti-tumor activity; Grifola frondosa acid-soluble polysaccharide; Structural characteristics.

The edible mushroom G. frondosa has been used as a kind of functional food for the prevention and therapy of various diseases in Asian countries. In the present work, a novel acid-soluble polysaccharide (GFAP) was successfully isolated from G. frondosa under room temperature and hydrochloric acid solution treatment. Results of chem. composition anal., UV and HPGPC spectra showed that GFAP mainly contained 94.28% of carbohydrate with the average mol. weight of about 644.9 kDa. GC, FT-IR, NMR and methylation anal. further indicated that GFAP was a neutral sugar mainly composed of (1 → 3)-β-D-Glcp and (1 → 3)-α-D-Manp. The in vivo antitumor experiments demonstrated that GFAP could effectively protect thymuses and spleens of tumor-bearing mice and inhibit the growth of H22 solid tumors with the inhibitory rate of 36.72%. Besides, GFAP could significantly improve the activities of NK cells, macrophages, CD19+ B cells and CD4+ T cells, leading to the apoptosis of H22 cells via G0/G1 phase arrested. Our data demonstrated that GFAP holds great application prospect to be a safe and effective antitumor adjuvant in the future.

International Journal of Biological Macromolecules published new progress about Apoptosis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cerulli, Antonietta; Masullo, Milena; Piacente, Sonia published the artcile< Metabolite Profiling of Helichrysum italicum Derived Food Supplements by 1H-NMR-Based Metabolomics>, COA of Formula: C6H12O6, the main research area is Helichrysum italicum food supplement metabolomics multivariate data analysis; Helichrysum italicum derived food supplements; NMR metabolomics; green extractions; multivariate data analysis.

Helichrysum italicum is a medicinal plant from the Mediterranean area, widely used in traditional medicine for its anti-inflammatory, antibacterial and antioxidant properties and for its preventive effects on microcirculation diseases. Due to these properties, it finds large applications in cosmetic, food and pharmaceutical fields. Addnl., hydroalcoholic extracts and mother tinctures based on H. italicum represent products with a high com. value, widely distributed not only in drug stores but also on online markets. The different extraction procedures used can greatly affect the fingerprints of the extracts, resulting in a different qual. or quant. profile of the chem. constituents responsible for biol. activity. The aim of the present study was to characterize the composition of bioactive compounds present in water-ethanol and glycerol extracts of H. italicum derived food supplements. Metabolite profiles of the extracts were obtained by 1H NMR experiments and data were processed by multivariate statistical anal. to highlight differences in the extracts and to evidence the extracts with the highest concentrations of bioactive metabolites. In detail, this work highlights how derived food supplements of H. italicum obtained using ethanol-water mixtures ranging from 45% to 20% of ethanol represent the products with the highest amount of both primary (amino acids) and secondary metabolites including 3,4-dicaffeoylquinic acid (9), chlorogenic acid (10), 3,5-dicaffeoylquinic acid (11), and kaempferol 3-O-glucopyranoside (12). Moreover, it is evident that the use of an ethanol-water mixture 20:80 is the most suitable method to afford the highest number of phenolic compounds, while food-derived supplements obtained by glycerol extraction are characterized by a high amount of β-glucose and α-glucose and a low content of phenolic compounds

Molecules published new progress about Bioactive agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Junqiang; Zhang, Hua; Wang, Zhenyu published the artcile< Ultrasonic degradation of Polysaccharides from Auricularia auricula and the antioxidant activity of their degradation products>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Auricularia polysaccharide antioxidant ultrasonic degradation.

Auricularia auricula polysaccharide (AAP) were purified and degraded using ultrasonic wave with the degradation kinetics model fitted to 1/Mt – 1/M0 = k • t. Followed that the morphol., intrinsic viscosity, viscosity-average mol. weight, antioxidant activity of AAP and their degradation products were in vitro investigated. Results showed the intrinsic viscosity and viscosity-average mol. weight of AAP decreased significantly (p < 0.05) with increasing ultrasonic time and their microscopic sizes were reduced after degradation In addition, ultrasonic wave destroyed the helix structure and changed the monosaccharide proportion of AAP. SEM anal. displayed some morphol. difference existing in polysaccharides before and after degradation More importantly, the antioxidant activities in vitro of AAP after degradation were significantly increased (p < 0.05) and AAPUD12h displayed the strongest antioxidant activity. These results indicate that ultrasonic degradation may be a suitable way to improve the antioxidant activity of natural polysaccharides. LWT--Food Science and Technology published new progress about Auricularia auricula-judae. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wen, Jiawei; Wu, Jie; Yu, Haiqing; Fan, Gang; He, Yang published the artcile< Correlation analysis between genetic and chemical differences of Nardostachys jatamansi from different habitats in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China>, Electric Literature of 492-62-6, the main research area is nardostachys jatamansi metabolite marker extract phylogenetic mol evolution.

In the traditional Tibetan medicinal system, the medicinal parts of Nardostachys jatamansi (D.Don) DC. include the dried roots and rhizomes, which is effective in treating various diseases. In this study, mol. evolutionary anal. based on three markers (i.e., ITS, matK and rbcL), and principal component anal. combined with 1H NMR measurements were used to assess the genetic and chem. differences of the N. jatamansi from different habitats in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China. The results showed that the ITS marker was highly effective to identify the intraspecific variation of N. jatamansi. Furthermore, the results of the chem. anal. indicated that the nardosinone and sucrose, as the metabolite landmarks, can distinguish the different habitats of N. jatamansi in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China. Moreover, combining the chem. anal. with phylogenetic anal., the results indicated that the metabolites differences may be affected not only by genetic structures but also by environmental factors. These findings provide valuable references for the effective protection and exploitation of N. jatamansi resources.

Biochemical Systematics and Ecology published new progress about DNA extraction. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Lopez, Maria Isabel; Mercader-Ros, Maria Teresa; Pellicer, Jose Antonio; Gomez-Lopez, Vicente M.; Martinez-Romero, Domingo; Nunez-Delicado, Estrella; Gabaldon, Jose A. published the artcile< Evaluation of monoterpene-cyclodextrin complexes as bacterial growth effective hurdles>, COA of Formula: C10H18O, the main research area is monoterpene cyclodextrin complex antimicrobial agent.

Monoterpenes have antimicrobial properties but are associated with strong smells and flavors that limit their use in foods; therefore, strategies to keep their effectivity using lower concentrations are required. This work tested the antimicrobial capacity of thymol, carvacrol and linalool free or complexed in hydroxypropyl-β-cyclodextrins (HP- β-CDs) using two complexation methods. To this, these monoterpenes were complexed in HP- β-CDs by the solubility method or a microwave-assisted method, spray dried and their antimicrobial capacity was tested on Escherichia coli and Staphylococcus aureus by determining minimal inhibitory concentration and minimal bactericidal concentration The results show significant differences (p < 0.05) between the complexed and uncomplexed forms. In addition, thanks to the complexation of monoterpenes, the use of lower concentrations of these has been reached to achieve the same level of inhibition than uncomplexed forms. Likewise, it has been found that a lower minimal inhibitory concentration (MIC) is achieved for the solubility method for both microorganisms (3.82 mM for thymol and 2.44 mM for carvacrol in E. coli; and 3.91 and 2.61 mM, resp. for S. aureus) than for the microwave method. This implies that a lower concentration of these compounds can be used to inhibit microbial growth in foods, which should minimize their effects on their smell and taste. Food Control published new progress about Escherichia coli. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bai, Renren; Zhu, Junlong; Bai, Ziqiang; Mao, Qing; Zhang, Yingqian; Hui, Zi; Luo, Xinyu; Ye, Xiang-Yang; Xie, Tian published the artcile< Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma>, Computed Properties of 699-12-7, the main research area is beta elemene nitric oxide malignant brain glioma antitumor; NO donor; anti-tumour; malignant glioma; natural product; β-Elemene.

Elemene is a second-line broad-spectrum anti-tumor drug that has been used in China for more than two decades. However, its main anti-tumor ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumor efficacy. To improve the anti-tumor activity of β-elemene, based on its minor mol. weight character, we introduced furoxan nitric oxide (NO) donors into the β-elemene structure and designed six series of new generation β-elemene NO donor hybrids. The synthesized compounds could effectively release NO in vitro, displayed significant anti-proliferative effects on U87MG, NCI-H520, and SW620 cell lines. In the orthotopic glioma model, compound significantly and continuously suppressed the growth of gliomas in nude mice, and the brain glioma of the treatment group was markedly inhibited (>90%). In short, the structural fusion design of NO donor and β-elemene is a feasible strategy to improve the in vivo anti-tumor activity of β-elemene.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Amidation. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Computed Properties of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moeini, Nazanin; Molaei, Somayeh; Ghadermazi, Mohammad published the artcile< Selective oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles on Ce (III) immobilized CoFe2O4 as a magnetically separable, highly active, and reusable nanocatalyst>, Safety of 2-(Phenylthio)ethanol, the main research area is cobalt iron oxide nanocatalyst cerium immobilized amino glycol preparation; tetrazole green preparation; nitrile sodium azide cobalt iron oxide nanocatalyst cerium immobilized; sulfoxide green preparation; sulfide oxidation cobalt iron oxide nanocatalyst cerium immobilized.

Reactions of CoFe2O4 magnetic nanoparticles supported ligands, 2-amino-2-methyl-1,3-propanediol (Amino glycol), with cerium salts provided the resp. anchored complex CoFe2O4 @Amino glycol/Ce. The nanocatalyst was characterized perfectly using thermogravimetric analyzes, FT-IR spectroscopy, SEM, energy-dispersive X-ray inductively coupled plasma optical emission spectroscopy vibrational sample magnetometry and powder X-ray diffraction. CoFe2O4 magnetic nanoparticles supported ligands with cerium salts afforded active catalysts for the synthesis of 5-substituted 1H-tetrazoles I [R = Ph, 2-ClC6H4, Bn, etc.] via reaction of nitriles and sodium azide/oxidation of sulfides RSR1 [R = Ph, n-Pr, Et, etc.; R1 = Me, Bn, Ph, etc.] using Me Ph sulfide with H2O2 as oxidant at mild reaction conditions in the green medium under optimized conditions. The ligand and metal atom identity influenced the catalytic activity of the nanocatalyst. The immobilized complexes were easily collected via an external magnetic field and further reused at least 6 times without significant loss of catalytic activity and selectivity.

Research on Chemical Intermediates published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Newton, Christopher G.; Tran, Duc N.; Wodrich, Matthew D.; Cramer, Nicolai published the artcile< One-Step Multigram-Scale Biomimetic Synthesis of Psiguadial B>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is caryophyllene benzaldehyde diformylphloroglucinol biomimetic three component coupling cascade; psiguadial B biomimetic synthesis; biomimetic synthesis; cyclization; natural products; terpenoids; total synthesis.

A gram-scale synthesis of psiguadial B (I), a purported inhibitor of human hepatoma cell growth, has been achieved in one step by a biomimetic three-component coupling of caryophyllene, benzaldehyde, and diformylphloroglucinol. This cascade reaction is catalyzed by N,N’-dimethylethylenediamine, and proceeds at ambient temperature to generate four stereocenters, two rings, one C-O bond, and three C-C bonds. Combined computational and exptl. investigations suggest the biosynthesis of the natural product is non-enzyme mediated, and is the result of a Michael addition between caryophyllene and a reactive ortho-quinone methide, followed by two sequential intramol. cationic cyclization events.

Angewandte Chemie, International Edition published new progress about Biomimetic synthesis. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Yang; Ye, Yun-Fang; Zhang, Bi-Wei; Liu, Yong; Wang, Jun-Hui published the artcile< Purification, structural characterization and immunostimulatory activity of polysaccharides from Umbilicaria esculenta>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Umbilicaria esculenta polysaccharide immunostimulatory activity; Immunostimulatory activity; Polysaccharides of Umbilicaria esculenta; Structural characterization.

In this study, an active component UP1-1 was isolated from Chinese Huangshan Umbilicaria esculenta via hot water extraction and purified by anion-exchange and gel-filtration chromatog. UP1-1 mainly composed of galactose, mannose and glucose in a molar ratio of 0.8:1.0:4.6 with an average mol. weight of 281 kDa. Methylation anal. of UP1-1 revealed the major glycosidic bonds comprised 1,6-linked Glcp, 1,4-linked Glcp, t-linked Glcp, 1,3,6-linked Manp, 1,3-linked Galp, t-linked Galp at the ratio of 2.28:0.38:0.32:0.63:0.25:0.29. Structural anal. results revealed that the backbone of UP1-1 consisted of (6)-β-D-Glcp-(1→ ,→6)-β-D-Manp-(1→, → 4)-β-D-Glcp-(1 → residues with side chains of →3)-β-D-Galp-1→, β-D-Galp-1→ and β-D-Glcp-1→ branches located at O-3 position of → 6-β-D-Manp-1→. Immunostimulatory activity tests showed that UP1-1 could promote the phagocytic activity and NO production of RAW 264.7 cells in a dose-dependent manner. UP1-1 could significantly improve the proliferation effect of RAW 264.7 cells at the concentration of 50 μg/mL. Thus, UP1-1 exerted good immunostimulatory activity, suggesting that UP1-1 has a great potential application in pharmacol. industry.

International Journal of Biological Macromolecules published new progress about Anion exchange membranes. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts