Tag: M.W=150-200

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Synthetic Route of 141699-55-0

Rudolph, Joachim;Murray, Lesley J.;Ndubaku, Chudi O.;O’Brien, Thomas;Blackwood, Elizabeth;Wang, Weiru;Aliagas, Ignacio;Gazzard, Lewis;Crawford, James J.;Drobnick, Joy;Lee, Wendy;Zhao, Xianrui;Hoeflich, Klaus P.;Favor, David A.;Dong, Ping;Zhang, Haiming;Heise, Christopher E.;Oh, Angela;Ong, Christy C.;La, Hank;Chakravarty, Paroma;Chan, Connie;Jakubiak, Diana;Epler, Jennifer;Ramaswamy, Sreemathy;Vega, Roxanne;Cain, Gary;Diaz, Dolores;Zhong, Yu research published 《 Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window》, the research content is summarized as follows. P21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with PAK1 amplification. Animal studies with the selective group I PAK (pan-PAK1, 2, 3) inhibitor G-5555 from the pyrido[2,3-d]pyrimidin-7-one class uncovered acute toxicity with a narrow therapeutic window. To attempt mitigating the toxicity, we introduced significant structural changes, culminating in the discovery of the potent pyridone side chain analog G-9791. Mouse tolerability studies with this compound, other members of this series, and compounds from two structurally distinct classes revealed persistent toxicity and a correlation of min. toxic concentrations and PAK1/2 mediated cellular potencies. Broad screening of selected PAK inhibitors revealed PAK1, 2, and 3 as the only overlapping targets. Our data suggest acute cardiovascular toxicity resulting from the inhibition of PAK2, which may be enhanced by PAK1 inhibition, and cautions against continued pursuit of pan-group I PAK inhibitors in drug discovery.

Synthetic Route of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 141699-55-0, formula is C8H15NO3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. SDS of cas: 141699-55-0

Sang, Ruocheng;Korkis, Stamatis E.;Su, Wanqi;Ye, Fei;Engl, Pascal S.;Berger, Florian;Ritter, Tobias research published 《 Site-selective C-H Oxygenation via Aryl Sulfonium Salts》, the research content is summarized as follows. Herein, we report a two-step process forming arene C-O bonds in excellent site-selectivity at a late-stage. The C-O bond formation is achieved by selective introduction of a thianthrenium group, which is then converted into C-O bonds using photoredox chem. Electron-rich, -poor and -neutral arenes as well as complex drug-like small mols. are successfully transformed into both phenols and various ethers. The sequence differs conceptually from all previous arene oxygenation reactions in that oxygen functionality can be incorporated into complex small mols. at a late stage site-selectively, which has not been shown via aryl halides.

SDS of cas: 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 72824-04-5, formula is C9H17BO2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Reference of 72824-04-5

Rao, Junxin;Zhao, Jianli;Zhu, Xin;Guo, Zhen;Wang, Chengming;Zhou, Cong-Ying research published 《 Rhodium-catalyzed reaction of diazoquinones with allylboronates to synthesize allylphenols》, the research content is summarized as follows. Herein, a Rh₂(esp)₂-catalyzed reaction of diazoquinones with allylboronates, which provides access to a range of allylphenols I [Ar = 2-F-4-OHC₆H₃, 2-OH-4-MeC₆H₃, 3-Br-4-OHC₆H₃, etc.; R² = H, Me, Br, etc.; R³ = H, Me; R⁴ = H, Me; R³R⁴ = CH₂CH₂, CH₂CH₂CH₂] including para-allylphenols, ortho-allylphenols and allylnaphthols, in 44-94% yields and under mild conditions was reported. The synthetic utility of the method was demonstrated by the short synthesis of two bioactive anti-inflammatory and the anticancer compounds The mechanistic studies suggested that the reaction proceeds through a cyclopropanation/ring opening/aromatization pathway.

Reference of 72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Application of C8H15NO3

Reilly, Sean W.;Puentes, Laura N.;Schmitz, Alexander;Hsieh, Chia-Ju;Weng, Chi-Chang;Hou, Catherine;Li, Shihong;Kuo, Yin-Ming;Padakanti, Prashanth;Lee, Hsiaoju;Riad, Aladdin A.;Makvandi, Mehran;Mach, Robert H. research published 《 Synthesis and evaluation of an AZD2461 [¹⁸F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant》, the research content is summarized as follows. Poly(ADP-ribose)polymerase-1 inhibitor (PARPi) AZD2461 was designed to be a weak P-glycoprotein (P-gp) analog of FDA approved olaparib. With this chem. property in mind, we utilized the AZD2461 ligand architecture to develop a CNS penetrant and PARP-1 selective imaging probe, in order to investigate PARP-1 mediated neuroinflammation and neurodegenerative diseases, such as Alzheimer′s and Parkinson′s. Our work led to the identification of several high-affinity PARPi, including AZD2461 congener 9e (PARP-1 IC₅₀ = 3.9 ± 1.2 nM), which was further evaluated as a potential ¹⁸F-PET brain imaging probe. However, despite the similar mol. scaffolds of 9e and AZD2461, our studies revealed non-appreciable brain-uptake of [¹⁸F]9e in non-human primates, suggesting AZD2461 to be non-CNS penetrant.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Application of C8H15NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 141699-55-0, formula is C8H15NO3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. COA of Formula: C8H15NO3

Reiners, Felix;Joseph, Emanuel;Nissl, Benedikt;Didier, Dorian research published 《 Stereoselective access to azetidine-based α-amino acids and applications to small peptide synthesis》, the research content is summarized as follows. Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asym. reduction allowed for the synthesis of a new library of 2-azetidinylcarboxylic acids, which were finally employed in the formation of small peptide chains.

COA of Formula: C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 72824-04-5, formula is C9H17BO2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Category: alcohols-buliding-blocks

Ren, Xiaoxiao;Gao, Xing;Min, Qiao-Qiao;Zhang, Shu;Zhang, Xingang research published 《 (Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes》, the research content is summarized as follows. An unprecedented example of alkylzirconocenes Cp₂ZrCl(CH₂)₂R (R = Bn, dimethyl(phenyl)silyl, trimethylsilyl, etc.) promoted difluoroalkylation of alkyl- and silyl-alkenes RCH=CH₂ with a variety of unactivated difluoroalkyl iodides and bromides R¹C(F₂)X (R¹ = [(ethanesulfonyl)oxy]methyl, (morpholin-4-yl)carbonyl, 3-[(4-chlorophenyl)carbonyloxy]propyl, etc.; X = I, Br) under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds RC(F₂)R¹ can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalkyl, and nonfluorinated alkyl halides, providing a general method to controllably access fluorinated compounds Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway induced by a Zr(III) species is involved in the reaction, in which the Zr(III) species is generated by the photolysis of alkylzirconocene with blue light.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 141699-55-0, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 141699-55-0, name is tert-Butyl 3-hydroxyazetidine-1-carboxylate, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Rice, Kenneth D.;Aay, Naing;Anand, Neel K.;Blazey, Charles M.;Bowles, Owen J.;Bussenius, Joerg;Costanzo, Simona;Curtis, Jeffry K.;Defina, Steven C.;Dubenko, Larisa;Engst, Stefan;Joshi, Anagha A.;Kennedy, Abigail R.;Kim, Angie I.;Koltun, Elena S.;Lougheed, Julie C.;Manalo, Jean-Claire L.;Martini, Jean-Francois;Nuss, John M.;Peto, Csaba J.;Tsang, Tsze H.;Yu, Peiwen;Johnston, Stuart research published 《 Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)》, the research content is summarized as follows. The ERK/MAP kinase cascade is a key mechanism subject to dysregulation in cancer and is constitutively activated or highly upregulated in many tumor types. Mutations associated with upstream pathway components RAS and Raf occur frequently and contribute to the oncogenic phenotype through activation of MEK and then ERK. Inhibitors of MEK have been shown to effectively block upregulated ERK/MAPK signaling in a range of cancer cell lines and have further demonstrated early evidence of efficacy in the clinic for the treatment of cancer. Guided by structural insight, a strategy aimed at the identification of an optimal diphenylamine-based MEK inhibitor with an improved metabolism and safety profile vs. PD-0325901 led to the discovery of development candidate 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2S)-piperidin-2-yl]azetidin-3-ol (XL518, GDC-0973) (I). I exhibits robust in vitro and in vivo potency and efficacy in preclin. models with sustained duration of action and is currently in early stage clin. trials.

HPLC of Formula: 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 72824-04-5, formula is C9H17BO2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Name: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Peranantham, Pazhanisami;Jeyachandran, Yekkoni Lakshmanan research published 《 Sub-2 nm boron doping in silicon using novel ultra-thin SiO₂ film produced by sol-gel dip coating as a capping layer》, the research content is summarized as follows. Advancements in semiconductor electronics and sensor technologies demand a more robust doping approach and process to fabricate ultra-shallow doping with abrupt depth, particularly on complex structured surfaces. Mol. monolayer doping (MLD) is a potential approach, but is limited by the difficulty in depositing a high-quality SiO₂ capping film without damaging the dopant mol. layer. In this work, a relative humidity condition during deposition of the film in the sol-gel dip-coating process is found to produce continuous, dense and stoichiometric ultra-thin SiO₂ films of quality equivalent to that produced by complicated thermal oxidation/etching and sophisticated chem. vapor deposition and at. layer deposition methods. Applying these ultra-thin SiO₂ films as capping layers in the mol. MLD method, B doping in Si with sub-2 nm effective depth and sub-5 nm abrupt depth is achieved. Remarkably, around 82%-86% of doped B atoms in Si are found to be elec. active as estimated from sheet resistance measurements. The established sol-gel dip coating conditions to deposit ultra-thin SiO₂ films are generic and can be extended to produce high-quality ultra-thin films of other metal oxide materials required for advanced technol. applications.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Name: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: tert-Butyl 3-hydroxyazetidine-1-carboxylate

Pettersson, Martin;Campbell, Brian M.;Dounay, Amy B.;Gray, David L.;Xie, Longfei;O’Donnell, Christopher J.;Stratman, Nancy C.;Zoski, Kim;Drummond, Elena;Bora, Gary;Probert, Al;Whisman, Tammy research published 《 Design, synthesis, and pharmacological evaluation of azetidine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT_1A partial agonists》, the research content is summarized as follows. Compounds with combined norepinephrine reuptake inhibitor (NRI) and serotonin 1A (5-HT_1A) partial agonist pharmacol. may offer a new therapeutic approach for treating symptoms of neuropsychiatric disorders including ADHD, depression, and anxiety. Herein is described the design and optimization of novel chem. matter that exhibits favorable dual NRI and 5-HT_1A partial agonist activity. Lead compounds in this series were found to be devoid of activity at the dopamine transporter and were shown to be brain penetrant with high receptor occupancy.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Recommanded Product: tert-Butyl 3-hydroxyazetidine-1-carboxylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Application of C8H15NO3

Pryde, David C.;Corless, Martin;Fenwick, David R.;Mason, Helen J.;Stammen, Blanda C.;Stephenson, Peter T.;Ellis, David;Bachelor, David;Gordon, David;Barber, Christopher G.;Wood, Anthony;Middleton, Donald S.;Blakemore, David C.;Parsons, Gemma C.;Eastwood, Rachel;Platts, Michelle Y.;Statham, Keith;Paradowski, Kerry A.;Burt, Catherine;Klute, Wolfgang research published 《 The design and discovery of novel amide CCR5 antagonists》, the research content is summarized as follows. The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chem. strategy and SAR’s which led to the identification of the piperidine amide compounds I and II as excellent leads for further evaluation is described, along with key physicochem. data which highlighted their lead potential.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Application of C8H15NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts