Tag: M.W=150-200

Tan, Wen-Yun; Lu, Yi; Zhao, Jing-Feng; Chen, Wen; Zhang, Hongbin published the artcile< Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer>, Application of C8H10OS, the main research area is alc hydrogen transfer chemoselective oxidation reaction; aldehyde hydrogen transfer chemoselective oxidation reaction; carboxylic acid preparation.

In this paper,a new chemoselective process for the oxidation of primary alcs. and aldehydes was reported. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcs. and tert-butanesulfinamides.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fukutani, Tomonori; Miyazawa, Kohei; Iwata, Satoru; Satoh, Hiroko published the artcile< G-RMSD: Root Mean Square Deviation Based Method for Three-Dimensional Molecular Similarity Determination>, Quality Control of 492-62-6, the main research area is GRMSD Generalized Root Mean Square Deviation mol similarity determination.

We present the Generalized Root Mean Square Deviation (G-RMSD) method. G-RMSD is an optimization method to calculate the minimal RMSD value of two at. structures by optimal superimposition. G-RMSD is not restricted to systems with an equal number of atoms to compare or a unique atom mapping between two mols. The method can handle any type of chem. structure, including transition states and structures which cannot be explained only with valence bond (VB) theory (non-VB structures). It requires only Cartesian coordinates for the structures. Further information, i.e. atom- and bond types can also be included. Applications of G-RMSD to the classification of α-d-glucose conformers and 3D partial structure search using a dataset containing equilibrium (EQ), dissociation channel (DC), and transition state (TS) structures are demonstrated. We find that G-RMSD allows for a successful classification and mapping for a wide variety of mol. structures.

Bulletin of the Chemical Society of Japan published new progress about Algorithm. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Rugang; Wang, Congya; Zhang, Lijiao; Wang, Yu; Chen, Gang; Fan, Jungang; Jia, Youfeng; Yan, Fengwen; Ning, Chong published the artcile< Pectin oligosaccharides from fruit of Actinidia arguta: Structure-activity relationship of prebiotic and antiglycation potentials>, Related Products of 3458-28-4, the main research area is Actinidia fruit pectin oligosaccharide prebiotic antiglycation; Actinidia arguta; Antiglycation activity; Pectin oligosaccharides; Prebiotic activity; Structure-activity relationship.

Pectin oligosaccharides (POSs) have prebiotic and antiglycation activities in vitro, but the specific structure-activity relationship is unclear. In this study, POSs were obtained by enzymic and ultrasound-assisted enzymic degradation of pectin polysaccharide (PPS), resp. Based on the chem. characterization, the antiglycation in vitro and prebiotic activities of POSs were compared and the structure-activity relationship was studied. The results showed that the antiglycation activity of POSs in vitro was proportional to the galacturonic acid content and GalA:Rha molar ratios except for the low mol. weight POSs (LM-POSs), and inversely proportional to its branching degree, such as Ara:Rha and Gal:Rha molar ratios. In addition, it was also found that the prebiotic activity of POSs was pos. correlated with Ara:Rha and Gal:Rha molar ratios in mol. composition and the neutral sugar content, especially galactose and arabinose. The degree of esterification (DE) was less important for both antiglycation and prebiotic activity of POSs. These results provided an important theor. basis for POSs application in food.

Carbohydrate Polymers published new progress about Actinidia arguta. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Yi; Du, Nana; Li, Xueyuan; Zheng, Litao; Liu, Gang published the artcile< Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds>, SDS of cas: 4396-13-8, the main research area is fused tricyclic dienone chemoselective preparation; palladium copper catalyst aerobic dearomative cyclization alkenylphenylalkynyl carbonyl compound; tandem aerobic chloropalladation dearomative cyclization alkenylphenylalkynyl carbonyl compound; oxatricyclododecanecarboxamide mol crystal structure.

In the presence of PdCl2(MeCN)2 and CuCl2, o-alkenylphenylalkynyl carbonyl compounds such as allyloxyphenylpropynamide I underwent aerobic chemoselective dearomative cyclization reactions to yield fused tricyclic dienones such as II (R = MeO, BuO, EtO, PhCH2O, Me). The structure of II (R = PhCH2O) was determined by X-ray crystallog.

Organic Letters published new progress about Bicyclic compounds, ketones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (bridged). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tamoradi, Taiebeh; Moeini, Nazanin; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Fe3O4-AMPD-Pd: A novel and efficient magnetic nanocatalyst for synthesis of sulfides and oxidation reactions>, Application of C8H10OS, the main research area is iron oxide amino methyl propanediol palladium magnetic nanocatalyst; magnetic nanocatalyst sulfide oxidation reaction efficiency.

A novel magnetic nanoparticle was synthesized with effective catalytic properties and recyclable ability. This heterogeneous nanocatalyst was identified using Fourier transform IR, scanning electron microscopies, X-ray diffraction, vibrating sample magnetometer, inductively coupled plasma at. emission spectroscopy and thermogravimetric anal. methods. The nanocatalyst was used for the synthesis of the one-pot C-S coupling synthesis of sulfide in the presence of KOH, S8 as the sulfur source in DMSO as the solvent at 100 °C. Also, the oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides in the presence of the catalyst was tested. The catalyst has unique properties such as ability of magnetic separation from the reaction, high repeatability, and high thermal and chem. stability.

Polyhedron published new progress about IR spectra (transmittance). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reviejo, Irene; Tabernero, Vanessa; Mosquera, Marta E. G.; Ramos, Javier; Cuenca, Tomas; Jimenez, Gerardo published the artcile< Chiral Titanium(IV) Complexes Containing Polydentate Ligands Based on α-Pinene. Catalytic Activity in Sulfoxidation with Hydrogen Peroxide>, Formula: C8H10OS, the main research area is chiral aminoalkyliminopinene titanium isopropoxide preparation crystal mol structure catalyst; titanium polydentate alpha pinene complex preparation catalysis sulfoxidation; sulfoxidation catalyst terpenoid alpha pinene titanium isopropoxide preparation.

The reaction of TiCl4-n(OiPr)n (n = 0, 2, 4) with various terpenoid preligands based on α-pinene, C7H6Me3(OH)(NCH2CH2G) (G = NH2, I; NHMe, II; OH, III), stereoselectively affords a series of new chiral titanium(IV) complexes. Such complexes are either octahedral, [TiCl2X(OC7H6Me3NCH2CH2G-κ3N,N,O)] (X = Cl, G = NH2, 1; X = OiPr, G = NH2, 2; G = NHMe, 3), or trigonal bipyramidal, [Ti(OiPr)3(OC7H6Me3NCH2CH2G-κ2N,O)] (G = NH2, 4; NHMe, 5) and [TiX(OiPr)(OC7H6Me3NCH2CH2O-κ3N,O,O*)] (X = Cl, 6; OiPr, 8), depending on the acidity of titanium, the reaction conditions and the nature of the pendant ending group of the terpenoid ligand. D. functional theory (DFT) calculations have been carried out to assess the stability of the multiple possible diastereoisomers allowing to propose structural suggestions. The new titanium complexes efficiently catalyze the selective oxidation of various types of sulfides to either sulfoxides or sulfones using aqueous hydrogen peroxide, under mild conditions. All compounds have been characterized by multinuclear NMR spectroscopy and the mol. structure for some of them has been determined by x-ray diffraction.

Organometallics published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tekeli, Ibrahim Ozan; Atessahin, Ahmet; Sakin, Fatih; Aslan, Abdullah; Ceribasi, Songul; Yipel, Mustafa published the artcile< Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats>, Reference of 78-70-6, the main research area is lycopene linalool sulfasalazine antiinflammatory agent ulcerative colitis; Colon targeting; Linalool; Lycopene; Rat; Ulcerative colitis.

Objective: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. Methods: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochem. and histopathol. anal. Results: Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05). Conclusion: As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further. Inflammopharmacology published new progress about Anti-inflammatory agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhenming; Zhang, Guihua; Teixeira da Silva, Jaime A.; Zhao, Conghui; Duan, Jun published the artcile< The methyl jasmonate-responsive transcription factor DobHLH4 promotes DoTPS10, which is involved in linalool biosynthesis in Dendrobium officinale during floral development>, Application of C10H18O, the main research area is helix loop transcription factor floral volatile terpene synthase; orchid methyl jasmonate linalool; Floral volatiles; MeJA; Orchids; Terpene synthase; bHLH transcription factor.

Linalool is an aromatic monoterpene produced in the Chinese medicinal plant Dendrobium officinale, but little information is available on the regulation of linalool biosynthesis. Here, a novel basic helix-loop-helix (bHLH) transcription factor, DobHLH4 from D. officinale, was identified and functionally characterized. The expression profile of DobHLH4 was pos. correlated with that of DoTPS10 (R2 = 0.985, p < 0.01), which encodes linalool synthase that is responsible for linalool production, during floral development. DobHLH4 was highly expressed in petals, and was significantly induced by Me jasmonate. Anal. of subcellular localization showed that DobHLH4 was located in the nucleus. Yeast one-hybrid and dual-luciferase assays indicated that DobHLH4 bound directly to the DoTPS10 promoter harboring the G-box element, and up-regulated DoTPS10 expression. A yeast two-hybrid screen confirmed that DobHLH4 phys. interacted with DoJAZ1, suggesting that DobHLH4 might function in the jasmonic acid-mediated accumulation of linalool. Furthermore, transient overexpression of DobHLH4 in D. officinale petals significantly increased linalool production by triggering linalool biosynthetic pathway genes, especially DoTPS10. We suggest a hypothetical model that depicts how jasmonic acid signaling may regulate DoTPS10 by interacting with DobHLH4 and DoJAZ1. In doing so, the formation of linalool is controlled. Our results indicate that DobHLH4 is a pos. regulator of linalool biosynthesis and may be a promising target for in vitro-based metabolic engineering to produce linalool. Plant Science (Shannon, Ireland) published new progress about Dendrobium catenatum. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Weijuan; Zhang, Guohua published the artcile< Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway.>, SDS of cas: 78-70-6, the main research area is .

PURPOSE: Oral cancer is one of the prevalent types of cancer and has been reported to responsible for significant mortality and morbidity. Since treatment options for oral cancer are limited, there is need to explore novel molecules for treatment of oral cancer. In the current study we evaluated the anticancer activity of a plant derived monoterpene, Linalool against oral cancer cell line, OECM-1. METHODS: Cell viability was determined by MTT assay. Apoptosis was detected by DAPI and annexin V/PI staining. Cell cycle analysis was carried out by flow cytometry. Cell migration was assessed by wound healing assay and the expression of the proteins was determined by western blotting. RESULTS: The results showed that Linalool inhibited the viability of oral cancer OECM-1 cells in a concentration-dependent manner. The IC50 of Linalool against OECM-1 oral cancer cells was 10 µM as compared to its IC50 of 65 µM against non-cancer FR-2 cells. The anticancer effects were due to the induction of the apoptosis and sub-G1 cell cycle arrest. The results of annexin V/PI further revealed that the apoptotic cell populations increased from 2.6% in the control to 61.3% at 20 µM concentrations. It was observed that Linalool decreased the expression of p-PI3K and p-AKT in a concentration-dependent manner. However, the expression of PI3K and AKT remained almost unaltered. CONCLUSIONS: Taken together it was shown that Linalool monoterpene exerted significant anticancer effects in OECM-1 human oral cancer cells via inducing cell cycle arrest, loss of mitochondrial membrane potential (MMP) and suppressing PI3K/AKT signalling pathway.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pakvojoud, Saeedeh; Hatefi Ardakani, Mehdi; Saeednia, Samira; Heydari-Bafrooei, Esmaeil published the artcile< Efficient, selective and mild oxidation of sulfides and oxidative coupling of thiols catalyzed by Pd(II)-isatin Schiff base complex immobilized into three-dimensional mesoporous silica KIT-6>, Name: 2-(Phenylthio)ethanol, the main research area is palladium isatin Schiff base silica sulfide thiol oxidation coupling.

In this study, a palladium(II)-isatin Schiff base complex immobilized into three-dimensional (3D) mesoporous silica KIT-6 (Pd-isatin Schiff base@KIT-6) was synthesized and characterized by various techniques including inductively coupled plasma (ICP) and Fourier transform IR (FT-IR) spectroscopies, X-ray diffraction (XRD), SEM (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) technique and thermal gravimetric anal. (TGA). This new heterogeneous catalyst was successfully employed for the selective oxidation of sulfides to sulfoxides with tert-Bu hydroperoxide (tert-BuOOH) and oxidative coupling of thiols into corresponding disulfides using 30% H2O2 at room temperature The products were obtained in good to excellent yields and no over-oxidation of sulfoxides and disulfides was observed This catalytic system could also be applied for the chemo-selective oxidation of sulfides and thiols in the presence of other functional groups. The studied catalyst can be recovered easily by a simple filtration and reused five times in both oxidation reactions without a remarkable decrease in catalytic activity.

Journal of Sulfur Chemistry published new progress about Optimization. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts