Tag: M.W=150-200

Ibba, Francesco published the artcilePhotoinduced Multicomponent Synthesis of α-Silyloxy Acrylamides, an Unexplored Class of Silyl Enol Ethers, Synthetic Route of 17877-23-5, the publication is Organic Letters (2018), 20(4), 1098-1101, database is CAplus and MEDLINE.

The photoinduced, multicomponent reaction of α-diazoketones, silanols, and isocyanides affords α-silyloxy acrylamides, formally derived from α-keto amides. The presence of a secondary amido group makes classic preparative methods for silyl enol ethers unfeasible in this case, while the mild conditions required by this photochem. approach allow their synthesis in good yields; moreover, the general structure can be easily modified by varying each component of the multicomponent reaction. Fine-tuning of the reaction conditions (i.e., solvents, radiation, additives) can be exploited to obtain complete Z selectivity. The reactivity of this overlooked class of silyl enol ethers has been investigated, and features that could pave the way to new applications have been found.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salmon, Manuel published the artcileSubstituent effect on para-substituted N-phenylpyrrole monomers and their polyheterocyclic conductors, Quality Control of 23351-09-9, the publication is Journal of the Electrochemical Society (1984), 131(8), 1802-4, database is CAplus.

The electrochem. behavior of a variety of p-substituted N-phenylpyrrole monomers and their corresponding polymers was analyzed. The electron-attractive or electron-repulsive nature of each para group substituent was perceived in the pyrrole unit through the Ph ring and manifested in their oxidation potential values. Good linear correlations with Hammett σ⁺ constants were obtained.

Journal of the Electrochemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Westfall, Susan published the artcileOptimization of probiotic therapeutics using machine learning in an artificial human gastrointestinal tract, Formula: C8H8O3, the publication is Scientific Reports (2021), 11(1), 1067, database is CAplus and MEDLINE.

The gut microbiota’s metabolome is composed of bioactive metabolites that confer disease resilience. Probiotics’ therapeutic potential hinges on their metabolome altering ability; however, characterizing probiotics’ metabolic activity remains a formidable task. In order to solve this problem, an artificial model of the human gastrointestinal tract is introduced coined the ABIOME (A Bioreactor Imitation of the Microbiota Environment) and used to predict probiotic formulations’ metabolic activity and hence therapeutic potential with machine learning tools. The ABIOME is a modular yet dynamic system with real-time monitoring of gastrointestinal conditions that support complex cultures representative of the human microbiota and its metabolome. The fecal-inoculated ABIOME was supplemented with a polyphenol-rich prebiotic and combinations of novel probiotics that altered the output of bioactive metabolites previously shown to invoke anti-inflammatory effects. To dissect the synergistic interactions between exogenous probiotics and the autochthonous microbiota a multivariate adaptive regression splines (MARS) model was implemented towards the development of optimized probiotic combinations with therapeutic benefits. Using this algorithm, several probiotic combinations were identified that stimulated synergistic production of bioavailable metabolites, each with a different therapeutic capacity. Based on these results, the ABIOME in combination with the MARS algorithm could be used to create probiotic formulations with specific therapeutic applications based on their signature metabolic activity.

Scientific Reports published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H14O2, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cabrera-Afonso, Maria J. published the artcileSite-selective Oxidative Dearomatization of Phenols and Naphthols into ortho-Quinols or Epoxy ortho-Quinols using Oxone as the Source of Dimethyldioxirane, Computed Properties of 86-48-6, the publication is Advanced Synthesis & Catalysis (2019), 361(19), 4468-4473, database is CAplus.

A novel reactivity of dimethyldioxirane generated in-situ from oxone and acetone, with substituted phenols and naphthols was reported. This methodol. allowed the synthesis of ortho-quinols or epoxy ortho-quinols from a site-selective oxidative dearomatization process with good yields under very mild conditions. A short total synthesis of natural product lacinilene C Me ether was also described using this process as the key step.

Advanced Synthesis & Catalysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yasin Tabatabaei Dakhili, S. published the artcileRecombinant silicateins as model biocatalysts in organosiloxane chemistry, Computed Properties of 17877-23-5, the publication is Proceedings of the National Academy of Sciences of the United States of America (2017), 114(27), E5285-E5291, database is CAplus and MEDLINE.

The family of silicatein enzymes from marine sponges (phylum Porifera) is unique in nature for catalyzing the formation of inorganic silica structures, which the organisms incorporate into their skeleton. However, the synthesis of organosiloxanes catalyzed by these enzymes has thus far remained largely unexplored. To investigate the reactivity of these enzymes in relation to this important class of compounds, their catalysis of Si-O bond hydrolysis and condensation was investigated with a range of model organosilanols and silyl ethers. The enzymes’ kinetic parameters were obtained by a high-throughput colorimetric assay based on the hydrolysis of 4-nitrophenyl silyl ethers. These assays showed unambiguous catalysis with k_cat/K_m values on the order of 2-50 min^-1 μM^-1. Condensation reactions were also demonstrated by the generation of silyl ethers from their corresponding silanols and alcs. Notably, when presented with a substrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the latter group, in clear contrast to nonenzymic silylations. Furthermore, the silicateins are able to catalyze transetherifications, where the silyl group from one silyl ether may be transferred to a recipient alc. Despite close sequence homol. to the protease cathepsin L, the silicateins seem to exhibit no significant protease or esterase activity when tested against analogous substrates. Overall, these results suggest the silicateins are promising candidates for future elaboration into efficient and selective biocatalysts for organosiloxane chem.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C7H8BBrO3, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Fatima Alves Nonato, Carla published the artcileComparative analysis of chemical profiles and antioxidant activities of essential oils obtained from species of Lippia L. by chemometrics, Quality Control of 106-25-2, the publication is Food Chemistry (2022), 132614, database is CAplus and MEDLINE.

Due to the importance of diseases associated with oxidative stress, the search for natural antioxidants proves to be essential. This work aimed to compare the chem. composition and antioxidant potential of essential oils from the genus Lippia L. through chemometric anal. The essential oils were characterized by gas chromatog. coupled with mass spectrometry. Antioxidant potentials were determined by DPPH, ABTS, Deoxyribose and β-carotene protection, Iron chelation and reduction methods. All data were related by multivariate analyzes. Essential oils showed low similar chem. compositions and no statistically significant relationship. These showed relevant antioxidant activity, especially for L. sidoides that obtained IC50 of 5.22 ± 0.08μg/mL in ABTS capture. Multivariate analyzes showed the effectiveness of L. alba compounds to DPPH scavenging, Fe3+ reduction and β-carotene protection, and L. gracilis components to deoxyribose protect. Thus, studies proving the antioxidant potential of Lippia compounds against oxidative stress and their use in food conservation are fundamental.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Quality Control of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arrowsmith, John E. published the artcileLong-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents, Safety of 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (1986), 29(9), 1696-702, database is CAplus and MEDLINE.

Aminoalkoxymethyldihydropyridines I [R = Ph, substituted Ph, 1-naphthyl, 2-thienyl, 4-pyridyl; R¹ = (un)substituted NH₂; n = 2, 3] were prepared from RCHO, R¹(CH₂)_nOCH₂COCH₂CO₂Et, and H₂NCMe:CHCO₂Me or via I (R = N₃, phthalimido). Their potencies as Ca antagonists were determined I (R = 2-ClC₆H₄, R¹ = NH₂, n = 2) (amlodipine) was comparable in potency to nifedipine and had an elimination half-life of 30 h in dogs. Oral bioavailability approached 100%, and hemodynamic responses were gradual in onset and long-lasting in effect. The two enantiomers were prepared; the bulk of the activity resided with the (-)-isomer. X-ray crystallog. studies, carried out on I (R = 2-ClC₆H₄, R = morpholinosulfonyl, n = 2) suggest the existence of a weak H bond between the side-chain O and the H on the ring N.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Safety of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mero, Anna published the artcileHyaluronic Acid as a Protein Polymeric Carrier: An Overview and a Report on Human Growth Hormone, Application In Synthesis of 6346-09-4, the publication is Current Drug Targets (2015), 16(13), 1503-1511, database is CAplus and MEDLINE.

Hyaluronic acid (HA) is a natural polysaccharide primarily present in the vitreous humor and in cartilages where it plays a key structural role in organizing the cartilage extracellular matrix. HA is used in a wide range of applications including treatment of arthritis (as a viscosupplementation agent for joints) and in a variety of cosmetic injectable products. Its safety profile is thus well established. Thanks to its high biocompatibility and targeting properties, HA has also been investigated for use as a carrier of anticancer drugs and, recently, also of proteins. Its role in the last case is a particularly challenging one as dedicated coupling chemistries are required to preserve the protein′s conformation and activity. This study focuses on the state of the art on protein HAylation. New data from our laboratory on the local delivery of specific biologics to joints will also be outlined.

Current Drug Targets published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Li-na published the artcileEffect of metallic ions on the esterifying conversion of vitamin C, SDS of cas: 526-98-7, the publication is Liaoning Huagong (2014), 43(6), 713-714, database is CAplus.

The machines and pipes in chem. production industry are mainly made of metal. The corrosion can normally cause metallic ions to be separated from the equipments to diffuse into the product, which will lead to the deviation of the quality and productivity. In this paper, effect of iron ions coming from vitamin C production equipments on the esterifying conversion of vitamin C was investigated.

Liaoning Huagong published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C12H17NS2, SDS of cas: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dang, Ya-Li published the artcilePreparation of porous carbon spheres under different activation conditions from 2-keto-L-gulonic acid mother liquor for electric double-layer capacitor, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Waste and Biomass Valorization (2020), 11(8), 4429-4440, database is CAplus.

2-Keto-L-gulonic acid mother liquor (GAML) as an organic waste solution contained highly polluting contents would pollute the environment if discharged directly. As reported in our previous paper, GAML was used as the precursor to prepare porous carbon sphere (PCS) as carbon-based electrode materials of elec. double-layer capacitor (EDLC) to create its high value-added utilization, and in the carbonization process, Fe(NO₃)₃·9H₂O acted as an oxidizing agent. Since the carbon sphere was a carbon material with a special morphol., the effect of activation conditions (activation ratio, activation temperature and activation time) on the pore structure and the electrochem. performance of PCS were explored in this paper. PCS was derived via hydrothermal carbonization, carbonization and KOH activation successively, and the as-prepared samples had excellent porosity and high SSA of 2747 m² g^-1. Besides, the specific capacitance of PCS-7-700-1 could reach as high as 303.7 F g^-1 (206.5 F cm^-3) in 6 M KOH electrolyte at 40 mA g^-1.

Waste and Biomass Valorization published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts