Tag: M.W=150-200

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Quality Control of 141699-55-0

Qiu, Zhenjiang;Zhu, Mingxiang;Zheng, Lu;Li, Jingya;Zou, Dapeng;Wu, Yangjie;Wu, Yusheng research published 《 Regioselective α-benzylation of 3-iodoazetidines via Suzuki cross-coupling》, the research content is summarized as follows. An efficient protocol for the synthesis of α-benzyl azetidines I [R = 4-F₃COC₆H₄, 2-F-C₆H₄, naphthalen-2-yl, etc.; R¹ = C(O)OCH₂C₆H₅, C(O)OC(CH₃)₃] starting from benzylboronic acid pinacol ester derivatives II and 3-iodoazetidine III was developed. A wide range of α-benzyl azetidine derivatives I was obtained in moderate to good yields with high regioselectivity (>99%).

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Quality Control of 141699-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 141699-55-0, formula is C8H15NO3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Reference of 141699-55-0

Rabal, Obdulia;Sanchez-Arias, Juan A.;Cuadrado-Tejedor, Mar;de Miguel, Irene;Perez-Gonzalez, Marta;Garcia-Barroso, Carolina;Ugarte, Ana;Estella-Hermoso de Mendoza, Ander;Saez, Elena;Espelosin, Maria;Ursua, Susana;Tan, Haizhong;Wu, Wei;Xu, Musheng;Pineda-Lucena, Antonio;Garcia-Osta, Ana;Oyarzabal, Julen research published 《 Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles》, the research content is summarized as follows. Here, we present a series of dual-target phosphodiesterase 9 (PDE9) and histone deacetylase (HDAC) inhibitors devised as pharmacol. tool compounds for assessing the implications of these two targets in Alzheimer’s disease (AD). These novel inhibitors were designed taking into account the key pharmacophoric features of known selective PDE9 inhibitors as well as privileged chem. structures, bearing zinc binding groups (hydroxamic acids and ortho-amino anilides) that hit HDAC targets. These substituents were selected according to rational criteria and previous knowledge from our group to explore diverse HDAC selectivity profiles (pan-HDAC, HDAC6 selective, and class I selective) that were confirmed in biochem. screens. Their functional response in inducing acetylation of histone and tubulin and phosphorylation of cAMP response element binding (CREB) was measured as a requisite for further progression into complete in vitro absorption, distribution, metabolism and excretion (ADME) and in vivo brain penetration profiling. Compound 31b, a selective HDAC6 inhibitor with acceptable brain permeability, was chosen for assessing in vivo efficacy of these first-in-class inhibitors, as well as studying their mode of action (MoA).

Reference of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. COA of Formula: C8H15NO3

Palkowitz, Maximilian D.;Tan, Bo;Hu, Haitao;Roth, Kenneth;Bauer, Renato A. research published 《 Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities》, the research content is summarized as follows. Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.

COA of Formula: C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 72824-04-5, formula is C9H17BO2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Pan, Yu-Liang;Zheng, Han-Liang;Wang, Jie;Yang, Chen;Li, Xin;Cheng, Jin-Pei research published 《 Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)₃/Chiral Phosphoric Acid》, the research content is summarized as follows. Phthalides as the crucial core skeletons are found extensively in natural products and biol. active mols. Disclosed an asym. allylation of 3-hydroxyisobenzofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives The simple Bi(OAc)₃/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biol. activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 72824-04-5, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 72824-04-5, name is 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Pan, Yu-Liang;Shao, Ying-Bo;Wang, Jie;Liu, Zhen;Chen, Li;Li, Xin research published 《 Kinetic Resolution of 2H-Azirines by Asymmetric Allylation Reactions》, the research content is summarized as follows. A practical and efficient method for kinetic resolution of azirines was achieved via asym. allylations of racemic 2H-azirines with boron allylation reagents enabled by Bi(OAc)₃/chiral phosphoric acid catalysis.A broad range of azirine substrates with electron-withdrawing and electron-donating groups at the two aromatic rings, as well as the different allyl boron reagents, were well tolerated in this methodol., providing high kinetic resolution performance (with an s-factor of up to 127) under very mild reaction conditions with only 2 mol % catalyst loading. In addition, the synthetic utility of the protocol was proved by the scaled-up reaction and transformations of the product. Computational studies suggested that the various weak interactions were essential for enantioselectivity. Moreover, the effect of different metal acetates and counter anions on the reaction outcome was also interpreted by the calculations

Quality Control of 72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Synthetic Route of 141699-55-0

Nguyen, William;Jacobson, Jonathan;Jarman, Kate E.;Blackmore, Timothy R.;Sabroux, Helene Jousset;Lewin, Sharon R.;Purcell, Damian F.;Sleebs, Brad E. research published 《 Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents》, the research content is summarized as follows. Here, two strategies to further improve the activation of viral gene expression and physicochem. properties of this class was implemented. Firstly, rigidification of the central oxy-carbon linker with a variety of saturated heterocycles and secondly, investigated bioisosteric replacement of the 2-acylaminothiazole moiety was explored. The optimization process afforded lead compounds, imidazopyridine derivatives such as I from the 2-piperazinyl thiazolyl urea and the imidazopyridine class. The imidazopyridine derivatives from each class demonstrated potent activation of HIV gene expression in the FlpIn. FM HEK293 cellular assay (both with LTR EC₅₀s of 80 nM) and in the Jurkat Latency 10.6 cell model (LTR EC₅₀ 220 and 320 nM resp.), but consequently activated gene expression non-specifically in the FlpIn. FM HEK293 cellular assay (CMV EC₅₀ 70 and 270 nM resp.) manifesting in cellular cytotoxicity. The lead compounds had potential for further development as novel latency reversing agents.

Synthetic Route of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Formula: C8H15NO3

Noguchi, Tetsuji;Tanaka, Naoki;Nishimata, Toyoki;Goto, Riki;Hayakawa, Miho;Sugidachi, Atsuhiro;Ogawa, Taketoshi;Asai, Fumitoshi;Matsui, Yumi;Fujimoto, Koichi research published 《 Indoline derivatives. Synthesis and factor Xa (FXa) inhibitory activities》, the research content is summarized as follows. A series of bisamidine derivatives each having a ring structure in the center of the mol. was synthesized and their Factor Xa (FXa) inhibitory activities were evaluated. Among them, some indoline derivatives showed potent inhibitory activities in vitro. In particular, compound (I) having an (R)-configuration at the 2-position of the indoline ring exhibited the most potent FXa inhibitory activity in vitro, more potent than DX-9065a. Furthermore, I exhibited more potent anticoagulant activity than DX-9065a. The authors also succeeded in obtaining an x-ray crystal structure of FXa bound with I.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Formula: C8H15NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 72824-04-5, formula is C9H17BO2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Application In Synthesis of 72824-04-5

O’Brien, Luke;Argent, Stephen P.;Ermanis, Kristaps;Lam, Hon Wai research published 《 Gold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates》, the research content is summarized as follows. Gold(I)-catalyzed nucleophilic allylations of pyridinium and quinolinium ions with various allyl pinacolboronates was reported. The reactions was completely selective with respect to the site of the azinium ion that was attacked, to give various functionalized 1,4-dihydropyridines and 1,4-dihydroquinolines. Evidence suggested that the reactions proceed through nucleophilic allylgold(I) intermediates formed by transmetalation from allylboronates. D. functional theory (DFT) calculations provided mechanistic insight.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Application In Synthesis of 72824-04-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 72824-04-5, formula is C9H17BO2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Oderinde, Martins S.;Ramirez, Antonio;Dhar, T. G. Murali;Cornelius, Lyndon A. M.;Jorge, Christine;Aulakh, Darpandeep;Sandhu, Bhupinder;Pawluczyk, Joseph;Sarjeant, Amy A.;Meanwell, Nicholas A.;Mathur, Arvind;Kempson, James research published 《 Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity》, the research content is summarized as follows. Indole and indoline rings are important pharmacophoric scaffolds found in marketed drugs, agrochems., and biol. active mols. The [2 + 2] cycloaddition reaction is a versatile strategy for constructing architecturally interesting, sp³-rich cyclobutane-fused scaffolds with potential applications in drug discovery programs. A general platform for visible-light mediated intermol. [2 + 2] cycloaddition of indoles with alkenes has been realized. A substrate-based screening approach led to the discovery of tert-butyloxycarbonyl (Boc)-protected indole-2-carboxyesters as suitable motifs for the intermol. [2 + 2] cycloaddition reaction. Significantly, the reaction proceeds in good yield with a wide variety of both activated and unactivated alkenes, including those containing free amines and alcs., and the transformation exhibits excellent regio- and diastereoselectivity. Moreover, the scope of the indole substrate is very broad, extending to previously unexplored azaindole heterocycles that collectively afford fused cyclobutane containing scaffolds that offer unique properties with functional handles and vectors suitable for further derivatization. DFT computational studies provide insights into the mechanism of this [2 + 2] cycloaddition, which is initiated by a triplet-triplet energy transfer process. The photocatalytic reaction was successfully performed on a 100 g scale to provide the dihydroindole analog.

Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 141699-55-0, formula is C8H15NO3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate

McDonald, Richard I.;Wong, Gene W.;Neupane, Ram P.;Stahl, Shannon S.;Landis, Clark R. research published 《 Enantioselective Hydroformylation of N-Vinyl Carboxamides, Allyl Carbamates, and Allyl Ethers Using Chiral Diazaphospholane Ligands》, the research content is summarized as follows. Rhodium complexes of diazaphospholane ligands catalyze the asym. hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates; products include 1,2- and 1,3-aminoaldehydes and 1,3-alkoxyaldehydes. Using glass pressure bottles, short reaction times (generally less than 6 h), and low catalyst loading (commonly 0.5 mol %), 20 substrates are successfully converted to chiral aldehydes with useful regioselectivity and high enantioselectivity (up to 99% ee). Chiral Roche aldehyde is obtained with 97% ee from the hydroformylation of allyl silyl ethers. Commonly difficult substrates such as 1,1- and 1,2-disubstituted alkenes undergo effective hydroformylation with 89-97% ee and complete conversion for six examples. Palladium-catalyzed aerobic oxidative amination of allyl benzyl ether followed by enantioselective hydroformylation yields the β³-aminoaldehyde with 74% ee.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts