Tag: M.W=150-200

Liu, Pin-jian published the artcileEstablishment and optimization of the two-dimensional gel electrophoresis for total protein in Bacillus cereus, Category: alcohols-buliding-blocks, the publication is Junshi Yixue (2012), 36(12), 942-945, 953, database is CAplus.

Objective: To establish a two-dimensional gel electrophoresis (2-DE) of proteome in Bacillus cereus and to explore how B. cereus stimulates the growth of Gluconobacter oxydans to produce 2-keto-L-gulonic acid (2-KLG) after entering the stationary phase. Methods: Different parameters, including protein preparation by different ultrasonic broken time, new type lysis, pH gradient and different sample of B. cereus protein, were used to evaluate the effect of 2-DE of proteins in B. cereus. Results and Conclusion: The clear background and reproducibility of 2-DE are established under conditions of 15 min of ultrasonic broken extraction, selection of protein cleavage I, pH 4-7, 24 cm IPG strips, 80 μg loading volume, and isoelec. focus at 60 V 15 min, and 120 V 6 h.

Junshi Yixue published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Liming published the artcileGelatin enhances 2-keto-L-gulonic acid production based on Ketogulonigenium vulgare genome annotation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Biotechnology (2011), 156(3), 182-187, database is CAplus and MEDLINE.

In the two-step fermentative production of vitamin C, its precursor 2-keto-L-gulonic acid (2-KLG) was synthesized by Ketogulonicigenium vulgare through co-culture with Bacillus megaterium. The reconstruction of the amino acid metabolic pathway through completed genome sequence annotation demonstrated that K. vulgare was deficient in one or more key enzymes in the de novo biosynthesis pathways of eight different amino acids (L-histidine, L-glycine, L-lysine, L-proline, L-threonine, L-methionine, L-leucine, and L-isoleucine). Among them, L-glycine, L-proline, L-threonine, and L-isoleucine play vital roles in K. vulgare growth and 2-KLG production The addition of those amino acids increased the 2-KLG productivity by 20.4%, 17.2%, 17.2%, and 11.8%, resp. Furthermore, food grade gelatin was developed as a substitute for the amino acids to increase the cell concentration, 2-KLG productivity, and L-sorbose consumption rate by 10.2%, 23.4%, and 20.9%, resp. As a result, the fermentation period decreased to 43 h in a 7-L fermentor.

Journal of Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Wei published the artcileRemote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of the American Chemical Society (2022), 144(29), 13071-13078, database is CAplus and MEDLINE.

Despite the frequent occurrence of γ-branched amines in bioactive mols., the direct catalytic asym. synthesis of this structural motif containing a remote stereocenter remains an important synthetic challenge. Here, authors report an amide-directed, rhodium-catalyzed highly diastereo- and enantioselective hydroboration of unactivated internal alkenes. This method provided facile access to enantioenriched amines containing β,γ-vicinal stereocenters. The application of this strategy to the synthesis of bioactive mols. was demonstrated. Computational studies indicated that migratory insertion of the alkene into rhodium hydride controls the enantioselectivity.

Journal of the American Chemical Society published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C15H21BO2, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Jun published the artcileIntestinal toxicity of micro- and nano-particles of foodborne titanium dioxide in juvenile mice: Disorders of gut microbiota-host co-metabolites and intestinal barrier damage, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Science of the Total Environment (2022), 153279, database is CAplus and MEDLINE.

The wide use of TiO2 particles in food and the high exposure risk to children have prompted research into the health risks of TiO2. We used the microbiome and targeted metabolomics to explore the potential mechanism of intestinal toxicity of foodborne TiO2 micro-/nanoparticles after oral exposure for 28 days in juvenile mice. Results showed that the gut microbiota-including the abundance of Bacteroides, Bifidobacterium, Lactobacillus, and Prevotella-changed dynamically during exposure. The organic inflammatory response was activated, and lipopolysaccharide levels increased. Intestinal toxicity manifested as increased mucosal permeability, impaired intestinal barrier, immune damage, and pathol. changes. The expression of antimicrobial peptides, occludin, and ZO-1 significantly reduced, while that of JNK2 and Src/pSrc increased. Compared with micro-TiO2 particles, the nano-TiO2 particles had strong toxicity. Fecal microbiota transplant confirmed the key role of gut microbiota in intestinal toxicity. The levels of gut microbiota-host co-metabolites, including pyroglutamic acid, L-glutamic acid, phenylacetic acid, and 3-hydroxyphenylacetic acid, changed significantly. Significant changes were observed in the glutathione and propanoate metabolic pathways. There was a significant correlation between the changes in gut microbiota, metabolites, and intestinal cytokine levels. These, together with the intestinal barrier damage signaling pathway, constitute the network mechanism of the intestinal toxicity of TiO2 particles.

Science of the Total Environment published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H11NO2, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Jianghao published the artcileStudy on Human Urinary Metabolic Profiles after Consumption of Kale and Daikon Radish using a High-resolution Mass Spectrometry-Based Non-targeted and Targeted Metabolomic Approach, Formula: C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2020), 68(48), 14307-14318, database is CAplus and MEDLINE.

In the present study, urine samples were collected from healthy human volunteers to determine the metabolic fates of phenolic compounds and glucosinolates after a single meal of kale and daikon radish. The major glucosinolates and phenolic compounds in kale and daikon radish were measured. The urinary metabolome after feeding at different time periods was investigated. A targeted metabolite anal. method was developed based on the known metabolic pathways for glucosinolates and phenolic compounds Using a targeted approach, a total of 18 metabolites were found in urine: 4 from phenolic compounds and 14 from glucosinolates. Among these metabolites, 4-methylsulfinyl-3-butenyl isothiocyanate, 4-methylsulfinyl-3-butenyl isothiocyanate-cysteine, and 4-methylsulfinyl-3-butenylglucosinolate-N-acetyl cysteine were reported for the first time in human urine. The combination of non-targeted and targeted metabolomic approaches can gain a full metabolite profile for human dietary intervention studies.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C5H9IO2, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatterjee, Maya published the artcileProduction of lactic acid mediated by compressed carbon dioxide on heterogeneous Ni(II) catalysts: a facile approach, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Green Chemistry (2022), 24(16), 6145-6155, database is CAplus.

Lactic acid is one of the appealing platform mols. in organic synthesis, currently in high demand after the innovation of bio-plastics. The limitations of traditional manufacturing routes (microbial process and chem. synthesis using petroleum resources) directed us to develop economically and environmentally viable catalytic strategies exploring renewable resources to meet the expected demand. In this study, we demonstrated a method of lactic acid synthesis by fixing CO₂ as a waste gas into acetaldehyde used as a biobased feedstock on a highly active, recyclable heterogeneous Ni catalyst. The significance of the developed process lies in the transformation of easily available low-cost starting materials to a high-value product without harsh reaction conditions, extra sensitive reagents, and addnl. steps to derive the right starting material or to remove impurities, which is advantageous in terms of sustainability. Moreover, the optimization of different reaction parameters ensures achieving high yields (>80%) and an excellent production rate of 6700μmol g^-1 h^-1. In addition, the characterization of the catalyst by different spectroscopic techniques suggested an interaction between the substrate and the catalyst, which provides an indication of the possible reaction path, thus a mechanism would be outlined. The successful extension of this process to various aldehydes was possible to produce their corresponding hydroxycarboxylic acid with broad functional group tolerance. Altogether, this methodol. opens up a promising avenue for the production of biochems. from renewable resources, which is a key to develop a sustainable society.

Green Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Le-Le published the artcilePredicting biological functions of compounds based on chemical-chemical interactions, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is PLoS One (2011), 6(12), e29491, database is CAplus and MEDLINE.

Given a compound, how can we effectively predict its biol. function. It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biol. processes and provide useful clues for drug design. In this study, based on the information of chem.-chem. interactions, a novel method was developed that can be used to identify which of the following eleven metabolic pathway classes a query compound may be involved with: (1) Carbohydrate Metabolism, (2) Energy Metabolism, (3) Lipid Metabolism, (4) Nucleotide Metabolism, (5) Amino Acid Metabolism, (6) Metabolism of Other Amino Acids, (7) Glycan Biosynthesis and Metabolism, (8) Metabolism of Cofactors and Vitamins, (9) Metabolism of Terpenoids and Polyketides, (10) Biosynthesis of Other Secondary Metabolites, (11) Xenobiotics Biodegradation and Metabolism It was observed that the overall success rate obtained by the method via the 5-fold cross-validation test on a benchmark dataset consisting of 3,137 compounds was 77.97%, which is much higher than 10.45%, the corresponding success rate obtained by the random guesses. Besides, to deal with the situation that some compounds may be involved with more than one metabolic pathway class, the method presented here is featured by the capacity able to provide a series of potential metabolic pathway classes ranked according to the descending order of their likelihood for each of the query compounds concerned. Furthermore, our method was also applied to predict 5,549 compounds whose metabolic pathway classes are unknown. Interestingly, the results thus obtained are quite consistent with the deductions from the reports by other investigators. It is anticipated that, with the continuous increase of the chem.-chem. interaction data, the current method will be further enhanced in its power and accuracy, so as to become a useful complementary vehicle in annotating uncharacterized compounds for their biol. functions. A dissertation.

PLoS One published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Dominguez, Raul published the artcileFood and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study, Related Products of alcohols-buliding-blocks, the publication is Molecular Nutrition & Food Research (2021), 65(23), 2100606, database is CAplus and MEDLINE.

Diet is considered an important modulator of cognitive decline and dementia, but the available evidence is, however, still fragmented and often inconsistent. The article studies the long-term prospective Three-City Cohort, which consists of two sep. nested case-control sample sets from different geog. regions (Bordeaux, n = 418; Dijon, n = 424). Cognitive decline is evaluated through five neuropsychol. tests (Mini-Mental State Examination, Benton Visual Retention Test, Isaac’s Set Test, Trail-Making Test part A, and Trail-Making Test part B). The food-related and microbiota-derived circulating metabolome is studied in participants free of dementia at baseline, by subjecting serum samples to large-scale quant. metabolomics anal. A protective association is found between metabolites derived from cocoa, coffee, mushrooms, red wine, the microbial metabolism of polyphenol-rich foods, and cognitive decline, as well as a neg. association with metabolites related to unhealthy dietary components, such as artificial sweeteners and alc. These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.

Molecular Nutrition & Food Research published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vlckova, Hana Kocova published the artcileFeaturing ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma, Product Details of C8H8O3, the publication is Journal of Separation Science (2021), 44(9), 1893-1903, database is CAplus and MEDLINE.

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments

Journal of Separation Science published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C13H26N2, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Semiz, Gurkan published the artcileChemical characterization of essential oil of local endemic Lamium Bilgilii Celep (Lamiaceae), Category: alcohols-buliding-blocks, the publication is Comptes Rendus de l’Academie Bulgare des Sciences (2022), 75(1), 34-42, database is CAplus.

In this study, the chem. constitution of the essential oil of Lamium bilgilii Celep, a local endemic species of Turkey, was studied by GC-MS for the first time. The essential oil was obtained by hydrodistillation method and forty-three compounds were successfully identified representing 98.2% of the oil. Bicyclogermacrene (14.22%) and linalyl acetate (8.33%) and linalool (7.86%) were the most abundant components of the essential oil. L. bilgilii essential oil was rich in sesquiterpenes (35.8%) and oxygenated monoterpenes (26.6%). The results showed that bicyclogermacrene was found, for the first time, as a most abundant component in the Lamium oils.

Comptes Rendus de l’Academie Bulgare des Sciences published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C7H5Cl2NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts