Tag: M.W=150-200

Macedo, M. C. S. S. published the artcileIron corrosion inhibition by imidazoles in 3.5% NaCl medium: experimental and theoretical results, Application In Synthesis of 23351-09-9, the publication is Journal of the Electrochemical Society (2012), 159(4), C160-C169, database is CAplus.

This paper presents exptl. and theor. results concerning the corrosion inhibitor effect of imidazole and five of its derivatives on iron surface. Gravimetric methods and polarization curves were the exptl. techniques used in this study. The polarization curves showed that the inhibitors have an anodic role on the electrochem. process. Weight-loss measurements indicated that the adsorption process obeys Langmuir’s isotherm. The theor. study was done using ab initio calculations for the organic mols. and complexes formed between imidazoles and a Fe atom, a Fe²⁺ ion, and a Fe³⁺ ion. Correlations between structural properties of the compounds and their exptl. inhibitor efficiencies were analyzed. A satisfactory correlation between quantum-mech. parameters and inhibition efficiency was found.

Journal of the Electrochemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nicholson, William I. published the artcileDirect Amidation of Esters by Ball Milling, Quality Control of 6346-09-4, the publication is Angewandte Chemie, International Edition (2021), 60(40), 21868-21874, database is CAplus and MEDLINE.

The direct mechanochem. amidation of esters RC(O)OR¹ (R = Cy, Ph, pyridin-2-yl, etc.; R¹ = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R²NHR³ (R² = H, Me, Et; R³ = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R²R³ = -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-, -(CH₂)₆-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R²)R³ and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

Angewandte Chemie, International Edition published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Witty, David R. published the artcileSAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849, Formula: C10H15NO, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(18), 4865-4871, database is CAplus and MEDLINE.

We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques were utilized to allow rapid exploration of the structure-activity relationship around this template, leading to compound SB-568849 (I) which possessed good receptor affinity and selectivity. This compound proved to be an antagonist with stability in vivo, an acceptable brain-blood ratio and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H14BNO2, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khim, Seock-Kyu published the artcileDiscovery of novel and potent aryl diamines as leukotriene A₄ hydrolase inhibitors, Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(14), 3895-3898, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of a series of aryl diamines as inhibitors of LTA₄ hydrolase inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the di-Ph ether moiety and diamine spacer is discussed. The resulting compounds such as I have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karpe, Avinash V. published the artcileUntargeted Metabolic Profiling of Winery-Derived Biomass Waste Degradation by Penicillium chrysogenum, Formula: C6H10O7, the publication is Journal of Agricultural and Food Chemistry (2015), 63(49), 10696-10704, database is CAplus and MEDLINE.

Winery-derived biomass waste was degraded by Penicillium chrysogenum under solid state fermentation over 8 days in a ²H₂O-supplemented medium. Multivariate statistical anal. of the gas chromatog.-mass spectrometry (GC-MS) data resulted in the identification of 94 significant metabolites, within 28 different metabolic pathways. The majority of biomass sugars were utilized by day 4 to yield products such as sugars, fatty acids, isoprenoids, and amino acids. The fungus was observed to metabolize xylose to xylitol, an intermediate of ethanol production However, enzyme inhibition and autolysis were observed from day 6, indicating 5 days as the optimal time for fermentation P. chrysogenum displayed metabolism of pentoses (to alcs.) and degraded tannins and lignins, properties that are lacking in other biomass-degrading ascomycetes. Rapid fermentation (3-5 days) may not only increase the pentose metabolizing efficiency but also increase the yield of medicinally important metabolites, such as syringate.

Journal of Agricultural and Food Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gitis, Vitaly published the artcileOrganosilane oxidation by water catalysed by large gold nanoparticles in a membrane reactor, Recommanded Product: Triisopropylsilanol, the publication is Catalysis Science & Technology (2014), 4(7), 2156-2160, database is CAplus.

We show that gold nanoparticles catalyze the oxidation of organosilanes using water as oxidant at ambient conditions. Remarkably, monodispersions of small gold particles (3.5 nm diameter) and large ones (6-18 nm diameter) give equally good conversion rates. This is important because separating large nanoparticles is much easier, and can be done using ultrafiltration instead of nanofiltration. We introduce a simple setup, constructed inhouse, where the reaction products are extracted through a ceramic membrane under pressure, leaving the gold nanoparticles intact in the vessel. The nominal substrate/catalyst ratios are ca. 1800 : 1, with typical TONs of 1500-1600, and TOFs around 800 h^-1. But the actual activity of the large nanoparticles is much higher, because most of their gold atoms are “inside”, and therefore unavailable. Control experiments confirm that no gold escapes to the membrane permeate. The role of surface oxygen as a possible co-catalyst is discussed. Considering the ease of product separation and the robustness of the ceramic membrane, this approach opens opportunities for actual applications of gold catalysts in water oxidation reactions.

Catalysis Science & Technology published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fernandez-Jalao, Irene published the artcileImpact of high-pressure processed onion on colonic metabolism using a dynamic gastrointestinal digestion simulator, Formula: C8H8O3, the publication is Metabolites (2021), 11(5), 262, database is CAplus and MEDLINE.

Onions are the main dietary source of flavonols that have been associated with important health-promoting properties. Onion treated by high-pressure processing (HPP-treated onion) was subjected to a dynamic gastrointestinal digestion and colon fermentation simulator (DGID-CF) to study the effect on the gut microbiota metabolism in the three colon regions (ascending-AC, transverse-TC, and descending-DC) by means of chronic feeding with 27 g/day for 14 days. HPP-treated onion presented a high content of the flavonols quercetin-3,4-diglucoside and quercetin-4-glucoside, and a large percentage of them reached the AC without change. TC and DC progressively increased the total phenolic metabolites 2.5 times resp. to day 2, mainly 3-hydroxyphenylacetic, 4-hydroxyphenylacetic, 3-(4-hydroxyphenyl)-propionic, and 3,4-dihydroxyphenylpropionic acids. In addition, the chronic feeding increased the beneficial colon bacteria Bifidobacterium spp. and Lactobacillus spp. and the production of total SCFAs (acetic, propionic, and butyric acids) 9 times (AC), 2.2 times (TC), and 4.4 times (DC) resp. to day 1. A multivariate anal. (principal component anal., PCA) showed a clear separation between the three colon regions based on their phenolic composition (precursors and metabolites). These results showed that HPP-treated onion modulated the human gut microbiotas metabolism and the DGID-CF is a good system to study these changes.

Metabolites published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Santana, Alisson da Silva published the artcileSynergism between essential oils, promising alternative to control Sitophilus zeamais (Coleoptera: Curculionidae), Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Crop Protection (2022), 105882, database is CAplus.

Combinations of essential oils (EOs) are promising alternatives for pest management in storage grains. A high diversity of compounds in EOs and EO mixtures can increase their toxicity. Addnl., EOs can be useful in insecticide resistance programs. For this reason, we evaluated the fumigant toxicity and repellent effects of six essential oils (Dysphania ambrosioides, DA; Pelargonium graveolens, PE; Piper arboreum, PA; Piper diospyrifolium, PD; Piper gaudichaudianum, PG; and Piper tuberculatum, PT) sep. and in binary combinations against adults of Sitophilus zeamais (the maize weevil). First, the insecticidal activity of all possible combinations of the six EOs were assessed. Next, the concentrations needed to cause 50% and 90% mortality (LC50 and LC90, resp.) in the S. zeamais population were determined for the most toxic EOs and mixtures After that, the synergistic effect of the mixtures was also verified. Finally, the most toxic treatments were assessed to determine the time required to cause mortality of 50% of the population and check the repellent effects on S. zeamais. The binary mixtures of DA and PE, PT, PG, PD, and PA were the most toxic against S. zeamais. The LC50 and LC90 values for these treatments ranged between 1.77 and 2.25μL L-1 and from 2.42 to 7.64μL L-1, resp. The mixtures were more toxic than the EOs tested sep., which indicates the occurrence of synergistic effects. All treatments caused mortality of 50% of the population of S. zeamais in less than 42 h of exposure. In addition, the combinations DA + PE, DA + PT, DA + PG, and DA + PA were repellent to S. zeamais. Based on these results, we conclude that the mixtures of EOs evaluated in this study are highly promising for the control of S. zeamais populations and can also be used for resistance management of this species.

Crop Protection published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oliver-Meseguer, Judit published the artcileNanotitania catalyzes the chemoselective hydration and alkoxylation of epoxides, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Molecular Catalysis (2021), 111927, database is CAplus.

The com. available, inexpensive, non-toxic, solid and recyclable nanotitania catalyzed hydration and alkoxylation of epoxides, with water and primary and secondary alcs. but not with phenols, carboxylic acids and tertiary alcs was discussed. In this way, the chemoselective synthesis of different glycols and 1,4-dioxanones, and the implementation of nanotitania for the production in-flow of glycols and alkoxylated alcs., were achieved. Mechanistic studies supported the key role of vacancies in the nano-oxide catalyst.

Molecular Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rai, Roopa published the artcileTemozolomide analogs with improved brain/plasma ratios – Exploring the possibility of enhancing the therapeutic index of temozolomide, Application of 4,4-Diethoxybutan-1-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(20), 5103-5109, database is CAplus and MEDLINE.

Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA alkylation, but treatment is limited by its systemic toxicity and neutralization of DNA alkylation by upregulation of the O⁶-methylguanine-DNA methyltransferase gene. Both of these limiting factors can be addressed by achieving higher concentrations of TMZ in the brain. Our research has led to the discovery of new analogs of temozolomide with improved brain:plasma ratios when dosed in vivo in rats. These compounds are imidazotetrazine analogs, expected to act through the same mechanism as temozolomide. With reduced systemic exposure, these new agents have the potential to improve efficacy and therapeutic index in the treatment of glioblastoma.

Bioorganic & Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts