Tag: M.W=150-200

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 141699-55-0

He, Jian;Bai, Zhi-Qin;Yuan, Pan-Feng;Wu, Li-Zhu;Liu, Qiang research published 《 Highly Efficient Iridium-Based Photosensitizers for Thia-Paterno-Buchi Reaction and Aza-Photocyclization》, the research content is summarized as follows. Substrates in excited state differ significantly from the corresponding ground state so that they are treated as different chem. species with diverse phys. properties and chem. reactivity. Therefore, applying photocatalytic systems to activate substrates becomes increasingly popular. Although photosensitizers serve as the core of the photocatalytic reaction, the design of a photosensitizer was not taken for granted. By modifying ligands of organometallic complexes to optimize properties of photosensitizers, the authors successfully achieved Ir complexes with long excited triplet-state lifetime, high triplet excited-state energy, strong absorption, and robust stability. The efficacies of the prepared Ir complexes as photosensitizers were evaluated toward various challenging photocycloaddition reactions (e.g., thia-Paterno-Buchi reaction and multicomponent 1-pot aza-photocyclization) between heterocyclic compound maleimides and unsaturated moieties that are not efficient to complete with well-established photosensitizers.

Computed Properties of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Reference of 141699-55-0

Hecker, Scott J.;Reddy, K. Raja;Lomovskaya, Olga;Griffith, David C.;Rubio-Aparicio, Debora;Nelson, Kirk;Tsivkovski, Ruslan;Sun, Dongxu;Sabet, Mojgan;Tarazi, Ziad;Parkinson, Jonathan;Totrov, Maxim;Boyer, Serge H.;Glinka, Tomasz W.;Pemberton, Orville A.;Chen, Yu;Dudley, Michael N. research published 《 Discovery of CyclicBoronic Acid QPX7728, an Ultrabroad-SpectrumInhibitor of Serine and Metallo-β-lactamases》, the research content is summarized as follows. Despite major advances in the beta-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the Class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the Class D (OXA) enzymes of Acinetobacter baumannii. Continuing the boronic acid program that led to vaborbactam, efforts were directed toward expanding the spectrum to allow treatment of a wider range of organisms. Through key structural modifications of a bicyclic lead, stepwise gains in spectrum of inhibition were achieved, ultimately resulting in QPX7728, I. This compound displays a remarkably broad spectrum of inhibition, including Class B and Class D enzymes, and is little affected by porin modifications and efflux. I is a promising agent for use in combination with a beta-lactam antibiotic for the treatment of a wide range of multidrug resistant gram-neg. bacterial infections, by both i.v. and oral administration.

Reference of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 72824-04-5, formula is C9H17BO2, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Formula: C9H17BO2

Henley, Zoe A.;Amour, Augustin;Barton, Nick;Bantscheff, Marcus;Bergamini, Giovanna;Bertrand, Sophie M.;Convery, Maire;Down, Kenneth;Dumpelfeld, Birgit;Edwards, Chris D.;Grandi, Paola;Gore, Paul M.;Keeling, Steve;Livia, Stefano;Mallett, David;Maxwell, Aoife;Price, Mark;Rau, Christina;Reinhard, Friedrich B. M.;Rowedder, James;Rowland, Paul;Taylor, Jonathan A.;Thomas, Daniel A.;Hessel, Edith M.;Hamblin, J. Nicole research published 《 Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target》, the research content is summarized as follows. Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδ over Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicol. outcomes at similar exposure levels to compound 19.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Formula: C9H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Qi; Gu, Peng; Zhang, Hao; Luo, Xin; Zhang, Jibiao; Zheng, Zheng published the artcile< Response of submerged macrophytes and leaf biofilms to the decline phase of Microcystis aeruginosa: Antioxidant response, ultrastructure, microbial properties, and potential mechanism>, Product Details of C6H12O6, the main research area is Microcystis leaf biofilm submerged macrophyte; Cyanobacterial exudates and extracts; Decline phase; Microbial properties; N-acylated-L-homoserine lactones; Submerged macrophyte.

Decaying cyanobacterial blooms carry a potential risk for submerged macrophyte and periphyton biofilms in aquatic environments. This study comprehensively studied the responses in growth, oxidative response, detoxification pathway, and ultrastructure characteristics of aquatic plants to Microcystis aeruginosa (M. aeruginosa) exudates and extracts released during the decline phase. Particular emphasis was placed on the variation of extracellular polymeric substances (EPS) and quorum-sensing signaling mols. The results showed that superoxide dismutase, peroxidase, and glutathione S-transferase were significantly induced as antioxidant response, and the malondialdehyde content increased. Increased content of MC-LR (1.129 μg L-1) and NH+4-N (1.35 mg L-1) were found in the decline phase of M. aeruginosa, which played a vital role in the damage to submerged plants. In addition, a change in the amount of osmophilic granules and a variation of organelles and membranes was observed A broad distribution of α-D-glucopyranose polysaccharides was dominant and aggregated into clusters in biofilm EPS in response to exposure to decaying M. aeruginosa. Furthermore, exposure to exudates and extracts changed the abundance and structure of the microbial biofilm community. Increased contents of N-acylated-L-homoserine lactone signal mol. might result in a variation of biofilm EPS production in response to decaying M. aeruginosa. These results expand the understanding of how submerged macrophyte and periphyton biofilms respond to environmental stress caused by exudates and extracts of decaying M. aeruginosa.

Science of the Total Environment published new progress about Allelochemicals Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moeini, Nazanin; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Anchoring Ni (II) on Fe3O4@tryptophan: A recyclable, green and extremely efficient magnetic nanocatalyst for one-pot synthesis of 5-substituted 1H-tetrazoles and chemoselective oxidation of sulfides and thiols>, Synthetic Route of 699-12-7, the main research area is sulfoxide preparation; disulfide preparation; tetrazole preparation; sulfide oxidation nickel ironoxide tryptophan nanoparticle catalyst; thiol oxidation nickel ironoxide tryptophan nanoparticle catalyst; cyanide azide cycloaddition nickel ironoxide tryptophan nanoparticle catalyst.

A green, novel and extremely efficient nanocatalyst was successfully synthesized by the immobilization of Ni as a transition metal on Fe3O4 nanoparticles coated with tryptophan. This nanostructured material was characterized using Fourier transform IR spectroscopy, transmission electron microscopy, SEM, energy-dispersive X-ray spectroscopy, thermogravimetric anal., inductively coupled plasma optical emission spectroscopy, vibrating sample magnetometry and X-ray diffraction. The prepared nanocatalyst was applied for the oxidation of sulfides, oxidative coupling of thiols and synthesis of 5-substituted 1H-tetrazoles. The use of non-toxic, green and inexpensive materials, easy separation of magnetic nanoparticles from a reaction mixture using a magnetic field, efficient and one-pot synthesis, and high yields of products are the most important advantages of this nanocatalyst.

Applied Organometallic Chemistry published new progress about Cyanides (inorganic) Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Synthetic Route of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jixian; Wen, Chaoting; Gu, Jinyan; Ji, Chenchen; Duan, Yuqing; Zhang, Haihui published the artcile< Effects of subcritical water extraction microenvironment on the structure and biological activities of polysaccharides from Lentinus edodes>, Quality Control of 3458-28-4, the main research area is Lentinus polysaccharide structure subcritical water extraction microenvironment antioxidant antitumor; Biological activities; Microenvironment; Polysaccharides; Structure; Subcritical water.

In the present study, we investigated the effects of subcritical water microenvironment on the structure and biol. activities of polysaccharides from Lentinus edodes. The results showed that, under different SWE conditions (100-150°C for 15 min, and 150°C for 10-30 min), all the polysaccharides were heteropolysaccharides and consisted of glucose, mannose and galactose with different molar ratios. In addition, FT-IR results showed that all samples were typical β-pyranose and protein-free polysaccharides. Moreover, Congo red staining and at. force microscope (AFM) analyses showed that when the temperature was above 150°C for 15 min, the triple-helix structure no longer existed. Furthermore, various polysaccharides had varying degrees of inhibitory effect on HepG2 cells and MCF-7 cells in vitro. These findings indicated that subcritical water microenvironment has an extremely important effect on the structure and bioactivities of polysaccharides. The polysaccharides may be extracted more effectively by changing the subcritical water microenvironment.

International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jabir, Majid; Sahib, Usama I.; Taqi, Zainab; Taha, Ali; Sulaiman, Ghassan; Albukhaty, Salim; Al-Shammari, Ahmed; Alwahibi, Mona; Soliman, Dina; Dewir, Yaser Hassan; Rizwana, Humaira published the artcile< Linalool-loaded glutathione-modified gold nanoparticles conjugated with CALNN peptide as apoptosis inducer and NF-κB translocation inhibitor in SKOV-3 cell line>, Electric Literature of 78-70-6, the main research area is linalool glutathione gold nanoparticles peptide apoptosis NFkappaB translocation inhibitor; CALNN; NF-κB translocation; SKOV-3; caspase-8; gold nanoparticles; linalool; p53.

Linalool is a monoterpene compound with various potential therapeutic applications in several medical fields. Previous studies have indicated the activity of linalool against cell lines; however, its high level of toxicity restricts its use. The aim of this study was to design and manufacture compounds with a novel structure that can be used for loading linalool, to reduce its toxicity and improve its reachable ability. We synthesized and characterized a new mol. for loading linalool onto gold nanoparticles (GNPs) capped with glutathione and conjugated with a CALNN peptide. Linalool was loaded onto the GNPs via the reaction of the surface groups of both linalool and the GNPs. Moreover, the target peptide could be loaded onto the surface of the GNPs via a chem. reaction. The cytotoxic effects of linalool-GNP (LG) and linalool-GNP-CALNN peptide (LGC) conjugates against ovarian cancer cells were investigated, as were the possible mechanisms underlying the induction of apoptosis. Our findings illustrated the significant antiproliferative effect of LG and LGC on SKOV-3 cells. The cytotoxicity assay demonstrated that LG and LGC were selectively toxic in cancer cells and induced apoptosis by activating caspase-8, the p53 protein, and various proteins involved in apoptosis. The present data demonstrated that LG and LGC have a high therapeutic potential and should be given particular consideration as anticancer drug-delivery systems, as LG and LGC were remarkably more cytotoxic against a cancer cell line than were linalool and GNPs alone. We concluded that LG and LGC are promising compounds that can be used for treating ovarian cancer (SKOV-3) cells via the induction of apoptosis through extrinsic and intrinsic pathways.

International Journal of Nanomedicine published new progress about Antitumor agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uddin Pk, Moyen Md.; Islam, Mohammad Sayful; Pervin, Rumana; Dutta, Subhajit; Talukder, Rabiul Islam; Rahman, Matiar published the artcile< Optimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line>, SDS of cas: 3458-28-4, the main research area is Pleurotus polysaccharide antioxidant cytotoxicity lymphoid cancer cell.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P.Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide. In this investigation, polysaccharides from Pleurotus ostreatus (Jacq.) P.Kumm were extricated by utilizing the hot water. One-single factor and response surface methodol. was established to optimize the extraction conditions for polysaccharide from Pleurotus ostreatus (Jacq.) P.Kumm. Examination of antioxidant activity of Pleurotus ostreatus polysaccharide (POP) was directed by utilizing 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2-azino-bis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) techniques. Cytotoxicity of POP was evaluated using an MTT assay. The exptl. data were fitted to a quadratic equation utilizing multiple regression investigations, and the ideal conditions were as per the following: water/crude material proportion, 26.04 mL/g; an extraction time of 62.08 min; and an extraction temperature 70.5°C. Under such conditions, the polysaccharide yield was 5.32 ± 0.12% with the anticipated yield. POP showed good scavenging activity against DPPH radical (p<0.001, EC50 = 1036.38 μg/mL, R2 = 0.8313) and ABTS radicals (p<0.001, EC50 = 824.37 μg/mL, R2 = 0.8223), with a dose (p<0.001)-and-time (p<0.001) dependent cytotoxic potential on Ehrlich ascites carcinoma cell line in vitro. This demonstrated that polysaccharides (POP) had certain cancer prevention agent exercises. In this manner, these examinations give reference to addnl. research and reasonable improvement of Pleurotus ostreatus (Jacq.) P. Kumm polysaccharide and POP may prove a useful therapeutic agent, due to its robust antioxidant and cytotoxic activity. PLoS One published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Perez-Jimenez, Maria; Chaya, Carolina; Pozo-Bayon, Maria Angeles published the artcile< Individual differences and effect of phenolic compounds in the immediate and prolonged in-mouth aroma release and retronasal aroma intensity during wine tasting>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is phenol aroma retronasal perception wine tasting; Oral aroma release; Phenolic compounds; Retronasal aroma perception; Wine tasting.

To explore the role of phenolic compounds in oral aroma release during wine tasting, four rose ́wines supplemented with three types of com. phenolic extracts and a control wine were evaluated. Wines were aromatized with a mixture of six target aroma compounds In vivo oral aroma release was monitored in six volunteers at two different times after wine rinsing, just after spitting of the wine (immediate release), and four minutes later (prolonged release). To check the sensory meaning of these changes, descriptive anal. using a trained panel (n = 10) was also performed. Results showed a strong individual effect on total oral aroma release at the two sampling points. After the oral exposure to wines with phenolic extracts, a lower release of most target aroma compounds was also determined Lower intensity scores for some aroma attributes in wines with phenolic extracts were found, showing a good agreement between the two scientific approaches.

Food Chemistry published new progress about Mental perception. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Somenath; Singh, Vipin Kumar; Chaudhari, Anand Kumar; Dwivedy, Abhishek Kumar; Dubey, Nawal Kishore published the artcile< Fabrication, physico-chemical characterization, and bioactivity evaluation of chitosan-linalool composite nano-matrix as innovative controlled release delivery system for food preservation>, Product Details of C10H18O, the main research area is chitosan linalool composite nanomatrix food preservation; Antifungal; Linalool; Nanocomposite.

The aim of the present study was to encapsulate linalool into chitosan nanocomposite (Nm-linalool) for developing novel controlled release delivery system in order to protect stored rice against fungal infestation, aflatoxin B1 (AFB1) contamination, and lipid peroxidation The chitosan-linalool nanocomposite showed spherical shapes, smooth surface with monomodal distribution as revealed by SEM and AFM investigation. FTIR and XRD represented peak shifting and changes in degree of crystallinity after incorporation of linalool into chitosan nanocomposite. Nanoencapsulation of linalool showed higher zeta potential and lowered polydispersity index. TGA anal. reflected the stability of Nm-linalool with reduced weight loss at varying temperatures Biphasic pattern, with initial rapid release followed by sustained release illustrated controlled delivery of linalool from chitosan nanocomposite, a prerequisite for shelf-life enhancement of stored food products. Chitosan nanocomposite incorporating linalool displayed prominent antifungal and antiaflatoxigenic activity during in vitro as well as in situ investigation in rice with improved antioxidant potentiality. Further, Nm-linalool displayed considerable reduction of lipid peroxidation in rice without exerting any adverse impact on organoleptic attributes. In conclusion, the investigation strengthens the application of chitosan-linalool nanocomposite as an innovative controlled nano-delivery system for its practical application as novel environmentally friendly eco-smart preservative in food and agricultural industries.

International Journal of Biological Macromolecules published new progress about Aflatoxins Role: ADV (Adverse Effect, Including Toxicity), BIOL (Biological Study) (AFM). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts