Tag: M.W=150-200

Lawrence, Andrew L.; Adlington, Robert M.; Baldwin, Jack E.; Lee, Victor; Kershaw, Jessica A.; Thompson, Amber L. published the artcile< A Short Biomimetic Synthesis of the Meroterpenoids Guajadial and Psidial A>, HPLC of Formula: 4396-13-8, the main research area is caryophyllene benzaldehyde diformylphloroglucinol hetero Diels Alder reaction; meroterpenoid guajadial biomimetic synthesis; psidial A meroterpenoid biomimetic synthesis.

The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial (I) and psidial A (II) in an aqueous three-component coupling reaction, between caryophyllene, benzaldehyde, and diformylphloroglucinol.

Organic Letters published new progress about Absolute configuration. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, HPLC of Formula: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liang, Ying; Li, Yi; Sun, Aidong; Liu, Xianjin published the artcile< Chemical compound identification and antibacterial activity evaluation of cinnamon extracts obtained by subcritical n-butane and ethanol extraction>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is chem compound identification antibacterial activity evaluation cinnamon extract obtained; subcritical butane ethanol extraction; GC‐MS; HPLC‐MS; antibacterial activity; cinnamon; subcritical extraction.

Four important Cinnamomum species in China including C. cassia, C. loureiroi, C. wilsonii, and C. burmannii were chosen to be extracted by subcritical n-butane and ethanol. The chem. compounds of extracts were identified by GC-MS and HPLC-MS, and the antibacterial activities were evaluated by agar-well diffusion assay and twofold microdilution broth method. There were 47 compounds identified in n-butane extracts and 11 compounds in ethanol extracts totally. The major compounds in n-butane extracts varied significantly among different Cinnamomum species, and (E)-cinnamaldehyde and coumarin were major compounds for C. cassia with area percentage of 74.32%; (E)-cinnamaldehyde and a-copaene for C. loureiroi with area percentage of 67.83%; linalool, (E)-cinnamaldehyde, and citral for C. wilsonii with area percentage of 58.74%; and eugenol, (E)-cinnamaldehyde, and coumarin for C. burmannii with area percentage of 76.43%. The maximum compounds in ethanol extracts were (E)-cinnamaldehyde and (Z)-cinnamaldehyde, and others varied among the Cinnamomum species. All cinnamon extracts showed antibacterial activities that n-butane extracts were much more sensitive than ethanol extracts The inhibition zone for N-butane extracts against Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella anatum was from 18.98 to 37.45 mm while for ethanol extracts from 7.11 to 10.11 mm. The min. bactericidal concentrations for n-butane extracts were ranged from 0.31 to 2.50 mg/mL and for ethanol extracts ranged from 20.00 to 160.00 mg/mL. N-butane extracts of C. cassia and C. loureiroi processed much higher antibacterial activities than C. wilsonii and C. burmannii. N-butane extracts of C. cassia and C. loureiroi have the potential to be used as food biopreservative.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koolivand, Mostafa; Nikoorazm, Mohsen; Ghorbani-Choghamarani, Arash; Tahmasbi, Bahman published the artcile< Cu-citric acid metal-organic framework: Synthesis, characterization and catalytic application in Suzuki-Miyaura cross-coupling reaction and oxidation of sulfides>, Safety of 2-(Phenylthio)ethanol, the main research area is copper citrate metal organic framework preparation catalyst; Suzuki Miyaura cross coupling oxidation sulfide catalyst copper citrate.

Citric acid with three carboxylic groups was used as an outstanding chelating agent was utilized for the preparation of Cu-citric acid metal-organic framework (Cu-CA-MOF). The prepared MOF was characterized by FT-IR, XRD, EDS, AAS, SEM, WDX and BET anal. N2 adsorption-desorption isotherms indicated acceptable BET surface area for Cu-CA-MOF. SEM images were shown that Cu-CA-MOF has geometric polyhedral shapes. Also, catalytic activity of Cu-CA-MOF successfully examined for the Suzuki-Miyaura cross-coupling reaction and chemoselective oxidation of sulfides to sulfoxides.

Applied Organometallic Chemistry published new progress about Adsorption. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Major, Mate M.; Balogh, Szabolcs; Simon, Jozsef; Bakos, Jozsef; Farkas, Gergely published the artcile< New chiral thioether-phosphite ligands and their rhodium-coordination chemistry: steric and electronic properties, dynamic processes and application in catalysis>, Safety of 2-(Phenylthio)ethanol, the main research area is rhodium thioether phosphite chiral BINOL ester complex preparation; asym hydrogenation catalyst rhodium thioether BINOL phosphite cyclooctadiene complex.

Thioether-phosphite ligands (S)-BINOL-PO(CH2)nSPh (SP’s, n = 2, 3; BINOL-H2 = 1,1′-binaphthyl-2,2′-diol, H8-1,1′-binaphthyl-2,2′-diol) with axially chiral binaphthyl or 5,5′,6,6′,7,7′,8,8′-octahydrobinaphthyl moiety and their [Rh(COD)(SP)]BF4 complexes have been synthesized to study their coordination chem. and catalytic features and to compare them to those of the structurally analogous phosphine-phosphites (S)-BINOL-PO(CH2)nPPh2 (PP’s). NMR exchange studies on [Rh(COD)(SP)]BF4 complexes showed selective 1,5-cyclooctadiene dynamics. Firm evidence has been found that this fluxional process involves dissociation of the Rh-sulfur bond. Based on in situ NMR studies, SP ligands can form two types of bis-ligated species at ligand-to-metal ratio higher than 1. Unlike bis-ligated phosphine-phosphite complexes, bis-ligated thioether-phosphite Rh-complexes can efficiently catalyze asym. hydrogenation reactions due to their distinct coordination chem.

Journal of Coordination Chemistry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alfonzo, Edwin; Hande, Sudhir M. published the artcile< α-Heteroarylation of Thioethers via Photoredox and Weak Bronsted Base Catalysis>, Safety of 2-(Phenylthio)ethanol, the main research area is Heteroarylation thioether photoredox weak Bronsted base catalysis; Classical Minisci Reaction with Thioethers.

We report the C-H activation of thioethers to α-thio alkyl radicals and their addition to N-methoxyheteroarenium salts for the redox-neutral synthesis of α-heteroaromatic thioethers. Studies are consistent with a two-step activation mechanism, where oxidation of thioethers to sulfide radical cations by a photoredox catalyst is followed by α-C-H deprotonation by a weak Bronsted base catalyst to afford α-thio alkyl radicals. Further, N-methoxyheteroarenium salts play addnl. roles as a source of methoxyl radical that contributes to α-thio alkyl radical generation and a sacrificial oxidant that regenerates the photoredox catalytic cycle.

Organic Letters published new progress about Bronsted bases Role: CAT (Catalyst Use), USES (Uses). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Changchen; Wang, Hongquan; Bo, Zhao; Xia, Leilei; Jiang, Haiyue; Bo, Pan published the artcile< The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects>, Electric Literature of 492-62-6, the main research area is decellularized cartilage tissue regeneration cytotoxicity macrophage response; Costal cartilage defect; Decellularized cartilage; Macrophage response; Thoracic deformity.

After harvesting multiple costal cartilages, the local defect disrupts the integrity of the chest wall and may lead to obvious thoracic complications, such as local depression and asymmetry of the bilateral thoracic height. Decellularized materials have been used for tissue reconstruction in clin. surgeries. To apply xenogenic decellularized cartilage in costal cartilage defects, porcine-derived auricular and costal cartilage was tested for characterization, cytotoxicity, macrophage response, and tissue regeneration. Most of the DNA and α-Gal were effectively removed, and the collagen was well preserved after the decellularization process. The glycosaminoglycan (GAG) content decreased significantly compared to that in untreated cartilage. The decellularized auricular cartilage had a larger pore size, more pores, and a higher degradation rate than the decellularized costal cartilage. No apparent nuclei or structural damage was observed in the extracellular matrix. The decellularized auricular cartilage had a higher cell proliferation rate and more prominent immunomodulatory effect than the other groups. Two types of decellularized cartilage, particularly decellularized auricular cartilage, promoted the tissue regeneration in the cartilage defect area, combined with noticeable cartilage morphol. and increased chondrogenic gene expression. In our research, the functional components and structure of the extracellular matrix were well preserved after the decellularization process. The decellularized cartilage had better biocompatibility and suitable microenvironment for tissue regeneration in the defect area, suggesting its potential application in cartilage repair during the surgery. Autologous costal cartilage has been widely used in various surgeries, while the cartilage defects after the harvesting of multiple costal cartilages may cause localized chest wall deformities. Decellularized cartilage is an ideal material that could be produced in the factory and applied in surgeries. In this study, both decellularized costal cartilage and auricular cartilage preserved original structure, functional biocompatibility, immunosuppressive effects, and promoted tissue regeneration in the cartilage defect area.

Acta Biomaterialia published new progress about Aggrecans Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scaglione, Francesco; Musazzi, Umberto M.; Minghetti, Paola published the artcile< Considerations on D-mannose mechanism of action and consequent classification of marketed healthcare products>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is review Dmannose mechanism healthcare product; D-mannose; FimH adhesin; medical device; product administrative classification; urinary tract infection.

A review. Urinary tract infections (UTls) are very common disorders that affect adult women. Indeed, 50% of all women suffer from UTIs at least one time in their lifetime; 20-40% of them experience recurrent episodes. The majority of UTIs seems to be due to uropathogenic Escherichia coli that invades urothelial cells and forms quiescent bacterial reservoirs. Recurrences of UTls are often treated with non-prescribed antibiotics by the patients, with increased issues connected to antibiotics resistance. D-mannose, a monosaccharide that is absorbed but not metabolized by the human body, has been proposed as an alternative approach for managing UTIs since it can inhibit the bacterial adhesion to the urothelium. This manuscript discusses the mechanisms through which D-mannose acts to highlight the regulatory aspects relevant for determining the administrative category of healthcare products placed on the market. The existing literature permits to conclude that the anti- adhesive effect of D-mannose cannot be considered as a pharmacol. effect and, therefore, D-mannose-based products should be classified as medical devices composed of substances.

Frontiers in Pharmacology published new progress about Antibiotics (resistance). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Markert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Luond, Rainer M.; Miltz, Wolfgang; Walchli, Rudolf; Wolf, Romain; Hinrichs, Jurgen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jager, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Rohn, Till A. published the artcile< Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase>, HPLC of Formula: 167938-56-9, the main research area is tetrazole derivative LYS 006 preparation LTA4H inhibitor antiinflammatory activity.

The cytosolic metalloenzyme leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclin. studies have validated this enzyme as an attractive drug target in chronic inflammatory diseases. Despite several attempts, no LTA4H inhibitor has reached the market, yet. Herein, we disclose the discovery and preclin. profile of LYS006 (I), a highly potent and selective LTA4H inhibitor. A focused fragment screen identified hits that could be cocrystd. with LTA4H and inspired a fragment merging. Further optimization led to chiral amino acids and ultimately to LYS006, a picomolar LTA4H inhibitor with exquisite whole blood potency and long-lasting pharmacodynamic effects. Due to its high selectivity and its ability to fully suppress LTB4 generation at low exposures in vivo, LYS006 has the potential for a best-in-class LTA4H inhibitor and is currently investigated in phase II clin. trials in inflammatory acne, hidradenitis suppurativa, ulcerative colitis, and NASH.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, HPLC of Formula: 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Durgadevi, Ravindran; Veera Ravi, Arumugam; Alexpandi, Rajaiah; Krishnan Swetha, Thirukannamangai; Abirami, Gurusamy; Vishnu, Selvam; Karutha Pandian, Shunmugaiah published the artcile< Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis>, Related Products of 78-70-6, the main research area is urinary tract infection linalool proteus biofilm virulence; Antibiofilm activity; antivirulence activity; crystalline biofilm; linalool; motility; proteus.

Proteus mirabilis is one of the leading causes of catheter-associated UTIs (CAUTI) in individuals with prolonged urinary catheterization. Since, biofilm assisted antibiotic resistance is reported to complicate the treatment strategies of P. mirabilis infections, the present study was aimed to attenuate biofilm and virulence factor production in P. mirabilis. Linalool is a naturally occurring monoterpene alc. found in a wide range of flowers and spice plants and has many biol. applications. In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of P. mirabilis through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR anal. unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the in vitro bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against P. mirabilis mediated CAUTI.

Biofouling published new progress about Biofilms (microbial). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, John; Borah, Parijat; Modak, Arindam; Zhao, Yanli; Bhaumik, Asim published the artcile< Cu-Grafted Functionalized Mesoporous SBA-15: A Novel Heterogeneous Catalyst for Facile One-Pot Three-Component C-S Cross-Coupling Reaction of Aryl Halides in Water>, Computed Properties of 4396-13-8, the main research area is copper grafted SBA15 coupling aryl halide benzyl bromide thiourea; aryl alkyl thioether synthesis.

A highly ordered 2D hexagonal Cu-grafted functionalized mesoporous SBA-15 (Cu-PIF-SBA-15) has been designed through postsynthetic modification of mesoporous SBA-15. Surface functionalization technique has been employed to synthesize -NH2 functionalized mesoporous SBA-15 material. Schiff base condensation of this -NH2 functionalized SBA-15 with phloroglucinol dialdehyde leads to the formation of PIF-SBA-15. Reaction of PIF-SBA-15 with Cu-(OAc)2·H2O in ethanol under reflux leads to the formation of Cu-PIF-SBA-15 catalyst. This Cu-PIF-SBA-15 catalyst exhibits excellent catalytic activity in a one-pot three-component C-S coupling reaction for a diverse range of aryl halides (bromide and chloride) with thiourea and benzyl bromide in aqueous medium to offer aryl alkyl thioether in very good yields [e.g., 4-bromoanisole + thiourea + benzyl bromide → 4-MeOC6H4SCH2Ph (79%)]. Due to the strong binding ability of the imine-N and phenolic-OH functional groups present in the phloroglucinol diimine moiety of the framework, the anchored Cu-(II) could not leach out from the surface of the mesoporous catalyst during the course of reaction, and it has been observed that six repetitive reaction cycles could not cause any appreciable loss in the catalytic activity of this material.

Organic Process Research & Development published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Computed Properties of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts