Tag: M.W=150-200

Marciniec, Bogdan published the artcileSynthesis, first structures, and catalytic activity of the monomeric rhodium(I)-siloxide phosphine complexes, Product Details of C9H22OSi, the publication is Canadian Journal of Chemistry (2003), 81(11), 1292-1298, database is CAplus.

Four new square-plane rhodium siloxide complexes of the general formula [Rh(cod)(PR₃‘)(OSiR₃)] (R = Me, i-Pr, O-t-Bu, R’ = Cy, Ph) were synthesized and the structures of three of them were resolved by the x-ray method. [Rh(cod)(PCy₃)(OSiMe₃)] (1) appeared to be a very efficient catalyst for hydrosilylation of allyl glycidyl ether to yield, selectively, 3-glycidoxypropyltriethoxysilane, a com. important silane coupling agent. Catalytic measurements and stoichiometric experiments of 1 with triethoxysilane suggest a mechanism where an unsaturated Rh-H species is responsible for the catalysis.

Canadian Journal of Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schuepbach, Bjoern published the artcileGrafting Organic n-Semiconductors to Surfaces: (Perfluoro-p-terphenyl-4-yl)alkanethiols, HPLC of Formula: 17877-23-5, the publication is European Journal of Organic Chemistry (2010), 3041-3048, database is CAplus.

Perfluoroterphenyl, an organic n-semiconductor, has been derivatized by short ω-mercaptoalkyl chains to permit the formation of self-assembled monolayers on semiconductor and coinage metal substrates. Because the perfluoroaryl rings are prone to nucleophilic attack, strategies for the introduction of the side chains had to be developed that avoid the use of any nucleophiles. Keeping this in mind, the resp. derivatives with one, two, and three methylene groups in the alkyl linker could be obtained in good yields. The crystal structure of one of the intermediates, (perfluoroterphenyl-4-yl)methanol, exhibits a parallel arrangement of the mols. as well as a helical structure of the perfluoroterphenyl part, which is in contrast to the structure found for most nonfluorinated terphenyl derivatives Using Au(111) as a test substrate, it could be demonstrated that all three thiols form dense monolayers with a pronounced odd-even effect governed by the parity of the number of methylene groups in the alkyl chain.

European Journal of Organic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, HPLC of Formula: 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gros, Philippe published the artcileFirst activation of sodium amide by polymer-supported alkoxides and amino-alkoxides, HPLC of Formula: 101-98-4, the publication is Reactive & Functional Polymers (2000), 43(1,2), 117-122, database is CAplus.

Polystyrene-supported alkoxides and amino-alkoxides are shown to act as efficient and reusable activating agents of sodium amide. This constitutes an unprecedented example of heterogeneous activation in sodium carbanion chem.

Reactive & Functional Polymers published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guan, Renpeng published the artcileDecarboxylative oxygenation of carboxylic acids with O₂via a non-heme manganese catalyst, HPLC of Formula: 90-64-2, the publication is Green Chemistry (2022), 24(7), 2946-2952, database is CAplus.

Decarboxylative oxygenation of carboxylic acids using a non-heme manganese catalyst under blue light irradiation with O₂ as the sole oxidant. Featuring mild reaction conditions, the protocol allowed readily available carboxylic acids to be converted into a wide variety of valuable aldehydes, ketones and amides. Mechanistic studies indicated that the decarboxylation and oxygenation involved the formation of active Mn-oxygen species.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Na-Na published the artcileA bifunctional probe based on naphthalene derivative for absorbance-ratiometic detection of Ag⁺ and fluorescence “turn-on” sensing of Zn²⁺ and its practical application in water samples, walnut and living cells, Application of 1-Hydroxy-2-naphthoic acid, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2020), 112299, database is CAplus.

In this work, naphthalene with good biocompatibility was selected, and the probe NBOS was synthesized with 2-Amino-phenol and 2-Amino-benzenethiol. The structure of probe NBOS was confirmed by X-ray Crystallog. Furthermore, the probe showed absorbance-ratiometic sensing for Ag⁺ over a pH range from 6 to 7.5 and fluorescence “turn on” signal response towards Zn²⁺ in the pH range of 6-10 in EtOH/H₂O (9/1, V/V, pH = 7.4) mixture The detection limit was obtained to be 4.24μM for Ag⁺ and 3.17 nM for Zn²⁺. Moreover, it could be efficiently recycled by treating Na₂EDTA. The sensing mechanism of probe NBOS toward Ag⁺ and Zn²⁺ was investigated by FT-IR, HNMR, job’plot and ESI-MS. Typically, the coordination mode of NBOS with Zn²⁺ was confirmed by DFT calculation Moreover, probe NBOS was successfully applied in the detection Ag⁺ and Zn²⁺ in real water samples. Importantly, probe NBOS could be used to detect Zn²⁺ in walnut and living cells. Based on the high throughput anal. strategy, absorbance and fluorescence signals of NBOS could be designed as a NOT and OR logic gate controlled by Ag⁺ (Input 1) and Zn²⁺ (Input 2).

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Jian-Dong published the artcileWettability-Driven Palladium Catalysis for Enhanced Dehydrogenative Coupling of Organosilanes, Name: Triisopropylsilanol, the publication is ACS Catalysis (2017), 7(3), 1720-1727, database is CAplus.

Direct coupling of Si-H bonds has emerged as a promising strategy for designing chem. and biol. useful organosilicon compounds Heterogeneous catalytic systems sufficiently active, selective, and durable for dehydrosilylation reactions under mild conditions have been lacking to date. Herein, we report that the hydrophobic characteristics of the underlying supports can be advantageously utilized to enhance the efficiency of palladium nanoparticles (Pd NPs) for the dehydrogenative coupling of organosilanes. As a result of this prominent surface wettability control, the modulated catalyst showed a significantly higher level of efficiency and durability characteristics toward the dehydrogenative condensation of organosilanes with water, alcs., or amines in comparison to existing catalysts. In a broader context, this work illustrates a powerful approach to maximize the performance of supported metals through surface wettability modulation under catalytically relevant conditions.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Name: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gross, Hans published the artcileα-Halo ethers. XII. Preparation of N-substituted pyrroles from 2,5-dicblorotetrahydrofuran, Product Details of C10H9NO, the publication is Chemische Berichte (1962), 2270-5, database is CAplus.

cf. CA 56, 12838b. 2,5-Di-Cl (I), 2,5-di-PrO (II), 2,5-di-AcO (III), and 2,5-di-BzO (IV) derivatives of tetrahydrofuran with primary amino derivatives gave in good yields the corresponding N-substituted pyrroles. The appropriate amine (0.065-0.07 mole) in 5 cc. dry dioxane treated dropwise with shaking during 1 min. with 2.82 g. I, boiled briefly, diluted after 15 min. with 20 cc. H₂O, and steam distilled, and the distillate extracted with Et₂O yielded the corresponding pyrrole; method A. The appropriate primary amine (0.015-0.018 mole) in 5 cc. dry C₅H₅N treated dropwise with 1.41 g. I, diluted with 50 cc. H₂O, acidified weakly with dilute HCl, and steam distilled or filtered gave the corresponding pyrrole derivative; method B. II (1.88 g.) and 0.013-0.015 mole amine and a granule of p-MeC₆H₄SO₃H refluxed a few min. with the removal of the PrOH, cooled, diluted with dilute AcOH, and filtered or steam distilled gave the corresponding pyrrole; method C; the runs with o-C₆H₄(NH₂)₂, p-HOC₆H₄NH₂, and p-O₂NC₆H₄NH₂ were refluxed 5-10 min. with 3 cc. AcOH instead of the p-MeC₆H₄SO₃H. III (1.88 g.) and 0.013-0.015 mole amine in 5 cc. AcOH refluxed 5 min., cooled, diluted with 50 cc. H₂O, and filtered gave the corresponding pyrrole; method D; the crude products from the runs with 2.21 g. IV were stirred with dilute NH₄OH and filtered; in the run with IV and cyclohexylamine the product was isolated by steam distillation By these methods were prepared the following 1-substituted pyrroles (1-substituent, m.p. or b.p./mm., % yield, starting material, and method used are given): Bu, 62-3°/18 (n²²_D 1.4734), 53, I, A; C₇H₁₅, 104.5-7.5°/12 (n²²_D 1.4717), 50, I, A; cyclohexyl (V), 95°/10 (n²¹_D 1.5125), 54, I, A; V, –, 50D, IV; PhCH₂, 116-19°/11 (n¹⁹_D 1.5690), 53, I, A; Ph, 61-2°, 64, I, B; Ph, –, 85, II, C; Ph, –, 65, IV, D; p-MeC₆H₄ (VI), 80-2°, 76, I, B; VI, –, 93, II, C; VI, –, 84, III, D; VI, –, 89, IV, D; 1-C₁₀H₇, 40°, 57, III, D; p-HOC₆H₄, 119-21°, 81, II, C; p-MeOC₆H₄ (VII), 111-13°, 65, I, B; VII, –, 57, II, C; VII, –, 68, III, D; VII, –, 68, IV, D; o-H₂NC₆H₄, 97-9°, 57, II, C; p-O₂NC₆H₄ (VIII), 180-1°, 87, II, C; VIII, –, 83, III, D; VIII, –, 96, IV, D; PhOCO, 46-7°, 28, II, C. H₂NCH₂CO₂Et (IX) (3.2 g.) in 5 cc. dioxane treated dropwise with stirring and cooling with 1.41 g. I during 2 min., warmed after 20 min., kept 3 hrs. at room-temperature, diluted with 40 cc. H₂O, and extracted with Et₂O, and the residue from the extract shaken 2 hrs. with concentrated NH₄OH and evaporated after 24 hrs. yielded 750 mg. 1-pyrrylacetamide, m. 166-7° (EtOAcEt₂O-petr. ether). IX treated in the usual manner with I, shaken 2 hrs. with aqueous N₂H₄, and kept 24 hrs. at room temperature yielded 36% 1-pyrrylacethydrazide, m. 119-21° (EtOAc-Et₂O-petr. ether). MeCH(NH₂)CO₂Et (1.7 g.) in 5 cc. C₅H₅N with 1.41 g. I and then with concentrated NH₄OH yielded 30% α-(1-pyrryl)propionamide, m. 90-2° (EtOAc-Et₂O-petr. ether). AcNH₂ (3.8 g.) in 10 cc. warm Me₂CO treated dropwise with 2.82 g. I, refluxed 20 min. with stirring, filtered, and evaporated, and the residue steam distd, gave 20% 1-acetylpyrrole, b₁₂ 70-1°, n²¹_D 1.5107. BzNH₂ (3 g.) in 20 cc. dioxane treated with about 2 g. Na₂SO₄, refluxed 10 min. with 2.82 g. I, cooled, diluted with 80 cc. H₂O, and extracted with Et₂O, and the residue steam distilled gave 1.0 g. colorless oil which boiled briefly with dilute aqueous NaOH and acidified gave 0.66 g. BzOH; the crude oily product consisted of at least 92% of 1-benzoylpyrrole. PhCH₂CONH₂ (1.4 g.) in 10 cc. MePh and 1.41 g. I refluxed 3 min., cooled, washed, and evaporated gave 0.77 g. 1-phenylacetylpyrrole, m. 72-4°. O-Butylurethan (2.4 g.) in 15 cc. MePh refluxed 3 min. with 2.82 g. I, the mixture worked up in the same manner, and the crude product steam distilled yielded 49% 1-carbobutoxypyrrole, b₁₂ 97°, n²¹ 1.4670. PhNHNH₂ and I (1.1 mole equivalent) gave by method B (CH₂CH:NNHPh)₂, yellowish leaflets, m. 123-4° (80% EtOH). PhCH₂O₂CNHNH₂ and I gave similarly (CH₂CH:NNHCO₂CH₂Ph)₂, needles, m. 219-21° (HCONMe₂).

Chemische Berichte published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Product Details of C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morlock, Gertrud E. published the artcileEffect-Directed Profiling of Monofloral Honeys from Ethiopia by High-Performance Thin-Layer Chromatography and High-Resolution Mass Spectrometry, HPLC of Formula: 90-64-2, the publication is Molecules (2022), 27(11), 3541, database is CAplus and MEDLINE.

Ethiopian honey is used not only as food but also for treatment in traditional medicine. For its valorization, bioactive compounds were analyzed in nine types of monofloral Ethiopian honey. Therefore, a non-target effect-directed profiling was developed via high-performance thin-layer chromatog. combined with multi-imaging and planar effect-directed assays. Characteristic bioactivity profiles of the different honeys were determined in terms of antibacterial, free-radical scavenging, and various enzyme inhibitory activities. Honeys from Hypoestes spp. and Leucas abyssinica showed low activity in all assays. In contrast, others from Acacia spp., Becium grandiflorum, Croton macrostachyus, Eucalyptus globulus, Schefflera abyssinica, Vernonia amygdalina, and Coffea arabica showed more intense activity profiles, but these differed depending on the assay. In particular, the radical scavenging activity of Croton macrostachyus and Coffea arabica honeys, the acetylcholinesterase-inhibiting activity of Eucalyptus globulus and Coffea arabica honeys, and the antibacterial activity of Schefflera abyssinica honey are highlighted. Bioactive compounds of interest were further characterized by high-resolution mass spectrometry. Identifying differences in bioactivity between mono-floral honey types affects quality designation and branding. Effect-directed profiling provides new insights that are valuable for food science and nutrition as well as for the market, and contributes to honey differentiation, categorization, and authentication.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileThree-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides, COA of Formula: C10H9NO, the publication is Journal of the American Chemical Society (2020), 142(22), 10173-10183, database is CAplus and MEDLINE.

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging mol. complexity from simple feedstocks. Unfortunately, carrying-out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different com. available nitrogen-, oxygen-, sulfur- or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy has been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone and tertiary amine products, some of which would be difficult to access via currently established methods.

Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileThree-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides, Recommanded Product: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2020), 142(22), 10173-10183, database is CAplus and MEDLINE.

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging mol. complexity from simple feedstocks. Unfortunately, carrying-out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different com. available nitrogen-, oxygen-, sulfur- or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy has been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone and tertiary amine products, some of which would be difficult to access via currently established methods.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts